ATE465247T1 - Identifikation von 3-ketosteroid 9-alfa- hydroxylase genen und blockierte mikroorganismen in 3-ketosteroid 9-alfa-hydroxylase aktivität - Google Patents

Identifikation von 3-ketosteroid 9-alfa- hydroxylase genen und blockierte mikroorganismen in 3-ketosteroid 9-alfa-hydroxylase aktivität

Info

Publication number
ATE465247T1
ATE465247T1 AT03714925T AT03714925T ATE465247T1 AT E465247 T1 ATE465247 T1 AT E465247T1 AT 03714925 T AT03714925 T AT 03714925T AT 03714925 T AT03714925 T AT 03714925T AT E465247 T1 ATE465247 T1 AT E465247T1
Authority
AT
Austria
Prior art keywords
ketosteroid
alfa
hydroxylase
blocked
microorganisms
Prior art date
Application number
AT03714925T
Other languages
English (en)
Inventor
Der Geize Robert Van
Der Meijden Peter Van
Gerda Hessels
Lubbert Dijkhuizen
Original Assignee
Organon Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Organon Nv filed Critical Organon Nv
Application granted granted Critical
Publication of ATE465247T1 publication Critical patent/ATE465247T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0071—Oxidoreductases (1.) acting on paired donors with incorporation of molecular oxygen (1.14)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P33/00—Preparation of steroids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
  • Enzymes And Modification Thereof (AREA)
AT03714925T 2002-02-21 2003-02-19 Identifikation von 3-ketosteroid 9-alfa- hydroxylase genen und blockierte mikroorganismen in 3-ketosteroid 9-alfa-hydroxylase aktivität ATE465247T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP02075723 2002-02-21
PCT/EP2003/050025 WO2003070925A2 (en) 2002-02-21 2003-02-19 Identification of 3-ketosteroid 9-alfa-hydroxylase genes and microorganisms blocked in 3-ketosteroid 9-alfa-hydroxylase activity

Publications (1)

Publication Number Publication Date
ATE465247T1 true ATE465247T1 (de) 2010-05-15

Family

ID=27741192

Family Applications (1)

Application Number Title Priority Date Filing Date
AT03714925T ATE465247T1 (de) 2002-02-21 2003-02-19 Identifikation von 3-ketosteroid 9-alfa- hydroxylase genen und blockierte mikroorganismen in 3-ketosteroid 9-alfa-hydroxylase aktivität

Country Status (8)

Country Link
US (3) US7223579B2 (de)
EP (1) EP1478742B1 (de)
JP (1) JP2005517443A (de)
AT (1) ATE465247T1 (de)
AU (1) AU2003219134A1 (de)
DE (1) DE60332213D1 (de)
ES (1) ES2342271T3 (de)
WO (1) WO2003070925A2 (de)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102006057218A1 (de) * 2006-12-01 2008-06-05 Gkn Driveline International Gmbh Antriebsanordnung mit Zwischenwelle und Kupplungseinheit
WO2009024572A1 (en) * 2007-08-21 2009-02-26 N.V. Organon Method for the production of modified steroid degrading microorganisms and their use
WO2010094810A1 (en) * 2009-02-23 2010-08-26 N.V. Organon Pharmaceutical compositions and methods for treating tuberculosis
EP3112472B1 (de) 2014-02-27 2019-03-27 Consejo Superior De Investigaciones Científicas Selektive rekombinante mutanten aus mycobacterium smegmatis mc2 155 und verwendung davon zur herstellung von 1,4-androstadien-3,17-dion oder 4-androsten-3,17-dion aus natürlichen sterolen
GB2577037A (en) * 2018-08-09 2020-03-18 Cambrex Karlskoga Ab Genetically-modified bacteria and uses thereof
CN114621965B (zh) * 2022-02-15 2023-10-03 复旦大学 一种3-甾酮-δ1-脱氢酶突变体及应用

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3521111A1 (de) * 1985-06-10 1986-12-11 Schering AG, 1000 Berlin und 4709 Bergkamen Verfahren zur herstellung von 4-androsten-3,17-dion und 1,4-androstadien-3,17-dion
CN1224716C (zh) 1999-10-22 2005-10-26 阿克佐诺贝尔公司 类固醇的微生物9α－羟基化

Also Published As

Publication number Publication date
WO2003070925A2 (en) 2003-08-28
ES2342271T3 (es) 2010-07-05
US20070178550A1 (en) 2007-08-02
DE60332213D1 (de) 2010-06-02
US20070111277A1 (en) 2007-05-17
JP2005517443A (ja) 2005-06-16
EP1478742A2 (de) 2004-11-24
US7223579B2 (en) 2007-05-29
EP1478742B1 (de) 2010-04-21
AU2003219134A1 (en) 2003-09-09
US7432075B2 (en) 2008-10-07
WO2003070925A3 (en) 2004-04-08
US7514236B2 (en) 2009-04-07
WO2003070925A9 (en) 2005-01-06
US20060040343A1 (en) 2006-02-23

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