DE60211935D1 - Alkandiol derivate zur behandlung von knochenkrankheiten - Google Patents

Alkandiol derivate zur behandlung von knochenkrankheiten

Info

Publication number
DE60211935D1
DE60211935D1 DE60211935T DE60211935T DE60211935D1 DE 60211935 D1 DE60211935 D1 DE 60211935D1 DE 60211935 T DE60211935 T DE 60211935T DE 60211935 T DE60211935 T DE 60211935T DE 60211935 D1 DE60211935 D1 DE 60211935D1
Authority
DE
Germany
Prior art keywords
inhibit
esters
activity
compounds
independently
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60211935T
Other languages
English (en)
Other versions
DE60211935T2 (de
Inventor
Stuart Ralston
Robert Greig
T Hof Robert Jurgen Van
John Armour
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Aberdeen
Original Assignee
University of Aberdeen
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of Aberdeen filed Critical University of Aberdeen
Publication of DE60211935D1 publication Critical patent/DE60211935D1/de
Application granted granted Critical
Publication of DE60211935T2 publication Critical patent/DE60211935T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A61K31/047—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates having two or more hydroxy groups, e.g. sorbitol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/235—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Rheumatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Emergency Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
DE60211935T 2001-10-31 2002-10-31 Alkandiol derivate zur behandlung von knochenkrankheiten Expired - Lifetime DE60211935T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB0126157 2001-10-31
GBGB0126157.7A GB0126157D0 (en) 2001-10-31 2001-10-31 Therapeutic compounds
PCT/GB2002/004933 WO2003037321A1 (en) 2001-10-31 2002-10-31 Alkane diol derivatives as therapeutic agents for the treatment of bone conditions

Publications (2)

Publication Number Publication Date
DE60211935D1 true DE60211935D1 (de) 2006-07-06
DE60211935T2 DE60211935T2 (de) 2007-01-11

Family

ID=9924891

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60211935T Expired - Lifetime DE60211935T2 (de) 2001-10-31 2002-10-31 Alkandiol derivate zur behandlung von knochenkrankheiten

Country Status (9)

