DE60219419D1 - Flt4 (vegfr-3) als ein ziel für krebs darstellung und anti-krebs-behandlung - Google Patents
Flt4 (vegfr-3) als ein ziel für krebs darstellung und anti-krebs-behandlungInfo
- Publication number
- DE60219419D1 DE60219419D1 DE60219419T DE60219419T DE60219419D1 DE 60219419 D1 DE60219419 D1 DE 60219419D1 DE 60219419 T DE60219419 T DE 60219419T DE 60219419 T DE60219419 T DE 60219419T DE 60219419 D1 DE60219419 D1 DE 60219419D1
- Authority
- DE
- Germany
- Prior art keywords
- cancer
- flt4
- vegfr
- goal
- presentation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 102000016663 Vascular Endothelial Growth Factor Receptor-3 Human genes 0.000 title abstract 3
- 108010053100 Vascular Endothelial Growth Factor Receptor-3 Proteins 0.000 title 2
- 206010028980 Neoplasm Diseases 0.000 title 1
- 238000011394 anticancer treatment Methods 0.000 title 1
- 201000011510 cancer Diseases 0.000 title 1
- 229920001184 polypeptide Polymers 0.000 abstract 2
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 2
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 2
- 239000012634 fragment Substances 0.000 abstract 1
- 102000040430 polynucleotide Human genes 0.000 abstract 1
- 108091033319 polynucleotide Proteins 0.000 abstract 1
- 239000002157 polynucleotide Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2863—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/71—Receptors; Cell surface antigens; Cell surface determinants for growth factors; for growth regulators
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
- C12N9/1205—Phosphotransferases with an alcohol group as acceptor (2.7.1), e.g. protein kinases
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/62—DNA sequences coding for fusion proteins
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y207/00—Transferases transferring phosphorus-containing groups (2.7)
- C12Y207/10—Protein-tyrosine kinases (2.7.10)
- C12Y207/10001—Receptor protein-tyrosine kinase (2.7.10.1)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US765534 | 2001-01-19 | ||
US09/765,534 US7034105B2 (en) | 1992-10-09 | 2001-01-19 | FLT4 (VEGFR-3) as a target for tumor imaging and anti-tumor therapy |
PCT/US2002/001784 WO2002060950A2 (en) | 1994-11-14 | 2002-01-22 | Flt4(vegfr-3) as a target for tumor imaging and anti-tumor therapy |
Publications (2)
Publication Number | Publication Date |
---|---|
DE60219419D1 true DE60219419D1 (de) | 2007-05-24 |
DE60219419T2 DE60219419T2 (de) | 2007-08-16 |
Family
ID=27805582
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE60219419T Expired - Lifetime DE60219419T2 (de) | 2001-01-19 | 2002-01-22 | Flt4 (vegfr-3) als ein ziel für krebsdarstellung und anti-krebs-behandlung |
Country Status (10)
Country | Link |
---|---|
US (3) | US8940695B2 (de) |
EP (1) | EP1353952B1 (de) |
JP (2) | JP4669984B2 (de) |
CN (1) | CN1494552A (de) |
AT (1) | ATE359300T1 (de) |
AU (1) | AU2002248372B8 (de) |
CA (1) | CA2435503C (de) |
DE (1) | DE60219419T2 (de) |
NO (1) | NO20033285L (de) |
WO (1) | WO2002060950A2 (de) |
Families Citing this family (38)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU710696C (en) | 1995-09-08 | 2002-10-24 | Genentech Inc. | VEGF-related protein |
WO2000058511A1 (en) | 1999-03-26 | 2000-10-05 | Ludwig Institute For Cancer Research | Screening and therapy for lymphatic disorders involving the flt4 receptor tyrosine kinase (vegfr-3) |
ATE359300T1 (de) | 2001-01-19 | 2007-05-15 | Ludwig Inst Cancer Res | Flt4 (vegfr-3) als ein ziel für krebs darstellung und anti-krebs-behandlung |
US8623822B2 (en) | 2002-03-01 | 2014-01-07 | Bracco Suisse Sa | KDR and VEGF/KDR binding peptides and their use in diagnosis and therapy |
US7794693B2 (en) | 2002-03-01 | 2010-09-14 | Bracco International B.V. | Targeting vector-phospholipid conjugates |
EP1587944A4 (de) | 2002-03-01 | 2007-03-21 | Dyax Corp | Kdr und vegf/kdr-bindende peptide und ihre diagnostische und therapeutische veranwendung bei der diagnose und therapie |
US7261876B2 (en) | 2002-03-01 | 2007-08-28 | Bracco International Bv | Multivalent constructs for therapeutic and diagnostic applications |
DE10242663A1 (de) * | 2002-09-13 | 2004-03-25 | Forschungszentrum Karlsruhe Gmbh | Verfahren zur Identifizierung von Inhibitoren in vivo |
SI2949658T1 (sl) | 2003-03-03 | 2018-10-30 | Dyax Corp. | Peptidi, ki specifično vežejo HGF receptor (cMet) in njihove uporabe |
WO2005087177A2 (en) | 2004-03-05 | 2005-09-22 | Ludwig Institute For Cancer Research | Chimeric anti-vegf-d antibodies and humanized anti-vegf-d antibodies and methods of using same |
AU2005222384A1 (en) | 2004-03-05 | 2005-09-22 | Vegenics Limited | Growth factor binding constructs materials and methods |
WO2007022287A2 (en) | 2005-08-15 | 2007-02-22 | Vegenics Limited | Modified vegf and pdgf with improved angiogenic properties |
CA2623405C (en) | 2005-09-20 | 2014-11-25 | Immunivest Corporation | Methods and composition to generate unique sequence dna probes labeling of dna probes and the use of these probes |
US9134237B2 (en) | 2005-09-20 | 2015-09-15 | Janssen Diagnotics, LLC | High sensitivity multiparameter method for rare event analysis in a biological sample |
IL172297A (en) * | 2005-10-03 | 2016-03-31 | Compugen Ltd | Soluble vegfr-1 variants for the diagnosis of preeclampsia |
KR20090035011A (ko) * | 2006-07-26 | 2009-04-08 | 인트렉손 코포레이션 | 질병을 치료하는 방법 및 조성물 |
EP2125895B1 (de) | 2007-02-02 | 2015-04-08 | Vegenics Pty Ltd | Vegf-rezeptorantagonisten zur behandlung von allommunität bei organtransplantationen und atherosklerose |
CN101564540B (zh) * | 2008-04-22 | 2011-05-11 | 上海交通大学医学院附属瑞金医院 | 一种Gd-DTPA-Polylysine-McAb联结体的制备方法 |
WO2010021993A1 (en) * | 2008-08-19 | 2010-02-25 | Cytori Therapeutics, Inc. | Methods of using adipose tissue-derived cells in the treatment of the lymphatic system and malignant disease |
DE102009030321A1 (de) * | 2009-06-24 | 2011-01-05 | Siemens Aktiengesellschaft | Verfahren zur Abbildung von Tumorgewebe |
WO2011056494A1 (en) * | 2009-10-26 | 2011-05-12 | Genentech, Inc. | Activin receptor-like kinase-1 antagonist and vegfr3 antagonist combinations |
TWI505836B (zh) * | 2009-12-11 | 2015-11-01 | Genentech Inc | 抗-vegf-c抗體及其使用方法 |
EP2538965B1 (de) | 2010-02-25 | 2017-04-12 | Schepens Eye Research Institute | Therapeutische zusammensetzungen zur behandlung des syndroms des trockenen auges |
WO2011116026A2 (en) | 2010-03-15 | 2011-09-22 | The Board Of Trustees Of The University Of Illinois | Inhibitors of beta integrin-g protein alpha subunit binding interactions |
AR082641A1 (es) * | 2010-09-07 | 2012-12-19 | Imclone Llc | Composiciones de anticuerpo anti-vegfr-3 |
EP2655401B1 (de) | 2010-12-20 | 2016-03-09 | The Regents of the University of Michigan | Hemmer der bindeinteraktion des epidermalen wachstumsfaktor-rezeptor-wärmeschock-proteins 90 |
WO2013184209A1 (en) | 2012-06-04 | 2013-12-12 | Ludwig Institute For Cancer Research Ltd. | Mif for use in methods of treating subjects with a neurodegenerative disorder |
US20150246118A1 (en) | 2012-10-26 | 2015-09-03 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Lyve-1 antagonists for preventing or treating a pathological condition associated with lymphangiogenesis |
US9745558B2 (en) | 2013-02-18 | 2017-08-29 | Vegenics Pty Limited | VEGFR-3 ligand binding molecules and uses thereof |
US10274503B2 (en) | 2013-05-08 | 2019-04-30 | Vegenics Pty Limited | Methods of using VEGF-C biomarkers for age-related macular degeneration (AMD) diagnosis |
KR102060187B1 (ko) * | 2013-07-19 | 2019-12-27 | 삼성전자주식회사 | Vegf-c, vegf-d 및/또는 안지오포이에틴-2를 동시에 저해하는 융합 폴리펩타이드 및 이의 용도 |
US9616114B1 (en) | 2014-09-18 | 2017-04-11 | David Gordon Bermudes | Modified bacteria having improved pharmacokinetics and tumor colonization enhancing antitumor activity |
JP7264592B2 (ja) | 2015-01-26 | 2023-04-25 | ザ ユニバーシティー オブ シカゴ | IL13Rα2結合剤及び癌治療におけるその使用 |
JP6912386B2 (ja) | 2015-01-26 | 2021-08-04 | ザ ユニバーシティー オブ シカゴ | 癌特異的なIL13Rα2を認識するCAR T細胞 |
JP7084878B2 (ja) | 2016-05-16 | 2022-06-15 | 武田薬品工業株式会社 | 抗第IX因子Padua抗体 |
US11129906B1 (en) | 2016-12-07 | 2021-09-28 | David Gordon Bermudes | Chimeric protein toxins for expression by therapeutic bacteria |
US11180535B1 (en) | 2016-12-07 | 2021-11-23 | David Gordon Bermudes | Saccharide binding, tumor penetration, and cytotoxic antitumor chimeric peptides from therapeutic bacteria |
EP4055032A1 (de) | 2019-11-07 | 2022-09-14 | The Board Of Trustees Of The University Of Illinois | Peptide und verfahren zur behandlung von sepsis, atherosklerose, thrombose, schlaganfall, herzinfarkt und entzündung |
Family Cites Families (79)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4652639A (en) | 1982-05-06 | 1987-03-24 | Amgen | Manufacture and expression of structural genes |
US4543439A (en) | 1982-12-13 | 1985-09-24 | Massachusetts Institute Of Technology | Production and use of monoclonal antibodies to phosphotyrosine-containing proteins |
AU3934085A (en) | 1984-01-30 | 1985-08-09 | Icrf Patents Ltd. | Improvements relating to growth factors |
IL85688A0 (en) | 1987-03-11 | 1988-08-31 | Erba Carlo Spa | Immunoglobulin conjugates,their preparation and pharmaceutical compositions containing them |
ES2092468T3 (es) | 1988-01-22 | 1996-12-01 | Zymogenetics Inc | Metodos para producir analogos de receptores secretados. |
US5530101A (en) | 1988-12-28 | 1996-06-25 | Protein Design Labs, Inc. | Humanized immunoglobulins |
US5198359A (en) | 1989-03-07 | 1993-03-30 | Boehringer Ingelheim International Gmbh | Recombinant protein receptor for il-2 |
EP0474744B1 (de) | 1989-05-22 | 1994-08-03 | Zymogenetics, Inc. | Pdgf-alpha-rezeptor |
US5183884A (en) | 1989-12-01 | 1993-02-02 | United States Of America | Dna segment encoding a gene for a receptor related to the epidermal growth factor receptor |
ES2147729T3 (es) | 1991-01-31 | 2000-10-01 | Cor Therapeutics Inc | Dominios de la region extracelular de polipeptidos receptores de factor de crecimiento derivado de plaquetas humano. |
US5256766A (en) | 1991-02-19 | 1993-10-26 | The Regents Of The University Of California | Recombinant thrombin receptor and related pharmaceuticals |
CA2083401C (en) | 1991-02-22 | 2003-03-25 | Bruce I. Terman | Identification of a novel human receptor tyrosine kinase gene |
