DE60235287D1 - Löslich gemachte topoisomerase-gifte - Google Patents

Löslich gemachte topoisomerase-gifte

Info

Publication number
DE60235287D1
DE60235287D1 DE60235287T DE60235287T DE60235287D1 DE 60235287 D1 DE60235287 D1 DE 60235287D1 DE 60235287 T DE60235287 T DE 60235287T DE 60235287 T DE60235287 T DE 60235287T DE 60235287 D1 DE60235287 D1 DE 60235287D1
Authority
DE
Germany
Prior art keywords
formula
solubly
gifts
topoisomerase
compounds
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60235287T
Other languages
German (de)
English (en)
Inventor
Edmond J Lavoie
Alexander L Ruchelman
Leroy F Liu
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Rutgers State University of New Jersey
Original Assignee
Rutgers State University of New Jersey
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Rutgers State University of New Jersey filed Critical Rutgers State University of New Jersey
Application granted granted Critical
Publication of DE60235287D1 publication Critical patent/DE60235287D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
    • C07D491/14—Ortho-condensed systems
    • C07D491/147—Ortho-condensed systems the condensed system containing one ring with oxygen as ring hetero atom and two rings with nitrogen as ring hetero atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
    • C07D491/14—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/22—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains four or more hetero rings
DE60235287T 2001-11-14 2002-11-14 Löslich gemachte topoisomerase-gifte Expired - Lifetime DE60235287D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US33273401P 2001-11-14 2001-11-14
PCT/US2002/036901 WO2003041660A2 (en) 2001-11-14 2002-11-14 Solubilized topoisomerase poisons

Publications (1)

Publication Number Publication Date
DE60235287D1 true DE60235287D1 (de) 2010-03-25

Family

ID=23299632

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60235287T Expired - Lifetime DE60235287D1 (de) 2001-11-14 2002-11-14 Löslich gemachte topoisomerase-gifte

Country Status (15)

Country Link
US (4) US7049315B2 (US07049315-20060523-C00024.png)
EP (3) EP1465625B1 (US07049315-20060523-C00024.png)
JP (3) JP4628675B2 (US07049315-20060523-C00024.png)
KR (1) KR20050044491A (US07049315-20060523-C00024.png)
AT (1) ATE456952T1 (US07049315-20060523-C00024.png)
AU (1) AU2002363658B2 (US07049315-20060523-C00024.png)
CA (1) CA2467774C (US07049315-20060523-C00024.png)
CY (1) CY1110631T1 (US07049315-20060523-C00024.png)
DE (1) DE60235287D1 (US07049315-20060523-C00024.png)
DK (1) DK1465625T3 (US07049315-20060523-C00024.png)
ES (1) ES2340473T3 (US07049315-20060523-C00024.png)
MX (1) MXPA04004606A (US07049315-20060523-C00024.png)
PT (1) PT1465625E (US07049315-20060523-C00024.png)
SI (1) SI1465625T1 (US07049315-20060523-C00024.png)
WO (1) WO2003041660A2 (US07049315-20060523-C00024.png)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003051289A2 (en) 2001-11-14 2003-06-26 Rutgers, The State University Solubilized topoisomerase poison agents
AU2002364953A1 (en) 2001-11-14 2003-06-17 Edmond J. Lavoie Topoisomerase poison agents
JP4628675B2 (ja) * 2001-11-14 2011-02-09 ラトガーズ，ザ ステイト ユニバーシティ 可溶化トポイソメラーゼ毒
ATE405568T1 (de) 2001-11-14 2008-09-15 Univ Rutgers Cytotoxische mittel
AU2003265406A1 (en) 2002-08-09 2004-02-25 Edmond J. Lavoie Nitro and amino substituted topoisomerase agents
WO2004014906A2 (en) * 2002-08-09 2004-02-19 Rutgers, The State University Nitro and amino substituted dibenzonaphthyridines as topoisomerase agents
WO2004014862A1 (en) 2002-08-09 2004-02-19 Rutgers, The State University Nitro and amino substituted heterocycles as topoisomerase i targeting agents
AU2003290818A1 (en) 2002-11-12 2004-06-03 Edmond J. Lavoie Topoisomerase-targeting agents
EP1778228A4 (en) 2004-07-09 2010-08-11 Medisyn Technologies Inc THERAPEUTIC CONNECTION AND TREATMENTS
KR20090040265A (ko) * 2006-05-24 2009-04-23 닥터 레디스 레보러터리즈 리미티드 5(ｓ)-(2'-히드록시에톡시)-20(ｓ)-캄프토테신의 결정질 형태
US8394818B2 (en) 2008-10-17 2013-03-12 Dana-Farber Cancer Institute, Inc. Soluble mTOR complexes and modulators thereof
TW201038578A (en) * 2009-01-30 2010-11-01 Univ Rutgers Methods to treat cancer
DK2403856T3 (da) 2009-03-06 2013-04-08 Univ Rutgers Methylendioxybenzo[i]phenanthridinderivater anvendt til behandling af cancer
WO2010127363A1 (en) 2009-05-01 2010-11-04 Rutgers, The State University Of New Jersey Toposiomerase inhibitors
WO2010127360A1 (en) * 2009-05-01 2010-11-04 Rutgers, The State University Of New Jersey Toposiomerase inhibitors
WO2012015901A1 (en) * 2010-07-28 2012-02-02 Genzyme Corporation Methods for treating gastric and pancreatic malignancies
WO2012015875A1 (en) * 2010-07-28 2012-02-02 Genzyme Corporation Methods for treating hematological malignancies
WO2013154778A1 (en) 2012-04-11 2013-10-17 Dana-Farber Cancer Institute, Inc. Host targeted inhibitors of dengue virus and other viruses
WO2014063054A1 (en) 2012-10-19 2014-04-24 Dana-Farber Cancer Institute, Inc. Bone marrow on x chromosome kinase (bmx) inhibitors and uses thereof
EP3442979A4 (en) 2016-04-04 2019-12-18 Rutgers, the State University of New Jersey topoisomerase poisons
CN111925370B (zh) * 2020-09-01 2023-07-21 湖北科苑生物药业有限公司 一种吡嗪并吡唑并萘啶类化合物及其制备方法与应用

