DE60303040D1 - Dihydro-dibenzo[b,e]oxepin-basierte, selektive oestrogen-rezeptor modulatoren, zusammensetzungen und methoden - Google Patents

Dihydro-dibenzo[b,e]oxepin-basierte, selektive oestrogen-rezeptor modulatoren, zusammensetzungen und methoden

Info

Publication number
DE60303040D1
DE60303040D1 DE60303040T DE60303040T DE60303040D1 DE 60303040 D1 DE60303040 D1 DE 60303040D1 DE 60303040 T DE60303040 T DE 60303040T DE 60303040 T DE60303040 T DE 60303040T DE 60303040 D1 DE60303040 D1 DE 60303040D1
Authority
DE
Germany
Prior art keywords
sub
sup
alkyl
methods
oxepin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE60303040T
Other languages
English (en)
Other versions
DE60303040T2 (de
Inventor
Brendan Wallace
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eli Lilly and Co
Original Assignee
Eli Lilly and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eli Lilly and Co filed Critical Eli Lilly and Co
Publication of DE60303040D1 publication Critical patent/DE60303040D1/de
Application granted granted Critical
Publication of DE60303040T2 publication Critical patent/DE60303040T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/32—Antioestrogens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D313/00—Heterocyclic compounds containing rings of more than six members having one oxygen atom as the only ring hetero atom
    • C07D313/02—Seven-membered rings
    • C07D313/06—Seven-membered rings condensed with carbocyclic rings or ring systems
    • C07D313/10—Seven-membered rings condensed with carbocyclic rings or ring systems condensed with two six-membered rings
    • C07D313/12—[b,e]-condensed
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
    • C07D333/54—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C07D333/56—Radicals substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Endocrinology (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Reproductive Health (AREA)
  • Diabetes (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Pyrane Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Epoxy Resins (AREA)
DE60303040T 2002-07-24 2003-07-11 Dihydro-dibenzo[b,e]oxepin-basierte, selektive oestrogen-rezeptor modulatoren, zusammensetzungen und methoden Expired - Fee Related DE60303040T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US39853802P 2002-07-24 2002-07-24
US398538P 2002-07-24
PCT/US2003/019554 WO2004009603A1 (en) 2002-07-24 2003-07-11 Dihydro-dibenzo[b,e]oxepine based selective estrogen receptor modulators, compositions and methods

Publications (2)

Publication Number Publication Date
DE60303040D1 true DE60303040D1 (de) 2006-02-02
DE60303040T2 DE60303040T2 (de) 2006-08-03

Family

ID=30771225

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60303040T Expired - Fee Related DE60303040T2 (de) 2002-07-24 2003-07-11 Dihydro-dibenzo[b,e]oxepin-basierte, selektive oestrogen-rezeptor modulatoren, zusammensetzungen und methoden

Country Status (8)

Country Link
US (2) US7067510B2 (de)
EP (1) EP1527076B1 (de)
JP (1) JP2005538091A (de)
AT (1) ATE314375T1 (de)
AU (1) AU2003281632A1 (de)
DE (1) DE60303040T2 (de)
ES (1) ES2253691T3 (de)
WO (1) WO2004009603A1 (de)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007098086A2 (en) * 2006-02-17 2007-08-30 Avalon Pharmaceuticals Hydroxypiperidine derivatives and uses thereof
JP2010527915A (ja) * 2007-04-26 2010-08-19 アバロン ファーマシューティカルズ，インコーポレイテッド 多重環化合物及びその用途
AU2016366680B2 (en) 2015-12-09 2021-06-24 The Board Of Trustees Of The University Of Illinois Benzothiophene-based selective estrogen receptor downregulators
CN110177554B (zh) 2017-01-06 2023-06-02 G1治疗公司 用于治疗癌症的组合疗法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6391892B1 (en) * 1995-03-10 2002-05-21 Eli Lilly And Company Naphthyl pharmaceutical compounds
US5726186A (en) 1995-09-08 1998-03-10 Eli Lilly And Company Pentacyclic compounds, intermediates, processes, compositions, and methods
IL138084A0 (en) 1998-03-02 2001-10-31 Lilly Co Eli Fluoxetine hydrochloride for decreasing hot flashes
US6471979B2 (en) * 1999-12-29 2002-10-29 Estrogen Vascular Technology, Llc Apparatus and method for delivering compounds to a living organism

