DE60233668D1 - Multipartikuläre verabreichungsformen von propranolol mit zeitgesteuerter und verlängerter wirkstofffreigabe - Google Patents
Multipartikuläre verabreichungsformen von propranolol mit zeitgesteuerter und verlängerter wirkstofffreigabeInfo
- Publication number
- DE60233668D1 DE60233668D1 DE60233668T DE60233668T DE60233668D1 DE 60233668 D1 DE60233668 D1 DE 60233668D1 DE 60233668 T DE60233668 T DE 60233668T DE 60233668 T DE60233668 T DE 60233668T DE 60233668 D1 DE60233668 D1 DE 60233668D1
- Authority
- DE
- Germany
- Prior art keywords
- propranolol
- multiparticular
- active ingredients
- pharmaco
- time controlled
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- AQHHHDLHHXJYJD-UHFFFAOYSA-N propranolol Chemical compound C1=CC=C2C(OCC(O)CNC(C)C)=CC=CC2=C1 AQHHHDLHHXJYJD-UHFFFAOYSA-N 0.000 title abstract 4
- 229960003712 propranolol Drugs 0.000 title abstract 2
- 239000004480 active ingredient Substances 0.000 title 1
- 239000011324 bead Substances 0.000 abstract 2
- 230000027288 circadian rhythm Effects 0.000 abstract 2
- 208000024172 Cardiovascular disease Diseases 0.000 abstract 1
- 239000002775 capsule Substances 0.000 abstract 1
- 239000002327 cardiovascular agent Substances 0.000 abstract 1
- 229940125692 cardiovascular agent Drugs 0.000 abstract 1
- 230000002060 circadian Effects 0.000 abstract 1
- 239000002552 dosage form Substances 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 238000012377 drug delivery Methods 0.000 abstract 1
- 239000008187 granular material Substances 0.000 abstract 1
- 238000000338 in vitro Methods 0.000 abstract 1
- 238000001727 in vivo Methods 0.000 abstract 1
- 239000002245 particle Substances 0.000 abstract 1
- 239000008188 pellet Substances 0.000 abstract 1
- 230000003285 pharmacodynamic effect Effects 0.000 abstract 1
- 238000013268 sustained release Methods 0.000 abstract 1
- 239000012730 sustained-release form Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
- A61K31/138—Aryloxyalkylamines, e.g. propranolol, tamoxifen, phenoxybenzamine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
- A61K9/5078—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings with drug-free core
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5084—Mixtures of one or more drugs in different galenical forms, at least one of which being granules, microcapsules or (coated) microparticles according to A61K9/16 or A61K9/50, e.g. for obtaining a specific release pattern or for combining different drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US09/971,167 US6500454B1 (en) | 2001-10-04 | 2001-10-04 | Timed, sustained release systems for propranolol |
PCT/US2002/031535 WO2003028708A1 (en) | 2001-10-04 | 2002-10-02 | Timed, sustained release multi-particulate dosage forms of propranolol |
Publications (1)
Publication Number | Publication Date |
---|---|
DE60233668D1 true DE60233668D1 (de) | 2009-10-22 |
Family
ID=25518009
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE60233668T Expired - Lifetime DE60233668D1 (de) | 2001-10-04 | 2002-10-02 | Multipartikuläre verabreichungsformen von propranolol mit zeitgesteuerter und verlängerter wirkstofffreigabe |
Country Status (12)
Country | Link |
---|---|
US (2) | US6500454B1 (de) |
EP (1) | EP1432411B1 (de) |
JP (1) | JP4369752B2 (de) |
KR (1) | KR101090719B1 (de) |
AT (1) | ATE442134T1 (de) |
AU (1) | AU2002330211B2 (de) |
CA (1) | CA2462637C (de) |
DE (1) | DE60233668D1 (de) |
ES (1) | ES2333306T3 (de) |
MX (1) | MXPA04003234A (de) |
NO (1) | NO335070B1 (de) |
WO (1) | WO2003028708A1 (de) |
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US6500454B1 (en) * | 2001-10-04 | 2002-12-31 | Eurand Pharmaceuticals Ltd. | Timed, sustained release systems for propranolol |
US9358214B2 (en) * | 2001-10-04 | 2016-06-07 | Adare Pharmaceuticals, Inc. | Timed, sustained release systems for propranolol |
US8367111B2 (en) * | 2002-12-31 | 2013-02-05 | Aptalis Pharmatech, Inc. | Extended release dosage forms of propranolol hydrochloride |
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US7387793B2 (en) * | 2003-11-14 | 2008-06-17 | Eurand, Inc. | Modified release dosage forms of skeletal muscle relaxants |
US20050142203A1 (en) * | 2003-12-30 | 2005-06-30 | Grant Heinicke | Oral dosage formulations of active pharmaceutical ingredients and methods of preparing the same |
MXPA06009054A (es) * | 2004-02-11 | 2007-04-16 | Athpharma Ltd | Composiciones cronoterapeuticas y metodos de su uso. |
JP2005306778A (ja) * | 2004-04-21 | 2005-11-04 | Basf Ag | 徐放性製剤及びその製造方法 |
US8747895B2 (en) | 2004-09-13 | 2014-06-10 | Aptalis Pharmatech, Inc. | Orally disintegrating tablets of atomoxetine |
US20060173081A1 (en) * | 2004-10-01 | 2006-08-03 | Rotenberg Keith S | Treating morning migraines with propranolol |
EP1799264A2 (de) * | 2004-10-08 | 2007-06-27 | Neuromolecular Pharmaceuticals Inc | Verfahren und zusammensetzungen zur behandlung von migräne |
US9884014B2 (en) | 2004-10-12 | 2018-02-06 | Adare Pharmaceuticals, Inc. | Taste-masked pharmaceutical compositions |
EP1802285B1 (de) | 2004-10-21 | 2013-02-27 | Aptalis Pharmatech, Inc. | Geschmacksverdeckende pharmazeutische zusammensetzungen mit magenlöslichen porenbildnern |
US20060099259A1 (en) * | 2004-11-05 | 2006-05-11 | Grant Heinicke | Propranolol formulations |
US20060099258A1 (en) * | 2004-11-05 | 2006-05-11 | Grant Heinicke | Propranolol formulations |
US20060182806A1 (en) * | 2004-11-08 | 2006-08-17 | Mintong Guo | Extended-release propranolol composition |
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WO2007016948A1 (de) | 2005-08-10 | 2007-02-15 | Add Advanced Drug Delivery Technologies Ltd. | Orales präparat mit kontrollierter freisetzung |
KR20140088230A (ko) * | 2006-01-27 | 2014-07-09 | 앱탈리스 파마테크, 인코포레이티드 | 약 염기성 약물과 유기산을 포함하는 약물 전달 시스템 |
AU2007211091B8 (en) * | 2006-01-27 | 2013-08-29 | Adare Pharmaceuticals, Inc. | Drug delivery systems comprising weakly basic selective serotonin 5-HT3 blocking agent and organic acids |
MX2008010322A (es) * | 2006-02-13 | 2009-03-05 | Vanda Pharmaceuticals Inc | Formulaciones de dosificacion estable de imidazolilalquil-piridina s. |
US8846100B2 (en) * | 2006-05-12 | 2014-09-30 | Shire Llc | Controlled dose drug delivery system |
AU2007267912A1 (en) * | 2006-05-26 | 2007-12-06 | Auspex Pharmaceuticals, Inc. | Deuterated aminoglycidyl compounds |
WO2008027557A2 (en) * | 2006-08-31 | 2008-03-06 | Spherics, Inc. | Topiramate compositions and methods of enhancing its bioavailability |
KR20140114887A (ko) * | 2006-08-31 | 2014-09-29 | 앱탈리스 파마테크, 인코포레이티드 | 약 염기성 약물의 고용체를 포함하는 약물 전달 시스템 |
CA2618240C (en) | 2006-11-17 | 2015-01-20 | Supernus Pharmaceuticals, Inc. | Sustained-release formulations of topiramate |
CN102218044A (zh) * | 2006-12-04 | 2011-10-19 | 苏佩努斯制药公司 | 托吡酯的增强的立即释放制剂 |
