ATE397019T1 - Herstellung von f(ab')2 fragmenten in saügetierzelle - Google Patents
Herstellung von f(ab')2 fragmenten in saügetierzelleInfo
- Publication number
- ATE397019T1 ATE397019T1 AT02789019T AT02789019T ATE397019T1 AT E397019 T1 ATE397019 T1 AT E397019T1 AT 02789019 T AT02789019 T AT 02789019T AT 02789019 T AT02789019 T AT 02789019T AT E397019 T1 ATE397019 T1 AT E397019T1
- Authority
- AT
- Austria
- Prior art keywords
- fragments
- preparation
- mammal cells
- cells
- antibody fragments
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/55—Fab or Fab'
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
- C07K2317/624—Disulfide-stabilized antibody (dsFv)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2799/00—Uses of viruses
- C12N2799/02—Uses of viruses as vector
- C12N2799/021—Uses of viruses as vector for the expression of a heterologous nucleic acid
- C12N2799/022—Uses of viruses as vector for the expression of a heterologous nucleic acid where the vector is derived from an adenovirus
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2800/00—Nucleic acids vectors
- C12N2800/10—Plasmid DNA
- C12N2800/108—Plasmid DNA episomal vectors
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2840/00—Vectors comprising a special translation-regulating system
- C12N2840/20—Vectors comprising a special translation-regulating system translation of more than one cistron
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Medicinal Chemistry (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Immunology (AREA)
- Microbiology (AREA)
- Plant Pathology (AREA)
- Physics & Mathematics (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
NL0100917 | 2001-12-17 |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE397019T1 true ATE397019T1 (de) | 2008-06-15 |
Family
ID=19760784
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT02789019T ATE397019T1 (de) | 2001-12-17 | 2002-12-17 | Herstellung von f(ab')2 fragmenten in saügetierzelle |
Country Status (11)
Country | Link |
---|---|
US (2) | US20050048038A1 (de) |
EP (1) | EP1456238B1 (de) |
AT (1) | ATE397019T1 (de) |
AU (1) | AU2002353662B2 (de) |
CA (1) | CA2470579C (de) |
DE (1) | DE60226896D1 (de) |
DK (1) | DK1456238T3 (de) |
ES (1) | ES2307807T3 (de) |
NZ (1) | NZ533332A (de) |
SI (1) | SI1456238T1 (de) |
WO (1) | WO2003051927A2 (de) |
Families Citing this family (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8236561B2 (en) | 1999-04-15 | 2012-08-07 | Crucell Holland B.V. | Efficient production of IgA in recombinant mammalian cells |
US7297680B2 (en) | 1999-04-15 | 2007-11-20 | Crucell Holland B.V. | Compositions of erythropoietin isoforms comprising Lewis-X structures and high sialic acid content |
US6855544B1 (en) | 1999-04-15 | 2005-02-15 | Crucell Holland B.V. | Recombinant protein production in a human cell |
US7604960B2 (en) | 1999-04-15 | 2009-10-20 | Crucell Holland B.V. | Transient protein expression methods |
US7192759B1 (en) | 1999-11-26 | 2007-03-20 | Crucell Holland B.V. | Production of vaccines |
US7527961B2 (en) | 1999-11-26 | 2009-05-05 | Crucell Holland B.V. | Production of vaccines |
US7521220B2 (en) | 1999-11-26 | 2009-04-21 | Crucell Holland B.V. | Production of vaccines |
KR100979025B1 (ko) | 2001-12-07 | 2010-08-30 | 크루셀 홀란드 비.브이. | 바이러스, 바이러스 단리물 및 백신의 생산 |
SI1456238T1 (sl) | 2001-12-17 | 2008-08-31 | Crucell Holland Bv | Proizvodnja f(ab)2 fragmentov v sesalskih celicah |
EP1623023B1 (de) | 2003-05-09 | 2008-11-12 | Crucell Holland B.V. | Kulturen von e1-immortalisierten zellen und verfahren zu deren kultivierung zur erhöhung der produktausbeuten davon |
WO2019070108A1 (es) | 2017-10-02 | 2019-04-11 | Laboratorios Silanes S.A. De C.V. | Proceso de alto rendimiento para la producción de antivenenos de fragmentos f (ab') 2 de anticuerpos |
WO2023205656A2 (en) * | 2022-04-18 | 2023-10-26 | John Paul Ii Medical Research Institute | Immortalized cells for production of bioproducts, methods of producing bioproducts with an immortalized cell, and methods of making immortalized cells for production of bioproducts |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4624846A (en) * | 1983-07-29 | 1986-11-25 | Immunomedics, Inc. | Method for enhancing target specificity of antibody localization and clearance of non-target diagnostic and therapeutic principles |
DE3584341D1 (de) | 1984-08-24 | 1991-11-14 | Upjohn Co | Rekombinante dna-verbindungen und expression von polypeptiden wie tpa. |
US5168062A (en) * | 1985-01-30 | 1992-12-01 | University Of Iowa Research Foundation | Transfer vectors and microorganisms containing human cytomegalovirus immediate-early promoter-regulatory DNA sequence |
