DE60311731D1 - Verfahren zur rekombinanten Herstellung von Antifusogenikpeptide - Google Patents

Verfahren zur rekombinanten Herstellung von Antifusogenikpeptide

Info

Publication number
DE60311731D1
DE60311731D1 DE60311731T DE60311731T DE60311731D1 DE 60311731 D1 DE60311731 D1 DE 60311731D1 DE 60311731 T DE60311731 T DE 60311731T DE 60311731 T DE60311731 T DE 60311731T DE 60311731 D1 DE60311731 D1 DE 60311731D1
Authority
DE
Germany
Prior art keywords
peptide
antifusogenic
inclusion bodies
recombinant production
repeat
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60311731T
Other languages
English (en)
Other versions
DE60311731T2 (de
Inventor
Alexandra Kaczmarek
Erhard Kopetzki
Christian Schantz
Stefan Seeber
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Application granted granted Critical
Publication of DE60311731D1 publication Critical patent/DE60311731D1/de
Publication of DE60311731T2 publication Critical patent/DE60311731T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2740/00—Reverse transcribing RNA viruses
    • C12N2740/00011—Details
    • C12N2740/10011—Retroviridae
    • C12N2740/16011—Human Immunodeficiency Virus, HIV
    • C12N2740/16111—Human Immunodeficiency Virus, HIV concerning HIV env
    • C12N2740/16122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Virology (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Biotechnology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Microbiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biophysics (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • AIDS & HIV (AREA)
  • Pulmonology (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
DE60311731T 2002-11-19 2003-11-18 Verfahren zur rekombinanten Herstellung von Antifusogenikpeptide Expired - Lifetime DE60311731T2 (de)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
EP02025618 2002-11-19
EP02025618 2002-11-19
EP03000988 2003-01-17
EP03000988 2003-01-17

Publications (2)

Publication Number Publication Date
DE60311731D1 true DE60311731D1 (de) 2007-03-29
DE60311731T2 DE60311731T2 (de) 2007-10-31

Family

ID=32510122

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60311731T Expired - Lifetime DE60311731T2 (de) 2002-11-19 2003-11-18 Verfahren zur rekombinanten Herstellung von Antifusogenikpeptide

Country Status (11)

Country Link
US (1) US20050191729A1 (de)
EP (1) EP1422237B1 (de)
JP (1) JP3904553B2 (de)
KR (1) KR100553510B1 (de)
CN (1) CN1254542C (de)
AT (1) ATE353911T1 (de)
CA (1) CA2443365C (de)
DE (1) DE60311731T2 (de)
DK (1) DK1422237T3 (de)
ES (1) ES2280673T3 (de)
MX (1) MXPA03010433A (de)