US5231001A (en) | 1991-03-14 | 1993-07-27 | The United States Of America As Represented By The Department Of Health And Human Services | Trk tyrosine kinase receptor is the physiological receptor for nerve growth factor |
US5185438A (en) | 1991-04-02 | 1993-02-09 | The Trustees Of Princeton University | Nucleic acids encoding hencatoporetic stem cell receptor flk-2 |
US5270458A (en) | 1991-04-02 | 1993-12-14 | The Trustees Of Princeton University | Nucleic acids encoding fragments of hematopoietic stem cell receptor flk-2 |
US5367057A (en) | 1991-04-02 | 1994-11-22 | The Trustees Of Princeton University | Tyrosine kinase receptor flk-2 and fragments thereof |
CA2078539C (en) | 1991-09-18 | 2005-08-02 | Kenya Shitara | Process for producing humanized chimera antibody |
JPH07506242A (ja) | 1992-01-09 | 1995-07-13 | ヘルシンキ ユニバーシティ ホルディング リミテッド | Tie,新規内皮細胞受容体チロシンキナーゼ |
US5635177A (en) | 1992-01-22 | 1997-06-03 | Genentech, Inc. | Protein tyrosine kinase agonist antibodies |
US6331302B1 (en) | 1992-01-22 | 2001-12-18 | Genentech, Inc. | Protein tyrosine kinase agonist antibodies |
AU3482493A (en) | 1992-01-22 | 1993-09-01 | New England Deaconess Hospital | Novel protein tyrosine kinases |
US5776427A (en) | 1992-03-05 | 1998-07-07 | Board Of Regents, The University Of Texas System | Methods for targeting the vasculature of solid tumors |
US6107046A (en) | 1992-10-09 | 2000-08-22 | Orion Corporation | Antibodies to Flt4, a receptor tyrosine kinase and uses thereof |
US5776755A (en) | 1992-10-09 | 1998-07-07 | Helsinki University Licensing, Ltd. | FLT4, a receptor tyrosine kinase |
US6824777B1 (en) | 1992-10-09 | 2004-11-30 | Licentia Ltd. | Flt4 (VEGFR-3) as a target for tumor imaging and anti-tumor therapy |
CA2145985C (en) | 1992-10-28 | 2003-09-16 | Napoleone Ferrara | Vascular endothelial cell growth factor antagonists |
US5712395A (en) | 1992-11-13 | 1998-01-27 | Yissum Research Development Corp. | Compounds for the treatment of disorders related to vasculogenesis and/or angiogenesis |
US5763441A (en) | 1992-11-13 | 1998-06-09 | Sugen, Inc. | Compounds for the treatment of disorders related to vasculogenesis and/or angiogenesis |
DE4337197C1 (de) | 1993-10-30 | 1994-08-25 | Biotest Pharma Gmbh | Verfahren zur selektiven Herstellung von Hybridomazellinien, die monoklonale Antikörper mit hoher Zytotoxizität gegen humanes CD16-Antigen produzieren, sowie Herstellung bispezifischer monoklonaler Antikörper unter Verwendung derartiger monoklonaler Antikörper und des CD30-HRS-3-Antikörpers zur Therapie menschlicher Tumore |
US5700823A (en) | 1994-01-07 | 1997-12-23 | Sugen, Inc. | Treatment of platelet derived growth factor related disorders such as cancers |
US6734285B2 (en) | 1994-03-08 | 2004-05-11 | Human Genome Sciences, Inc. | Vascular endothelial growth factor 2 proteins and compositions |
ES2249762T3 (es) | 1994-03-08 | 2006-04-01 | Human Genome Sciences, Inc. | Factor de crecimiento del endotelio vascular 2. |
US6608182B1 (en) | 1994-03-08 | 2003-08-19 | Human Genome Sciences, Inc. | Human vascular endothelial growth factor 2 |
US6040157A (en) | 1994-03-08 | 2000-03-21 | Human Genome Sciences, Inc. | Vascular endothelial growth factor 2 |
US5932540A (en) | 1994-03-08 | 1999-08-03 | Human Genome Sciences, Inc. | Vascular endothelial growth factor 2 |
GB9410534D0 (en) | 1994-05-26 | 1994-07-13 | Lynxvale Ltd | Improvements in or relating to growth factor inhibitors |
NZ288235A (en) * | 1994-06-09 | 1999-05-28 | Orion Corp | Monoclonal antibody directed against the receptor tyrosine kinase flt4 and use in diagnosis and therapy |
US5763733A (en) | 1994-10-13 | 1998-06-09 | Enzon, Inc. | Antigen-binding fusion proteins |
US6245530B1 (en) | 1995-08-01 | 2001-06-12 | Ludwig Institute For Cancer Research | Receptor ligand |
US6221839B1 (en) | 1994-11-14 | 2001-04-24 | Helsinki University Licensing Ltd. Oy | FIt4 ligand and methods of use |
US6645933B1 (en) | 1995-08-01 | 2003-11-11 | Helsinki University Licensing Ltd. Oy | Receptor ligand VEGF-C |
US6403088B1 (en) | 1995-08-01 | 2002-06-11 | Helsinki University Licensing, Ltd. | Antibodies reactive with VEGF-C, a ligand for the Flt4 receptor tyrosine kinase (VEGFR-3) |
US6130071A (en) | 1997-02-05 | 2000-10-10 | Helsinki University Licensing, Ltd. | Vascular endothelial growth factor C (VEGF-C) ΔCys156 protein and gene, and uses thereof |
WO1998033917A1 (en) | 1994-11-14 | 1998-08-06 | The Ludwig Institute For Cancer Research | Vascular endothelial growth factor c (vegf-c) protein and gene, mutants thereof, and uses thereof |
US6361946B1 (en) | 1997-02-05 | 2002-03-26 | Licentia Ltd | Vascular endothelial growth factor C (VEGF-C) protein and gene, mutants thereof, and uses thereof |
AU710696C (en) | 1995-09-08 | 2002-10-24 | Genentech Inc. | VEGF-related protein |
AU7142996A (en) | 1995-09-29 | 1997-04-28 | Universita' Degli Studi Di Siena | Regulated genes and uses thereof |
US6100071A (en) | 1996-05-07 | 2000-08-08 | Genentech, Inc. | Receptors as novel inhibitors of vascular endothelial growth factor activity and processes for their production |
AU733322B2 (en) | 1996-07-15 | 2001-05-10 | Chugai Seiyaku Kabushiki Kaisha | Novel VEGF-like factor |
DK0956339T3 (da) | 1996-08-23 | 2006-01-30 | Licentia Oy | Rekombinant vaskulær endotelcellevækstfaktor D (VEGF-D) |
US7125714B2 (en) | 1997-02-05 | 2006-10-24 | Licentia Ltd. | Progenitor cell materials and methods |
KR100628697B1 (ko) | 1997-12-24 | 2006-09-28 | 루드빅 인스티튜트 포 캔서 리서치 | 맥관 내피 성장인자 d를 발현하는 발현 벡터와 셀라인,및 흑색종을 치료하는 방법 |
WO2000021560A1 (en) | 1998-10-09 | 2000-04-20 | Ludwig Institute For Cancer Research | Flt4 (VEGFR-3) AS A TARGET FOR TUMOR IMAGING AND ANTI-TUMOR THERAPY |
WO2000025805A1 (en) | 1998-11-02 | 2000-05-11 | Ludwig Institute For Cancer Research | Vascular endothelial growth factor-like protein from orf virus nz2 binds and activates mammalian vegf receptor-2 |
KR20010081089A (ko) | 1998-12-21 | 2001-08-25 | 에드워드 에이. 맥더모 2세, 로이드 제이. 오울드 | 절단된 vegf-d에 대한 항체 및 그것의 이용 |
DE60039416D1 (de) | 1999-02-08 | 2008-08-21 | Human Genome Sciences Inc | Verwendung vom vaskulären endothelialen wachstumsfaktor 2 (vegf-2) |
US6393484B1 (en) * | 1999-04-12 | 2002-05-21 | International Business Machines Corp. | System and method for controlled access to shared-medium public and semi-public internet protocol (IP) networks |
IL146890A0 (en) | 1999-06-08 | 2002-08-14 | Regeneron Pharma | Modified chimeric polypeptides with improved pharmacokinetic properties |
CA2381985A1 (en) | 1999-08-16 | 2001-02-22 | Universita'degli Studi Di Siena | Vegf-d and angiogenic use thereof |
EP1248642A4 (de) | 2000-01-18 | 2005-05-18 | Ludwig Inst Cancer Res | Peptidomimetischer inhibitor von vegf sowie vegf-c und -d |