DE3920358A1 (de) * | 1989-06-22 | 1991-01-17 | Behringwerke Ag | Bispezifische und oligospezifische, mono- und oligovalente antikoerperkonstrukte, ihre herstellung und verwendung |
CA2116774C (en) * | 1991-09-19 | 2003-11-11 | Paul J. Carter | Expression in e. coli antibody fragments having at least a cysteine present as a free thiol. use for the production of bifunctional f(ab') 2 antibodies |
ES2333425T5 (es) | 1995-06-15 | 2012-08-28 | Crucell Holland B.V. | Sistemas de empaquetado para adenovirus recombinante humano destinados a terapia génica |
EP1533380B1 (de) * | 1999-04-15 | 2009-11-04 | Crucell Holland B.V. | Verwendung von Rekombinanten Proteinen in Menschlichen Zellen |
EP1103610A1 (de) * | 1999-11-26 | 2001-05-30 | Introgene B.V. | Impfstoffherstellung von immortalisierten Säugetierzellinien |
EP1130099A1 (de) * | 2000-02-25 | 2001-09-05 | Crucell Holland B.V. | Aktiviertes Vitronektin als Angiogenesemarker nachgewiesen durch Phagen-Antikörper |
SI1456238T1 (sl) | 2001-12-17 | 2008-08-31 | Crucell Holland Bv | Proizvodnja f(ab)2 fragmentov v sesalskih celicah |
-
2002
- 2002-12-17 SI SI200230701T patent/SI1456238T1/sl unknown
- 2002-12-17 DK DK02789019T patent/DK1456238T3/da active
- 2002-12-17 CA CA2470579A patent/CA2470579C/en not_active Expired - Lifetime
- 2002-12-17 ES ES02789019T patent/ES2307807T3/es not_active Expired - Lifetime
- 2002-12-17 DE DE60226896T patent/DE60226896D1/de not_active Expired - Lifetime
- 2002-12-17 EP EP02789019A patent/EP1456238B1/de not_active Expired - Lifetime
- 2002-12-17 US US10/499,298 patent/US20050048038A1/en not_active Abandoned
- 2002-12-17 NZ NZ533332A patent/NZ533332A/en not_active IP Right Cessation
- 2002-12-17 AT AT02789019T patent/ATE397019T1/de active
- 2002-12-17 WO PCT/NL2002/000841 patent/WO2003051927A2/en not_active Application Discontinuation
- 2002-12-17 AU AU2002353662A patent/AU2002353662B2/en not_active Ceased
-
2008
- 2008-02-14 US US12/070,145 patent/US7537916B2/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
EP1456238B1 (de) | 2008-05-28 |
EP1456238A2 (de) | 2004-09-15 |
WO2003051927A3 (en) | 2003-11-20 |
ES2307807T3 (es) | 2008-12-01 |
SI1456238T1 (sl) | 2008-08-31 |
CA2470579A1 (en) | 2003-06-26 |
US20080166767A1 (en) | 2008-07-10 |
WO2003051927A2 (en) | 2003-06-26 |
NZ533332A (en) | 2005-07-29 |
AU2002353662A1 (en) | 2003-06-30 |
AU2002353662B2 (en) | 2009-04-23 |
CA2470579C (en) | 2012-03-06 |
DE60226896D1 (de) | 2008-07-10 |
US7537916B2 (en) | 2009-05-26 |
US20050048038A1 (en) | 2005-03-03 |
DK1456238T3 (da) | 2008-08-18 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
TR200001946T2 (tr) | Aşı | |
DE60216959D1 (de) | Sich in schlagende kardiomyozyten verwandelnde stammzellen | |
ATE397019T1 (de) | Herstellung von f(ab')2 fragmenten in saügetierzelle | |
TR200300478T2 (tr) | Hümanize antiLT-ß-R antikorları | |
DE60040012D1 (de) | Rekombinantes gelatin in impstoffen | |
ATE430580T1 (de) | Glycoprotein-zusammensetzungen | |
TR200102338T2 (tr) | Siklik ikame edilmiş bağlı pirolokarbazoller ve izoindolonlar. | |
BR0015224A (pt) | Anticorpo anti-antìgeno de célula estaminal prostática (psca) isolado, anticorpo monoclonal anti-psca, ácido nucleico isolado, vetor de expressão, célula, célula hospedeira, método de produção de anticorpo, composição método in vitro para matar uma célula cancerosa que expresse psca, uso de uma anticorpo monoclonal anti-psca e artigo industrializado | |
NL300754I2 (de) | ||
DK1157037T3 (da) | GCSF-konjugater | |
DK1210411T3 (da) | Sammensætninger og fremgangsmåder til forbedret celledyrkning | |
ATE500323T1 (de) | Subtilisin-variante | |
DK1379671T3 (da) | Fremgangsmåder til dyrkning af circovirus | |
DE69734605D1 (de) | Abgeschwächter salmonellenstamm, gebraucht als vehikel zur oralen immunisierung | |
AR032394A1 (es) | Una composicion oral. | |
BR0113162A (pt) | Ariloxialquilaminas nao-imidazóis | |
BR0215266A (pt) | Preparação liofilizada compreendendo anticorpos contra o receptor de egf | |
BR0312693A (pt) | Células indutoras de aceitação de transplante de origem monocìtica e sua preparação e aplicação | |
WO2002010337A3 (en) | Method of cloning porcine animals | |
PT1200561E (pt) | Clone celular recombinante estavel, sua producao e utilizacao | |
NO20031860D0 (no) | Kahalaolid F | |
AR030735A1 (es) | Un procedimiento para la produccion de un extracto de champinon natural | |
IS6654A (is) | Stöðugt gabapentín með pH innan stýrðra marka | |
AU2001258373A1 (en) | Method for identifying helicobacter antigens | |
WO2002022573A3 (en) | Methods and compositions relating to hydrogen peroxide and superoxide production by antibodies |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
UEP | Publication of translation of european patent specification |
Ref document number: 1456238 Country of ref document: EP |