ATE272616T1 - Neues verfahren zur herstellung von alpha-(2,4- disulphophenyl)-n-tert-butylnitron und seine pharmazeutisch akzeptablen salze - Google Patents

Neues verfahren zur herstellung von alpha-(2,4- disulphophenyl)-n-tert-butylnitron und seine pharmazeutisch akzeptablen salze

Info

Publication number
ATE272616T1
ATE272616T1 AT01901620T AT01901620T ATE272616T1 AT E272616 T1 ATE272616 T1 AT E272616T1 AT 01901620 T AT01901620 T AT 01901620T AT 01901620 T AT01901620 T AT 01901620T AT E272616 T1 ATE272616 T1 AT E272616T1
Authority
AT
Austria
Prior art keywords
butylnitron
disulphophenyl
tert
pharmaceutically acceptable
acceptable salts
Prior art date
Application number
AT01901620T
Other languages
English (en)
Inventor
Joergen Blixt
Henry Kruk
Ulf Larsson
John Mcginley
Sergei Pouhov
John Vajda
Allan Wilcox
Original Assignee
Astrazeneca Ab
Renovis
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astrazeneca Ab, Renovis filed Critical Astrazeneca Ab
Application granted granted Critical
Publication of ATE272616T1 publication Critical patent/ATE272616T1/de

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C309/00Sulfonic acids; Halides, esters, or anhydrides thereof
    • C07C309/01Sulfonic acids
    • C07C309/28Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C309/45Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing nitrogen atoms, not being part of nitro or nitroso groups, bound to the carbon skeleton
    • C07C309/46Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing nitrogen atoms, not being part of nitro or nitroso groups, bound to the carbon skeleton having the sulfo groups bound to carbon atoms of non-condensed six-membered aromatic rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C303/00Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides
    • C07C303/32Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of salts of sulfonic acids
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C303/00Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides
    • C07C303/02Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of sulfonic acids or halides thereof
    • C07C303/22Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of sulfonic acids or halides thereof from sulfonic acids, by reactions not involving the formation of sulfo or halosulfonyl groups; from sulfonic halides by reactions not involving the formation of halosulfonyl groups
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02PCLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00Technologies relating to chemical industry
    • Y02P20/10Process efficiency

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
AT01901620T 2000-01-10 2001-01-04 Neues verfahren zur herstellung von alpha-(2,4- disulphophenyl)-n-tert-butylnitron und seine pharmazeutisch akzeptablen salze ATE272616T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SE0000056A SE0000056D0 (sv) 2000-01-10 2000-01-10 Novel process
PCT/SE2001/000008 WO2001051461A1 (en) 2000-01-10 2001-01-04 NOVEL PROCESS FOR THE PREPARATION OF α-(2-4-DISULFOPHENYL)-N-TERT-BUTYLNITRONE AND PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF

Publications (1)

Publication Number Publication Date
ATE272616T1 true ATE272616T1 (de) 2004-08-15

Family

ID=20278056

Family Applications (1)

Application Number Title Priority Date Filing Date
AT01901620T ATE272616T1 (de) 2000-01-10 2001-01-04 Neues verfahren zur herstellung von alpha-(2,4- disulphophenyl)-n-tert-butylnitron und seine pharmazeutisch akzeptablen salze

Country Status (21)

Country Link
US (1) US6689911B2 (de)
EP (1) EP1250320B1 (de)
JP (1) JP2003519679A (de)
KR (1) KR100721882B1 (de)
CN (1) CN1263735C (de)
AR (1) AR029430A1 (de)
AT (1) ATE272616T1 (de)
AU (1) AU783256B2 (de)
BR (1) BR0107480A (de)
CA (1) CA2396008A1 (de)
DE (1) DE60104649T2 (de)
ES (1) ES2225467T3 (de)
IL (1) IL150402A0 (de)
MX (1) MXPA02006673A (de)
MY (1) MY120868A (de)
NO (1) NO20023318L (de)
PT (1) PT1250320E (de)
SE (1) SE0000056D0 (de)
SI (1) SI1250320T1 (de)
WO (1) WO2001051461A1 (de)
ZA (1) ZA200204875B (de)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050059638A1 (en) * 2003-08-04 2005-03-17 Kelly Michael G. Aryl, heteroaromatic and bicyclic aryl nitrone compounds, prodrugs and pharmaceutical compositions of the same to treat human disorders
US20050182060A1 (en) * 2004-02-13 2005-08-18 Kelly Michael G. 2-Substituted and 4-substituted aryl nitrone compounds
CA2715326C (en) 2008-02-12 2017-06-13 Tosk, Incorporated Toxicity-reducing nitrone adjuvants for doxorubicin and use of the same

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3397234A (en) 1964-06-17 1968-08-13 Du Pont Process for the preparation of alpha-phenyl-nu-methyl nitrone
FR1437188A (fr) 1964-06-17 1966-04-29 Du Pont Procédé de fabrication d'alpha-phényl-nu-méthyl nitrone
US5488145A (en) * 1993-12-23 1996-01-30 Oklahoma Medical Research Foundation 2,4-disulfonyl phenyl butyl nitrone, its salts, and their use as pharmaceutical free radical traps

Also Published As

Publication number Publication date
PT1250320E (pt) 2004-11-30
US6689911B2 (en) 2004-02-10
ES2225467T3 (es) 2005-03-16
MY120868A (en) 2005-11-30
CN1394200A (zh) 2003-01-29
IL150402A0 (en) 2002-12-01
SE0000056D0 (sv) 2000-01-10
AU783256B2 (en) 2005-10-06
JP2003519679A (ja) 2003-06-24
AR029430A1 (es) 2003-06-25
CA2396008A1 (en) 2001-07-19
CN1263735C (zh) 2006-07-12
MXPA02006673A (es) 2004-09-10
EP1250320B1 (de) 2004-08-04
SI1250320T1 (en) 2005-02-28
US20030069442A1 (en) 2003-04-10
WO2001051461A1 (en) 2001-07-19
EP1250320A1 (de) 2002-10-23
KR100721882B1 (ko) 2007-05-25
NO20023318D0 (no) 2002-07-09
ZA200204875B (en) 2003-09-18
KR20020091078A (ko) 2002-12-05
AU2720401A (en) 2001-07-24
NO20023318L (no) 2002-08-15
DE60104649T2 (de) 2005-08-11
BR0107480A (pt) 2002-09-03
DE60104649D1 (de) 2004-09-09

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