Country Link
US (1) US7745424B2 (de)
EP (1) EP1441716B1 (de)
JP (1) JP2005511556A (de)
KR (1) KR20050042044A (de)
AT (1) ATE327748T1 (de)
CA (1) CA2465399A1 (de)
DE (1) DE60211935T2 (de)
GB (1) GB0126157D0 (de)
WO (1) WO2003037321A1 (de)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060286064A1 (en) * 2000-08-30 2006-12-21 Medivas, Llc Therapeutic polymers and methods
US20060177416A1 (en) 2003-10-14 2006-08-10 Medivas, Llc Polymer particle delivery compositions and methods of use
DE602004010514T2 (de) 2003-05-07 2008-11-27 The University Court Of The University Of Aberdeen, Aberdeen Ketone und reduzierte ketone als therapeutische mittel zur behandlung von knochenerkrankungen
US20060188469A1 (en) * 2003-10-14 2006-08-24 Medivas, Llc Vaccine delivery compositions and methods of use
KR20060048138A (ko) * 2004-05-28 2006-05-18 가부시키가이샤 닛폰 쇼쿠바이 불소 함유 화합물
GB0412553D0 (en) 2004-06-04 2004-07-07 Univ Aberdeen Therapeutic agents for the treatment of bone conditions
US20070053984A1 (en) * 2005-03-03 2007-03-08 Monique Spann-Wade Topical gels compositions
CA2623198C (en) 2005-09-22 2014-08-05 Medivas, Llc Bis-(a-amino)-diol-diester-containing poly(ester amide) and poly(ester urethane) compositions and methods of use
US8652504B2 (en) 2005-09-22 2014-02-18 Medivas, Llc Solid polymer delivery compositions and methods for use thereof
US20080317684A1 (en) * 2006-09-06 2008-12-25 Isw Group, Inc. Topical Compositions
GB0705400D0 (en) 2007-03-21 2007-05-02 Univ Aberdeen Therapeutic compounds andm their use
GB0817207D0 (en) 2008-09-19 2008-10-29 Pimco 2664 Ltd therapeutic apsac compounds and their use
GB0817208D0 (en) 2008-09-19 2008-10-29 Pimco 2664 Ltd Therapeutic apsap compounds and their use
WO2010036973A1 (en) * 2008-09-25 2010-04-01 Comgenrx, Inc. Treatment of hyperproliferative disorders using cardiac glycosides
US9873765B2 (en) 2011-06-23 2018-01-23 Dsm Ip Assets, B.V. Biodegradable polyesteramide copolymers for drug delivery
JP6045575B2 (ja) 2011-06-23 2016-12-14 ディーエスエム アイピー アセッツ ビー．ブイ． 薬物送達のための新規な生分解性ポリエステルアミドコポリマー
US20140112978A1 (en) * 2011-07-21 2014-04-24 Hellongjoamg Baoqinglong Biotechnology Co. Ltd. Ibuprofen-based compound, preparation method, use, and formulation of the same
US11964956B2 (en) 2012-09-06 2024-04-23 Northeastern University Cannabinergic compounds and uses thereof
WO2014039042A1 (en) 2012-09-06 2014-03-13 Northeastern University Novel cannabinergic compounds and uses thereof
US9580400B2 (en) 2013-02-26 2017-02-28 Northeastern University Cannabinergic nitrate esters and related analogs
EP2818531B1 (de) * 2013-06-25 2017-07-26 Merck Patent GmbH Polymerisierbare Verbindungen und ihre Verwendung für Flüssigkristallanzeigen
GB201311361D0 (en) 2013-06-26 2013-08-14 Pimco 2664 Ltd Compounds and their therapeutic use
CA2970578C (en) 2014-12-17 2024-01-02 Pimco 2664 Limited N-(4-hydroxy-4-methyl-cyclohexyl)-4-phenyl-benzenesulfonamide and n-(4-hydroxy-4-methyl-cyclohexyl)-4-(2-pyridyl)-benzenesulfonamide compounds and their therapeutic use
AU2015366355B2 (en) 2014-12-18 2020-05-28 Dsm Ip Assets B.V. Drug delivery system for delivery of acid sensitive drugs
CN113402386B (zh) * 2021-05-28 2024-05-03 武汉亿科德精细化工有限公司 一种新戊二醇二苯甲酸酯的合成方法
WO2024083934A1 (en) 2022-10-19 2024-04-25 Basf Se Method for preparing 1,4-butanediol diesters

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB663072A (en) 1947-05-24 1951-12-19 British Celanese Improvements relating to compositions comprising organic thermoplastic substances
GB661185A (en) 1947-11-24 1951-11-21 Sterling Drug Inc Improvements in or relating to the production of alkoxyalkyl esters of iodobenzoic acids
GB716877A (en) 1951-07-25 1954-10-13 British Celanese Improvements in polyesters and their intermediates
GB774180A (en) 1953-11-18 1957-05-08 Cecil Reginald Burch Grading or separation of solid materials in liquid suspension
GB774635A (en) 1954-06-29 1957-05-15 Thomae Gmbh Dr K New benzoic acid derivatives, and processes for their preparation
JPS4326316Y1 (de) 1964-11-21 1968-11-01
CH496647A (de) 1967-12-15 1970-09-30 Hoechst Ag Verfahren zur Herstellung von Terephthalsäure-(B-hydroxy-äthyl)-estern
US3689535A (en) 1968-09-26 1972-09-05 John Kollar Process for preparing ethylene glycol esters
US3715389A (en) 1971-03-01 1973-02-06 Halcon International Inc Process for preparing glycol esters from olefinically unsaturated compounds
DE2602030C2 (de) * 1976-01-21 1983-12-01 Henkel KGaA, 4000 Düsseldorf Diphosphonoalkancarbonsäuren und Verfahren zu deren Herstellung
JP2748005B2 (ja) 1988-10-13 1998-05-06 旭電化工業株式会社 光学活性ビフェニル化合物および該化合物含有液晶組成物
IT1256450B (it) 1992-11-26 1995-12-05 Soldato Piero Del Esteri nitrici con attivita' farmacologica e procedimento per la loro preparazione
US5374707A (en) * 1993-02-18 1994-12-20 Monsanto Company Hydroxy ethyl bibenzoate
JP3538444B2 (ja) * 1993-09-30 2004-06-14 株式会社三光開発科学研究所 ジヒドロキシ化合物およびその製造方法
US6124474A (en) 1999-12-21 2000-09-26 Abbott Laboratories Synthesis of chiral 2-azetidinemethanol compounds
JP4326316B2 (ja) 2003-12-09 2009-09-02 日産自動車株式会社 車両のトラクションコントロール装置

