DE60305813D1 - Stabile Oxazaphosphorin-2-Mercaptoethansulphonat Formulierungen - Google Patents

Stabile Oxazaphosphorin-2-Mercaptoethansulphonat Formulierungen

Info

Publication number
DE60305813D1
DE60305813D1 DE60305813T DE60305813T DE60305813D1 DE 60305813 D1 DE60305813 D1 DE 60305813D1 DE 60305813 T DE60305813 T DE 60305813T DE 60305813 T DE60305813 T DE 60305813T DE 60305813 D1 DE60305813 D1 DE 60305813D1
Authority
DE
Germany
Prior art keywords
mercaptoethanesulphonate
oxazaphosphorine
cyclodextrin
formulations
beta
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60305813T
Other languages
English (en)
Other versions
DE60305813T2 (de
Inventor
Gautam Vinod Daftary
Srikanth Annappa Pai
Sangeeta Hanurmesh Rivankar
Kumar Subbappa Praveen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bharat Serums and Vaccines Ltd
Original Assignee
Bharat Serums and Vaccines Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bharat Serums and Vaccines Ltd filed Critical Bharat Serums and Vaccines Ltd
Publication of DE60305813D1 publication Critical patent/DE60305813D1/de
Application granted granted Critical
Publication of DE60305813T2 publication Critical patent/DE60305813T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/716—Glucans
    • A61K31/724—Cyclodextrins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/02—Antidotes

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Molecular Biology (AREA)
  • Urology & Nephrology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Toxicology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Detergent Compositions (AREA)
DE60305813T 2002-09-05 2003-09-05 Stabile Oxazaphosphorin-2-Mercaptoethansulphonat Formulierungen Expired - Lifetime DE60305813T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
INMU08092002 2002-09-05
IN809MU2002 2002-09-05

Publications (2)

Publication Number Publication Date
DE60305813D1 true DE60305813D1 (de) 2006-07-20
DE60305813T2 DE60305813T2 (de) 2007-06-28

Family

ID=31503923

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60305813T Expired - Lifetime DE60305813T2 (de) 2002-09-05 2003-09-05 Stabile Oxazaphosphorin-2-Mercaptoethansulphonat Formulierungen

Country Status (16)

Country Link
US (1) US20050272698A1 (de)
EP (1) EP1396268B1 (de)
JP (1) JP2006508917A (de)
KR (1) KR101037313B1 (de)
CN (1) CN1694713A (de)
AT (1) ATE328598T1 (de)
AU (1) AU2003276689B2 (de)
BR (1) BR0314068A (de)
CA (1) CA2497898C (de)
DE (1) DE60305813T2 (de)
EA (1) EA008776B1 (de)
ES (1) ES2266734T3 (de)
MX (1) MXPA05002453A (de)
NZ (1) NZ538584A (de)
WO (1) WO2004022699A2 (de)
ZA (1) ZA200501869B (de)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR0316968A (pt) * 2002-12-02 2005-10-25 Bharat Serums & Vaccines Ltd Composições estáveis, claras, aquosas de ifosfamida para administração parenteral que apresentam pouca toxicidade; processo para a preparação de composições de ifosfamida; e composições de ifosfamida e um processo para a preparação das mesmas
ES2369776T3 (es) * 2003-10-01 2011-12-05 Baxter International Inc. Nueva utilización, preparados farmacéuticos y procedimiento para su producción.
DE10346134A1 (de) * 2003-10-01 2005-04-21 Baxter Healthcare Sa Neue Verwendung, pharmazeutische Zubereitungen sowie Verfahren zu deren Herstellung
EP1799266A2 (de) * 2004-09-13 2007-06-27 Bharat Serums & Vaccines Ltd. Stabile emulsionszusammensetzungen für die intravenöse verabreichung mit antimikrobiell erhaltender wirksamkeit
EP1957082B1 (de) * 2005-12-02 2012-04-11 The Johns Hopkins University Verwendung von hochdosierten oxazaphosphorin-arzneimitteln zur behandlung von immunstörungen
WO2008034074A2 (en) 2006-09-15 2008-03-20 The Johns Hopkins University Cyclosphosphamide in combination with anti-idiotypic vaccines
WO2008034071A2 (en) 2006-09-15 2008-03-20 The Johns Hopkins University Method of identifying patients suitable for high-dose cyclophosphamide treatment
WO2008034076A2 (en) 2006-09-15 2008-03-20 The Johns Hopkins University Cyclophosphamide in combination with immune therapeutics
US9026372B2 (en) * 2007-11-21 2015-05-05 Accentia Biopharmaceuticals, Inc. Methods for providing a system of care for a high-dose oxazaphosphorine drug regimen
WO2009067690A2 (en) * 2007-11-21 2009-05-28 Accentia Biopharmaceuticals, Inc. Methods for safe and effective treatment using oxazaphosphorine drugs
WO2016005962A2 (en) 2014-07-11 2016-01-14 Dr. Reddy’S Laboratories Limited Stable liquid formulations of cyclophosphamide and processes
US10849916B2 (en) 2014-07-11 2020-12-01 Dr. Reddys Laboratories Limited Stable liquid formulations of cyclophosphamide and its impurities