AU3988401A (en) * | 2000-02-25 | 2001-09-03 | Ludwig Inst Cancer Res | Materials and methods involving hybrid vascular endothelial growth factor dnas and proteins |
ATE284701T1 (de) | 2000-03-02 | 2005-01-15 | Ludwig Inst Cancer Res | Methode zur behandlung von tumoren welche den vaskulären endothelialen wachstumsfaktor d exprimieren |
US20020102260A1 (en) | 2000-03-02 | 2002-08-01 | Marc Achen | Methods for treating neoplastic disease characterized by vascular endothelial growth factor D expression, for screening for neoplastic disease or metastatic risk, and for maintaining vascularization of tissue |
AU2001264565B2 (en) | 2000-05-03 | 2006-12-07 | Vegenics Limited | A method for activating only the vascular endothelial growth factor receptor-3 and uses thereof |
NZ518077A (en) | 2000-08-04 | 2003-11-28 | Human Genome Sciences Inc | Biologically active fragments, analogues and derivatives of VEGF-2 for the treatment of peripheral artery diseases such as critical limb ischemia and coronary disease |
US20020151489A1 (en) | 2000-10-02 | 2002-10-17 | St. Elizabeth's Medical Center Of Boston, Inc. | Use of lymphangiogenic agents to treat lymphatic disorders |
US20020197691A1 (en) | 2001-04-30 | 2002-12-26 | Myriad Genetics, Incorporated | FLT4-interacting proteins and use thereof |
US20030211988A1 (en) | 2001-01-09 | 2003-11-13 | Epstein Stephen E | Enhancing lymph channel development and treatment of lymphatic obstructive disease |
US7611711B2 (en) * | 2001-01-17 | 2009-11-03 | Vegenics Limited | VEGFR-3 inhibitor materials and methods |
ATE359300T1 (de) | 2001-01-19 | 2007-05-15 | Ludwig Inst Cancer Res | Flt4 (vegfr-3) als ein ziel für krebs darstellung und anti-krebs-behandlung |
US20030170786A1 (en) | 2001-04-13 | 2003-09-11 | Rosen Craig A. | Vascular endothelial growth factor 2 |
DE60236646D1 (de) | 2001-04-13 | 2010-07-22 | Human Genome Sciences Inc | Anti-VEGF-2 Antikörper |
US20030176674A1 (en) | 2001-04-13 | 2003-09-18 | Rosen Craig A. | Vascular endothelial growth factor 2 |
US20030180294A1 (en) | 2002-02-22 | 2003-09-25 | Devries Gerald W. | Methods of extending corneal graft survival |
US20030232437A1 (en) | 2002-06-17 | 2003-12-18 | Isis Pharmaceuticals Inc. | Antisense modulation of VEGF-C expression |
WO2003093419A2 (en) | 2002-05-03 | 2003-11-13 | Ludwig Institute For Cancer Research | Preventing secondary lymphedema with vegf-d dna |
AU2003252039A1 (en) | 2002-07-23 | 2004-02-09 | Vegenics Limited | Methods and compositions for activating or inhibiting vegf-d and vegf-c |
WO2004084353A1 (de) * | 2003-03-17 | 2004-09-30 | Lear Corporation | Elektrisches kontaktelement für einen flachleiter |
AU2005222384A1 (en) | 2004-03-05 | 2005-09-22 | Vegenics Limited | Growth factor binding constructs materials and methods |
-
2002
- 2002-01-22 AT AT02717361T patent/ATE359300T1/de not_active IP Right Cessation
- 2002-01-22 AU AU2002248372A patent/AU2002248372B8/en not_active Expired
- 2002-01-22 CN CNA028060490A patent/CN1494552A/zh active Pending
- 2002-01-22 EP EP02717361A patent/EP1353952B1/de not_active Expired - Lifetime
- 2002-01-22 WO PCT/US2002/001784 patent/WO2002060950A2/en active IP Right Grant
- 2002-01-22 CA CA2435503A patent/CA2435503C/en not_active Expired - Lifetime
- 2002-01-22 DE DE60219419T patent/DE60219419T2/de not_active Expired - Lifetime
- 2002-01-22 JP JP2002561517A patent/JP4669984B2/ja not_active Expired - Lifetime
-
2003
- 2003-07-21 NO NO20033285A patent/NO20033285L/no unknown
-
2006
- 2006-01-06 US US11/327,075 patent/US8940695B2/en active Active
-
2009
- 2009-10-30 JP JP2009251019A patent/JP2010088433A/ja not_active Withdrawn
-
2014
- 2014-11-17 US US14/543,277 patent/US9260526B2/en not_active Expired - Fee Related
-
2016
- 2016-01-06 US US14/989,379 patent/US20160200793A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
EP1353952B1 (de) | 2007-04-11 |
JP2010088433A (ja) | 2010-04-22 |
JP4669984B2 (ja) | 2011-04-13 |
AU2002248372B2 (en) | 2007-08-23 |
AU2002248372B8 (en) | 2008-03-20 |
CA2435503A1 (en) | 2002-08-08 |
EP1353952A2 (de) | 2003-10-22 |
WO2002060950B1 (en) | 2003-11-27 |
US20160200793A1 (en) | 2016-07-14 |
CN1494552A (zh) | 2004-05-05 |
WO2002060950A3 (en) | 2003-02-06 |
US9260526B2 (en) | 2016-02-16 |
US20150141622A1 (en) | 2015-05-21 |
DE60219419T2 (de) | 2007-08-16 |
ATE359300T1 (de) | 2007-05-15 |
WO2002060950A2 (en) | 2002-08-08 |
CA2435503C (en) | 2011-02-22 |
JP2004532004A (ja) | 2004-10-21 |
NO20033285L (no) | 2003-09-19 |
NO20033285D0 (no) | 2003-07-21 |
US8940695B2 (en) | 2015-01-27 |
US20060177901A1 (en) | 2006-08-10 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
DE60219419D1 (de) | Flt4 (vegfr-3) als ein ziel für krebs darstellung und anti-krebs-behandlung | |
DE69942981D1 (de) | Flt4 (vegfr-3) als ziel für tumornachweis (imaging) und antitumortherapie | |
CY1119291T1 (el) | Πολυσθενη αντισωματα και χρησεις για αυτα | |
UA89017C2 (uk) | ЛЮДСЬКЕ АНТИТІЛО, ЩО СПЕЦИФІЧНО ЗВ'ЯЗУЄТЬСЯ З ЛЮДСЬКИМ TNFSF13b | |
WO2005077981A3 (en) | Fc POLYPEPTIDES WITH NOVEL Fc LIGAND BINDING SITES | |
MX2007006830A (es) | Porciones de la familia del polipeptido pancreatico, polipeptidos y metodos que comprenden las mismas. | |
PL2097453T3 (pl) | Przeciwciała monoklonalne przeciw ludzkiemu receptorowi hormonu anty-Mullerowskiego typu II (AMHR-II) | |
TW200631594A (en) | Toll like receptor 3 antagonists, methods and uses | |
CY1112101T1 (el) | Νευροτροφικοι παραγοντες | |
WO2003101401A3 (en) | Use of nrg4, or inhibitors thereof, in the treatment of colon and pancreatic cancer | |
EP1983002A3 (de) | Tyrosinphosphorylations-Stellen und spezifische Antikörper | |
DK1124568T3 (da) | Polyspecifikke bindingsmolekyler og anvendelser deraf | |
ATE461220T1 (de) | Anti-egfr-antikörper | |
WO2005087793A3 (en) | Immunostimulatory compositions and uses thereof | |
DE60239097D1 (de) | Drei-hybrid-assaysystem | |
CY1111966T1 (el) | Αντισωματα που δεσμευονται με κυτταροσυνδετο ca 125/0722ρ και μεθοδοι χρησεις αυτων | |
WO2003048301A3 (en) | Anti-hla-dr antibodies and the methods of using thereof | |
WO2007051164A3 (en) | Toll like receptor 3 modulators, methods and uses | |
WO2003016471A3 (en) | Periostin-based diagnostic assays | |
WO2006054000A3 (fr) | Netrine 4 mutee, ses fragments et leur utilisation comme medicaments | |
WO2006063028A3 (en) | Immunostimulatory compositions and uses thereof | |
ATE533783T1 (de) | Potente und selektive mittlersubstanzen von cholesterolefflux | |
ATE346864T1 (de) | Mu-1, ein mitglied der cytokine rezeptor familie | |
EP1988103A3 (de) | Tyrosinphosphorylationsstellen und spezifische Antikörper | |
ATE270332T1 (de) | Polynucleotide and polypeptide basb033 aus neisseria meningitidis und ihre verwendungen |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition | ||
8327 | Change in the person/name/address of the patent owner |
Owner name: VEGENICS LTD., TOORAK, VICTORIA, AU |