DE60235354D1 - Markierungsreagentien, verfahren zur synthese dieser reagenzien und verfahren zum nachweis biologischer moleküle - Google Patents

Markierungsreagentien, verfahren zur synthese dieser reagenzien und verfahren zum nachweis biologischer moleküle

Info

Publication number
DE60235354D1
DE60235354D1 DE60235354T DE60235354T DE60235354D1 DE 60235354 D1 DE60235354 D1 DE 60235354D1 DE 60235354 T DE60235354 T DE 60235354T DE 60235354 T DE60235354 T DE 60235354T DE 60235354 D1 DE60235354 D1 DE 60235354D1
Authority
DE
Germany
Prior art keywords
synthesis
biological molecules
alkyl
linking arm
aryl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60235354T
Other languages
English (en)
Inventor
Cecile Bourget
Jean Lhomme
Ali Laayoun
Mitsuharu Kotera
Emmanuelle Trevisiol
Lionel Menou
Mendez Eloy Bernal
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Biomerieux SA
Centre National de la Recherche Scientifique CNRS
Universite Joseph Fourier Grenoble 1
Original Assignee
Biomerieux SA
Centre National de la Recherche Scientifique CNRS
Universite Joseph Fourier Grenoble 1
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biomerieux SA, Centre National de la Recherche Scientifique CNRS, Universite Joseph Fourier Grenoble 1 filed Critical Biomerieux SA
Application granted granted Critical
Publication of DE60235354D1 publication Critical patent/DE60235354D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C245/00—Compounds containing chains of at least two nitrogen atoms with at least one nitrogen-to-nitrogen multiple bond
    • C07C245/12—Diazo compounds, i.e. compounds having the free valencies of >N2 groups attached to the same carbon atom
    • C07C245/14—Diazo compounds, i.e. compounds having the free valencies of >N2 groups attached to the same carbon atom having diazo groups bound to acyclic carbon atoms of a carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C245/00—Compounds containing chains of at least two nitrogen atoms with at least one nitrogen-to-nitrogen multiple bond
    • C07C245/12—Diazo compounds, i.e. compounds having the free valencies of >N2 groups attached to the same carbon atom
    • C07C245/14—Diazo compounds, i.e. compounds having the free valencies of >N2 groups attached to the same carbon atom having diazo groups bound to acyclic carbon atoms of a carbon skeleton
    • C07C245/18—Diazo compounds, i.e. compounds having the free valencies of >N2 groups attached to the same carbon atom having diazo groups bound to acyclic carbon atoms of a carbon skeleton the carbon skeleton being further substituted by carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/78—Ring systems having three or more relevant rings
    • C07D311/80—Dibenzopyrans; Hydrogenated dibenzopyrans
    • C07D311/82—Xanthenes
    • C07D311/90—Xanthenes with hydrocarbon radicals, substituted by amino radicals, directly attached in position 9
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Saccharide Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Indole Compounds (AREA)
DE60235354T 2001-05-04 2002-05-03 Markierungsreagentien, verfahren zur synthese dieser reagenzien und verfahren zum nachweis biologischer moleküle Expired - Lifetime DE60235354D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR0106040A FR2824323B1 (fr) 2001-05-04 2001-05-04 Reactif de marquage et procede de detection de molecules biologiques
PCT/FR2002/001543 WO2002090319A1 (fr) 2001-05-04 2002-05-03 Reactifs de marquage, procedes de synthese de tels reactifs et procedes de detection de molecules biologiques

Publications (1)

Publication Number Publication Date
DE60235354D1 true DE60235354D1 (de) 2010-04-01

Family

ID=8863021

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60235354T Expired - Lifetime DE60235354D1 (de) 2001-05-04 2002-05-03 Markierungsreagentien, verfahren zur synthese dieser reagenzien und verfahren zum nachweis biologischer moleküle

Country Status (11)