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0002495B1 (de) * 1977-12-14 1984-02-15 Asta-Werke Aktiengesellschaft Chemische Fabrik Erzeugnisse zur Anwendung in der cytostatischen Therapie
US4727064A (en) * 1984-04-25 1988-02-23 The United States Of America As Represented By The Department Of Health And Human Services Pharmaceutical preparations containing cyclodextrin derivatives
US6407079B1 (en) * 1985-07-03 2002-06-18 Janssen Pharmaceutica N.V. Pharmaceutical compositions containing drugs which are instable or sparingly soluble in water and methods for their preparation
EP0254902B1 (de) * 1986-07-11 1991-08-28 ASTA Pharma Aktiengesellschaft Lösungen von Oxazaphosphorinen mit verbesserter Stabilität und Verfahren zu deren Herstellung
NO873860L (no) * 1986-10-31 1988-05-02 Asta Pharma Ag Ifosfamid-lyofilisat og fremgangsmaate til deres fremstilling.
US4879286A (en) * 1987-01-28 1989-11-07 Lyphomed, Inc. Cyclophosphamide
DE58900183D1 (de) * 1988-03-19 1991-08-29 Asta Pharma Ag Ifosfamid-mesna-lyophilisat und verfahren zu dessen herstellung.
IE62095B1 (en) * 1988-03-29 1994-12-14 Univ Florida Pharmaceutical formulations for parenteral use
EP0491812A4 (en) * 1989-09-14 1992-11-04 Australian Commercial Research & Development Limited Drug delivery compositions
US5227373A (en) * 1991-10-23 1993-07-13 Bristol-Myers Squibb Co. Lyophilized ifosfamide compositions
US5602112A (en) * 1992-06-19 1997-02-11 Supergen, Inc. Pharmaceutical formulation
SI9300470A (en) * 1993-09-10 1995-04-30 Lek Tovarna Farmacevtskih Inclusion complexes of optically active and racemic ibuproxan with cyclodextrin derivates,process for their preparation,pharmaceutical preparations comprising the same and their use
US5919816A (en) * 1994-11-14 1999-07-06 Bionumerik Pharmaceuticals, Inc. Formulations and methods of reducing toxicity of antineoplastic agents
PL178713B1 (pl) * 1995-03-31 2000-06-30 Centrum Badan Molekularnych I Makromolekularnych Pan Środek farmaceutyczny o działaniu przeciwnowotworowym
DE19733305A1 (de) * 1997-08-01 1999-02-04 Asta Medica Ag Pharmazeutische Zusammensetzung enthaltend Ifosfamid und Carnitin
ITMI20011338A1 (it) 2001-06-26 2002-12-26 Farmatron Ltd Composizioni farmaceutiche orali a rilascio immediato del principio attivo

Also Published As

Publication number Publication date
ATE328598T1 (de) 2006-06-15
JP2006508917A (ja) 2006-03-16
KR20050057229A (ko) 2005-06-16
EA008776B1 (ru) 2007-08-31
MXPA05002453A (es) 2005-05-27
CA2497898C (en) 2012-02-07
ZA200501869B (en) 2007-11-28
EP1396268B1 (de) 2006-06-07
ES2266734T3 (es) 2007-03-01
AU2003276689B2 (en) 2009-04-09
CA2497898A1 (en) 2004-03-18
DE60305813T2 (de) 2007-06-28
EP1396268A1 (de) 2004-03-10
US20050272698A1 (en) 2005-12-08
AU2003276689A1 (en) 2004-03-29
KR101037313B1 (ko) 2011-05-26
WO2004022699A3 (en) 2005-03-24
NZ538584A (en) 2007-05-31
EA200500315A1 (ru) 2005-08-25
CN1694713A (zh) 2005-11-09
BR0314068A (pt) 2005-07-05
WO2004022699A2 (en) 2004-03-18

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Legal Events

Date Code Title Description
8328 Change in the person/name/address of the agent

Representative=s name: JUNG, SCHIRDEWAHN, GRUENBERG, SCHNEIDER PATENTANWAELTE

8364 No opposition during term of opposition
8328 Change in the person/name/address of the agent

Representative=s name: ADVOTEC. PATENT- UND RECHTSANWAELTE, 80538 MUENCHE