EA200500315A1 - Жидкая стабильная композиция оксазафосфорина с месной - Google Patents

Жидкая стабильная композиция оксазафосфорина с месной

Info

Publication number
EA200500315A1
EA200500315A1 EA200500315A EA200500315A EA200500315A1 EA 200500315 A1 EA200500315 A1 EA 200500315A1 EA 200500315 A EA200500315 A EA 200500315A EA 200500315 A EA200500315 A EA 200500315A EA 200500315 A1 EA200500315 A1 EA 200500315A1
Authority
EA
Eurasian Patent Office
Prior art keywords
mesna
oxazaphosphorin
cyclodextrin
stable composition
liquid stable
Prior art date
Application number
EA200500315A
Other languages
English (en)
Other versions
EA008776B1 (ru
Inventor
Гаутам Винод Дафтари
Срикантх Аннаппа Паи
Санджита Ханурмеш Риванкар
Кумар Суббаппа Правин
Original Assignee
Бхарат Сирумс Энд Вэксинс Лтд.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Бхарат Сирумс Энд Вэксинс Лтд. filed Critical Бхарат Сирумс Энд Вэксинс Лтд.
Publication of EA200500315A1 publication Critical patent/EA200500315A1/ru
Publication of EA008776B1 publication Critical patent/EA008776B1/ru

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/716—Glucans
    • A61K31/724—Cyclodextrins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/02—Antidotes

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Molecular Biology (AREA)
  • Urology & Nephrology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Toxicology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Detergent Compositions (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Описаны имеющие низкую токсичность, стабильные, содержащие оксазафосфорин композиции с месной для парентерального введения. Способ, по существу, требует добавления оксазафосфоринового противоопухолевого средства к водному раствору превращенного в простой эфир β-циклодекстрина с последующим добавлением месны как таковой или в виде водного раствора, содержащего, необязательно, превращенный в простой эфир β-циклодекстрин. Оксазафосфориновым противоопухолевым средством предпочтительно является ифосфамид и превращенным в простой эфир β-циклодекстрином является 2-гидроксипропил-β-циклодекстрин.Отчет о международном поиске был опубликован 2005.03.24.
EA200500315A 2002-09-05 2003-09-04 Жидкая стабильная композиция оксазафосфорина с месной EA008776B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN809MU2002 2002-09-05
PCT/IN2003/000298 WO2004022699A2 (en) 2002-09-05 2003-09-04 Liquid stable composition of oxazaphosphorine with mesna

Publications (2)

Publication Number Publication Date
EA200500315A1 true EA200500315A1 (ru) 2005-08-25
EA008776B1 EA008776B1 (ru) 2007-08-31

Family

ID=31503923

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200500315A EA008776B1 (ru) 2002-09-05 2003-09-04 Жидкая стабильная композиция оксазафосфорина с месной

Country Status (16)

Country Link
US (1) US20050272698A1 (ru)
EP (1) EP1396268B1 (ru)
JP (1) JP2006508917A (ru)
KR (1) KR101037313B1 (ru)
CN (1) CN1694713A (ru)
AT (1) ATE328598T1 (ru)
AU (1) AU2003276689B2 (ru)
BR (1) BR0314068A (ru)
CA (1) CA2497898C (ru)
DE (1) DE60305813T2 (ru)
EA (1) EA008776B1 (ru)
ES (1) ES2266734T3 (ru)
MX (1) MXPA05002453A (ru)
NZ (1) NZ538584A (ru)
WO (1) WO2004022699A2 (ru)
ZA (1) ZA200501869B (ru)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE60332385D1 (de) * 2002-12-02 2010-06-10 Bharat Serums & Vaccines Ltd Ifosfamid-zusammensetzungen zur parenteralen verabreichung und verfahren für ihre herstellung
DE10346134A1 (de) * 2003-10-01 2005-04-21 Baxter Healthcare Sa Neue Verwendung, pharmazeutische Zubereitungen sowie Verfahren zu deren Herstellung
PT1667655E (pt) * 2003-10-01 2011-08-18 Baxter Int NOVA UTILIZAÇÃO, PREPARAÇÕES FARMACjUTICAS ASSIM COMO O PROCESSO PARA A SUA PRODUÇÃO
US20080262084A1 (en) * 2004-09-13 2008-10-23 Gautam Vinod Daftary Stable Emulsion Compositions for Intravenous Administration Having Preservatie Efficacy
EP1957082B1 (en) * 2005-12-02 2012-04-11 The Johns Hopkins University Use of high-dose oxazaphosphorine drugs for treating immune disorders
WO2008034076A2 (en) 2006-09-15 2008-03-20 The Johns Hopkins University Cyclophosphamide in combination with immune therapeutics
WO2008034071A2 (en) 2006-09-15 2008-03-20 The Johns Hopkins University Method of identifying patients suitable for high-dose cyclophosphamide treatment
WO2008034074A2 (en) 2006-09-15 2008-03-20 The Johns Hopkins University Cyclosphosphamide in combination with anti-idiotypic vaccines
US9026372B2 (en) * 2007-11-21 2015-05-05 Accentia Biopharmaceuticals, Inc. Methods for providing a system of care for a high-dose oxazaphosphorine drug regimen
WO2009067690A2 (en) * 2007-11-21 2009-05-28 Accentia Biopharmaceuticals, Inc. Methods for safe and effective treatment using oxazaphosphorine drugs
US10849916B2 (en) 2014-07-11 2020-12-01 Dr. Reddys Laboratories Limited Stable liquid formulations of cyclophosphamide and its impurities
WO2016005962A2 (en) 2014-07-11 2016-01-14 Dr. Reddy’S Laboratories Limited Stable liquid formulations of cyclophosphamide and processes