Also Published As

Publication number Publication date
ATE314375T1 (de) 2006-01-15
EP1527076A1 (de) 2005-05-04
ES2253691T3 (es) 2006-06-01
US20050240017A1 (en) 2005-10-27
AU2003281632A1 (en) 2004-02-09
US7375229B2 (en) 2008-05-20
EP1527076B1 (de) 2005-12-28
DE60303040T2 (de) 2006-08-03
US7067510B2 (en) 2006-06-27
JP2005538091A (ja) 2005-12-15
US20060142267A1 (en) 2006-06-29
WO2004009603A1 (en) 2004-01-29

Similar Documents

Publication Publication Date Title
NZ294177A (en) 1-aralkyl-, 2-aryl-substituted naphthyl derivatives and pharmaceutical formulations
HUP0000901A2 (hu) 16-Hidroxi-11-(szubsztituált fenil)ösztra-4,9-dién-származékok, eljárás előállításukra és ezeket tartalmazó gyógyszerkészítmények
NO20062032L (no) Derivater av N-[fenyl(pyrrolidin-2-yl)-metyl]benzamid og N-[(azepan-2-yl)fenylmetyl]benzamid, fremgangsmate for fremstilling derav og anvendelse derav i terapeutiske midler
UY27384A1 (es) Analogos de prostaglandina
CA2632567A1 (en) Medical uses of a selective estrogen receptor modulator in combination with sex steroid precursors
HUP0301422A2 (hu) Ösztrogén hatású szereket tartalmazó gyógyászati készítmények
DE69628246D1 (de) Naphthyl- und Dihydronaphthylverbindungen als Arzneimittel
JP2005531488A5 (de)
KR960701878A (ko) 수용성 캄프토테신 유도체, 이의 제조 방법 및 항종양제로서의 이의 용도(Water-soluble camptothecin derivatives, process for their preparation and their use as antitumor agents)
DE69532079D1 (de) Benzofuranverbindungen, präparate und verfahren
DE60303040D1 (de) Dihydro-dibenzo[b,e]oxepin-basierte, selektive oestrogen-rezeptor modulatoren, zusammensetzungen und methoden
NO975581L (no) Fremgangsmåte for å redusere bentap
KR970705999A (ko) 타목시펜 및 타목시펜 유사체의 자궁향성 효과를 최소화시키는 방법 (a method for minimizing the uterotrophic effect of tamoxifen and tamoxifen analogs)
AU2003247589A8 (en) Pentacyclic oxepines and derivatives thereof, process for their preparation and pharmaceutical compositions containing them
MXPA05003166A (es) Derivados de dihidro-dibenzo (a) antracenos y su uso como modulares de receptores de estrogenos selectivos.
HUP0200913A2 (hu) Izoindoloindolonszármazékok eljárás előállításukra és a vegyületeket tartalmazó gyógyszerkészítmények
JP2005538091A5 (de)
JP2004531559A5 (de)
DE60031557D1 (de) Steroide, ihre herstellung , pharmazeutische zusammensetzungen mit ihnen und verwendungen dieser verbindungen
YU34296A (en) Use a compounds for medicament obtaining and pharmaceutical composition thereof
HUP0002715A2 (hu) Benzotiofénszármazékok alkalmazása trombocitaszám csökkentésére szolgáló gyógyszerkészítmények előállítására
HUP0004994A2 (hu) 2,3-Benzodiazepin-származékok, ilyen hatóanyagot tartalmazó gyógyászati készítmények és alkalmazásuk
RS49886B (sr) Benzotiofenska jedinjenja, intermedijari, kompozicije i metode

Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee