DE60208703D1 - Prozess zur herstellung von 4- (8-chloro-5, 6-dihydro-11h-benzo-ä5,6ü-cyclohepta-ä1,2-bü-pyridin-11-ylidene)-1-piperidinecarbonsäureethylester (loratadine) - Google Patents

Prozess zur herstellung von 4- (8-chloro-5, 6-dihydro-11h-benzo-ä5,6ü-cyclohepta-ä1,2-bü-pyridin-11-ylidene)-1-piperidinecarbonsäureethylester (loratadine)

Info

Publication number
DE60208703D1
DE60208703D1 DE60208703T DE60208703T DE60208703D1 DE 60208703 D1 DE60208703 D1 DE 60208703D1 DE 60208703 T DE60208703 T DE 60208703T DE 60208703 T DE60208703 T DE 60208703T DE 60208703 D1 DE60208703 D1 DE 60208703D1
Authority
DE
Germany
Prior art keywords
chloro
loratadine
pyridin
dihydro
benzo
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60208703T
Other languages
English (en)
Other versions
DE60208703T2 (de
DE60208703T8 (de
Inventor
Vincenzo Cannata
Livius Cotarca
Ivan Michieletto
Stefano Poli
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Zach System SpA
Original Assignee
Zambon SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Zambon SpA filed Critical Zambon SpA
Publication of DE60208703D1 publication Critical patent/DE60208703D1/de
Publication of DE60208703T2 publication Critical patent/DE60208703T2/de
Application granted granted Critical
Publication of DE60208703T8 publication Critical patent/DE60208703T8/de
Active legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
DE60208703T 2001-11-05 2002-10-29 Prozess zur herstellung von 4-(8-chloro-5, 6-dihydro-11h-benzo-[5,6]-cyclo-hepta-[1,2-b]-pyridin-11-ylidene)-1-piperidinecarbon-säureethylester (loratadine) Active DE60208703T8 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
ITMI20010230 2001-11-05
IT2001MI002308A ITMI20012308A1 (it) 2001-11-05 2001-11-05 Processo per la preparazione dell'estere etilico dell'acido 4-(8-cloro-5,6-diidro-11h-benzo-5,67-cicloepta-1,2-b-piridin-11-ilidene)-1-piper
PCT/EP2002/012056 WO2003040140A1 (en) 2001-11-05 2002-10-29 Process for the preparation of 4-(8-chloro-5,6-dihydro-11h-benzo(5,6)-cyclohepta-(1,2b)-pyridin-11-ylidene)-1-piperidinecarboxyli c acid ethyl ester (loratadine)

Publications (3)

Publication Number Publication Date
DE60208703D1 true DE60208703D1 (de) 2006-04-06
DE60208703T2 DE60208703T2 (de) 2006-10-19
DE60208703T8 DE60208703T8 (de) 2007-05-03

Family

ID=11448567

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60208703T Active DE60208703T8 (de) 2001-11-05 2002-10-29 Prozess zur herstellung von 4-(8-chloro-5, 6-dihydro-11h-benzo-[5,6]-cyclo-hepta-[1,2-b]-pyridin-11-ylidene)-1-piperidinecarbon-säureethylester (loratadine)

Country Status (19)

Country Link
US (2) US7449583B2 (de)
EP (1) EP1442035B1 (de)
JP (1) JP4307262B2 (de)
CN (1) CN100366620C (de)
AT (1) ATE315565T1 (de)
AU (1) AU2002340487B2 (de)
BR (1) BR0213909A (de)
CA (1) CA2465686C (de)
DE (1) DE60208703T8 (de)
EA (1) EA007740B1 (de)
ES (1) ES2256543T3 (de)
HU (1) HUP0402390A3 (de)
IL (1) IL161734A0 (de)
IT (1) ITMI20012308A1 (de)
MX (1) MXPA04004255A (de)
NO (1) NO326489B1 (de)
NZ (1) NZ533287A (de)
WO (1) WO2003040140A1 (de)
ZA (1) ZA200404262B (de)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ITMI20012308A1 (it) * 2001-11-05 2003-05-05 Zambon Spa Processo per la preparazione dell'estere etilico dell'acido 4-(8-cloro-5,6-diidro-11h-benzo-5,67-cicloepta-1,2-b-piridin-11-ilidene)-1-piper
WO2015084693A2 (en) * 2013-12-05 2015-06-11 Merck Sharp & Dohme Corp. New process for preparing loratadine from a ketone intermediate
CN109897027B (zh) * 2019-04-28 2021-11-02 梯尔希（南京）药物研发有限公司 一种3-羟基地氯雷他定代谢物的合成方法
CN113135893B (zh) * 2021-06-21 2022-02-11 北京鑫开元医药科技有限公司 苯并环庚烷并吡啶化合物、其制备方法及其用途
CN115778924A (zh) * 2022-12-22 2023-03-14 河北三禾实创生物科技有限公司 一种氯雷他定制剂及其制备方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4731447A (en) * 1985-05-13 1988-03-15 Schering Corporation Process for preparing piperidylidene dihydro-dibenzo(a,d)-cycloheptenes or aza-derivatives thereof
AU3264695A (en) * 1994-08-23 1996-03-14 Nissan Chemical Industries Ltd. Pyridine derivative
WO2000005215A1 (en) * 1998-07-24 2000-02-03 Russinsky Limited A process for preparing benzocycloheptapyridin-11-ones
TWI225056B (en) * 1998-12-18 2004-12-11 Schering Corp Process for preparing tricyclic compounds having antihistaminic activity
ITMI20012308A1 (it) * 2001-11-05 2003-05-05 Zambon Spa Processo per la preparazione dell'estere etilico dell'acido 4-(8-cloro-5,6-diidro-11h-benzo-5,67-cicloepta-1,2-b-piridin-11-ilidene)-1-piper

Also Published As

Publication number Publication date
HUP0402390A2 (en) 2006-02-28
MXPA04004255A (es) 2005-03-31
JP4307262B2 (ja) 2009-08-05
ATE315565T1 (de) 2006-02-15
NO326489B1 (no) 2008-12-15
CN100366620C (zh) 2008-02-06
CN1599736A (zh) 2005-03-23
EP1442035B1 (de) 2006-01-11
EA200400642A1 (ru) 2004-12-30
DE60208703T2 (de) 2006-10-19
WO2003040140A1 (en) 2003-05-15
AU2002340487B2 (en) 2007-12-13
BR0213909A (pt) 2004-08-31
JP2005513005A (ja) 2005-05-12
CA2465686C (en) 2010-03-23
ITMI20012308A1 (it) 2003-05-05
US20050171352A1 (en) 2005-08-04
CA2465686A1 (en) 2003-05-15
ES2256543T3 (es) 2006-07-16
EP1442035A1 (de) 2004-08-04
ZA200404262B (en) 2005-08-11
EA007740B1 (ru) 2006-12-29
US7449583B2 (en) 2008-11-11
IL161734A0 (en) 2005-11-20
NO20042297L (no) 2004-06-04
NZ533287A (en) 2005-08-26
US20090005567A1 (en) 2009-01-01
DE60208703T8 (de) 2007-05-03
HUP0402390A3 (en) 2011-03-28

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Legal Events

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8327 Change in the person/name/address of the patent owner

Owner name: ZACH SYSTEM S.P.A., BRESSO, (MILANO), IT