Family Cites Families (54)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2981731A (en) 1961-04-25 Acridine derivatives
US2985681A (en) * 1953-08-28 1961-05-23 Knoll Ag Phenylacetic acid and aminoalkyl esters thereof
US2985661A (en) 1956-02-06 1961-05-23 American Cyanamid Co Preparation of 2(omicron-aminophenyl)-benzimidazole
US2915523A (en) 1956-12-03 1959-12-01 Parke Davis & Co Benzacridine compounds
US3272707A (en) 1964-07-17 1966-09-13 Smith Kline French Lab Pharmaceutical compositions and methods for their use
CH420044A (de) 1964-09-01 1967-03-15 Ciba Geigy Verwendung von neuen Azol-Derivaten als optische Aufheller für textile organische Materialien
US3267107A (en) 1964-09-17 1966-08-16 American Home Prod 3-(4'-5'-methylenedioxy-phenyl)-7, 8-dimethoxy-1, 2, 3, 4,-tetrahydroisoquinolines
US3849561A (en) 1964-10-20 1974-11-19 S Naruto Anti-peptic ulcer substance from corydalis tubers
DE1670684A1 (de) 1966-04-01 1970-12-03 Hoechst Ag Verfahren zur Herstellung von basisch substituierten Bis-benzimidazol-derivaten
US3542782A (en) 1967-03-15 1970-11-24 Sandoz Ag 5,6-dihydro-8h-isoquino(1,2-b)quinazolines
JPS4942700A (US07049315-20060523-C00024.png) 1972-08-25 1974-04-22
US3912740A (en) 1974-02-28 1975-10-14 Us Health Method for the preparation of oxygenated benzo{8 c{9 phenanthridine compounds
PT73763B (fr) 1981-10-01 1983-10-26 Quatrum Empresa Nacional De Qu Procede pour la preparation de nouveaux epoxides d'alkaloides benzofenantridiniques et de compositions pharmaceutiques qui les contiennent
US4761417A (en) 1982-05-14 1988-08-02 Maroko Peter R Compounds, compositions and method of treatments for improving circulatory performance
US4749708A (en) 1982-05-14 1988-06-07 Maroko Peter R Composition for improving circulatory performance
US5153178A (en) 1982-05-14 1992-10-06 Maroko Peter R Compositions and method of treatment for improving circulatory performance
IE55519B1 (en) 1982-05-14 1990-10-10 Maroko Peter R Use of a protoberberine alkaloid and composition containing same
US4980344A (en) 1982-05-14 1990-12-25 Maroko Peter R Compositions for improving circulatory performance
US4559157A (en) 1983-04-21 1985-12-17 Creative Products Resource Associates, Ltd. Cosmetic applicator useful for skin moisturizing
LU84979A1 (fr) 1983-08-30 1985-04-24 Oreal Composition cosmetique ou pharmaceutique sous forme aqueuse ou anhydre dont la phase grasse contient un polyether oligomere et polyethers oligomeres nouveaux
JPS61130289A (ja) 1984-11-29 1986-06-18 Ss Pharmaceut Co Ltd １３−プロピルベルベリンの塩
FR2595356B1 (fr) 1986-03-05 1991-05-24 Pasteur Strasbourg Universite Derives des nitro ou aminobenzyltetrahydroisoquinoleines, procedes d'obtention, compositions pharmaceutiques les contenant, proprietes pharmacologiques et applications
US5244903A (en) 1987-03-31 1993-09-14 Research Triangle Institute Camptothecin analogs as potent inhibitors of topoisomerase I
US4820508A (en) 1987-06-23 1989-04-11 Neutrogena Corporation Skin protective composition
SU1530628A1 (ru) 1987-11-20 1989-12-23 Ленинградский Технологический Институт Им.Ленсовета Тригидрохлорид 2-[2-фенил-5(6)-бензимидазолил]-N-(3-диметиламинопропил)-5(6)-бензимидазолкарбоксамида в качестве флуоресцентного красител дл исследовани ДНК
