ATE348878T1 - Sich in schlagende kardiomyozyten verwandelnde stammzellen - Google Patents

Sich in schlagende kardiomyozyten verwandelnde stammzellen

Info

Publication number
ATE348878T1
ATE348878T1 AT02773854T AT02773854T ATE348878T1 AT E348878 T1 ATE348878 T1 AT E348878T1 AT 02773854 T AT02773854 T AT 02773854T AT 02773854 T AT02773854 T AT 02773854T AT E348878 T1 ATE348878 T1 AT E348878T1
Authority
AT
Austria
Prior art keywords
stem cells
cardiomyocytes
cells
beating cardiomyocytes
spoc cells
Prior art date
Application number
AT02773854T
Other languages
English (en)
Inventor
Neal D Epstein
Thiru V Gopal
Steve O Winitsky
Shahin Hassanzadeh
Original Assignee
Us Health
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Us Health filed Critical Us Health
Application granted granted Critical
Publication of ATE348878T1 publication Critical patent/ATE348878T1/de

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5044—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving specific cell types
    • G01N33/5073—Stem cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/34—Muscles; Smooth muscle cells; Heart; Cardiac stem cells; Myoblasts; Myocytes; Cardiomyocytes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
    • C12N5/0657—Cardiomyocytes; Heart cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
    • C12N5/0662—Stem cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2500/00—Specific components of cell culture medium
    • C12N2500/05—Inorganic components
    • C12N2500/10—Metals; Metal chelators
    • C12N2500/20—Transition metals
    • C12N2500/24—Iron; Fe chelators; Transferrin
    • C12N2500/25—Insulin-transferrin; Insulin-transferrin-selenium
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/11—Epidermal growth factor [EGF]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/115—Basic fibroblast growth factor (bFGF, FGF-2)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2503/00—Use of cells in diagnostics
    • C12N2503/02—Drug screening
AT02773854T 2001-10-22 2002-10-22 Sich in schlagende kardiomyozyten verwandelnde stammzellen ATE348878T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US10/003,400 US20030082153A1 (en) 2001-10-22 2001-10-22 Stem cells that transform to beating cardiomyocytes

Publications (1)

Publication Number Publication Date
ATE348878T1 true ATE348878T1 (de) 2007-01-15

Family

ID=21705682

Family Applications (1)

Application Number Title Priority Date Filing Date
AT02773854T ATE348878T1 (de) 2001-10-22 2002-10-22 Sich in schlagende kardiomyozyten verwandelnde stammzellen

Country Status (8)

Country Link
US (3) US20030082153A1 (de)
EP (1) EP1444329B1 (de)
JP (1) JP4377690B2 (de)
AT (1) ATE348878T1 (de)
AU (1) AU2002337949B1 (de)
CA (1) CA2464088A1 (de)
DE (1) DE60216959D1 (de)
WO (1) WO2003035838A2 (de)

