GB661185A - Improvements in or relating to the production of alkoxyalkyl esters of iodobenzoic acids - Google Patents

Improvements in or relating to the production of alkoxyalkyl esters of iodobenzoic acids

Info

Publication number
GB661185A
GB661185A GB30275/48A GB3027548A GB661185A GB 661185 A GB661185 A GB 661185A GB 30275/48 A GB30275/48 A GB 30275/48A GB 3027548 A GB3027548 A GB 3027548A GB 661185 A GB661185 A GB 661185A
Authority
GB
United Kingdom
Prior art keywords
ethoxyethyl
acid
iodo
iodobenzoates
methoxyethyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB30275/48A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
STWB Inc
Original Assignee
Sterling Drug Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sterling Drug Inc filed Critical Sterling Drug Inc
Publication of GB661185A publication Critical patent/GB661185A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/76—Esters of carboxylic acids having a carboxyl group bound to a carbon atom of a six-membered aromatic ring
    • C07C69/78—Benzoic acid esters
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/66—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
    • C07C69/73—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of unsaturated acids
    • C07C69/734—Ethers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/76—Esters of carboxylic acids having a carboxyl group bound to a carbon atom of a six-membered aromatic ring
    • C07C69/84—Esters of carboxylic acids having a carboxyl group bound to a carbon atom of a six-membered aromatic ring of monocyclic hydroxy carboxylic acids, the hydroxy groups and the carboxyl groups of which are bound to carbon atoms of a six-membered aromatic ring
    • C07C69/92—Esters of carboxylic acids having a carboxyl group bound to a carbon atom of a six-membered aromatic ring of monocyclic hydroxy carboxylic acids, the hydroxy groups and the carboxyl groups of which are bound to carbon atoms of a six-membered aromatic ring with etherified hydroxyl groups

Abstract

Alkoxyalkyl iodobenzoates of the formula <FORM:0661185/IV (b)/1> where Y is alkylene, R is alkyl and the total number of carbon atoms in the molecule is 10-18, or of the formula <FORM:0661185/IV (b)/2> where Y is alkylene, R and R1 are alkyl and the total number of carbon atoms in the molecule is 11-16, are prepared from (1) the iodobenzoic acid or iodoalkoxybenzoic acid and an alkoxyalkanol in the presence of an acid catalyst; (2) as in (1) using a reactive derivative of the acid, e.g. chloride or anhydride, in which case no catalyst is necessary; (3) a metallic (e.g. alkali metal) salt of the iodobenzoic or iodo-alkoxy-benzoic acid and an alkoxyalkyl halide. Preferably Y has 2-3 carbon atoms, R has 1-6 and R1 has 1-2. In the examples, the following compounds are prepared: 2-ethoxyethyl o-iodobenzoate; 2-methoxyethyl and 2-ethoxyethyl m-iodobenzoates; 2-methoxyethyl, 2-ethoxyethyl, 3-methoxypropyl, 3-ethoxypropyl, 2-butoxyethyl and 2 - (21 - ethyl - butoxy) - ethyl p - iodobenzoates; 2-ethoxyethyl, 2-butoxyethyl and 5-methoxypropyl 3-iodo-4-methoxy-benzoates, 2-methoxyethyl, 2-ethoxyethyl and 3-ethoxypropyl 3 - iodo - 4 - ethoxy - benzoates; 2-ethoxyethyl 2 - iodo - 5 - methoxy - benzoate. Mixtures of two of these esters form eutectic mixtures with low melting points.
GB30275/48A 1947-11-24 1948-11-22 Improvements in or relating to the production of alkoxyalkyl esters of iodobenzoic acids Expired GB661185A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US661185XA 1947-11-24 1947-11-24

Publications (1)

Publication Number Publication Date
GB661185A true GB661185A (en) 1951-11-21

Family

ID=22067355

Family Applications (1)

Application Number Title Priority Date Filing Date
GB30275/48A Expired GB661185A (en) 1947-11-24 1948-11-22 Improvements in or relating to the production of alkoxyalkyl esters of iodobenzoic acids

Country Status (1)

Country Link
GB (1) GB661185A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7745424B2 (en) 2001-10-31 2010-06-29 The Univeristy Court of the University of Aberdeen Alkane diol derivatives as therapeutic agents for the treatment of bone conditions

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7745424B2 (en) 2001-10-31 2010-06-29 The Univeristy Court of the University of Aberdeen Alkane diol derivatives as therapeutic agents for the treatment of bone conditions

Similar Documents

Publication Publication Date Title
GB661185A (en) Improvements in or relating to the production of alkoxyalkyl esters of iodobenzoic acids
GB986579A (en) 5-ethylidene dibenzocycloheptadienes and the preparation thereof
GB1059813A (en) Novel processes for the preparation of intermediates useful in the preparation of colchicine compounds, and the intermediates thus prepared
GB748064A (en) Substances having spasmolytic activity and method of producing the same
SE7710933L (en) 5-ALCOXY-PICOLIC ACIDS
GB615137A (en) Manufacture of amides of ª‡,ª‰-unsaturated carboxylic acids
GB674298A (en) Improvements in or relating to sulphamylbenzoic acids
GB605737A (en) Improvements in or relating to the production of esters of hydroxy-alkoxy benzoic acids
GB1107036A (en) Esters of dibenzocycloheptenyl-carboxylic acids
GB1057219A (en) Basic-substituted xanthen-9-ol-9-carboxylic acid esters
GB1073485A (en) New 1-subustituted cycloheptimidaszol-2(1h)-one compounds and a process for the same
GB638039A (en) Improvements in and relating to the production of colour photographic images
GB802186A (en) Bis-(hydroxy-alkyl) ethers and their production
GB935205A (en) Derivatives of indazolone and their use as colour couplers
GB667199A (en) Process for stabilizing photographic emulsions
GB1070714A (en) (alkylaminoethoxy)-dihaloanilines and process of preparation thereof
ES8105743A1 (en) Process for the production of branched S-alkyl phosphonodithioic halide intermediates.
GB1101112A (en) New steroidal pyrazoles
GB649358A (en) Improved chemotherapeutic compounds
GB729331A (en) Improvements in or relating to thiazole derivatives
GB1083166A (en) Pyrazolone compounds and methods for making same
GB647759A (en) Improvements in the manufacture of stilbene derivatives
GB721349A (en) Esters of n-(1-methyl-3-keto-1-butenyl)-n-(2:3-dicarboxy-3-keto-1-propenyl) amine
GB807257A (en) Sulphosuccinic acid mono amides
GB728677A (en) Manufacture of new dioxopyrrolidines