DE60223250D1 - Verfahren zur herstellung von alpha-hydroxysäure, glycolsäure und 2-hydroxyisobuttersäure aus dem entsprechenden alpha-hydroxynitril mittels nitrilase - Google Patents

Verfahren zur herstellung von alpha-hydroxysäure, glycolsäure und 2-hydroxyisobuttersäure aus dem entsprechenden alpha-hydroxynitril mittels nitrilase

Info

Publication number
DE60223250D1
DE60223250D1 DE60223250T DE60223250T DE60223250D1 DE 60223250 D1 DE60223250 D1 DE 60223250D1 DE 60223250 T DE60223250 T DE 60223250T DE 60223250 T DE60223250 T DE 60223250T DE 60223250 D1 DE60223250 D1 DE 60223250D1
Authority
DE
Germany
Prior art keywords
acid
alpha
hydroxynitril
hydroxyisobutteric
nitrilase
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60223250T
Other languages
English (en)
Other versions
DE60223250T2 (de
Inventor
Sarita Chauhan
Robert Dicosimo
Robert D Fallon
John E Gavagan
Mark S Payne
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
EIDP Inc
Original Assignee
EI Du Pont de Nemours and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by EI Du Pont de Nemours and Co filed Critical EI Du Pont de Nemours and Co
Publication of DE60223250D1 publication Critical patent/DE60223250D1/de
Application granted granted Critical
Publication of DE60223250T2 publication Critical patent/DE60223250T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/40—Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids
    • C12P7/42—Hydroxy-carboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/40—Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/78—Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5)

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
DE60223250T 2001-02-23 2002-02-20 Verfahren zur herstellung von alpha-hydroxysäure, glycolsäure und 2-hydroxyisobuttersäure aus dem entsprechenden alpha-hydroxynitril mittels nitrilase Expired - Lifetime DE60223250T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US791929P 2001-02-23
US09/791,929 US6416980B1 (en) 2001-02-23 2001-02-23 Method for producing glycolic acid from glycolonitrile using nitrilase
PCT/US2002/008156 WO2002068658A1 (en) 2001-02-23 2002-02-20 Method for producing alpha-hydroxy acid, glycolic acid 2-hydroxyisobutyric acid from a corresponding alpha-hydroxy nitrile using nitrilase

Publications (2)

Publication Number Publication Date
DE60223250D1 true DE60223250D1 (de) 2007-12-13
DE60223250T2 DE60223250T2 (de) 2008-08-14

Family

ID=25155251

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60223250T Expired - Lifetime DE60223250T2 (de) 2001-02-23 2002-02-20 Verfahren zur herstellung von alpha-hydroxysäure, glycolsäure und 2-hydroxyisobuttersäure aus dem entsprechenden alpha-hydroxynitril mittels nitrilase

Country Status (9)

Country Link
US (2) US6416980B1 (de)
EP (1) EP1399567B1 (de)
JP (1) JP4235450B2 (de)
KR (1) KR20040004535A (de)
CN (1) CN100402652C (de)
CA (1) CA2433036A1 (de)
DE (1) DE60223250T2 (de)
MX (1) MXPA03007484A (de)
WO (1) WO2002068658A1 (de)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030199526A1 (en) * 2001-12-07 2003-10-23 Deborah Choquette Pyrimidine-based compounds useful as GSK-3 inhibitors
US7148051B2 (en) * 2004-08-16 2006-12-12 E. I. Du Pont De Nemours And Company Production of 3-hydroxycarboxylic acid using nitrilase
CN1772912B (zh) * 2004-11-12 2012-12-26 上海市农药研究所 生物催化生产羟基乙酸
WO2006069110A2 (en) 2004-12-22 2006-06-29 E.I. Dupont De Nemours And Company Enzymatic production of glycolic acid
CN101087750B (zh) * 2004-12-22 2011-10-05 纳幕尔杜邦公司 通过醇解从羧酸铵盐制备羧酸酯的方法
US7445917B2 (en) * 2004-12-22 2008-11-04 E.I. Du Pont De Nemours And Company Process for producing glycolic acid from formaldehyde and hydrogen cyanide
US7198927B2 (en) 2004-12-22 2007-04-03 E. I. Du Pont De Nemours And Company Enzymatic production of glycolic acid
US20060160197A1 (en) * 2004-12-22 2006-07-20 Xu Li Method for the production of glycolic acid from ammonium glycolate by solvent extraction
WO2006069129A1 (en) * 2004-12-22 2006-06-29 E.I. Dupont De Nemours And Company Method for the production of glycolic acid from ammonium glycolate by direct deammoniation
WO2006069114A2 (en) * 2004-12-22 2006-06-29 E.I. Dupont De Nemours And Company Process for producing glycolic acid from formaldehyde and hydrogen cyanide
EP2361900B1 (de) 2005-05-27 2015-04-08 Asahi Kasei Chemicals Corporation Verfahren zur Herstellung von Glykolsäure
JPWO2007049707A1 (ja) * 2005-10-26 2009-04-30 三井化学株式会社 グリコール酸の製造方法
JP2007289062A (ja) * 2006-04-25 2007-11-08 Asahi Kasei Chemicals Corp 生体触媒を用いたα−ヒドロキシ酸或いはα−ヒドロキシ酸アンモニウムの製造方法
JP4901293B2 (ja) * 2006-04-28 2012-03-21 旭化成ケミカルズ株式会社 バイオ法グリコール酸水溶液又はグリコール酸アンモニウム水溶液の脱色方法
JP5024855B2 (ja) * 2006-05-01 2012-09-12 旭化成ケミカルズ株式会社 グリコール酸とアンモニアからなる新規結晶並びにその製造方法
JP4906395B2 (ja) * 2006-05-01 2012-03-28 旭化成ケミカルズ株式会社 高純度グリコール酸水溶液の製造法
WO2007140816A1 (en) * 2006-06-09 2007-12-13 Metabolic Explorer Glycolic acid production by fermentation from renewable resources
US20100267100A1 (en) * 2007-03-21 2010-10-21 Ling Hua Enzymatic synthesis of optically pure beta-hydroxy carboxylic acids and their derivatives
US20090004720A1 (en) * 2007-06-26 2009-01-01 Ling Hua Smart Biocatalysts For Organic Synthesis
US7741088B2 (en) 2007-10-31 2010-06-22 E.I. Dupont De Nemours And Company Immobilized microbial nitrilase for production of glycolic acid
US7871802B2 (en) 2007-10-31 2011-01-18 E.I. Du Pont De Nemours And Company Process for enzymatically converting glycolonitrile to glycolic acid
US7695945B2 (en) * 2007-10-31 2010-04-13 E. I. Du Pont De Nemours And Company Immobilized microbial nitrilase for production of glycolic acid
FR2974803B1 (fr) 2011-05-06 2013-05-03 Roquette Freres Procede de preparation d'un acide glycolique partiellement purifie
FR2974804B1 (fr) 2011-05-06 2013-05-03 Roquette Freres Procede de preparation d'un acide glycolique de haute purete
FR2974802B1 (fr) 2011-05-06 2013-09-13 Roquette Freres Procede de purification de l'acide glycolique par distillation
JP2017504339A (ja) * 2014-01-28 2017-02-09 ランザテク・ニュージーランド・リミテッド 酪酸に対する増加した耐性を有する細菌
CN110205315B (zh) * 2019-05-30 2021-01-01 中国石油大学(华东) 腈水解酶XiNit2及其编码基因和应用

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2245585B1 (de) 1973-09-19 1976-05-14 Anvar
EP0449648B1 (de) 1990-03-30 1999-05-12 Nitto Chemical Industry Co., Ltd. Verfahren zur Herstellung von R(-)Mandelsäure und deren Derivaten
JP2974737B2 (ja) 1990-08-16 1999-11-10 三菱レイヨン株式会社 光学活性乳酸の製造法
DE69126762T2 (de) 1990-11-14 1997-10-23 Nitto Chemical Industry Co Ltd Biologisches Verfahren zur Herstellung von Alpha-Hydroxyamid und Alpha-Hydroxysäure
JP2676568B2 (ja) 1991-06-26 1997-11-17 日東化学工業株式会社 Ｒ（−）−マンデル酸およびその誘導体の製造法
JP3354688B2 (ja) 1994-01-28 2002-12-09 三菱レイヨン株式会社 微生物によるα−ヒドロキシ酸またはα−ヒドロキシアミドの製造法
JP3154646B2 (ja) 1995-07-19 2001-04-09 三菱レイヨン株式会社 グリコール酸の微生物学的製造法
US5756306A (en) 1995-11-10 1998-05-26 Nitto Chemical Industry Co., Ltd. Process for producing a-hydroxy acid or a-hydroxyamide by microorganism
US5858736A (en) 1996-05-17 1999-01-12 E. I. Du Pont De Nemours And Company Preparation of lactams from aliphatic α,ω-dinitriles
US6037155A (en) * 1997-02-27 2000-03-14 Nippon Soda Co., Ltd. Process for preparing α-hydroxy acids using microorganism and novel microorganism
EP1280892B1 (de) * 2000-03-31 2011-01-12 E.I. Du Pont De Nemours And Company Isolierung und expression eines nitrilase-gens von acidovorax facilis 72w
US6562603B2 (en) * 2000-08-04 2003-05-13 E. I. Du Pont De Nemours And Company 3-hydroxycarboxylic acid production and use in branched polymers
US6455730B1 (en) * 2000-08-04 2002-09-24 E. I. Du Pont De Nemours & Company Preparation of dicarboxylic acid monoesters from cyanocarboxylic acid esters

Also Published As

Publication number Publication date
WO2002068658A1 (en) 2002-09-06
JP4235450B2 (ja) 2009-03-11
DE60223250T2 (de) 2008-08-14
US6383786B1 (en) 2002-05-07
CA2433036A1 (en) 2002-09-06
EP1399567B1 (de) 2007-10-31
CN1549860A (zh) 2004-11-24
EP1399567A1 (de) 2004-03-24
MXPA03007484A (es) 2003-12-04
KR20040004535A (ko) 2004-01-13
JP2005504506A (ja) 2005-02-17
CN100402652C (zh) 2008-07-16
US6416980B1 (en) 2002-07-09

Similar Documents

Publication Publication Date Title
DE60223250D1 (de) Verfahren zur herstellung von alpha-hydroxysäure, glycolsäure und 2-hydroxyisobuttersäure aus dem entsprechenden alpha-hydroxynitril mittels nitrilase
DE60211535D1 (de) Verfahren zur herstellung von 2,5-diformylfuran aus kohlenhydraten
DE60228118D1 (de) Verfahren zur herstellung von o-desmethylvenlafaxin
DE60302682D1 (de) Verfahren zur Herstellung von Nanopartikeln
DE50303749D1 (de) Verfahren zur herstellung von phthalocyaninpigmentzubereitungen
DE602004010234D1 (de) Verfahren zur herstellung von 4-aminodiphenylamin
DE50112916D1 (de) Verfahren zur herstellung von alkylarylsulfonaten
DE50201891D1 (de) Verfahren zur herstellung von 1-octen
DE60223070D1 (de) Verfahren zur herstellung von dihalogenadamantanen
DE60206996D1 (de) Verfahren zur Herstellung von 3-l-Menthoxypropan-1,2-diol
DE60216507D1 (de) Verfahren zur herstellung von polyetherimiden
DE60208738D1 (de) Verfahren zur Herstellung von Chlorfluorpolyoxyalkylenolen
DE60219193D1 (de) Verfahren zur herstellung von silylorganomercaptanen
DE60110200D1 (de) Verfahren zur Herstellung von Prepregs
DE10290269T1 (de) Verfahren zur Herstellung von Zyklischem Formal
DE50205766D1 (de) Verfahren zur herstellung von 2-halogenpyridincarbonsäureamiden
DE60239842D1 (de) Verfahren zur Herstellung von 10,11-dihydro-10-oxo-5h-dibenzoÄb,fÜazepin-5-carboxamid
DE60239286D1 (de) Verfahren zur herstellung von trans-1,4-cyclohexandicarbonsäure
DE50311721D1 (de) Verfahren zur Herstellung von Aryl-aminopropanolen
DE60233589D1 (de) Verfahren zur herstellung von echinocandinderivaten
DE50210487D1 (de) Verfahren zur Herstellung von 1-Amino-4-hydroxyanthrachinonen
DE60210778D1 (de) Verfahren zur herstellung von 4-amino-2,5-bisheterocyclylchinazolinen
DE502004009152D1 (de) Verfahren zur herstellung von derivaten des 4a,5,9,10,11,12-hexahydrobenzofuro ä3a,3,2üä 2 ü- benzazepins
DE60214469D1 (de) Verfahren zur Herstellung von Zirkoniapulver
DE60209171D1 (de) Verfahren zur Herstellung von Bromfluorenen

Legal Events

Date Code Title Description
8364 No opposition during term of opposition