ATE361299T1 - Oligomere der gadolinium chelate, ihre verwendung als nmr-kontrastmittel und zwischenverbindungen - Google Patents
Oligomere der gadolinium chelate, ihre verwendung als nmr-kontrastmittel und zwischenverbindungenInfo
- Publication number
- ATE361299T1 ATE361299T1 AT03727569T AT03727569T ATE361299T1 AT E361299 T1 ATE361299 T1 AT E361299T1 AT 03727569 T AT03727569 T AT 03727569T AT 03727569 T AT03727569 T AT 03727569T AT E361299 T1 ATE361299 T1 AT E361299T1
- Authority
- AT
- Austria
- Prior art keywords
- oligomers
- contrast agents
- intermediate compounds
- line
- formulae
- Prior art date
Links
- 229910052688 Gadolinium Inorganic materials 0.000 title abstract 2
- UIWYJDYFSGRHKR-UHFFFAOYSA-N gadolinium atom Chemical compound [Gd] UIWYJDYFSGRHKR-UHFFFAOYSA-N 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 title 1
- 239000002872 contrast media Substances 0.000 title 1
- 239000008280 blood Substances 0.000 abstract 1
- 210000004369 blood Anatomy 0.000 abstract 1
- 239000013522 chelant Substances 0.000 abstract 1
- 238000002595 magnetic resonance imaging Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
- A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
- A61K49/10—Organic compounds
- A61K49/12—Macromolecular compounds
- A61K49/124—Macromolecular compounds dendrimers, dendrons, hyperbranched compounds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
- C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/08—Bridged systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6564—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms
- C07F9/6581—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and nitrogen atoms with or without oxygen or sulfur atoms, as ring hetero atoms
- C07F9/65812—Cyclic phosphazenes [P=N-]n, n>=3
- C07F9/65815—Cyclic phosphazenes [P=N-]n, n>=3 n = 3
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Molecular Biology (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- Radiology & Medical Imaging (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Magnetic Resonance Imaging Apparatus (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR0202791A FR2836916B1 (fr) | 2002-03-05 | 2002-03-05 | Oligomeres de chelates de gadolinium, leur application comme produits de contraste en imagerie par resonance magnetique et leurs intermediaires de synthese |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE361299T1 true ATE361299T1 (de) | 2007-05-15 |
Family
ID=27763565
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT03727569T ATE361299T1 (de) | 2002-03-05 | 2003-03-05 | Oligomere der gadolinium chelate, ihre verwendung als nmr-kontrastmittel und zwischenverbindungen |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US20070098643A1 (de) |
| EP (1) | EP1480979B1 (de) |
| AT (1) | ATE361299T1 (de) |
| AU (1) | AU2003233361A1 (de) |
| DE (1) | DE60313585T2 (de) |
| FR (1) | FR2836916B1 (de) |
| WO (1) | WO2003074523A2 (de) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2004307356A (ja) * | 2003-04-02 | 2004-11-04 | Hamamatsu Kagaku Gijutsu Kenkyu Shinkokai | 新規なデンドリマーおよび造影剤 |
| FR2856689A1 (fr) * | 2003-06-25 | 2004-12-31 | Guerbet Sa | Composes specifiques a forte relaxivite |
| FR2857967B1 (fr) * | 2003-07-25 | 2015-04-24 | Centre Nat Rech Scient | Complexes de lanthanide, leur preparation et leurs utilisations |
| FR2867473B1 (fr) | 2004-03-12 | 2006-06-23 | Guerbet Sa | Compose de porphyrines et utilisation a haut champ en irm |
| JP4956426B2 (ja) | 2004-07-02 | 2012-06-20 | ブラッコ・イメージング・ソシエタ・ペル・アチオニ | 高緩和能造影剤 |
| FR2883562B1 (fr) * | 2005-03-24 | 2009-02-27 | Guerbet Sa | Chelates lipophiles et leur utilisation en imagerie |
| US20060275217A1 (en) * | 2005-05-06 | 2006-12-07 | Caravan Peter D | Chemical exchange saturation transfer contrast agents |
| US8986650B2 (en) | 2005-10-07 | 2015-03-24 | Guerbet | Complex folate-NOTA-Ga68 |
| EP1940841B9 (de) | 2005-10-07 | 2017-04-19 | Guerbet | Verbindungen mit einem eine biologische zielstruktur erkennenden teil, das mit einem zum komplexieren von gallium fähigen signalteil gekoppelt ist |
| FR2891830B1 (fr) * | 2005-10-07 | 2011-06-24 | Guerbet Sa | Composes a chaines aminoalcools courtes et complexes metalliques pour l'imagerie medicale |
| AU2006321058B2 (en) * | 2005-12-02 | 2012-06-28 | Ge Healthcare As | Multimeric magentic resonance contrast agents |
| US20110038805A1 (en) * | 2008-04-18 | 2011-02-17 | Andreas Meijer | Compounds comprising paramagnetic chelates arranged around a central core and their use in magneto resonance imaging and spectroscopy |
| NO331773B1 (no) * | 2009-12-18 | 2012-03-26 | Ge Healthcare As | Mangankelater, sammensetninger omfattende slike og anvendelse av disse som kontrastmidler for magnettomografi (MR) |
| EP3101012A1 (de) | 2015-06-04 | 2016-12-07 | Bayer Pharma Aktiengesellschaft | Neue gadoliniumchelat-verbindung zur verwendung in der magnetresonanzbildgebung |
| GB201610738D0 (en) | 2016-06-20 | 2016-08-03 | Ge Healthcare As | Chelate compounds |
| RU2755181C2 (ru) | 2016-11-28 | 2021-09-14 | Байер Фарма Акциенгезельшафт | Новые хелатные соединения гадолиния с высокой релаксивностью для применения в магнитно-резонансной визуализации |
| FR3069245B1 (fr) * | 2017-07-21 | 2019-07-26 | Guerbet | Ligands macrocycliques lipophiles, leurs complexes ainsi que leurs utilisations medicales |
| ES2938015T3 (es) * | 2018-08-06 | 2023-04-03 | Bracco Imaging Spa | Agentes de contraste basados en PCTA que comprenden gadolinio |
| MX2021006024A (es) | 2018-11-23 | 2021-07-06 | Bayer Ag | Formulacion de medios de contraste y proceso para prepararlos. |
| CN111875667B (zh) * | 2020-07-16 | 2021-12-21 | 南方科技大学 | 有机金属螯合物及其制备方法与应用、探针 |
| EP4284443A1 (de) * | 2021-02-01 | 2023-12-06 | Inventure, LLC | Syntheseverfahren und zusammensetzungen mit niedrigem zwischen- und niedrigdichelat-zwischenkontrastmittel |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5567411A (en) * | 1986-11-10 | 1996-10-22 | State Of Oregon Acting By And Through The State Board Of Higher Education On Behalf Of The University Of Oregon | Dendritic amplifier molecules having multiple terminal active groups stemming from a benzyl core group |
| FR2736051B3 (fr) * | 1995-06-29 | 1997-09-26 | Guerbet Sa | Complexes metalliques de polyaminoacides, leur procede de preparation et leur utilisation en imagerie diagnostique |
| FR2772025B1 (fr) * | 1997-12-10 | 2000-03-03 | Guerbet Sa | Chelates metalliques de macrocycles polyaminocarboxyliques et leur application a l'imagerie par resonance magnetique |
| FR2794744B1 (fr) * | 1999-06-09 | 2001-09-21 | Guerbet Sa | Complexes metalliques de polyaminoacides bicycliques, leur procede de preparation et leur application en imagerie medicale |
-
2002
- 2002-03-05 FR FR0202791A patent/FR2836916B1/fr not_active Expired - Fee Related
-
2003
- 2003-03-05 EP EP03727569A patent/EP1480979B1/de not_active Expired - Lifetime
- 2003-03-05 DE DE60313585T patent/DE60313585T2/de not_active Expired - Fee Related
- 2003-03-05 AT AT03727569T patent/ATE361299T1/de not_active IP Right Cessation
- 2003-03-05 US US10/505,875 patent/US20070098643A1/en not_active Abandoned
- 2003-03-05 WO PCT/FR2003/000712 patent/WO2003074523A2/fr active IP Right Grant
- 2003-03-05 AU AU2003233361A patent/AU2003233361A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| FR2836916A1 (fr) | 2003-09-12 |
| WO2003074523A3 (fr) | 2004-03-25 |
| FR2836916B1 (fr) | 2004-06-11 |
| EP1480979A2 (de) | 2004-12-01 |
| AU2003233361A1 (en) | 2003-09-16 |
| WO2003074523A2 (fr) | 2003-09-12 |
| DE60313585T2 (de) | 2007-12-27 |
| US20070098643A1 (en) | 2007-05-03 |
| AU2003233361A8 (en) | 2003-09-16 |
| EP1480979B1 (de) | 2007-05-02 |
| DE60313585D1 (de) | 2007-06-14 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |