DE60236605D1 - Zusammensetzungen und deren verwendung zur behandlung von krebs - Google Patents
Zusammensetzungen und deren verwendung zur behandlung von krebsInfo
- Publication number
- DE60236605D1 DE60236605D1 DE60236605T DE60236605T DE60236605D1 DE 60236605 D1 DE60236605 D1 DE 60236605D1 DE 60236605 T DE60236605 T DE 60236605T DE 60236605 T DE60236605 T DE 60236605T DE 60236605 D1 DE60236605 D1 DE 60236605D1
- Authority
- DE
- Germany
- Prior art keywords
- compositions
- cancer
- treatment
- tumorigenesis
- present
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/17—Amides, e.g. hydroxamic acids having the group >N—C(O)—N< or >N—C(S)—N<, e.g. urea, thiourea, carmustine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/401—Proline; Derivatives thereof, e.g. captopril
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/475—Quinolines; Isoquinolines having an indole ring, e.g. yohimbine, reserpine, strychnine, vinblastine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US31730201P | 2001-09-05 | 2001-09-05 | |
US37673202P | 2002-05-01 | 2002-05-01 | |
PCT/US2002/028576 WO2003020279A2 (en) | 2001-09-05 | 2002-09-05 | Compositions and methods of treatment of cancer |
Publications (1)
Publication Number | Publication Date |
---|---|
DE60236605D1 true DE60236605D1 (de) | 2010-07-15 |
Family
ID=26980879
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE60236605T Expired - Lifetime DE60236605D1 (de) | 2001-09-05 | 2002-09-05 | Zusammensetzungen und deren verwendung zur behandlung von krebs |
Country Status (7)
Country | Link |
---|---|
US (4) | US8349853B2 (de) |
EP (4) | EP2329822A1 (de) |
JP (1) | JP2005507876A (de) |
AT (1) | ATE469648T1 (de) |
CA (1) | CA2459583A1 (de) |
DE (1) | DE60236605D1 (de) |
WO (1) | WO2003020279A2 (de) |
Families Citing this family (49)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7230000B1 (en) | 1999-10-27 | 2007-06-12 | Cytokinetics, Incorporated | Methods and compositions utilizing quinazolinones |
US7671200B2 (en) | 1999-10-27 | 2010-03-02 | Cytokinetics, Inc. | Quinazolinone KSP inhibitors |
US6545004B1 (en) * | 1999-10-27 | 2003-04-08 | Cytokinetics, Inc. | Methods and compositions utilizing quinazolinones |
EP2322929B1 (de) * | 2000-11-27 | 2016-04-06 | Minerva Biotechnologies Corporation | Diagnostika, Drogenscreening und Behandlung für Krebs |
JP2005507876A (ja) | 2001-09-05 | 2005-03-24 | ミナーバ バイオテクノロジーズ コーポレイション | 癌を治療する組成物および方法 |
AU2003213092A1 (en) * | 2002-02-15 | 2003-09-09 | Smithkline Beecham Corporation | Syntheses of quinazolinones |
ES2361403T3 (es) | 2002-03-07 | 2011-06-16 | X-Ceptor Therapeutics, Inc. | Moduladores de quinazolinona de receptores nucleares. |
BR0309892A2 (pt) * | 2002-05-09 | 2011-04-05 | Cytokinetics Inc | composto, composição, métodos para modular a atividade da cinesina de ksp, para inibir a ksp, e para o tratamento de uma doença proliferativa celular, e, uso de um composto |
JP2005530785A (ja) * | 2002-05-09 | 2005-10-13 | サイトキネティクス・インコーポレーテッド | 化合物、組成物、及び方法 |
US7038048B2 (en) * | 2002-05-23 | 2006-05-02 | Cytokinetics, Inc. | 3H-pyridopyrimidin-4-one compounds, compositions, and methods of their use |
EP1556357A4 (de) * | 2002-06-14 | 2006-09-13 | Cytokinetics Inc | Verbindungen, zusammensetzungen und verfahren |
AU2003256805A1 (en) * | 2002-07-23 | 2004-02-09 | Cytokinetics, Inc. | Compounds compositions and methods |
US20040048853A1 (en) * | 2002-08-21 | 2004-03-11 | Gustave Bergnes | Compounds, compositions, and methods |
EP1558083A4 (de) * | 2002-09-30 | 2008-04-16 | Cytokinetics Inc | Verbindungen, zusammensetzungen und verfahren |
EP2363410B1 (de) * | 2002-11-27 | 2017-10-11 | Minerva Biotechnologies Corporation | MUC1-Isoformen |
US20060173171A1 (en) * | 2003-08-26 | 2006-08-03 | Bamdad Cynthia C | Techniques and compositions for diagnosis and treatment of cancer (muci) |
JP2007510652A (ja) * | 2003-11-03 | 2007-04-26 | サイトキネティクス・インコーポレーテッド | ピリミジン−4−オン化合物、組成物、および方法 |
EP1680420A4 (de) * | 2003-11-07 | 2008-09-24 | Cytokinetics Inc | Verbindungen, zusammensetzungen und verfahren |
JP2007513154A (ja) * | 2003-12-08 | 2007-05-24 | サイトキネティクス・インコーポレーテッド | 化合物、組成物及び方法 |
US7767689B2 (en) * | 2004-03-15 | 2010-08-03 | Ptc Therapeutics, Inc. | Carboline derivatives useful in the treatment of cancer |
UA92317C2 (ru) * | 2004-03-15 | 2010-10-25 | Пи-Ти-Си ТЕРАПЬЮТИКС, ИНК. | Производные карболина, пригодные для ингибирования развития кровеносных сосудов |
US20080064680A1 (en) * | 2004-09-14 | 2008-03-13 | Bamdad Cynthia C | Methods for Diagnosis and Treatment of Cancer |
US11202775B2 (en) | 2007-09-25 | 2021-12-21 | Minerva Biotechnologies Corporation | Methods for treatment of cancer |
WO2009042815A1 (en) * | 2007-09-25 | 2009-04-02 | Minerva Biotechnologies Corp. | Methods for treatment of cancer |
MX2010007430A (es) * | 2008-01-11 | 2010-12-21 | Albany Molecular Res Inc | Piridoindoles (1-azinona)-sustituidos como antagonistas de la hormona de concentracion melanina humana. |
EP4083072A1 (de) | 2008-10-06 | 2022-11-02 | Minerva Biotechnologies Corporation | Muc1*-antikörper |
US8703726B2 (en) | 2009-05-27 | 2014-04-22 | Ptc Therapeutics, Inc. | Methods for treating prostate conditions |
US8697662B2 (en) | 2009-05-27 | 2014-04-15 | Ptc Therapeutics, Inc. | Methods for treating Kaposi sarcoma |
TWI671297B (zh) | 2009-05-27 | 2019-09-11 | Ptc治療公司 | 治療癌症及非腫瘤病症之方法 |
WO2011003021A1 (en) * | 2009-07-01 | 2011-01-06 | Albany Molecular Research, Inc. | Azinone-substituted azabicycloalkane-indole and azabicycloalkane-pyrrolo-pyridine mch-1 antagonists, methods of making, and use thereof |
US8618299B2 (en) * | 2009-07-01 | 2013-12-31 | Albany Molecular Research, Inc. | Azinone-substituted azapolycycle MCH-1 antagonists, methods of making, and use thereof |
US8637501B2 (en) * | 2009-07-01 | 2014-01-28 | Albany Molecular Research, Inc. | Azinone-substituted azepino[b]indole and pyrido-pyrrolo-azepine MCH-1 antagonists, methods of making, and use thereof |
WO2011003007A1 (en) * | 2009-07-01 | 2011-01-06 | Albany Molecular Research, Inc. | Azabicycloalkane-indole and azabicycloalkane-pyrrolo-pyridine mch-1 antagonists, methods of making, and use thereof |
WO2012088038A2 (en) | 2010-12-21 | 2012-06-28 | Albany Molecular Research, Inc. | Piperazinone-substituted tetrahydro-carboline mch-1 antagonists, methods of making, and uses thereof |
WO2012088124A2 (en) | 2010-12-21 | 2012-06-28 | Albany Molecular Research, Inc. | Tetrahydro-azacarboline mch-1 antagonists, methods of making, and uses thereof |
AU2012326137B2 (en) | 2011-10-17 | 2018-11-29 | Minerva Biotechnologies Corporation | Media for stem cell proliferation and induction |
US8940742B2 (en) | 2012-04-10 | 2015-01-27 | Infinity Pharmaceuticals, Inc. | Heterocyclic compounds and uses thereof |
