DE60216959D1 - Sich in schlagende kardiomyozyten verwandelnde stammzellen - Google Patents
Sich in schlagende kardiomyozyten verwandelnde stammzellenInfo
- Publication number
- DE60216959D1 DE60216959D1 DE60216959T DE60216959T DE60216959D1 DE 60216959 D1 DE60216959 D1 DE 60216959D1 DE 60216959 T DE60216959 T DE 60216959T DE 60216959 T DE60216959 T DE 60216959T DE 60216959 D1 DE60216959 D1 DE 60216959D1
- Authority
- DE
- Germany
- Prior art keywords
- cardiomyocytes
- stem cells
- bangken
- cells
- spoc cells
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 210000000130 stem cell Anatomy 0.000 title abstract 2
- 230000001131 transforming effect Effects 0.000 title 1
- 210000004027 cell Anatomy 0.000 abstract 4
- 210000004413 cardiac myocyte Anatomy 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- 230000007547 defect Effects 0.000 abstract 1
- 238000000338 in vitro Methods 0.000 abstract 1
- 238000001727 in vivo Methods 0.000 abstract 1
- 230000000302 ischemic effect Effects 0.000 abstract 1
- 230000002107 myocardial effect Effects 0.000 abstract 1
- 238000012216 screening Methods 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
- 230000000472 traumatic effect Effects 0.000 abstract 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/5044—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving specific cell types
- G01N33/5073—Stem cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/34—Muscles; Smooth muscle cells; Heart; Cardiac stem cells; Myoblasts; Myocytes; Cardiomyocytes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
- C12N5/0657—Cardiomyocytes; Heart cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
- C12N5/0662—Stem cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2500/00—Specific components of cell culture medium
- C12N2500/05—Inorganic components
- C12N2500/10—Metals; Metal chelators
- C12N2500/20—Transition metals
- C12N2500/24—Iron; Fe chelators; Transferrin
- C12N2500/25—Insulin-transferrin; Insulin-transferrin-selenium
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/11—Epidermal growth factor [EGF]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/115—Basic fibroblast growth factor (bFGF, FGF-2)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2503/00—Use of cells in diagnostics
- C12N2503/02—Drug screening
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US10/003,400 US20030082153A1 (en) | 2001-10-22 | 2001-10-22 | Stem cells that transform to beating cardiomyocytes |
PCT/US2002/033860 WO2003035838A2 (en) | 2001-10-22 | 2002-10-22 | Stem cells that transform to beating cardiomyocytes |
Publications (1)
Publication Number | Publication Date |
---|---|
DE60216959D1 true DE60216959D1 (de) | 2007-02-01 |
Family
ID=21705682
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE60216959T Expired - Lifetime DE60216959D1 (de) | 2001-10-22 | 2002-10-22 | Sich in schlagende kardiomyozyten verwandelnde stammzellen |
Country Status (8)
Country | Link |
---|---|
US (3) | US20030082153A1 (de) |
EP (1) | EP1444329B1 (de) |
JP (1) | JP4377690B2 (de) |
AT (1) | ATE348878T1 (de) |
AU (1) | AU2002337949B1 (de) |
CA (1) | CA2464088A1 (de) |
DE (1) | DE60216959D1 (de) |
WO (1) | WO2003035838A2 (de) |
Families Citing this family (64)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
USRE42643E1 (en) | 1991-03-27 | 2011-08-23 | Panasonic Corporation | Communication system |
USRE39890E1 (en) | 1991-03-27 | 2007-10-23 | Matsushita Electric Industrial Co., Ltd. | Communication system |
USRE40241E1 (en) | 1991-03-27 | 2008-04-15 | Matsushita Electric Industrial Co., Ltd. | Communication system |
CA2332405C (en) * | 1992-03-26 | 2007-01-23 | Matsushita Electric Industrial Co., Ltd. | Communication system |
US6724976B2 (en) * | 1992-03-26 | 2004-04-20 | Matsushita Electric Industrial Co., Ltd. | Communication system |
US6728467B2 (en) * | 1992-03-26 | 2004-04-27 | Matsushita Electric Industrial Co., Ltd. | Communication system |
USRE38513E1 (en) | 1992-03-26 | 2004-05-11 | Matsushita Electric Industrial Co., Ltd. | Communication system |
US7158577B1 (en) | 1992-03-26 | 2007-01-02 | Matsushita Electric Industrial Co., Ltd. | Communication system |
US5802241A (en) | 1992-03-26 | 1998-09-01 | Matsushita Electric Industrial Co., Ltd. | Communication system |
US7894541B2 (en) * | 1992-03-26 | 2011-02-22 | Panasonic Corporation | Communication system |
US7166280B2 (en) | 2000-04-06 | 2007-01-23 | Franco Wayne P | Combination growth factor therapy and cell therapy for treatment of acute and chronic heart disease |
US20100303769A1 (en) * | 2000-04-06 | 2010-12-02 | Franco Wayne P | Combination growth factor therapy and cell therapy for treatment of acute and chronic heart disease |
FR2819265B1 (fr) * | 2001-01-10 | 2004-01-02 | Centre Nat Rech Scient | Cellules du tissu adipeux extramedullaire et leurs applications dans la reconstitution des lignees hematopoietiques |
US7150990B2 (en) * | 2002-03-06 | 2006-12-19 | Reprocell, Inc. | Self-renewing pluripotent hepatic stem cells |
US8263375B2 (en) | 2002-12-20 | 2012-09-11 | Acea Biosciences | Dynamic monitoring of activation of G-protein coupled receptor (GPCR) and receptor tyrosine kinase (RTK) in living cells using real-time microelectronic cell sensing technology |
WO2005047482A2 (en) | 2003-11-12 | 2005-05-26 | Xiao Xu | Real time electronic cell sensing systems and applications for cell-based assays |
WO2004019767A2 (en) * | 2002-08-29 | 2004-03-11 | Baylor College Of Medicine | Heart derived cells for cardiac repair |
US11346797B2 (en) | 2002-12-20 | 2022-05-31 | Agilent Technologies, Inc. | System and method for monitoring cardiomyocyte beating, viability, morphology and electrophysiological properties |
US10551371B2 (en) | 2003-11-10 | 2020-02-04 | Acea Biosciences, Inc. | System and method for monitoring cardiomyocyte beating, viability and morphology and for screening for pharmacological agents which may induce cardiotoxicity or modulate cardiomyocyte function |
US10215748B2 (en) | 2002-12-20 | 2019-02-26 | Acea Biosciences, Inc. | Using impedance-based cell response profiling to identify putative inhibitors for oncogene addicted targets or pathways |
US10539523B2 (en) | 2002-12-20 | 2020-01-21 | Acea Biosciences, Inc. | System and method for monitoring cardiomyocyte beating, viability, morphology, and electrophysiological properties |
ITRM20030376A1 (it) * | 2003-07-31 | 2005-02-01 | Univ Roma | Procedimento per l'isolamento e l'espansione di cellule staminali cardiache da biopsia. |
US8859273B2 (en) | 2003-12-24 | 2014-10-14 | Medtronic, Inc. | Methods of using HCN genes to treat cardiac arrhythmias |
BRPI0507429A (pt) * | 2004-02-06 | 2007-06-26 | Theradigm Inc | composição, meio condicionado de células estromais de medula óssea, métodos de modular a expressão da molécula do complexo principal de histocompatibilidade e da molécula de mhc sobre uma nsc isolada, nsc isolada, e, dispositivo de cultura de células neurais |
US20090074669A1 (en) | 2004-03-31 | 2009-03-19 | Ebert Steven N | PNMT as a novel marker for progenitor cells |
JP2007534946A (ja) * | 2004-04-23 | 2007-11-29 | アメリカ合衆国 | 幹細胞に特異的に結合するモノクローナル抗体の使用 |
JP4814875B2 (ja) | 2004-05-11 | 2011-11-16 | アキシオジェネシス エージー | invitro分化細胞に基づく薬物発見のための検定 |
JP2008506416A (ja) * | 2004-07-19 | 2008-03-06 | ザ・トラスティーズ・オブ・コロンビア・ユニバーシティ・イン・ザ・シティ・オブ・ニューヨーク | 遺伝子組み換えされた細胞が合胞体の機能を変える効果を監視するための分析システム |
ATE507290T1 (de) * | 2004-07-27 | 2011-05-15 | Kowa Co | Zellfusionspromotor und dessen nutzung |
US11660317B2 (en) | 2004-11-08 | 2023-05-30 | The Johns Hopkins University | Compositions comprising cardiosphere-derived cells for use in cell therapy |
US20080241111A1 (en) * | 2005-03-04 | 2008-10-02 | Kyoto University | Pluripotent Stem Cell Derived from Cardiac Tissue |
EP1857544B1 (de) * | 2005-03-04 | 2012-06-20 | Kyoto University | Aus herzgewebe stammende pluripotente stammzelle |
CN103356704B (zh) * | 2005-03-31 | 2015-09-30 | 斯丹姆涅恩有限公司 | 制备用以治疗由糖尿病性神经病引发的溃疡的药物的方法 |
JPWO2007010858A1 (ja) * | 2005-07-15 | 2009-01-29 | 国立大学法人京都大学 | 骨格筋組織由来の単一細胞よりクローン化した多能性幹細胞 |
FR2896511B1 (fr) * | 2006-01-26 | 2012-10-26 | Centre Nat Rech Scient | Procede de culture de cellules issues du tissu adipeux et leurs applications. |
TW200734462A (en) | 2006-03-08 | 2007-09-16 | In Motion Invest Ltd | Regulating stem cells |
WO2008040027A2 (en) * | 2006-09-28 | 2008-04-03 | The Regents Of The University Of California | Directed differentiation and maturation of stem cell-derived cardiomyocytes |
WO2008043099A2 (en) | 2006-10-06 | 2008-04-10 | Medtronic, Inc. | Hybrid pacing system |
KR101240487B1 (ko) * | 2006-11-09 | 2013-03-08 | 더 존스 홉킨스 유니버시티 | 성체 포유동물 심근세포의 심장 줄기 세포로의 역분화 |
CA2699860A1 (en) * | 2007-07-18 | 2009-03-26 | Cellartis Ab | Cardiomyocyte-like cell clusters derived from hbs cells |
EP2198010A4 (de) * | 2007-09-12 | 2010-10-06 | Univ California | Zusammensetzungen und verfahren zur verbesserung der funktionellen wirksamkeit von stammzellen abgeleiteter herzmuskelzellen |
WO2009092005A2 (en) * | 2008-01-18 | 2009-07-23 | The J. David Gladstone Institutes | Methods of generating cardiomyocytes and cardiac progenitors and compositions |
WO2009120762A2 (en) | 2008-03-27 | 2009-10-01 | Mount Sinai School Of Medicine Of New York University | Human cardiovascular progenitor cells |
EP2291645B1 (de) | 2008-05-05 | 2015-09-09 | Acea Biosciences, Inc. | Markierungsfreie überwachung der elektromechanischen kopplung und erregbaren zellen anhand von systemen auf impedanzbasis mit millisekunden-zeitauflösung |
RU2662675C1 (ru) * | 2009-07-09 | 2018-07-26 | Янссен Байотек, Инк. | Клетки, производные от кардиальной ткани |
US9845457B2 (en) | 2010-04-30 | 2017-12-19 | Cedars-Sinai Medical Center | Maintenance of genomic stability in cultured stem cells |
US9249392B2 (en) | 2010-04-30 | 2016-02-02 | Cedars-Sinai Medical Center | Methods and compositions for maintaining genomic stability in cultured stem cells |
WO2011146531A1 (en) * | 2010-05-18 | 2011-11-24 | Acea Biosciences, Inc | Data analysis of impedance-based cardiomyocyte-beating signals as detected on real-time cell analysis (rtca) cardio instruments |
WO2012098260A1 (en) | 2011-01-21 | 2012-07-26 | Axiogenesis Ag | A non-viral system for the generation of induced pluripotent stem (ips) cells |
EP3088900B1 (de) * | 2011-10-17 | 2020-08-12 | Roche Diagniostics GmbH | Troponin als marker für intermittierendes vorhofflimmern |
EP2861238A4 (de) * | 2012-06-05 | 2016-03-16 | Capricor Inc | Optimierte verfahren zur erzeugung von herzstammzellen aus herzgewebe und deren verwendung in der herztherapie |
EP2882445B1 (de) | 2012-08-13 | 2019-04-24 | Cedars-Sinai Medical Center | Exosomen und mikroribonukleinsäuren zur geweberegeneration |
JP6312215B2 (ja) * | 2012-12-28 | 2018-04-18 | 国立大学法人京都大学 | 人工多能性幹細胞、心筋細胞又はその前駆細胞の製造方法 |
WO2014116874A1 (en) | 2013-01-23 | 2014-07-31 | Ronald Li | Engineered physical alignment of stem cell-derived cardiomyocytes |
US9493742B2 (en) | 2013-03-15 | 2016-11-15 | Emory University | Purification of cell mixtures using molecular beacons targeting cell specific RNA |
US10087436B2 (en) | 2014-02-06 | 2018-10-02 | The Regents Of The University Of California | Electrophysiologically mature cardiomyocytes and methods for making same |
AU2015327812B2 (en) | 2014-10-03 | 2021-04-15 | Cedars-Sinai Medical Center | Cardiosphere-derived cells and exosomes secreted by such cells in the treatment of muscular dystrophy |
WO2017123662A1 (en) | 2016-01-11 | 2017-07-20 | Cedars-Sinai Medical Center | Cardiosphere-derived cells and exosomes secreted by such cells in the treatment of heart failure with preserved ejection fraction |
US11351200B2 (en) | 2016-06-03 | 2022-06-07 | Cedars-Sinai Medical Center | CDC-derived exosomes for treatment of ventricular tachyarrythmias |
WO2018057542A1 (en) | 2016-09-20 | 2018-03-29 | Cedars-Sinai Medical Center | Cardiosphere-derived cells and their extracellular vesicles to retard or reverse aging and age-related disorders |
CN110582569B (zh) | 2017-03-03 | 2024-04-02 | 安捷伦科技有限公司 | 用于iPSC和ESC衍生的心肌细胞的功能成熟的方法和系统 |
AU2018255346B2 (en) | 2017-04-19 | 2024-05-02 | Capricor Inc | Methods and compositions for treating skeletal muscular dystrophy |
WO2019126068A1 (en) | 2017-12-20 | 2019-06-27 | Cedars-Sinai Medical Center | Engineered extracellular vesicles for enhanced tissue delivery |
USD941488S1 (en) | 2020-02-07 | 2022-01-18 | Agilent Technologies, Inc. | Instrument for analyzing biological cells |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5486359A (en) * | 1990-11-16 | 1996-01-23 | Osiris Therapeutics, Inc. | Human mesenchymal stem cells |
AU8401498A (en) | 1997-07-14 | 1999-02-10 | Osiris Therapeutics, Inc. | Cardiac muscle regeneration using mesenchymal stem cells |
US6248587B1 (en) * | 1997-11-26 | 2001-06-19 | University Of Southern Cailfornia | Method for promoting mesenchymal stem and lineage-specific cell proliferation |
EP1100870B1 (de) | 1998-07-31 | 2008-01-02 | Genzyme Corporation | Verbesserung der herzfunktion durch transplantation mesenchymaler stammzellen |
US6184035B1 (en) * | 1998-11-18 | 2001-02-06 | California Institute Of Technology | Methods for isolation and activation of, and control of differentiation from, skeletal muscle stem or progenitor cells |
AU5498800A (en) | 1999-06-25 | 2001-01-31 | Baylor College Of Medicine | Stem cells derived from skeletal muscle |
ATE514772T1 (de) | 1999-08-05 | 2011-07-15 | Abt Holding Co | Multipotente erwachsene stammzellen und verfahren zu deren isolierung |
AU5159901A (en) * | 2000-04-14 | 2001-10-30 | Univ Pittsburgh | Soft tissue and bone augmentation and bulking utilizing muscle-derived progenitor cells, compositions and treatments thereof |
-
2001
- 2001-10-22 US US10/003,400 patent/US20030082153A1/en not_active Abandoned
-
2002
- 2002-10-22 WO PCT/US2002/033860 patent/WO2003035838A2/en active IP Right Grant
- 2002-10-22 AT AT02773854T patent/ATE348878T1/de not_active IP Right Cessation
- 2002-10-22 EP EP02773854A patent/EP1444329B1/de not_active Expired - Lifetime
- 2002-10-22 AU AU2002337949A patent/AU2002337949B1/en not_active Ceased
- 2002-10-22 CA CA002464088A patent/CA2464088A1/en not_active Abandoned
- 2002-10-22 DE DE60216959T patent/DE60216959D1/de not_active Expired - Lifetime
- 2002-10-22 JP JP2003538339A patent/JP4377690B2/ja not_active Expired - Lifetime
-
2004
- 2004-06-07 US US10/863,004 patent/US7220582B2/en not_active Expired - Fee Related
-
2007
- 2007-05-10 US US11/747,060 patent/US20070212423A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
AU2002337949B1 (en) | 2003-05-06 |
EP1444329A2 (de) | 2004-08-11 |
US20050058633A1 (en) | 2005-03-17 |
US20030082153A1 (en) | 2003-05-01 |
WO2003035838A3 (en) | 2003-07-17 |
US7220582B2 (en) | 2007-05-22 |
ATE348878T1 (de) | 2007-01-15 |
US20070212423A1 (en) | 2007-09-13 |
WO2003035838A2 (en) | 2003-05-01 |
EP1444329B1 (de) | 2006-12-20 |
CA2464088A1 (en) | 2003-05-01 |
JP4377690B2 (ja) | 2009-12-02 |
EP1444329A4 (de) | 2004-11-24 |
JP2005506845A (ja) | 2005-03-10 |
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