Country Link
EP (1) EP1383732B1 (de)
JP (2) JP4494717B2 (de)
CN (1) CN100509761C (de)
AT (1) ATE457973T1 (de)
AU (1) AU2002314227B2 (de)
CA (1) CA2444918C (de)
DE (1) DE60235354D1 (de)
ES (1) ES2339337T3 (de)
FR (1) FR2824323B1 (de)
HK (1) HK1062014A1 (de)
WO (1) WO2002090319A1 (de)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2824323B1 (fr) * 2001-05-04 2008-04-25 Bio Merieux Reactif de marquage et procede de detection de molecules biologiques
FR2824335A1 (fr) * 2001-05-04 2002-11-08 Bio Merieux Procede de marquage et de fragmentation d'adn
US20050153371A1 (en) * 2004-01-07 2005-07-14 Ambit Biosciences Corporation Conjugated small molecules
FR2868071B1 (fr) * 2004-03-26 2006-06-09 Biomerieux Sa Reactifs de marquage, procedes de synthese de tels reactifs et procedes de detection de molecules biologiques
FR2881437B1 (fr) 2005-01-31 2010-11-19 Biomerieux Sa Procede pour le diagnostic/pronostic d'un syndrome septique
FR2886735B1 (fr) * 2005-06-01 2015-09-11 Biomerieux Sa Procede de marquage ou de traitement d'un echantillon biologique contenant des molecules biologiques d'interet, notamment des acides nucleiques
GB0616724D0 (en) * 2006-08-23 2006-10-04 Isis Innovation Surface adhesion using arylcarbene reactive intermediates
FR2917090B1 (fr) * 2007-06-11 2012-06-15 Biomerieux Sa Reactifs de marquage portant des fonctions diazo et nitro, procedes de synthese de tels reactifs et procedes de detection de molecules biologiques
FR2934595B1 (fr) * 2008-07-29 2013-04-05 Biomerieux Sa Reactifs de marquage ayant un noyau pyridine portant une fonction diazomethyle, procedes de synthese de tels reactifs et procedes de detection de molecules biologiques
KR101753917B1 (ko) 2009-03-02 2017-07-04 옥스포드 어드밴스드 서패이시즈 리미티드 공유결합 3차원 네트워크를 형성할 수 있는 화학제
JP5916718B2 (ja) 2010-06-04 2016-05-11 ビオメリューＢｉｏｍｅｒｉｅｕｘ 結腸直腸癌の予後判定のための方法及びキット
US9110079B2 (en) 2010-09-29 2015-08-18 Biomerieux Method and kit for establishing an in vitro prognosis on a patient exhibiting SIRS
FR2968302B1 (fr) 2010-12-06 2012-11-30 Biomerieux Sa Procedes de fonctionalisation et reactifs utilises dans de tels procedes utilisant un anhydride isatoique ou un de ses derives, molecules biologiques ainsi traitees et kits
WO2012129758A1 (en) 2011-03-25 2012-10-04 Biomerieux Method and kit for determining in vitro probability for individual to suffer from colorectal cancer
FR2994184B1 (fr) 2012-08-02 2017-12-08 Biomerieux Sa Procedes de fonctionalisation et reactifs utilises dans de tels procedes utilisant un anhydride aza-isatoique ou un de ses derives, molecules biologiques ainsi traitees et kits
KR101953819B1 (ko) * 2017-12-22 2019-03-06 (주)바이오액츠 생체 분자 표지를 위한 신규 시아닌 화합물 및 그 제조방법
CN113636931B (zh) * 2021-08-05 2024-02-13 康龙化成(宁波)科技发展有限公司 基因编码化合物库起始头片段化合物及其在基因编码化合物库合成上的应用
CN115873012A (zh) * 2022-12-02 2023-03-31 中国科学院生态环境研究中心 生物素连全氟羧酸类化合物及制备方法
CN115772174A (zh) * 2022-12-02 2023-03-10 中国科学院生态环境研究中心 生物素标记的全氟磺酸类化合物及制备方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2007431A1 (en) * 1989-01-10 1990-07-10 Larry W. Mclauglin Labeling of nucleic acids with fluorescent markers
FR2780059B1 (fr) * 1998-06-17 2002-10-11 Bio Merieux Procede de marquage d'un acide ribonucleique et fragments d'arn marques ainsi obtenus
FR2824323B1 (fr) * 2001-05-04 2008-04-25 Bio Merieux Reactif de marquage et procede de detection de molecules biologiques