US4992478A (en) 1988-04-04 1991-02-12 Warner-Lambert Company Antiinflammatory skin moisturizing composition and method of preparing same
US4938949A (en) 1988-09-12 1990-07-03 University Of New York Treatment of damaged bone marrow and dosage units therefor
US5106863A (en) 1990-03-26 1992-04-21 Ortho Pharmaceutical Corporation Substituted imidazole and pyridine derivatives
US5135934A (en) 1990-07-06 1992-08-04 Du Pont Merck Pharmaceutical Company 3-phenyl-5,6-dihydrobenz(c) acridine-7-carboxylic acids and related compounds as immunosuppressive agents
US5126351A (en) 1991-01-24 1992-06-30 Glaxo Inc. Antitumor compounds
DE4116593C1 (US07049315-20060523-C00024.png) * 1991-05-22 1993-01-07 Fa. Hermann Heye, 3063 Obernkirchen, De
US5223506A (en) 1991-06-04 1993-06-29 Glaxo Inc. Cyclic antitumor compounds
US5428040A (en) 1993-08-31 1995-06-27 The Du Pont Merck Pharmaceutical Company Carbocyclic fused-ring quinolinecarboxylic acids useful as immunosuppressive agents
AU7707094A (en) 1993-09-28 1995-04-18 Kyowa Hakko Kogyo Co. Ltd. Novel tetracyclic compound
WO1996036612A1 (en) 1995-05-17 1996-11-21 Rutgers, The State University Of New Jersey Tribenzimidazoles useful as topoisomerase i inhibitors
US5807874A (en) 1995-05-17 1998-09-15 Rutgers, The State University Of New Jersey Trisbenzimidazoles useful as topoisomerase I inhibitors
US5767142A (en) 1996-03-20 1998-06-16 Rutgers, The State University Of New Jersey Trisbenzimidazoles useful as topoisomerase I inhibitors
EP0888346B1 (en) 1996-02-12 2001-06-06 Rutgers, The State University Of New Jersey Coralyne analogs as topoisomerase inhibitors
US5770617A (en) 1996-03-20 1998-06-23 Rutgers, The State University Of New Jersey Terbenzimidazoles useful as antifungal agents
NZ334954A (en) 1996-09-23 2000-08-25 Univ Rutgers Substituted heterocycles as anti-tumor agents
US6140328A (en) * 1997-12-12 2000-10-31 Rutgers, The State University Of New Jersey Heterocyclic cytotoxic agents
US6509344B1 (en) 1998-10-14 2003-01-21 The United States Of America As Represented By The Department Of Health And Human Services Indenoisoquinolines as antineoplastic agents
US6740650B2 (en) 1999-10-29 2004-05-25 Rutgers, The State University Of New Jersey Heterocyclic cytotoxic agents
JP2003513079A (ja) 1999-10-29 2003-04-08 ラトガーズ， ザ ステイト ユニバーシティ オブ ニュー ジャージー 複素環式細胞傷害剤
CN1612723A (zh) 2001-11-13 2005-05-04 宝洁公司 包含由抑制剂稳定化的酶的局部组合物
WO2003051289A2 (en) 2001-11-14 2003-06-26 Rutgers, The State University Solubilized topoisomerase poison agents
JP4628675B2 (ja) * 2001-11-14 2011-02-09 ラトガーズ，ザ ステイト ユニバーシティ 可溶化トポイソメラーゼ毒
AU2002364953A1 (en) 2001-11-14 2003-06-17 Edmond J. Lavoie Topoisomerase poison agents
ATE405568T1 (de) * 2001-11-14 2008-09-15 Univ Rutgers Cytotoxische mittel
US7493607B2 (en) * 2002-07-09 2009-02-17 Bluerisc Inc. Statically speculative compilation and execution
WO2004014906A2 (en) * 2002-08-09 2004-02-19 Rutgers, The State University Nitro and amino substituted dibenzonaphthyridines as topoisomerase agents
WO2004014862A1 (en) * 2002-08-09 2004-02-19 Rutgers, The State University Nitro and amino substituted heterocycles as topoisomerase i targeting agents
AU2003265406A1 (en) 2002-08-09 2004-02-25 Edmond J. Lavoie Nitro and amino substituted topoisomerase agents
AU2003290818A1 (en) * 2002-11-12 2004-06-03 Edmond J. Lavoie Topoisomerase-targeting agents

