DE60225242D1 - Verfahren zur herstellung von nanopartikeln - Google Patents

Verfahren zur herstellung von nanopartikeln

Info

Publication number
DE60225242D1
DE60225242D1 DE60225242T DE60225242T DE60225242D1 DE 60225242 D1 DE60225242 D1 DE 60225242D1 DE 60225242 T DE60225242 T DE 60225242T DE 60225242 T DE60225242 T DE 60225242T DE 60225242 D1 DE60225242 D1 DE 60225242D1
Authority
DE
Germany
Prior art keywords
particles
droplets
carrier gas
liquid feed
feed stock
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60225242T
Other languages
English (en)
Other versions
DE60225242T2 (de
Inventor
Wiwik Watanabe
Esko Kauppinen
Petri Ahonen
David Brown
Esa Muttonen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Orion Oyj
Original Assignee
Orion Oyj
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Orion Oyj filed Critical Orion Oyj
Publication of DE60225242D1 publication Critical patent/DE60225242D1/de
Application granted granted Critical
Publication of DE60225242T2 publication Critical patent/DE60225242T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5192—Processes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J13/00—Colloid chemistry, e.g. the production of colloidal materials or their solutions, not otherwise provided for; Making microcapsules or microballoons
    • B01J13/0004—Preparation of sols
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/0075—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a dry powder inhaler [DPI], e.g. comprising micronized drug mixed with lactose carrier particles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1688—Processes resulting in pure drug agglomerate optionally containing up to 5% of excipient

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Dispersion Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Physics & Mathematics (AREA)
  • Biomedical Technology (AREA)
  • Nanotechnology (AREA)
  • Optics & Photonics (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
DE60225242T 2001-01-18 2002-01-18 Verfahren zur herstellung von nanopartikeln Expired - Lifetime DE60225242T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
FI20010115A FI20010115A0 (fi) 2001-01-18 2001-01-18 Menetelmä nanopartikkelien valmistamiseksi
FI20010115 2001-01-18
PCT/FI2002/000042 WO2002056866A1 (en) 2001-01-18 2002-01-18 A method for the preparation of nanoparticles

Publications (2)

Publication Number Publication Date
DE60225242D1 true DE60225242D1 (de) 2008-04-10
DE60225242T2 DE60225242T2 (de) 2009-03-19

Family

ID=8560060

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60225242T Expired - Lifetime DE60225242T2 (de) 2001-01-18 2002-01-18 Verfahren zur herstellung von nanopartikeln

Country Status (7)