Families Citing this family (64)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
USRE39890E1 (en) 1991-03-27 2007-10-23 Matsushita Electric Industrial Co., Ltd. Communication system
USRE40241E1 (en) 1991-03-27 2008-04-15 Matsushita Electric Industrial Co., Ltd. Communication system
USRE42643E1 (en) 1991-03-27 2011-08-23 Panasonic Corporation Communication system
US7894541B2 (en) * 1992-03-26 2011-02-22 Panasonic Corporation Communication system
US6724976B2 (en) * 1992-03-26 2004-04-20 Matsushita Electric Industrial Co., Ltd. Communication system
US7302007B1 (en) 1992-03-26 2007-11-27 Matsushita Electric Industrial Co., Ltd. Communication system
US5802241A (en) 1992-03-26 1998-09-01 Matsushita Electric Industrial Co., Ltd. Communication system
US6728467B2 (en) * 1992-03-26 2004-04-27 Matsushita Electric Industrial Co., Ltd. Communication system
US5819000A (en) * 1992-03-26 1998-10-06 Matsushita Electric Industrial Co., Ltd. Magnetic recording and playback apparatus
USRE38513E1 (en) 1992-03-26 2004-05-11 Matsushita Electric Industrial Co., Ltd. Communication system
US7166280B2 (en) 2000-04-06 2007-01-23 Franco Wayne P Combination growth factor therapy and cell therapy for treatment of acute and chronic heart disease
US20100303769A1 (en) * 2000-04-06 2010-12-02 Franco Wayne P Combination growth factor therapy and cell therapy for treatment of acute and chronic heart disease
FR2819265B1 (fr) * 2001-01-10 2004-01-02 Centre Nat Rech Scient Cellules du tissu adipeux extramedullaire et leurs applications dans la reconstitution des lignees hematopoietiques
US7150990B2 (en) * 2002-03-06 2006-12-19 Reprocell, Inc. Self-renewing pluripotent hepatic stem cells
US8263375B2 (en) 2002-12-20 2012-09-11 Acea Biosciences Dynamic monitoring of activation of G-protein coupled receptor (GPCR) and receptor tyrosine kinase (RTK) in living cells using real-time microelectronic cell sensing technology
WO2004019767A2 (en) * 2002-08-29 2004-03-11 Baylor College Of Medicine Heart derived cells for cardiac repair
US10215748B2 (en) 2002-12-20 2019-02-26 Acea Biosciences, Inc. Using impedance-based cell response profiling to identify putative inhibitors for oncogene addicted targets or pathways
US10539523B2 (en) 2002-12-20 2020-01-21 Acea Biosciences, Inc. System and method for monitoring cardiomyocyte beating, viability, morphology, and electrophysiological properties
US10551371B2 (en) 2003-11-10 2020-02-04 Acea Biosciences, Inc. System and method for monitoring cardiomyocyte beating, viability and morphology and for screening for pharmacological agents which may induce cardiotoxicity or modulate cardiomyocyte function
US9612234B2 (en) 2008-05-05 2017-04-04 Acea Biosciences, Inc. Data analysis of impedance-based cardiomyocyte-beating signals as detected on real-time cell analysis (RTCA) cardio instruments
US11346797B2 (en) 2002-12-20 2022-05-31 Agilent Technologies, Inc. System and method for monitoring cardiomyocyte beating, viability, morphology and electrophysiological properties
ITRM20030376A1 (it) 2003-07-31 2005-02-01 Univ Roma Procedimento per l'isolamento e l'espansione di cellule staminali cardiache da biopsia.
CA2550274A1 (en) 2003-11-12 2005-05-26 Acea Biosciences, Inc. Real time electronic cell sensing systems and applications for cell-based assays
US8859273B2 (en) * 2003-12-24 2014-10-14 Medtronic, Inc. Methods of using HCN genes to treat cardiac arrhythmias
AU2005213326A1 (en) * 2004-02-06 2005-08-25 Theradigm, Inc. Compositions and methods relating to culturing neural stem cells with bone marrow stromal cells
WO2005095652A2 (en) 2004-03-31 2005-10-13 Georgetown University Pnmt as a novel marker for progenitor cells
CA2563677A1 (en) * 2004-04-23 2005-12-01 The Government Of The United States Of America As Represented By The Sec Retary Of The Department Of Health And Human Services Use of a monoclonal antibody that specifically binds stem cells
DE602005025106D1 (de) 2004-05-11 2011-01-13 Axiogenesis Ag Methoden zur medikamentenaufspürung auf der basis von in vitro differenzierten zellen
US8192929B2 (en) * 2004-07-19 2012-06-05 The Trustees Of Columbia University In The City Of New York Assay system for monitoring the effects of genetically engineered cells to alter function of a synctium
WO2006011354A1 (ja) * 2004-07-27 2006-02-02 Kowa Company, Ltd. 細胞融合促進剤、及びその使用
US11660317B2 (en) 2004-11-08 2023-05-30 The Johns Hopkins University Compositions comprising cardiosphere-derived cells for use in cell therapy
WO2006093276A1 (ja) 2005-03-04 2006-09-08 Kyoto University 心臓組織由来の多能性幹細胞
US20080241111A1 (en) * 2005-03-04 2008-10-02 Kyoto University Pluripotent Stem Cell Derived from Cardiac Tissue
CN103356704B (zh) * 2005-03-31 2015-09-30 斯丹姆涅恩有限公司 制备用以治疗由糖尿病性神经病引发的溃疡的药物的方法
WO2007010858A1 (ja) * 2005-07-15 2007-01-25 Kyoto University 骨格筋組織由来の単一細胞よりクローン化した多能性幹細胞
FR2896511B1 (fr) * 2006-01-26 2012-10-26 Centre Nat Rech Scient Procede de culture de cellules issues du tissu adipeux et leurs applications.
TW200734462A (en) 2006-03-08 2007-09-16 In Motion Invest Ltd Regulating stem cells
US20080089874A1 (en) * 2006-09-28 2008-04-17 The Regents Of The University Of California Directed differentiation and maturation of stem cell-derived cardiomyocytes
WO2008043099A2 (en) 2006-10-06 2008-04-10 Medtronic, Inc. Hybrid pacing system
KR101240487B1 (ko) * 2006-11-09 2013-03-08 더 존스 홉킨스 유니버시티 성체 포유동물 심근세포의 심장 줄기 세포로의 역분화
US20100278787A1 (en) * 2007-07-18 2010-11-04 Cellartis Ab Cardiomyocyte-like cell clusters derived from hbs cells
EP2198010A4 (de) * 2007-09-12 2010-10-06 Univ California Zusammensetzungen und verfahren zur verbesserung der funktionellen wirksamkeit von stammzellen abgeleiteter herzmuskelzellen
WO2009092005A2 (en) * 2008-01-18 2009-07-23 The J. David Gladstone Institutes Methods of generating cardiomyocytes and cardiac progenitors and compositions
WO2009120762A2 (en) * 2008-03-27 2009-10-01 Mount Sinai School Of Medicine Of New York University Human cardiovascular progenitor cells
CA2723223C (en) 2008-05-05 2017-06-06 Acea Biosciences, Inc. Label-free monitoring of excitation-contraction coupling and excitable cells using impedance based systems with millisecond time resolution
PL2451941T3 (pl) * 2009-07-09 2018-10-31 Janssen Biotech, Inc Komórki pochodzące z tkanki sercowej
US9845457B2 (en) 2010-04-30 2017-12-19 Cedars-Sinai Medical Center Maintenance of genomic stability in cultured stem cells
US9249392B2 (en) 2010-04-30 2016-02-02 Cedars-Sinai Medical Center Methods and compositions for maintaining genomic stability in cultured stem cells
WO2012098260A1 (en) 2011-01-21 2012-07-26 Axiogenesis Ag A non-viral system for the generation of induced pluripotent stem (ips) cells
BR112014007007B1 (pt) * 2011-10-17 2022-04-19 F. Hoffmann-La Roche Ag Método in-vitro para diferenciação precoce da apoplexia isquêmica cardioembólica, uso de uma troponina cardíaca e dispositivo de diferenciação precoce da apoplexia isquêmica cardioembólica
WO2013184527A1 (en) * 2012-06-05 2013-12-12 Capricor, Inc. Optimized methods for generation of cardiac stem cells from cardiac tissue and their use in cardiac therapy
JP6433896B2 (ja) 2012-08-13 2018-12-05 シーダーズ−サイナイ・メディカル・センターＣｅｄａｒｓ−Ｓｉｎａｉ Ｍｅｄｉｃａｌ Ｃｅｎｔｅｒ 組織再生のためのエキソソームおよびマイクロリボ核酸
JP6312215B2 (ja) * 2012-12-28 2018-04-18 国立大学法人京都大学 人工多能性幹細胞、心筋細胞又はその前駆細胞の製造方法
US10160954B2 (en) 2013-01-23 2018-12-25 The Regents Of The University Of California Engineered physical alignment of stem cell-derived cardiomyocytes
US9493742B2 (en) 2013-03-15 2016-11-15 Emory University Purification of cell mixtures using molecular beacons targeting cell specific RNA
US10087436B2 (en) 2014-02-06 2018-10-02 The Regents Of The University Of California Electrophysiologically mature cardiomyocytes and methods for making same
AU2015327812B2 (en) 2014-10-03 2021-04-15 Cedars-Sinai Medical Center Cardiosphere-derived cells and exosomes secreted by such cells in the treatment of muscular dystrophy
US11253551B2 (en) 2016-01-11 2022-02-22 Cedars-Sinai Medical Center Cardiosphere-derived cells and exosomes secreted by such cells in the treatment of heart failure with preserved ejection fraction
WO2017210652A1 (en) 2016-06-03 2017-12-07 Cedars-Sinai Medical Center Cdc-derived exosomes for treatment of ventricular tachyarrythmias
WO2018057542A1 (en) 2016-09-20 2018-03-29 Cedars-Sinai Medical Center Cardiosphere-derived cells and their extracellular vesicles to retard or reverse aging and age-related disorders
WO2018161063A1 (en) 2017-03-03 2018-09-07 Acea Biosciences, Inc. METHODS AND SYSTEMS FOR FUNCTIONAL MATURATION OF iPSC AND ESC DERIVED CARDIOMYOCYTES
EP3612191A4 (de) 2017-04-19 2020-12-30 Cedars-Sinai Medical Center Verfahren und zusammensetzungen zur behandlung von skelettmuskeldystrophie
US11660355B2 (en) 2017-12-20 2023-05-30 Cedars-Sinai Medical Center Engineered extracellular vesicles for enhanced tissue delivery
USD941488S1 (en) 2020-02-07 2022-01-18 Agilent Technologies, Inc. Instrument for analyzing biological cells

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5486359A (en) * 1990-11-16 1996-01-23 Osiris Therapeutics, Inc. Human mesenchymal stem cells
AU8401498A (en) 1997-07-14 1999-02-10 Osiris Therapeutics, Inc. Cardiac muscle regeneration using mesenchymal stem cells
US6248587B1 (en) * 1997-11-26 2001-06-19 University Of Southern Cailfornia Method for promoting mesenchymal stem and lineage-specific cell proliferation
EP1100870B1 (de) 1998-07-31 2008-01-02 Genzyme Corporation Verbesserung der herzfunktion durch transplantation mesenchymaler stammzellen
US6184035B1 (en) * 1998-11-18 2001-02-06 California Institute Of Technology Methods for isolation and activation of, and control of differentiation from, skeletal muscle stem or progenitor cells
WO2001000031A1 (en) 1999-06-25 2001-01-04 Baylor College Of Medicine Stem cells derived from skeletal muscle
CA2852534A1 (en) 1999-08-05 2001-02-15 Abt Holding Company Multipotent adult stem cells and methods for isolation
ATE365045T1 (de) * 2000-04-14 2007-07-15 Univ Pittsburgh Vermehrung des weich- sowie des knochengewebes anhand von aus muskeln stammenden vorläuferzellen,sowie damit verbundene zusammensetzungen und behandlungsformen