CN104995518A (zh) * | 2012-07-24 | 2015-10-21 | 米纳瓦生物技术公司 | Nme变体物种表达和抑制 |
CN111388664A (zh) | 2012-08-14 | 2020-07-10 | 米纳瓦生物技术公司 | 干细胞增强疗法 |
KR20210082547A (ko) * | 2013-02-20 | 2021-07-05 | 미네르바 바이오테크놀로지 코포레이션 | Nme 저해제 및 nme 저해제의 사용 방법 |
MX2016004340A (es) | 2013-10-04 | 2016-08-08 | Infinity Pharmaceuticals Inc | Compuestos heterociclicos y usos de los mismos. |
WO2015051241A1 (en) | 2013-10-04 | 2015-04-09 | Infinity Pharmaceuticals, Inc. | Heterocyclic compounds and uses thereof |
PT3119397T (pt) | 2014-03-19 | 2022-04-11 | Infinity Pharmaceuticals Inc | Compostos heterocíclicos para utilização no tratamento de distúrbios mediados por pi3k-gama |
US9708348B2 (en) | 2014-10-03 | 2017-07-18 | Infinity Pharmaceuticals, Inc. | Trisubstituted bicyclic heterocyclic compounds with kinase activities and uses thereof |
WO2016130726A1 (en) | 2015-02-10 | 2016-08-18 | Minerva Biotechnologies Corporation | Humanized anti-muc1* antibodies |
US10160761B2 (en) | 2015-09-14 | 2018-12-25 | Infinity Pharmaceuticals, Inc. | Solid forms of isoquinolinones, and process of making, composition comprising, and methods of using the same |
WO2017161116A1 (en) | 2016-03-17 | 2017-09-21 | Infinity Pharmaceuticals, Inc. | Isotopologues of isoquinolinone and quinazolinone compounds and uses thereof as pi3k kinase inhibitors |
US10919914B2 (en) | 2016-06-08 | 2021-02-16 | Infinity Pharmaceuticals, Inc. | Heterocyclic compounds and uses thereof |
WO2019028171A1 (en) | 2017-08-01 | 2019-02-07 | Ptc Therapeutics, Inc. | DHODH INHIBITOR FOR USE IN THE TREATMENT OF HEMATOLOGICAL CANCERS |
Family Cites Families (28)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US46997A (en) * | 1865-03-28 | James m | ||
DE2027645A1 (de) | 1970-06-05 | 1971-12-09 | Byk Gulden Lomberg Chemische Fa bnk GmbH, 7750 Konstanz | Piperazinylalkyl chinazolon (4) den vate, Verfahren zu deren Herstellung und sie enthaltende Arzneimittel |
DE2351724A1 (de) * | 1972-10-28 | 1974-05-09 | Yamanouchi Pharma Co Ltd | Neue nitrosoharnstoff-derivate |
ATE115558T1 (de) * | 1990-03-12 | 1994-12-15 | Yamanouchi Pharma Co Ltd | Harnstoffderivate, deren herstellung sowie diese enthaltende pharmazeutische zusammensetzungen. |
GB9205907D0 (en) | 1992-03-18 | 1992-04-29 | Cancer Res Inst Royal | Anti-cancer compounds |
US5464866A (en) | 1992-08-17 | 1995-11-07 | Alcon Laboratories, Inc. | Substituted hydrindanes for the treatment of angiogenesis-dependent diseases |
CA2123728A1 (en) | 1993-05-21 | 1994-11-22 | Noriyoshi Sueda | Urea derivatives and their use as acat inhibitors |
JPH07258224A (ja) | 1994-03-24 | 1995-10-09 | Dai Ichi Seiyaku Co Ltd | 二環性化合物 |
US5756502A (en) * | 1994-08-08 | 1998-05-26 | Warner-Lambert Company | Quinazolinone derivatives as cholyecystokinin (CCK) ligands |
FR2748026B1 (fr) | 1996-04-26 | 1998-06-05 | Adir | Nouveaux inhibiteurs de metalloproteases, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
US6028075A (en) | 1997-02-11 | 2000-02-22 | Pines; Mark | Quinazolinone containing pharmaceutical compositions for prevention of neovascularization and for treating malignancies |
US6214879B1 (en) * | 1998-03-24 | 2001-04-10 | Virginia Commonwealth University | Allosteric inhibitors of pyruvate kinase |
WO2000034783A1 (en) | 1998-12-08 | 2000-06-15 | Smithkline Beecham Corporation | Methods of screening for agonists and antagonists of the hdpxu17 receptor |
JP2002535656A (ja) | 1999-01-23 | 2002-10-22 | ミナーヴァ・バイオテクノロジーズ・コーポレーション | コロイド固定化種と非コロイド構造上の種との相互作用 |
CA2361013A1 (en) | 1999-01-25 | 2000-07-27 | Minerva Biotechnologies Corporation | Rapid and sensitive detection of aberrant protein aggregation in neurodegenerative diseases |
AU5382200A (en) * | 1999-06-15 | 2001-01-02 | University Health Network | Muc1 ligands |
EP1216232B1 (de) | 1999-08-27 | 2006-10-11 | ChemoCentryx Inc | Heterozyclische verbindungen und verfahren zur modulierung von cxcr3 funktion |
US6319915B1 (en) * | 1999-08-27 | 2001-11-20 | Pfizer Inc. | Benzazepine derivatives as inhibitors of hyperproliferation diseases |
EP1516876A1 (de) | 1999-09-16 | 2005-03-23 | Curis, Inc. | Vermittler von Igel Signalwegen, deren Zusammenstellungen und Verwendungen |
US6545004B1 (en) * | 1999-10-27 | 2003-04-08 | Cytokinetics, Inc. | Methods and compositions utilizing quinazolinones |
NZ518480A (en) * | 1999-10-27 | 2004-02-27 | Cytokinetics Inc | Methods and compositions utilizing quinazolinones |
US6683108B1 (en) * | 2000-03-30 | 2004-01-27 | Curis, Inc. | Agonists of hedgehog signaling pathways and uses related thereto |
AU2001253597A1 (en) | 2000-04-12 | 2001-10-30 | Minerva Biotechnologies Corporation | Treatment of neurodegenerative disease |
EP2322929B1 (de) | 2000-11-27 | 2016-04-06 | Minerva Biotechnologies Corporation | Diagnostika, Drogenscreening und Behandlung für Krebs |
WO2002064590A2 (en) * | 2001-02-12 | 2002-08-22 | Lilly Icos Llc | Carboline derivatives |
US6794379B2 (en) * | 2001-06-06 | 2004-09-21 | Tularik Inc. | CXCR3 antagonists |
CA2459584A1 (en) * | 2001-09-05 | 2003-03-13 | Cynthia C. Bamdad | Compositions and use thereof in the treatment of cancer |
JP2005507876A (ja) | 2001-09-05 | 2005-03-24 | ミナーバ バイオテクノロジーズ コーポレイション | 癌を治療する組成物および方法 |
-
2002
- 2002-09-05 JP JP2003524586A patent/JP2005507876A/ja active Pending
- 2002-09-05 WO PCT/US2002/028576 patent/WO2003020279A2/en active Application Filing
- 2002-09-05 EP EP10183857A patent/EP2329822A1/de not_active Withdrawn
- 2002-09-05 US US10/237,150 patent/US8349853B2/en not_active Expired - Lifetime
- 2002-09-05 CA CA002459583A patent/CA2459583A1/en not_active Abandoned
- 2002-09-05 EP EP09159585A patent/EP2116248A1/de not_active Ceased
- 2002-09-05 AT AT02797864T patent/ATE469648T1/de not_active IP Right Cessation
- 2002-09-05 DE DE60236605T patent/DE60236605D1/de not_active Expired - Lifetime
- 2002-09-05 EP EP02797864A patent/EP1425016B1/de not_active Expired - Lifetime
- 2002-09-05 EP EP10182812A patent/EP2340838A1/de not_active Ceased
-
2012
- 2012-12-07 US US13/708,820 patent/US9649312B2/en not_active Expired - Lifetime
-
2016
- 2016-03-07 US US15/063,334 patent/US20160324858A1/en not_active Abandoned
-
2017
- 2017-05-05 US US15/587,928 patent/US20170246168A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
JP2005507876A (ja) | 2005-03-24 |
US20160324858A1 (en) | 2016-11-10 |
WO2003020279A3 (en) | 2003-10-23 |
US20030130293A1 (en) | 2003-07-10 |
WO2003020279A2 (en) | 2003-03-13 |
EP1425016A2 (de) | 2004-06-09 |
EP2116248A1 (de) | 2009-11-11 |
US20170246168A1 (en) | 2017-08-31 |
US8349853B2 (en) | 2013-01-08 |
EP2340838A1 (de) | 2011-07-06 |
EP1425016B1 (de) | 2010-06-02 |
CA2459583A1 (en) | 2003-03-13 |
US9649312B2 (en) | 2017-05-16 |
EP2329822A1 (de) | 2011-06-08 |
US20130190495A1 (en) | 2013-07-25 |
ATE469648T1 (de) | 2010-06-15 |
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