Country Link
US (1) US20040091542A1 (de)
EP (1) EP1351666B1 (de)
JP (1) JP4728558B2 (de)
AT (1) ATE387185T1 (de)
DE (1) DE60225242T2 (de)
FI (1) FI20010115A0 (de)
WO (1) WO2002056866A1 (de)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20070122353A1 (en) 2001-05-24 2007-05-31 Hale Ron L Drug condensation aerosols and kits
US7766013B2 (en) 2001-06-05 2010-08-03 Alexza Pharmaceuticals, Inc. Aerosol generating method and device
US6900317B2 (en) 2002-02-19 2005-05-31 Boehringer Ingelheim Pharma Gmbh & Co. Kg Salts of the CGRP antagonist BIBN4096 and inhalable powdered medicaments containing them
EP1625333A1 (de) 2003-05-21 2006-02-15 Alexza Pharmaceuticals, Inc. Unabhängige heizeinheit und diese benutzende medikamentenabgabevorrichtung
EP1718446A4 (de) * 2004-02-24 2009-12-09 Luna Innovations Inc Verfahren und systeme zur effizienten herstellung von polymeren mikrosphären
US8758821B2 (en) 2004-05-04 2014-06-24 Hormos Medical Ltd. Oral formulations of ospemifene
CN1950071A (zh) 2004-05-04 2007-04-18 霍尔莫斯医疗有限公司 ospemifene的新口服制剂
US20090028948A1 (en) * 2004-12-31 2009-01-29 Iceutica Pty Ltd Nanoparticle composition and methods of synthesis thereof
JP4979203B2 (ja) * 2005-05-31 2012-07-18 栗田工業株式会社 吸着構造体およびその製造方法
CN101384247B (zh) 2005-07-18 2013-05-22 麻萨诸塞州洛厄尔大学 制备与使用纳米乳剂的组合物和方法
US9486408B2 (en) * 2005-12-01 2016-11-08 University Of Massachusetts Lowell Botulinum nanoemulsions
HUE054852T2 (hu) * 2005-12-01 2021-10-28 Univ Massachusetts Lowell Botulinum nanoemulziók
CN1785153B (zh) * 2005-12-06 2010-04-21 青岛大学 纳米级材料制备装置及纳米抗氧化活性多肽药物的制备方法
JP2007301534A (ja) * 2006-05-15 2007-11-22 Ebara Corp 微細化装置
EP2018875A1 (de) 2006-05-15 2009-01-28 Ebara Corporation Pharmazeutischer wirkstoff mit geringer wasserlöslichkeit
DE102006026578B4 (de) * 2006-06-08 2009-01-08 Lts Lohmann Therapie-Systeme Ag Wirkstoffpartikelhaltiges Transdermales Therapeutisches System mit erhöhtem Wirkstofffluss und Verfahren zu seiner Herstellung sowie Verwendung
WO2008000042A1 (en) 2006-06-30 2008-01-03 Iceutica Pty Ltd Methods for the preparation of biologically active compounds in nanoparticulate form
AU2007329579A1 (en) 2006-12-01 2008-06-12 Anterios, Inc. Amphiphilic entity nanoparticles
CN107080703A (zh) 2006-12-01 2017-08-22 安特里奥公司 肽纳米粒子和其用途
CA2672261C (en) * 2006-12-11 2014-09-23 Drugrecure Aps Methods for treating cystic fibrosis or pneumonia with bacterial infection via pulmonary administration of fosfomycin
ES2594867T3 (es) 2007-03-09 2016-12-23 Alexza Pharmaceuticals, Inc. Unidad de calentamiento para usar en un dispositivo de administración de fármaco
EP2162117B1 (de) 2007-05-31 2018-02-21 Anterios, Inc. Nukleinsäure-nanoteilchen und ihre verwendungszwecke
US20110182994A1 (en) * 2008-07-25 2011-07-28 S.K. Pharmaceuticals, Inc. Methods and systems for production of nanoparticles
NZ595986A (en) 2009-04-24 2014-04-30 Iceutica Pty Ltd A novel formulation of indomethacin
DE102014011635A1 (de) 2013-09-04 2015-03-05 Chemiewerk Bad Köstritz GmbH Verfahren zur Herstellung von nanostrukturierbaren Mikropartikeln aus fluiden Medien mittels Sprühtrocknung
US9526734B2 (en) 2014-06-09 2016-12-27 Iceutica Pty Ltd. Formulation of meloxicam
JP2019535829A (ja) 2016-11-21 2019-12-12 エイリオン セラピューティクス， インコーポレイテッド 大型薬剤の経皮送達
CN110232214B (zh) * 2019-05-09 2020-07-28 北京大学 一种通过数值模拟的食品预冷性能评估和优化方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3306250A1 (de) * 1983-02-23 1984-08-23 Basf Ag, 6700 Ludwigshafen Sphaerische einkristalle fuer pharmazeutische zwecke
US5145684A (en) * 1991-01-25 1992-09-08 Sterling Drug Inc. Surface modified drug nanoparticles
GB9105705D0 (en) * 1991-03-18 1991-05-01 Sandoz Ltd Improvements in or relating to organic compounds
AU660852B2 (en) * 1992-11-25 1995-07-06 Elan Pharma International Limited Method of grinding pharmaceutical substances
US5819726A (en) * 1993-01-29 1998-10-13 Aradigm Corporation Method for the delivery of aerosolized drugs to the lung for the treatment of respiratory disease
US5833892A (en) * 1996-07-12 1998-11-10 Kemira Pigments, Inc. Formation of TiO2 pigment by spray calcination
US6338809B1 (en) * 1997-02-24 2002-01-15 Superior Micropowders Llc Aerosol method and apparatus, particulate products, and electronic devices made therefrom
US6051257A (en) * 1997-02-24 2000-04-18 Superior Micropowders, Llc Powder batch of pharmaceutically-active particles and methods for making same

Also Published As

Publication number Publication date
WO2002056866A1 (en) 2002-07-25
JP2004520157A (ja) 2004-07-08
ATE387185T1 (de) 2008-03-15
EP1351666A1 (de) 2003-10-15
DE60225242T2 (de) 2009-03-19
EP1351666B1 (de) 2008-02-27
US20040091542A1 (en) 2004-05-13
FI20010115A0 (fi) 2001-01-18
JP4728558B2 (ja) 2011-07-20

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