DE60312998D1 - 1-amido-4-phenyl-4-benzyloxymethyl-piperidin derivative und verwandte verbindungen als neurokinin-1 (nk-1) antagonsisten zur behandlung von erbrechen, depressionen, angstzustände und husten - Google Patents

1-amido-4-phenyl-4-benzyloxymethyl-piperidin derivative und verwandte verbindungen als neurokinin-1 (nk-1) antagonsisten zur behandlung von erbrechen, depressionen, angstzustände und husten

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Publication number
DE60312998D1
DE60312998D1 DE60312998T DE60312998T DE60312998D1 DE 60312998 D1 DE60312998 D1 DE 60312998D1 DE 60312998 T DE60312998 T DE 60312998T DE 60312998 T DE60312998 T DE 60312998T DE 60312998 D1 DE60312998 D1 DE 60312998D1
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Germany
Prior art keywords
husten
antagonsists
anxieties
neurokinin
benzyloxymethyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60312998T
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English (en)
Other versions
DE60312998T2 (de
Inventor
Neng-Yang Shih
Steven Wang
Gregory A Reichard
Dong Xiao
Cheng Wang
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Sharp and Dohme LLC
Original Assignee
Schering Corp
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Publication of DE60312998D1 publication Critical patent/DE60312998D1/de
Publication of DE60312998T2 publication Critical patent/DE60312998T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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    • A61P29/02—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] without antiinflammatory effect
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    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/92—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with a hetero atom directly attached to the ring nitrogen atom
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    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Addiction (AREA)
  • Diabetes (AREA)
  • Urology & Nephrology (AREA)
  • Hospice & Palliative Care (AREA)
  • Rheumatology (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Pulmonology (AREA)
  • Virology (AREA)
  • Endocrinology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Dermatology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Emergency Medicine (AREA)
  • AIDS & HIV (AREA)
  • Vascular Medicine (AREA)
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DE60312998T 2002-07-03 2003-07-02 1-amido-4-phenyl-4-benzyloxymethyl-piperidin derivative und verwandte verbindungen als neurokinin-1 (nk-1) antagonsisten zur behandlung von erbrechen, depressionen, angstzustände und husten Expired - Lifetime DE60312998T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US39370802P 2002-07-03 2002-07-03
US393708P 2002-07-03
PCT/US2003/020783 WO2004004722A1 (en) 2002-07-03 2003-07-02 1-amido-4-phenyl-4-benzyloxymethyl-piperidine derivatives and related compounds as neurokinin-1(nk-1) antagonists for the treatment of emesis, depression, anxiety and cough

Publications (2)

Publication Number Publication Date
DE60312998D1 true DE60312998D1 (de) 2007-05-16
DE60312998T2 DE60312998T2 (de) 2007-12-13

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DE60312998T Expired - Lifetime DE60312998T2 (de) 2002-07-03 2003-07-02 1-amido-4-phenyl-4-benzyloxymethyl-piperidin derivative und verwandte verbindungen als neurokinin-1 (nk-1) antagonsisten zur behandlung von erbrechen, depressionen, angstzustände und husten

Country Status (12)

Country Link
US (2) US7041682B2 (de)
EP (1) EP1536797B1 (de)
JP (1) JP4592077B2 (de)
CN (1) CN1678317B (de)
AT (1) ATE358482T1 (de)
AU (1) AU2003281213A1 (de)
CA (1) CA2490463A1 (de)
DE (1) DE60312998T2 (de)
ES (1) ES2285151T3 (de)
HK (1) HK1072006A1 (de)
MX (1) MXPA05000196A (de)
WO (1) WO2004004722A1 (de)

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AR066191A1 (es) * 2007-03-22 2009-08-05 Schering Corp Proceso e intermediarios para la sintesis de compuestos 8- [ ( 1- (3,5- bis- ( trifluorometil) fenil) - etoxi ) - metil]- 8 fenil - 1,7- diaza - espiro (4, 5) decan -2 ona
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ATE358482T1 (de) 2007-04-15
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US7041682B2 (en) 2006-05-09
EP1536797B1 (de) 2007-04-04
US20040072867A1 (en) 2004-04-15
JP2005535659A (ja) 2005-11-24
EP1536797A1 (de) 2005-06-08
DE60312998T2 (de) 2007-12-13
CA2490463A1 (en) 2004-01-15
WO2004004722A1 (en) 2004-01-15
CN1678317B (zh) 2010-10-27
US20060094720A1 (en) 2006-05-04
ES2285151T3 (es) 2007-11-16
JP4592077B2 (ja) 2010-12-01
CN1678317A (zh) 2005-10-05

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