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4220660A (en) * 1977-12-14 1980-09-02 Asta-werke Aktiengesellschaft, Chemische Farik Process for the treatment of humans suffering from undesired urotoxic side effects caused by cytostatically active alkylating agents
US4727064A (en) * 1984-04-25 1988-02-23 The United States Of America As Represented By The Department Of Health And Human Services Pharmaceutical preparations containing cyclodextrin derivatives
US6407079B1 (en) * 1985-07-03 2002-06-18 Janssen Pharmaceutica N.V. Pharmaceutical compositions containing drugs which are instable or sparingly soluble in water and methods for their preparation
DE3772482D1 (de) * 1986-07-11 1991-10-02 Asta Pharma Ag Loesungen von oxazaphosphorinen mit verbesserter stabilitaet und verfahren zu deren herstellung.
NO873860L (no) * 1986-10-31 1988-05-02 Asta Pharma Ag Ifosfamid-lyofilisat og fremgangsmaate til deres fremstilling.
US4879286A (en) * 1987-01-28 1989-11-07 Lyphomed, Inc. Cyclophosphamide
EP0334083B1 (de) * 1988-03-19 1991-07-24 ASTA Pharma Aktiengesellschaft Ifosfamid-Mesna-Lyophilisat und Verfahren zu dessen Herstellung
IE62095B1 (en) * 1988-03-29 1994-12-14 Univ Florida Pharmaceutical formulations for parenteral use
EP0491812A4 (en) * 1989-09-14 1992-11-04 Australian Commercial Research & Development Limited Drug delivery compositions
US5227373A (en) * 1991-10-23 1993-07-13 Bristol-Myers Squibb Co. Lyophilized ifosfamide compositions
US5602112A (en) * 1992-06-19 1997-02-11 Supergen, Inc. Pharmaceutical formulation
SI9300470A (en) * 1993-09-10 1995-04-30 Lek Tovarna Farmacevtskih Inclusion complexes of optically active and racemic ibuproxan with cyclodextrin derivates,process for their preparation,pharmaceutical preparations comprising the same and their use
US5919816A (en) * 1994-11-14 1999-07-06 Bionumerik Pharmaceuticals, Inc. Formulations and methods of reducing toxicity of antineoplastic agents
PL178713B1 (pl) * 1995-03-31 2000-06-30 Centrum Badan Molekularnych I Makromolekularnych Pan Środek farmaceutyczny o działaniu przeciwnowotworowym
DE19733305A1 (de) * 1997-08-01 1999-02-04 Asta Medica Ag Pharmazeutische Zusammensetzung enthaltend Ifosfamid und Carnitin
ITMI20011338A1 (it) * 2001-06-26 2002-12-26 Farmatron Ltd Composizioni farmaceutiche orali a rilascio immediato del principio attivo

Also Published As

Publication number Publication date
WO2004022699A3 (en) 2005-03-24
ES2266734T3 (es) 2007-03-01
JP2006508917A (ja) 2006-03-16
DE60305813T2 (de) 2007-06-28
CA2497898A1 (en) 2004-03-18
ATE328598T1 (de) 2006-06-15
DE60305813D1 (de) 2006-07-20
EP1396268A1 (en) 2004-03-10
NZ538584A (en) 2007-05-31
CA2497898C (en) 2012-02-07
ZA200501869B (en) 2007-11-28
AU2003276689B2 (en) 2009-04-09
EA008776B1 (ru) 2007-08-31
KR101037313B1 (ko) 2011-05-26
AU2003276689A1 (en) 2004-03-29
EP1396268B1 (en) 2006-06-07
US20050272698A1 (en) 2005-12-08
MXPA05002453A (es) 2005-05-27
BR0314068A (pt) 2005-07-05
CN1694713A (zh) 2005-11-09
WO2004022699A2 (en) 2004-03-18
KR20050057229A (ko) 2005-06-16

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Legal Events

Date Code Title Description
MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): RU