Also Published As

Publication number Publication date
US7220582B2 (en) 2007-05-22
EP1444329A2 (de) 2004-08-11
WO2003035838A3 (en) 2003-07-17
JP4377690B2 (ja) 2009-12-02
EP1444329A4 (de) 2004-11-24
US20030082153A1 (en) 2003-05-01
US20070212423A1 (en) 2007-09-13
AU2002337949B1 (en) 2003-05-06
EP1444329B1 (de) 2006-12-20
US20050058633A1 (en) 2005-03-17
CA2464088A1 (en) 2003-05-01
DE60216959D1 (de) 2007-02-01
WO2003035838A2 (en) 2003-05-01
JP2005506845A (ja) 2005-03-10

Similar Documents

Publication Publication Date Title
ATE348878T1 (de) Sich in schlagende kardiomyozyten verwandelnde stammzellen
DK1650307T3 (da) Fremgangsmåde til fremstilling af rekombinante proteiner ved anvendelse af apoptoseinhibitorer
NO20024200D0 (no) Serumfri dyrking av primate embryonale stamceller
HUP0400689A2 (hu) ABCA-1 szint-emelő vegyületek
HUP0301002A2 (hu) Kettős specifitású ellenanyagok, eljárások előállításukra és alkalmazásaik
NO20013770D0 (no) Metoder og blandinger for å öke antall hvite blodceller
DE60238058D1 (de) Verwendung von lysyloxydase inhibitoren zur zellkultur und gewebeaufbau
DK1226233T3 (da) Multipotente voksne stamceller og fremgangsmåder til isolering heraf
GB2393734B (en) Cells of the cardiomyocyte lineage produced from human pluripotent stem cells
BR0214029A (pt) Métodos e composições para o uso de células estromais para suportar células tronco embriÈnicas e adultas
ATE426023T1 (de) ßHEDGEHOG-LIKEß PROTEINE VON WIRBELTIEREN, DIE EMBRYONALE STRUKTUREN INDUZIEREN
ATE500323T1 (de) Subtilisin-variante
EA200501772A1 (ru) Способы измерения экспрессии генов из фиксированного и залитого в парафин образца ткани
DE60027768D1 (de) Behandlung von metastatischer krankheit
DE60213407D1 (de) Zusammensetzungen zur hemmung der angiogenese
DE60235836D1 (de) Ahren und verwendung davon
SE0401132D0 (sv) Endotelceller härledda från primata embryonala stamceller
FR2812004B1 (fr) Milieux de culture pour fecondation in vitro, ou pour la culture de follicules, cellules germinales males ou embryons
AU2001259353A1 (en) Novel mutated form of arginine deiminase
MXPA04001720A (es) Acido nucleicos bv8 y polipeptidos con actividad mitogenica.
ATE356204T1 (de) Antisense-zusammensetzungen und verfahren zur behandlung von krebs
NO20041633L (no) Fremgangsmate for fremstilling av heparin fra mastcelle kulturer
NO20004393L (no) Anvendelse av CD137 for Õ fremme proliferering av perifere monocytter
NO20040174L (no) Fremgangsmate for donorspesifikk krysstilpasning
ATE251106T1 (de) Herstellung von carvon

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties