IL161734A0 - Process for the preparation of 4-(8-chloro-5,6-dihydro-11H-benzo (5,6)-cyclohepta-(1,2B)-pyridin-11-ylidene)-1-piperidinecarboxylic acid ethyl - Google Patents

Process for the preparation of 4-(8-chloro-5,6-dihydro-11H-benzo (5,6)-cyclohepta-(1,2B)-pyridin-11-ylidene)-1-piperidinecarboxylic acid ethyl

Info

Publication number
IL161734A0
IL161734A0 IL16173402A IL16173402A IL161734A0 IL 161734 A0 IL161734 A0 IL 161734A0 IL 16173402 A IL16173402 A IL 16173402A IL 16173402 A IL16173402 A IL 16173402A IL 161734 A0 IL161734 A0 IL 161734A0
Authority
IL
Israel
Prior art keywords
chloro
pyridin
dihydro
methyl
benzo
Prior art date
Application number
IL16173402A
Other languages
English (en)
Original Assignee
Zambon Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Zambon Spa filed Critical Zambon Spa
Publication of IL161734A0 publication Critical patent/IL161734A0/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
IL16173402A 2001-11-05 2002-10-29 Process for the preparation of 4-(8-chloro-5,6-dihydro-11H-benzo (5,6)-cyclohepta-(1,2B)-pyridin-11-ylidene)-1-piperidinecarboxylic acid ethyl IL161734A0 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT2001MI002308A ITMI20012308A1 (it) 2001-11-05 2001-11-05 Processo per la preparazione dell'estere etilico dell'acido 4-(8-cloro-5,6-diidro-11h-benzo-5,67-cicloepta-1,2-b-piridin-11-ilidene)-1-piper
PCT/EP2002/012056 WO2003040140A1 (en) 2001-11-05 2002-10-29 Process for the preparation of 4-(8-chloro-5,6-dihydro-11h-benzo(5,6)-cyclohepta-(1,2b)-pyridin-11-ylidene)-1-piperidinecarboxyli c acid ethyl ester (loratadine)

Publications (1)

Publication Number Publication Date
IL161734A0 true IL161734A0 (en) 2005-11-20

Family

ID=11448567

Family Applications (1)

Application Number Title Priority Date Filing Date
IL16173402A IL161734A0 (en) 2001-11-05 2002-10-29 Process for the preparation of 4-(8-chloro-5,6-dihydro-11H-benzo (5,6)-cyclohepta-(1,2B)-pyridin-11-ylidene)-1-piperidinecarboxylic acid ethyl

Country Status (19)

Country Link
US (2) US7449583B2 (xx)
EP (1) EP1442035B1 (xx)
JP (1) JP4307262B2 (xx)
CN (1) CN100366620C (xx)
AT (1) ATE315565T1 (xx)
AU (1) AU2002340487B2 (xx)
BR (1) BR0213909A (xx)
CA (1) CA2465686C (xx)
DE (1) DE60208703T8 (xx)
EA (1) EA007740B1 (xx)
ES (1) ES2256543T3 (xx)
HU (1) HUP0402390A3 (xx)
IL (1) IL161734A0 (xx)
IT (1) ITMI20012308A1 (xx)
MX (1) MXPA04004255A (xx)
NO (1) NO326489B1 (xx)
NZ (1) NZ533287A (xx)
WO (1) WO2003040140A1 (xx)
ZA (1) ZA200404262B (xx)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ITMI20012308A1 (it) * 2001-11-05 2003-05-05 Zambon Spa Processo per la preparazione dell'estere etilico dell'acido 4-(8-cloro-5,6-diidro-11h-benzo-5,67-cicloepta-1,2-b-piridin-11-ilidene)-1-piper
WO2015084693A2 (en) * 2013-12-05 2015-06-11 Merck Sharp & Dohme Corp. New process for preparing loratadine from a ketone intermediate
CN109897027B (zh) * 2019-04-28 2021-11-02 梯尔希（南京）药物研发有限公司 一种3-羟基地氯雷他定代谢物的合成方法
CN113135893B (zh) * 2021-06-21 2022-02-11 北京鑫开元医药科技有限公司 苯并环庚烷并吡啶化合物、其制备方法及其用途
CN115778924A (zh) * 2022-12-22 2023-03-14 河北三禾实创生物科技有限公司 一种氯雷他定制剂及其制备方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4731447A (en) * 1985-05-13 1988-03-15 Schering Corporation Process for preparing piperidylidene dihydro-dibenzo(a,d)-cycloheptenes or aza-derivatives thereof
AU3264695A (en) * 1994-08-23 1996-03-14 Nissan Chemical Industries Ltd. Pyridine derivative
WO2000005215A1 (en) * 1998-07-24 2000-02-03 Russinsky Limited A process for preparing benzocycloheptapyridin-11-ones
AU2157100A (en) * 1998-12-18 2000-07-12 Schering Corporation Process for preparing tricyclic compounds having antihistaminic activity
ITMI20012308A1 (it) * 2001-11-05 2003-05-05 Zambon Spa Processo per la preparazione dell'estere etilico dell'acido 4-(8-cloro-5,6-diidro-11h-benzo-5,67-cicloepta-1,2-b-piridin-11-ilidene)-1-piper

Also Published As

Publication number Publication date
EP1442035A1 (en) 2004-08-04
DE60208703T2 (de) 2006-10-19
US20050171352A1 (en) 2005-08-04
JP2005513005A (ja) 2005-05-12
HUP0402390A3 (en) 2011-03-28
CA2465686C (en) 2010-03-23
NO20042297L (no) 2004-06-04
US20090005567A1 (en) 2009-01-01
JP4307262B2 (ja) 2009-08-05
CN100366620C (zh) 2008-02-06
CA2465686A1 (en) 2003-05-15
ATE315565T1 (de) 2006-02-15
EA007740B1 (ru) 2006-12-29
EA200400642A1 (ru) 2004-12-30
AU2002340487B2 (en) 2007-12-13
ZA200404262B (en) 2005-08-11
EP1442035B1 (en) 2006-01-11
DE60208703T8 (de) 2007-05-03
ES2256543T3 (es) 2006-07-16
DE60208703D1 (de) 2006-04-06
BR0213909A (pt) 2004-08-31
NO326489B1 (no) 2008-12-15
WO2003040140A1 (en) 2003-05-15
ITMI20012308A1 (it) 2003-05-05
MXPA04004255A (es) 2005-03-31
NZ533287A (en) 2005-08-26
CN1599736A (zh) 2005-03-23
HUP0402390A2 (en) 2006-02-28
US7449583B2 (en) 2008-11-11

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Legal Events

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MM9K Patent not in force due to non-payment of renewal fees