DE60228212D1 - Neue expressionsvektoren - Google Patents

Neue expressionsvektoren

Info

Publication number
DE60228212D1
DE60228212D1 DE60228212T DE60228212T DE60228212D1 DE 60228212 D1 DE60228212 D1 DE 60228212D1 DE 60228212 T DE60228212 T DE 60228212T DE 60228212 T DE60228212 T DE 60228212T DE 60228212 D1 DE60228212 D1 DE 60228212D1
Authority
DE
Germany
Prior art keywords
vectors
present
expression vectors
provides
expression
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60228212T
Other languages
English (en)
Inventor
John Daly
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Gene Stream Pty Ltd
Original Assignee
Gene Stream Pty Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gene Stream Pty Ltd filed Critical Gene Stream Pty Ltd
Application granted granted Critical
Publication of DE60228212D1 publication Critical patent/DE60228212D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/67—General methods for enhancing the expression
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01H—NEW PLANTS OR NON-TRANSGENIC PROCESSES FOR OBTAINING THEM; PLANT REPRODUCTION BY TISSUE CULTURE TECHNIQUES
    • A01H6/00—Angiosperms, i.e. flowering plants, characterised by their botanic taxonomy
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New breeds of animals
    • A01K67/027—New breeds of vertebrates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
DE60228212T 2001-03-09 2002-03-08 Neue expressionsvektoren Expired - Lifetime DE60228212D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US27477001P 2001-03-09 2001-03-09
PCT/AU2002/000351 WO2002072844A1 (en) 2001-03-09 2002-03-08 Novel expression vectors

Publications (1)

Publication Number Publication Date
DE60228212D1 true DE60228212D1 (de) 2008-09-25

Family

ID=23049549

Family Applications (2)

Application Number Title Priority Date Filing Date
DE60228212T Expired - Lifetime DE60228212D1 (de) 2001-03-09 2002-03-08 Neue expressionsvektoren
DE02708018T Pending DE02708018T1 (de) 2001-03-09 2002-03-08 Neue expressionsvektoren

Family Applications After (1)

Application Number Title Priority Date Filing Date
DE02708018T Pending DE02708018T1 (de) 2001-03-09 2002-03-08 Neue expressionsvektoren

Country Status (13)

Country Link
US (3) US7157272B2 (de)
EP (1) EP1373528B1 (de)
JP (2) JP2004530425A (de)
KR (1) KR100917939B1 (de)
CN (1) CN100471956C (de)
AT (1) ATE404679T1 (de)
AU (1) AU2002242474B2 (de)
CA (1) CA2440148C (de)
DE (2) DE60228212D1 (de)
IL (2) IL157756A0 (de)
NZ (1) NZ528000A (de)
WO (1) WO2002072844A1 (de)
ZA (1) ZA200306885B (de)