Also Published As

Publication number Publication date
US7781587B2 (en) 2010-08-24
PT1465625E (pt) 2010-03-09
SI1465625T1 (sl) 2010-06-30
WO2003041660A3 (en) 2003-10-16
WO2003041660A2 (en) 2003-05-22
ES2340473T3 (es) 2010-06-04
DK1465625T3 (da) 2010-05-31
JP2010184942A (ja) 2010-08-26
CY1110631T1 (el) 2015-04-29
EP1465625B1 (en) 2010-02-03
US20110136812A1 (en) 2011-06-09
AU2002363658B2 (en) 2008-09-11
CA2467774C (en) 2011-09-20
US20060052381A1 (en) 2006-03-09
JP2005511617A (ja) 2005-04-28
EP2286812A1 (en) 2011-02-23
JP2013166801A (ja) 2013-08-29
US7049315B2 (en) 2006-05-23
MXPA04004606A (es) 2004-09-10
US8389721B2 (en) 2013-03-05
JP5337104B2 (ja) 2013-11-06
ATE456952T1 (de) 2010-02-15
CA2467774A1 (en) 2003-05-22
US20050009824A1 (en) 2005-01-13
JP4628675B2 (ja) 2011-02-09
US20090239871A1 (en) 2009-09-24
EP1465625A4 (en) 2005-06-08
US7517883B2 (en) 2009-04-14
KR20050044491A (ko) 2005-05-12
EP2196205A1 (en) 2010-06-16
EP1465625A2 (en) 2004-10-13

Similar Documents

Publication Publication Date Title
CY1110631T1 (el) Διαλυτοποιημενα δηλητηρια τοποϊσομερασης
EP1652847A3 (en) Quinoline and quinazoline derivatives for the treatment of tumors
MXPA04004969A (es) 3-cianoquinolinas como inhibidores del receptor del factor de crecimiento epidermico y her2 cinasas.
MY136430A (en) N-adamantylmethyl derivatives, pharmaceutical compositions containing them and processes for their preparation
JO2311B1 (en) Alkyl inhibitors Ariel phosphodiesterase-4
ATE248837T1 (de) Chinuclidin-acrylamide
DE60225943D1 (de) Topoisomerase-giftmittel
WO2003018553A8 (en) Oral antidiabetic agents
EE200000472A (et) Kasvajavastased toimeained
DE60231426D1 (de) Solubilisierte topoisomerase-gift-mittel
DE60228484D1 (de) Cytotoxische mittel
GEP20074058B (en) 4-(7-halo-2-quino(xa) linyloxy-phenoxy-propionic acid derivatives as antineoplastic agents
FI935800A0 (fi) Antidepressiva och mot Parkisons sjukdom verksamma foereningar
WO2004014906A3 (en) Nitro and amino substituted dibenzonaphthyridines as topoisomerase agents
PL372769A1 (en) Cyanoguanidine prodrugs
WO2004044174A3 (en) Topoisomerase-targeting agents
BR9502079A (pt) Composto,formulação farmaceutica e processo para preparar um composto
CY1108259T1 (el) Ανταγωνιστες υποδοχεα διεγερτικου αμινοξεος

Legal Events

Date Code Title Description
8364 No opposition during term of opposition