Also Published As

Publication number Publication date
GB0126157D0 (en) 2002-01-02
ATE327748T1 (de) 2006-06-15
EP1441716A1 (de) 2004-08-04
DE60211935T2 (de) 2007-01-11
JP2005511556A (ja) 2005-04-28
WO2003037321A1 (en) 2003-05-08
CA2465399A1 (en) 2003-05-08
KR20050042044A (ko) 2005-05-04
US7745424B2 (en) 2010-06-29
EP1441716B1 (de) 2006-05-31
US20040254151A1 (en) 2004-12-16

Similar Documents

Publication Publication Date Title
DE60211935D1 (de) Alkandiol derivate zur behandlung von knochenkrankheiten
IL143978A0 (en) Colchinol derivatives as vascular damaging agents
RS20100077A (en) Pharamceutically active uridine esters
ES2169046T3 (es) Analogo de prostaglandina para el tratamiento de la osteoporosis.
DE60017279D1 (en) Pyrimidinderivate
IL133585A0 (en) Soluble prodrugs of paclitaxel
NO2011026I2 (no) Eribulin eller et farmasøytisk akseptabelt salt derav
TW200642685A (en) Novel spiroindoline or spiroisoquinoline compounds, methods of use and compositions thereof
HUP0400732A2 (hu) Gyógyászatilag hatékony uridin-észterek
BG104544A (en) Novel acylguanadine derivatives as inhibitors of bone resorption and as vitronectin receptor antagonists
PT1383756E (pt) Derivados de cumarina a utilizar como anticoagulantes
ES2110115T3 (es) Inhibidores de la agregacion de plaquetas.
WO2005118528A3 (en) Aryl alkyl sulfonamides as therapeutic agents for the treatment of bone conditions
WO2004098582A3 (en) Ketones and reduced ketones as therapeutic agents for the treatment of bone conditions
AU6826700A (en) Ceramide analogs, process for their preparation and their use as antitumor agents
ITMI922742A1 (it) Composti ad attivita' terapeutica utili per il trattamento di malattie connesse ad una carenza di glutatione, procedimento per la loro preparazione e composizioni farmaceutiche che li contengono.
BR0011845A (pt) Complexo farmacêutico
HUP0302255A2 (hu) Szulfonamidszármazékok, ezeket tartalmazó gyógyszerkészítmények és alkalmazásuk
MXPA05014127A (es) Uso de derivados de biciclo[2.2.1]heptano para la preparacion de composiciones farmaceuticas neuroprotectoras.
BR9306870A (pt) Derivados farmacologicamente ativos de (aminometila terciária) - benzenometanol
ATE155791T1 (de) Etoposid-derivate, ihre herstellung, ihre verwendung als medikament und ihre verwendung zur herstellung eines antikrebsmittels
HUP9903369A2 (hu) 8(9)-Dehidroösztradiol-származékok
ES2103237A1 (es) Nuevo compuesto derivado del cromeno
WO2003033491A1 (fr) Composition medicinale de prevention ou de soulagement d'effets secondaires chez les patients souffrant de cancer et composition anticancereuse medicinale

Legal Events

Date Code Title Description
8364 No opposition during term of opposition