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ATE490267T1 (de) 2001-06-05 2010-12-15 Curevac Gmbh Stabilisierte mrna mit erhöhtem g/c-gehalt, kodierend für ein virales antigen
WO2004025264A2 (en) * 2002-09-16 2004-03-25 Promega Corporation Rapidly degraded reporter fusion proteins
DE102004042546A1 (de) * 2004-09-02 2006-03-09 Curevac Gmbh Kombinationstherapie zur Immunstimulation
AR053279A1 (es) * 2005-05-19 2007-04-25 Monsanto Technology Llc Regulacion post-transcripcional de la expresion genica
US20070212332A1 (en) * 2005-08-11 2007-09-13 Department Of Veterans Affairs Methods for accelerating bone repair
EP1760092A1 (de) * 2005-08-26 2007-03-07 Applied Research Systems ARS Holding N.V. System für Screening von Zellen mit hoher Expression von einem interessierenden Protein
DE102005046490A1 (de) * 2005-09-28 2007-03-29 Johannes-Gutenberg-Universität Mainz Modifikationen von RNA, die zu einer erhöhten Transkriptstabilität und Translationseffizienz führen
WO2007038757A2 (en) * 2005-09-28 2007-04-05 Attagene Inc. Methods and compositions for non-invasive assessment of gene expression
US20070245258A1 (en) * 2006-04-13 2007-10-18 Codman Neuro Sciences Sàrl Graphical user interface of an external control device for controlling an implantable medical device while minimizing human error
WO2008076844A2 (en) * 2006-12-13 2008-06-26 Unl Technology Development Corporation Novel genes and rna molecules that confer stress tolerance
WO2008074025A2 (en) * 2006-12-13 2008-06-19 Idiverse, Inc. Novel genes and rna molecules that confer stress tolerance
EP2845909B1 (de) * 2006-12-21 2018-01-31 Gene Stream Pty Ltd. Biolumineszenz-Testverfahren mit Nutzung sezernierter Luciferasen
CN101688252A (zh) * 2007-07-11 2010-03-31 皇家飞利浦电子股份有限公司 使用超声诱导的报道分子构建体转染的体内表达分析
US20110071047A1 (en) * 2007-10-27 2011-03-24 O.D. 260 Inc. Promoter detection and analysis
US20090111099A1 (en) * 2007-10-27 2009-04-30 Yongsheng Ma Promoter Detection and Analysis
KR101204895B1 (ko) 2010-01-27 2012-11-26 단국대학교 산학협력단 Ｐｒｃ１ 유전자 프로모터의 삭제변이 프로모터를 함유하는 암세포 특이적 발현벡터
EP3578205A1 (de) 2010-08-06 2019-12-11 ModernaTX, Inc. Pharmazeutische zusammensetzungen enthaltenbearbeitete nukleinsäuren und ihre medizinische verwendung
CA2813466A1 (en) 2010-10-01 2012-04-05 Moderna Therapeutics, Inc. Modified nucleosides, nucleotides, and nucleic acids that disrupt major groove binding partner interactions
JP6147669B2 (ja) 2010-12-03 2017-06-14 ジーン・ストリーム・ピーティワイ・リミテッド 改良光放射分子
CA2831613A1 (en) 2011-03-31 2012-10-04 Moderna Therapeutics, Inc. Delivery and formulation of engineered nucleic acids
US9464124B2 (en) 2011-09-12 2016-10-11 Moderna Therapeutics, Inc. Engineered nucleic acids and methods of use thereof
CN110511939A (zh) 2011-10-03 2019-11-29 现代泰克斯公司 修饰的核苷、核苷酸和核酸及其用途
EP2791160B1 (de) 2011-12-16 2022-03-02 ModernaTX, Inc. Modifizierte mrna zusammensetzungen
EP2833923A4 (de) 2012-04-02 2016-02-24 Moderna Therapeutics Inc Modifizierte polynukleotide zur herstellung von proteinen
US9878056B2 (en) 2012-04-02 2018-01-30 Modernatx, Inc. Modified polynucleotides for the production of cosmetic proteins and peptides
US9283287B2 (en) 2012-04-02 2016-03-15 Moderna Therapeutics, Inc. Modified polynucleotides for the production of nuclear proteins
US9572897B2 (en) 2012-04-02 2017-02-21 Modernatx, Inc. Modified polynucleotides for the production of cytoplasmic and cytoskeletal proteins
PT2922554T (pt) 2012-11-26 2022-06-28 Modernatx Inc Arn modificado nas porções terminais
US8980864B2 (en) 2013-03-15 2015-03-17 Moderna Therapeutics, Inc. Compositions and methods of altering cholesterol levels
CN104099357B (zh) * 2013-04-12 2016-09-21 中国科学院上海生命科学研究院 检测蛋白质稳定性的方法及其应用
WO2015048744A2 (en) 2013-09-30 2015-04-02 Moderna Therapeutics, Inc. Polynucleotides encoding immune modulating polypeptides
SG11201602503TA (en) 2013-10-03 2016-04-28 Moderna Therapeutics Inc Polynucleotides encoding low density lipoprotein receptor
EP3452101A2 (de) * 2016-05-04 2019-03-13 CureVac AG Rna-codierung eines therapeutischen proteins
JP6683847B2 (ja) 2016-06-20 2020-04-22 ヤンセン ファッシンズ アンド プリベンション ベーフェーＪａｎｓｓｅｎ Ｖａｃｃｉｎｅｓ ＆ Ｐｒｅｖｅｎｔｉｏｎ Ｂ．Ｖ． 強力でバランスのとれた双方向性プロモーター
CN110121352B (zh) 2016-09-01 2020-12-11 嵌合体生物工程公司 Gold优化的car t-细胞
JP2021518747A (ja) * 2018-02-13 2021-08-05 キメラ・バイオエンジニアリング，インコーポレーテッド Ｒｎａ不安定化エレメントを使用した遺伝子発現の調整
CN114846145A (zh) * 2019-11-26 2022-08-02 韩国生命工学研究院 用于蛋白质表达的mRNA构建体及其用途
WO2022204471A1 (en) * 2021-03-26 2022-09-29 Ptc Therapeutics Inc. Regulation of transgene expression using a small molecule inducible splicing switch
WO2022250430A1 (ko) * 2021-05-25 2022-12-01 한국생명공학연구원 단백질 발현용 mRNA 제조방법 및 이에 의해 제조된 mRNA의 용도

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WO1994026776A1 (en) * 1993-05-18 1994-11-24 Biomolecular Research Institute Ltd. Therapeutic compounds
US5464758A (en) * 1993-06-14 1995-11-07 Gossen; Manfred Tight control of gene expression in eucaryotic cells by tetracycline-responsive promoters
US5587300A (en) * 1994-04-26 1996-12-24 Wisconsin Ulumni Research Foundation Method to increase regulatory molecule production
US5650135A (en) * 1994-07-01 1997-07-22 The Board Of Trustees Of The Leland Stanford Junior University Non-invasive localization of a light-emitting conjugate in a mammal
US5625048A (en) * 1994-11-10 1997-04-29 The Regents Of The University Of California Modified green fluorescent proteins
US5777079A (en) * 1994-11-10 1998-07-07 The Regents Of The University Of California Modified green fluorescent proteins
US5804387A (en) * 1996-02-01 1998-09-08 The Board Of Trustees Of The Leland Stanford Junior University FACS-optimized mutants of the green fluorescent protein (GFP)
US6743620B1 (en) * 1996-12-16 2004-06-01 Eisai Co., Ltd. Method for preparing retrovirus vector for gene therapy
US6231880B1 (en) * 1997-05-30 2001-05-15 Susan P. Perrine Compositions and administration of compositions for the treatment of blood disorders
WO1999014346A2 (en) * 1997-09-19 1999-03-25 Sequitur, Inc. SENSE mRNA THERAPY
US6130313A (en) * 1997-10-02 2000-10-10 Clontech Laboratories, Inc. Rapidly degrading GFP-fusion proteins
US6306600B1 (en) * 1998-04-17 2001-10-23 Clontech Laboratories, Inc. Rapidly degrading GFP-fusion proteins and methods of use
US5965421A (en) * 1997-11-26 1999-10-12 Human Genome Sciences, Inc. Human IRAK-2
JPH11266872A (ja) * 1998-03-20 1999-10-05 Suntory Ltd ＮＦ−κＢの活性化を抑制する物質のスクリーニング方法
US20040002056A1 (en) * 1998-05-12 2004-01-01 Lorens James B. Methods of screening for bioactive agents using cells transformed with self-inactivating viral vectors
US6307123B1 (en) * 1998-05-18 2001-10-23 Dekalb Genetics Corporation Methods and compositions for transgene identification
GB9828709D0 (en) * 1998-12-24 1999-02-17 Novartis Ag Assay
US6635671B1 (en) * 1998-12-24 2003-10-21 Novation Pharmaceuticals Inc. Compounds which affect mRNA stability and uses therefor
US20020102638A1 (en) * 2000-01-31 2002-08-01 Rosen Craig A. Nucleic acids, proteins, and antibodies
US6841362B1 (en) * 2000-02-29 2005-01-11 The Trustees Of Columbia University In The City Of New York Melanoma differentiation associated gene-7 promoter and uses thereof
WO2001084155A1 (en) * 2000-04-28 2001-11-08 Message Pharmaceuticals, Inc. Methods for identifying novel nucleic acid regulatory elements and compounds that affect the regulation
WO2002072844A1 (en) * 2001-03-09 2002-09-19 Gene Stream Pty Ltd Novel expression vectors
US9677071B2 (en) * 2011-04-20 2017-06-13 King Faisal Specialist Hospital And Research Centre Multiple interferon and virus response element cell-based fluorescence system
US20180305776A1 (en) * 2017-04-20 2018-10-25 The Board Of Trustees Of The Leland Stanford Junior University Myc-reporters, cells containing myc-reporters and methods of use thereof

Also Published As

Publication number Publication date
CN100471956C (zh) 2009-03-25
CA2440148A1 (en) 2002-09-19
CN1503844A (zh) 2004-06-09
EP1373528B1 (de) 2008-08-13
US7157272B2 (en) 2007-01-02
WO2002072844A1 (en) 2002-09-19
KR100917939B1 (ko) 2009-09-21
EP1373528A1 (de) 2004-01-02
IL157756A0 (en) 2004-03-28
KR20030092013A (ko) 2003-12-03
US20070298417A1 (en) 2007-12-27
US20040115704A1 (en) 2004-06-17
JP2004530425A (ja) 2004-10-07
EP1373528A4 (de) 2004-12-29
IL157756A (en) 2010-12-30
DE02708018T1 (de) 2004-09-30
US20040209274A2 (en) 2004-10-21
JP2011015685A (ja) 2011-01-27
ZA200306885B (en) 2009-03-25
AU2002242474B2 (en) 2004-05-20
US20180305705A1 (en) 2018-10-25
NZ528000A (en) 2005-09-30
ATE404679T1 (de) 2008-08-15
CA2440148C (en) 2012-07-10
US9994858B2 (en) 2018-06-12

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