KR100791400B1 - 티아졸리딘디온 유도체의 제조방법 - Google Patents
티아졸리딘디온 유도체의 제조방법 Download PDFInfo
- Publication number
- KR100791400B1 KR100791400B1 KR1020060085691A KR20060085691A KR100791400B1 KR 100791400 B1 KR100791400 B1 KR 100791400B1 KR 1020060085691 A KR1020060085691 A KR 1020060085691A KR 20060085691 A KR20060085691 A KR 20060085691A KR 100791400 B1 KR100791400 B1 KR 100791400B1
- Authority
- KR
- South Korea
- Prior art keywords
- ethyl
- formula
- ethoxy
- pyridin
- compound
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/427—Thiazoles not condensed and containing further heterocyclic rings
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Description
Claims (4)
- 이탈기(L)와 보호기(P)를 갖는 4-N-프로텍티드아미노페놀 유도체(Ⅲ)와 2-(5-에틸-피리딘-2-일)-에탄올(Ⅳ)을 염기 존재하에 짝지음 반응에 의해 화학식(Ⅴ)의 5-에틸-2-[2-(4-N-프로텍티드아미노페녹시)-에틸]-피리딘 화합물을 얻은 다음, 이 화학식(Ⅴ) 화합물을 가수분해 반응시켜 화학식(Ⅵ)의 4-[2-(5-에틸-피리딘-2-일)-에톡시]-페닐아민을 제조하는 단계를 포함하는 것을 특징으로 하는 화학식(Ⅰ)의 염산 5-{4-[2-(5-에틸-피리딘-2-일)-에톡시]-벤질}-티아졸리딘-2,4-디온(염산 피오글리타존)의 제조방법.[화학식 3]상기 식에서 P는 보호기로 아세틸기이고, L은 이탈기로 p-톨루엔 설포닐옥시기이다.[화학식 4][화학식 5][화학식 6][화학식 1]
- 제1항에 있어서,화학식(Ⅵ)의 4-[2-(5-에틸-피리딘-2-일)-에톡시]-페닐아민을 Meerwein 축합 반응을 시킨 후 티오우레아와의 고리화 반응을 시키는 것을 특징으로 하는 화학식(Ⅰ)의 염산 5-{4-[2-(5-에틸-피리딘-2-일)-에톡시]-벤질}-티아졸리딘-2,4-디온 (염산 피오글리타존)의 제조방법.
- 삭제
- 제1항에 있어서, 짝지음 반응에 사용되는 염기는 수소화 나트륨 또는 수산화나트륨이고, 짝지음 반응에 사용되는 용매는 디메틸포름아미드, 데트라히드로퓨란 또는 아세톤 임을 특징으로 하는 화학식 (Ⅰ)의 염산 5-{4-[2-(5-에틸-피리딘-2- 일)-에톡시]-벤질}-티아졸리딘-2,4-디온 (염산 피오글리타존)의 제조방법.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
KR1020060085691A KR100791400B1 (ko) | 2006-09-06 | 2006-09-06 | 티아졸리딘디온 유도체의 제조방법 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
KR1020060085691A KR100791400B1 (ko) | 2006-09-06 | 2006-09-06 | 티아졸리딘디온 유도체의 제조방법 |
Publications (1)
Publication Number | Publication Date |
---|---|
KR100791400B1 true KR100791400B1 (ko) | 2008-01-07 |
Family
ID=39216612
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
KR1020060085691A KR100791400B1 (ko) | 2006-09-06 | 2006-09-06 | 티아졸리딘디온 유도체의 제조방법 |
Country Status (1)
Country | Link |
---|---|
KR (1) | KR100791400B1 (ko) |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2002088120A1 (en) | 2001-04-26 | 2002-11-07 | Léciva, a.s. | Method for obtaining pioglitazone as an antidiabetic agent |
-
2006
- 2006-09-06 KR KR1020060085691A patent/KR100791400B1/ko active IP Right Grant
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2002088120A1 (en) | 2001-04-26 | 2002-11-07 | Léciva, a.s. | Method for obtaining pioglitazone as an antidiabetic agent |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
RU2151145C1 (ru) | Промежуточное соединение для получения гетероциклических соединений, обладающих антидиабетической активностью | |
CA1274523A (en) | Thiazolidine derivatives, their production and use | |
US8648189B2 (en) | Method for the preparation of rivoraxaban | |
CA2669069C (en) | Process for the preparation of 2-imino-thiazolidin-4-one derivatives | |
JPS6242903B2 (ko) | ||
CZ385098A3 (cs) | Nové heterocyklické sloučeniny, způsob jejich přípravy, farmaceutické kompozice s jejich obsahem a jejich použití v léčbě diabetu a příbuzných chorob | |
RU2281285C2 (ru) | Способ получения пиоглитазона в качестве противодиабетического средства | |
CA2105149A1 (en) | Oxazolidine derivatives having anti-diabetic and anti-obesity properties, their preparation and their therapeutic uses | |
JP2000515133A (ja) | 血糖降下性および脂質低下性の化合物 | |
CA2629995A1 (en) | Chemical process for the preparation of an amido-phenoxybenzoic acid compound | |
EP0128736A1 (en) | Novel 2-guanidinothiazoline compounds, their preparation, and their use as intermediates | |
CA2185082A1 (en) | Azole derivatives, their use, production and usage | |
EP0295051B1 (en) | Preparation of oxophthalazinyl acetic acids having benzothiazole or other heterocyclic side chains | |
JP4217924B2 (ja) | 3−アミノ−2−メルカプト安息香酸誘導体及びその製造方法 | |
JPH04330049A (ja) | ニトログアニジン誘導体の製造方法 | |
JPH10237049A (ja) | ベンズイソキサゾ−ル誘導体 | |
US6372933B1 (en) | Process for preparing certain phenyl urea compounds | |
EP0787725B1 (en) | Quinoline derivative | |
CA2475137C (fr) | Nouveaux derives d'oximes heterocycliques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent | |
KR100791400B1 (ko) | 티아졸리딘디온 유도체의 제조방법 | |
US4868301A (en) | Processes and intermediates for the preparation of oxophthalazinyl acetic acids having benzothiazole or other heterocyclic side chains | |
KR100791399B1 (ko) | 염산 피오글리타존의 제조방법 | |
JP4323718B2 (ja) | 置換アルキルアミン又はその塩の製造方法 | |
KR100697983B1 (ko) | 신규 중간체 및 이를 이용한 피오글리타존의 제조방법 | |
JPS6257635B2 (ko) |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
A201 | Request for examination | ||
E902 | Notification of reason for refusal | ||
E701 | Decision to grant or registration of patent right | ||
GRNT | Written decision to grant | ||
G170 | Publication of correction | ||
FPAY | Annual fee payment |
Payment date: 20121227 Year of fee payment: 6 |
|
FPAY | Annual fee payment |
Payment date: 20131202 Year of fee payment: 7 |
|
FPAY | Annual fee payment |
Payment date: 20141229 Year of fee payment: 8 |
|
FPAY | Annual fee payment |
Payment date: 20151228 Year of fee payment: 9 |
|
FPAY | Annual fee payment |
Payment date: 20161227 Year of fee payment: 10 |
|
FPAY | Annual fee payment |
Payment date: 20171227 Year of fee payment: 11 |
|
FPAY | Annual fee payment |
Payment date: 20181226 Year of fee payment: 12 |
|
FPAY | Annual fee payment |
Payment date: 20191219 Year of fee payment: 13 |