DE60218449D1 - Verfahren zur herstellung von pioglitazone als antidiabetisches mitttel - Google Patents

Verfahren zur herstellung von pioglitazone als antidiabetisches mitttel

Info

Publication number
DE60218449D1
DE60218449D1 DE60218449T DE60218449T DE60218449D1 DE 60218449 D1 DE60218449 D1 DE 60218449D1 DE 60218449 T DE60218449 T DE 60218449T DE 60218449 T DE60218449 T DE 60218449T DE 60218449 D1 DE60218449 D1 DE 60218449D1
Authority
DE
Germany
Prior art keywords
sup
formula
group
residue
general formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60218449T
Other languages
English (en)
Inventor
Ales Halama
Ludmila Hejtmankova
Petr Lustig
Jindrich Richter
Lucie Srsnova
Josef Jirman
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Zentiva KS
Original Assignee
Zentiva KS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from CZ20011502A external-priority patent/CZ20011502A3/cs
Priority claimed from CZ20011501A external-priority patent/CZ20011501A3/cs
Application filed by Zentiva KS filed Critical Zentiva KS
Application granted granted Critical
Publication of DE60218449D1 publication Critical patent/DE60218449D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Diabetes (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Saccharide Compounds (AREA)
  • Pyridine Compounds (AREA)
DE60218449T 2001-04-26 2002-04-25 Verfahren zur herstellung von pioglitazone als antidiabetisches mitttel Expired - Lifetime DE60218449D1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CZ20011502A CZ20011502A3 (cs) 2001-04-26 2001-04-26 Způsob výroby antidiabetika
CZ20011501A CZ20011501A3 (cs) 2001-04-26 2001-04-26 Způsob výroby meziproduktu pro výrobu antidiabetika
PCT/CZ2002/000024 WO2002088120A1 (en) 2001-04-26 2002-04-25 Method for obtaining pioglitazone as an antidiabetic agent

Publications (1)

Publication Number Publication Date
DE60218449D1 true DE60218449D1 (de) 2007-04-12

Family

ID=25746959

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60218449T Expired - Lifetime DE60218449D1 (de) 2001-04-26 2002-04-25 Verfahren zur herstellung von pioglitazone als antidiabetisches mitttel

Country Status (11)

Country Link
US (1) US7009057B2 (de)
EP (1) EP1387843B1 (de)
AT (1) ATE355286T1 (de)
AU (1) AU2002311057A1 (de)
DE (1) DE60218449D1 (de)
EE (1) EE200300519A (de)
HU (1) HUP0400091A2 (de)
PL (1) PL363738A1 (de)
RU (1) RU2281285C2 (de)
SK (1) SK14452003A3 (de)
WO (1) WO2002088120A1 (de)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8993773B2 (en) 2002-07-16 2015-03-31 Cadila Healthcare Limited Process to prepare pioglitazone via several novel intermediates
US7465801B2 (en) 2002-07-16 2008-12-16 Cadila Healthcare Limited Process to prepare pioglitazone via several novel intermediates
WO2004108721A1 (en) * 2003-04-01 2004-12-16 Sun Pharmaceutical Industries Limited Process for the preparation of 5-[[4-[2-(5-ethyl-2-pyridinyl)ethoxy]phenyl] methyl]-2,4-thiazolidinedione
ES2219180B1 (es) 2003-05-09 2006-03-01 Medichem, S.A. Compuesto intermedio util para la preparacion de pioglitazona.
US20050059708A1 (en) * 2003-05-13 2005-03-17 Karel Pospisilik Processes for making thiazolidinedione derivatives and compounds thereof
US7230016B2 (en) 2003-05-13 2007-06-12 Synthon Ip Inc. Pioglitazone salts, such as pioglitazone sulfate, and pharmaceutical compositions and processes using the same
WO2005021542A2 (en) * 2003-08-28 2005-03-10 Ranbaxy Laboratories Limited Process for the preparation of pioglitazone
CN1319956C (zh) * 2003-09-12 2007-06-06 深圳市海粤门生物科技开发有限公司 一种噻唑烷二酮的衍生物及其药用制剂的制备方法和应用
EP1716144A2 (de) 2004-02-20 2006-11-02 Synthon B.V. Verfahren zur herstellung von pioglitazon und verbindungen des verfahrens
US7402713B2 (en) * 2006-03-07 2008-07-22 E.I. Du Pont De Nemours And Company Processes for conversion of tyrosine to p-hydroxystyrene and p-acetoxystyrene
CN101454006B (zh) 2006-03-16 2012-12-26 新陈代谢解决方案开发公司 用于治疗高血压以及用于降低血脂的噻唑烷二酮类似物
AU2007227581B2 (en) 2006-03-16 2012-11-08 Metabolic Solutions Development Company, Llc Thiazolidinedione analogues for the treatment of metabolic inflammation mediated disease
KR100791400B1 (ko) 2006-09-06 2008-01-07 동우신테크 주식회사 티아졸리딘디온 유도체의 제조방법
US8304441B2 (en) 2007-09-14 2012-11-06 Metabolic Solutions Development Company, Llc Thiazolidinedione analogues for the treatment of metabolic diseases
RU2486179C2 (ru) 2007-09-14 2013-06-27 МЕТАБОЛИК СОЛЮШНЗ ДЕВЕЛОПМЕНТ КОМПАНИ, ЭлЭлСи Аналоги тиазолидиндиона для лечения диабета и дислипидемии
WO2009148195A1 (en) * 2008-06-02 2009-12-10 Daebong Ls, Ltd. 5-(4-hydroxybenzyl)thiazolidine-2,4-dione as intermediate for synthesis of thiazolidinedione based compounds and process for preparing the same
CN102753539B (zh) 2009-12-15 2015-09-09 新陈代谢解决方案开发公司 治疗代谢性疾病的ppar-节制的噻唑烷二酮盐
CN108003090A (zh) * 2018-01-05 2018-05-08 白银亿尔精细化工有限公司 一种制备4-[2-(5-乙基-2-吡啶基)乙氧基]硝基苯的方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS57209274A (en) * 1981-06-16 1982-12-22 Takeda Chem Ind Ltd Urea derivative, its preparation and its use
AR240698A1 (es) 1985-01-19 1990-09-28 Takeda Chemical Industries Ltd Procedimiento para preparar compuestos de 5-(4-(2-(5-etil-2-piridil)-etoxi)benzil)-2,4-tiazolidindiona y sus sales
JPS62205054A (ja) * 1986-03-05 1987-09-09 Takeda Chem Ind Ltd 尿素誘導体
US5952509A (en) * 1996-06-27 1999-09-14 Takeda Chemical Industries, Ltd. Production of benzaldehyde compounds
JP4316787B2 (ja) 2000-01-11 2009-08-19 壽製薬株式会社 エーテル又はアミド誘導体、その製法並びにそれを含有する糖尿病治療剤、

Also Published As

Publication number Publication date
ATE355286T1 (de) 2006-03-15
SK14452003A3 (sk) 2004-04-06
HUP0400091A2 (hu) 2004-06-28
AU2002311057A1 (en) 2002-11-11
EP1387843A1 (de) 2004-02-11
RU2003134542A (ru) 2005-06-10
EP1387843B1 (de) 2007-02-28
EE200300519A (et) 2004-02-16
WO2002088120A1 (en) 2002-11-07
WO2002088120B1 (en) 2004-02-26
PL363738A1 (en) 2004-11-29
US7009057B2 (en) 2006-03-07
US20050043360A1 (en) 2005-02-24
RU2281285C2 (ru) 2006-08-10

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8332 No legal effect for de