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JP5148989B2 (ja) * 2007-12-27 2013-02-20 イーストマン コダック カンパニー 撮像装置
US8730351B2 (en) 2008-12-18 2014-05-20 Intellectual Ventures Fund 83 Llc Method for deleting data files in an electronic device
US8432461B2 (en) * 2008-12-18 2013-04-30 Apple Inc. Wireless camera with automatic wake-up and transfer capability and transfer status display
US20110205397A1 (en) * 2010-02-24 2011-08-25 John Christopher Hahn Portable imaging device having display with improved visibility under adverse conditions
US8957981B2 (en) 2010-03-03 2015-02-17 Intellectual Ventures Fund 83 Llc Imaging device for capturing self-portrait images
US20110228075A1 (en) * 2010-03-22 2011-09-22 Madden Thomas E Digital camera with underwater capture mode
US20110228074A1 (en) * 2010-03-22 2011-09-22 Parulski Kenneth A Underwater camera with presssure sensor
US8665340B2 (en) 2010-04-29 2014-03-04 Intellectual Ventures Fund 83 Llc Indoor/outdoor scene detection using GPS
US8605221B2 (en) 2010-05-25 2013-12-10 Intellectual Ventures Fund 83 Llc Determining key video snippets using selection criteria to form a video summary
US8599316B2 (en) 2010-05-25 2013-12-03 Intellectual Ventures Fund 83 Llc Method for determining key video frames
US8619150B2 (en) 2010-05-25 2013-12-31 Intellectual Ventures Fund 83 Llc Ranking key video frames using camera fixation
US8446490B2 (en) 2010-05-25 2013-05-21 Intellectual Ventures Fund 83 Llc Video capture system producing a video summary
US8432965B2 (en) 2010-05-25 2013-04-30 Intellectual Ventures Fund 83 Llc Efficient method for assembling key video snippets to form a video summary
US8520088B2 (en) 2010-05-25 2013-08-27 Intellectual Ventures Fund 83 Llc Storing a video summary as metadata
US8432456B2 (en) 2010-06-18 2013-04-30 Apple Inc. Digital camera for sharing digital images
US8970720B2 (en) 2010-07-26 2015-03-03 Apple Inc. Automatic digital camera photography mode selection
RU2013111677A (ru) 2010-08-30 2014-10-10 Ф. Хоффманн-Ля Рош Аг Конструкция для экспрессии у прокариот
WO2012028522A1 (en) 2010-08-30 2012-03-08 F. Hoffmann-La Roche Ag Alkaline feed
CN103068368A (zh) 2010-08-30 2013-04-24 霍夫曼-拉罗奇有限公司 产生四连蛋白-载脂蛋白a-i脂质颗粒的方法，脂质颗粒本身及其应用
CA2807448A1 (en) 2010-08-30 2012-03-08 F. Hoffmann-La Roche Ag Tetranectin-apolipoprotein a-i, lipid particles containing it and its use
CA2807441A1 (en) 2010-08-30 2012-03-08 F. Hoffmann-La Roche Ag Method for producing a lipid particle, the lipid particle itself and its use
RU2013113723A (ru) 2010-09-14 2014-10-20 Ф.Хоффманн-Ля Рош Аг Гибридный полипептид с серпиновым "пальцем"
US8494301B2 (en) 2010-09-16 2013-07-23 Eastman Kodak Company Refocusing images using scene captured images
US8643734B2 (en) 2010-11-10 2014-02-04 Apple Inc. Automatic engagement of image stabilization
US9013602B2 (en) 2011-01-03 2015-04-21 Intellectual Ventures Fund 83 Llc Digital camera system having a retail mode
US8428308B2 (en) 2011-02-04 2013-04-23 Apple Inc. Estimating subject motion for capture setting determination
US8379934B2 (en) 2011-02-04 2013-02-19 Eastman Kodak Company Estimating subject motion between image frames
US8736697B2 (en) 2011-03-25 2014-05-27 Apple Inc. Digital camera having burst image capture mode
US8736704B2 (en) 2011-03-25 2014-05-27 Apple Inc. Digital camera for capturing an image sequence
US8736716B2 (en) 2011-04-06 2014-05-27 Apple Inc. Digital camera having variable duration burst mode
KR20140054115A (ko) 2011-08-25 2014-05-08 에프. 호프만-라 로슈 아게 단축 테트라넥틴-아포지단백질 a-i 융합 단백질, 그를 함유하는 지질 입자 및 그의 용도
EP2820040A1 (de) 2012-02-29 2015-01-07 F. Hoffmann-La Roche AG Verfahren zur reduktion von 1->2 leserahmenverschiebungen
CN104245937B (zh) 2012-04-17 2021-09-21 弗·哈夫曼-拉罗切有限公司 使用修饰的核酸表达多肽的方法
PL2959006T3 (pl) 2013-02-22 2018-11-30 F.Hoffmann-La Roche Ag Zastosowanie szczepu prokariotycznego z usuniętą auksotrofią aminokwasową do produkcji rekombinacyjnej polipeptydu
CN111303245B (zh) * 2020-02-21 2023-06-27 成都奥达生物科技有限公司 一种抗合胞病毒膜融合抑制剂
CN113004375B (zh) * 2021-03-15 2022-07-01 华南农业大学 一种高效介导重组多肽形成包涵体的小分子蛋白

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US5656456A (en) * 1992-07-13 1997-08-12 Bionebraska, Inc. Chemical method for selective modification of the N- and/or C-terminal amino acid α-carbon reactive group of a recombinant polypeptide or a portion thereof
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US6017536A (en) * 1993-06-07 2000-01-25 Trimeris, Inc. Simian immunodeficiency virus peptides with antifusogenic and antiviral activities
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CN1351611A (zh) * 1999-05-17 2002-05-29 康久化学公司 病毒感染的长效融合肽抑制剂
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KR100614714B1 (ko) * 2001-06-15 2006-08-21 에프. 호프만-라 로슈 아게 ｇｐ41 단편의 아세틸화

Also Published As

Publication number Publication date
KR20040044372A (ko) 2004-05-28
CN1502698A (zh) 2004-06-09
ES2280673T3 (es) 2007-09-16
US20050191729A1 (en) 2005-09-01
ATE353911T1 (de) 2007-03-15
CA2443365A1 (en) 2004-05-19
MXPA03010433A (es) 2004-10-15
KR100553510B1 (ko) 2006-02-20
JP3904553B2 (ja) 2007-04-11
EP1422237A3 (de) 2004-10-06
EP1422237A2 (de) 2004-05-26
EP1422237B1 (de) 2007-02-14
DK1422237T3 (da) 2007-06-11
DE60311731T2 (de) 2007-10-31
JP2004166703A (ja) 2004-06-17
CN1254542C (zh) 2006-05-03
CA2443365C (en) 2010-01-12

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