Also Published As

Publication number Publication date
EP1383732B1 (de) 2010-02-17
CA2444918C (fr) 2012-01-10
FR2824323A1 (fr) 2002-11-08
AU2002314227B2 (en) 2008-03-20
JP2005502027A (ja) 2005-01-20
WO2002090319A1 (fr) 2002-11-14
EP1383732A1 (de) 2004-01-28
ATE457973T1 (de) 2010-03-15
JP2009137954A (ja) 2009-06-25
CN1518536A (zh) 2004-08-04
FR2824323B1 (fr) 2008-04-25
HK1062014A1 (en) 2004-10-15
ES2339337T3 (es) 2010-05-19
CN100509761C (zh) 2009-07-08
JP4494717B2 (ja) 2010-06-30
CA2444918A1 (fr) 2002-11-14

Similar Documents

Publication Publication Date Title
DE60235354D1 (de) Markierungsreagentien, verfahren zur synthese dieser reagenzien und verfahren zum nachweis biologischer moleküle
DE69926797D1 (de) Sequenzierungsverfahren mit signalverstärkern
ATE256658T1 (de) Funktionelle vitamin-d-derivate und verfahren zur bestimmung von 25-hydroxy- und 1alpha,25- dihydroxy-vitamin-d
ATE208827T1 (de) Konjugate von dns und pns und verfahren zu deren herstellung
DE60237089D1 (de) Kompetitiver bindungstest zur identifikation von hcv-polymeraseinhibitoren
DE60238940D1 (de) Verfahren zur isolierung und markierung von probenmolekülen
DE59908477D1 (de) Verfahren zur markierung von biopolymeren mit isotopen
CA2380395A1 (en) Conditional-selex
ATE501277T1 (de) Monomere und polymere linker zur konjugierung von biologischen molekülen und anderen stoffen
FI102017B (fi) Elektrokemoluminoivat analyysimenetelmät
ATE454469T1 (de) Für den nachweis von nukleinsäuren kompetente biologische rohderivate
UY26057A1 (es) Amidas de aminoacidos modificadas, medicamentos que contienen estos compuestos y procedimiento para su preparacion
ATE458816T1 (de) Fluoreszierendes protein aus aequorea coerulescens und ihre verwendungen
EP1543007A4 (de) Neue zwitterionische fluoreszierende farbstoffe zur markierung bei proteomischen und anderen biologischen analysen
DE602004026500D1 (de) Verfahren zur Markierung phosphorylierten Peptiden, Komplexverbindunger, Verfahren zu deren Herstellung und Zwischenprodukte
DE60315343D1 (de) Neuartige verwendungen von durch ble-gene kodierten proteinen und antibiotika aus der bleomycin-familie
ATE496917T1 (de) Haptene, immunogene, antikörper und konjugate für 2-oxo-3-hydroxy lsd
EP1180549A4 (de) Verfahren zum messen von polymorphismen
DE60043618D1 (de) Verfahren zum nachweis einer reaktion zur molekularen erkennung
FR2868071A1 (fr) Reactifs de marquage, procedes de synthese de tels reactifs et procedes de detection de molecules biologiques
DE602004019047D1 (de) Grosstechnisches verfahren zur synthese von hochreinen 2-substituierten 1-(hydroxyethyliden)-1,1-bisphosphonsäuren und deren salzen
DE69826992D1 (de) Verfahren zur bestimmung einer nukleinsäure
ES2512615T3 (es) Reactivos de marcado que llevan funciones diazo y nitro, procedimientos de síntesis de tales reactivos y procedimientos de detección de moléculas biológicas
FI953897A (fi) Nukleiinihappokeottimia, jotka on kemiallisesti modifioituja asemassa 5'-OH ja/tai 3' -OH yhden tai useamman ei-radioaktiivisesti merkatun aineen viemiseksi näihin asemiin ja menetelmä näiden valmistamiseksi
Tsujita et al. Equilibrium shift by target DNA substrates for determination of DNA binding ligands

Legal Events

Date Code Title Description
8364 No opposition during term of opposition