US20080187579A1 (en) * | 2007-02-01 | 2008-08-07 | Pavan Bhat | Extended-release dosage form |
WO2008115797A1 (en) * | 2007-03-16 | 2008-09-25 | Pavo, Inc. | Therapeutic compositions and methods |
MX2010006520A (es) | 2007-12-13 | 2010-11-30 | Vanda Pharmaceuticals Inc | Metodo y composicion para el tratamiento de una condicion mediada por alfa-adrenoceptor. |
EP2222300B1 (de) | 2007-12-13 | 2014-06-11 | Vanda Pharmaceuticals Inc. | Verfahren und zusammensetzung zur behandlung eines zustands, der durch den serotonin-rezeptor vermittelt wird |
CA2753416A1 (en) * | 2009-02-23 | 2010-08-26 | Gopi Venkatesh | Controlled release compositions comprising anti-cholinergic drugs |
MX337603B (es) | 2009-11-30 | 2016-03-10 | Adare Pharmaceuticals Inc | Composiciones y tabletas farmaceuticas con recubrimiento compresible y metodos de fabricacion. |
AU2010325746B2 (en) | 2009-12-02 | 2016-02-25 | Adare Pharmaceuticals S.R.L. | Fexofenadine microcapsules and compositions containing them |
US20110142889A1 (en) * | 2009-12-16 | 2011-06-16 | Nod Pharmaceuticals, Inc. | Compositions and methods for oral drug delivery |
ES2813859T3 (es) | 2010-12-02 | 2021-03-25 | Adare Pharmaceuticals Inc | Gránulos de dispersión rápida, comprimidos de desintegración oral y métodos |
US20160143864A1 (en) * | 2013-07-09 | 2016-05-26 | Sun Pharmaceutical Industries Limited | Extended-release pharmaceutical compositions of metoprolol |
CN105287394A (zh) * | 2015-11-19 | 2016-02-03 | 哈尔滨圣吉药业股份有限公司 | 一种盐酸普萘洛尔缓释微丸及其制备方法 |
WO2019046251A1 (en) | 2017-08-28 | 2019-03-07 | Adare Pharmaceuticals, Inc. | TIZANIDINE FORMULATIONS |
JP2019052115A (ja) * | 2017-09-15 | 2019-04-04 | 国立研究開発法人理化学研究所 | 医薬組成物 |
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-
2001
- 2001-10-04 US US09/971,167 patent/US6500454B1/en not_active Expired - Lifetime
-
2002
- 2002-10-02 DE DE60233668T patent/DE60233668D1/de not_active Expired - Lifetime
- 2002-10-02 JP JP2003532041A patent/JP4369752B2/ja not_active Expired - Fee Related
- 2002-10-02 CA CA2462637A patent/CA2462637C/en not_active Expired - Lifetime
- 2002-10-02 KR KR1020047005057A patent/KR101090719B1/ko not_active IP Right Cessation
- 2002-10-02 EP EP02766476A patent/EP1432411B1/de not_active Expired - Lifetime
- 2002-10-02 AU AU2002330211A patent/AU2002330211B2/en not_active Ceased
- 2002-10-02 ES ES02766476T patent/ES2333306T3/es not_active Expired - Lifetime
- 2002-10-02 WO PCT/US2002/031535 patent/WO2003028708A1/en active Application Filing
- 2002-10-02 MX MXPA04003234A patent/MXPA04003234A/es active IP Right Grant
- 2002-10-02 AT AT02766476T patent/ATE442134T1/de not_active IP Right Cessation
- 2002-12-30 US US10/334,052 patent/US20030157173A1/en not_active Abandoned
-
2004
- 2004-04-28 NO NO20041740A patent/NO335070B1/no not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
KR20040084890A (ko) | 2004-10-06 |
ATE442134T1 (de) | 2009-09-15 |
CA2462637C (en) | 2010-12-07 |
NO335070B1 (no) | 2014-09-01 |
EP1432411A1 (de) | 2004-06-30 |
ES2333306T3 (es) | 2010-02-19 |
MXPA04003234A (es) | 2004-08-12 |
CA2462637A1 (en) | 2003-04-10 |
EP1432411B1 (de) | 2009-09-09 |
JP2005508922A (ja) | 2005-04-07 |
WO2003028708A1 (en) | 2003-04-10 |
US6500454B1 (en) | 2002-12-31 |
NO20041740L (no) | 2004-04-28 |
KR101090719B1 (ko) | 2011-12-08 |
AU2002330211B2 (en) | 2007-02-01 |
US20030157173A1 (en) | 2003-08-21 |
JP4369752B2 (ja) | 2009-11-25 |
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