DE602006021587D1 - Vektor zur zuführung einer zielsubstanz in den zellkern oder die zelle - Google Patents

Vektor zur zuführung einer zielsubstanz in den zellkern oder die zelle

Info

Publication number
DE602006021587D1
DE602006021587D1 DE602006021587T DE602006021587T DE602006021587D1 DE 602006021587 D1 DE602006021587 D1 DE 602006021587D1 DE 602006021587 T DE602006021587 T DE 602006021587T DE 602006021587 T DE602006021587 T DE 602006021587T DE 602006021587 D1 DE602006021587 D1 DE 602006021587D1
Authority
DE
Germany
Prior art keywords
cell
vector
introduction
target substance
core
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
DE602006021587T
Other languages
English (en)
Inventor
Hidetaka Akita
Asako Kudo
Hideyoshi Harashima
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Hokkaido University NUC
Shionogi and Co Ltd
Original Assignee
Hokkaido University NUC
Shionogi and Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hokkaido University NUC, Shionogi and Co Ltd filed Critical Hokkaido University NUC
Publication of DE602006021587D1 publication Critical patent/DE602006021587D1/de
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Liposomes
    • A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers
    • A61K9/1272—Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers with substantial amounts of non-phosphatidyl, i.e. non-acylglycerophosphate, surfactants as bilayer-forming substances, e.g. cationic lipids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • C12N15/88—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation using microencapsulation, e.g. using amphiphile liposome vesicle

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Dispersion Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Preparation (AREA)
DE602006021587T 2005-09-30 2006-09-29 Vektor zur zuführung einer zielsubstanz in den zellkern oder die zelle Active DE602006021587D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2005289411 2005-09-30
PCT/JP2006/319601 WO2007037444A1 (ja) 2005-09-30 2006-09-29 目的物質を核内又は細胞内に送達するためのベクター

Publications (1)

Publication Number Publication Date
DE602006021587D1 true DE602006021587D1 (de) 2011-06-09

Family

ID=37899864

Family Applications (1)

Application Number Title Priority Date Filing Date
DE602006021587T Active DE602006021587D1 (de) 2005-09-30 2006-09-29 Vektor zur zuführung einer zielsubstanz in den zellkern oder die zelle

Country Status (5)

Country Link
US (1) US20080241917A1 (de)
EP (1) EP1930436B1 (de)
JP (1) JPWO2007037444A1 (de)
DE (1) DE602006021587D1 (de)
WO (1) WO2007037444A1 (de)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPWO2006101201A1 (ja) * 2005-03-24 2008-09-04 国立大学法人 北海道大学 目的物質を効率的に核内に送達可能なリポソーム
WO2007102481A1 (ja) * 2006-03-07 2007-09-13 National University Corporation Hokkaido University 目的物質の核内送達用ベクター
CN102481309B (zh) * 2009-07-17 2014-06-18 翰林大学校产学协力团 包含脂质体包胶的寡核苷酸和表位的免疫刺激性组合物
WO2011074578A1 (ja) * 2009-12-14 2011-06-23 国立大学法人北海道大学 脂質膜構造体に細胞透過能を付与および／または脂質膜構造体の細胞透過能を増強するペプチド、ならびにそれらペプチドと結合した脂質を構成脂質として含む、細胞透過能を有するまたは細胞透過能が増強された脂質膜構造体
JPWO2012117971A1 (ja) * 2011-02-28 2014-07-07 国立大学法人北海道大学 脂質膜構造体、脂質膜構造体の製造方法および１の目的物質を１枚の脂質膜で封入する方法
US20150044192A1 (en) 2013-08-09 2015-02-12 President And Fellows Of Harvard College Methods for identifying a target site of a cas9 nuclease
KR101587343B1 (ko) * 2014-04-08 2016-01-20 성균관대학교산학협력단 핵산 하이드로젤을 포함하는 코어-쉘 나노입자체 및 이의 제조방법
WO2017041033A1 (en) * 2015-09-04 2017-03-09 Brinker C Jeffrey Mesoporous silica nanoparticles and supported lipid bi-layer nanoparticles for biomedical applications
US11672866B2 (en) 2016-01-08 2023-06-13 Paul N. DURFEE Osteotropic nanoparticles for prevention or treatment of bone metastases
WO2017127567A1 (en) * 2016-01-19 2017-07-27 Genebiologics, Llc Production of arginine-rich proteins and use as a fertilizer and germination enhancer
EP3519578B1 (de) * 2016-10-03 2021-12-22 Precision Nanosystems Inc Zusammensetzungen zur transfektion von resistenten zelltypen
US10745677B2 (en) 2016-12-23 2020-08-18 President And Fellows Of Harvard College Editing of CCR5 receptor gene to protect against HIV infection
US11344629B2 (en) 2017-03-01 2022-05-31 Charles Jeffrey Brinker Active targeting of cells by monosized protocells
US11898179B2 (en) 2017-03-09 2024-02-13 President And Fellows Of Harvard College Suppression of pain by gene editing
WO2019139645A2 (en) 2017-08-30 2019-07-18 President And Fellows Of Harvard College High efficiency base editors comprising gam
WO2020054851A1 (ja) * 2018-09-14 2020-03-19 国立大学法人北海道大学 光機能性化合物及び脂質ナノ粒子
EP3942042A1 (de) 2019-03-19 2022-01-26 The Broad Institute, Inc. Verfahren und zusammensetzungen zur editierung von nukleotidsequenzen
KR20230019843A (ko) 2020-05-08 2023-02-09 더 브로드 인스티튜트, 인코퍼레이티드 표적 이중 가닥 뉴클레오티드 서열의 두 가닥의 동시 편집을 위한 방법 및 조성물

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9014221D0 (en) * 1990-06-26 1990-08-15 Janssen Pharmaceutica Nv Method of treating alopecia
JPH09248182A (ja) * 1996-03-15 1997-09-22 Oyo Seikagaku Kenkyusho プラスミド包埋多重膜リポソーム
NZ513829A (en) * 1999-03-02 2001-09-28 Liposome Co Inc Encapsulation of bioactive complexes in liposomes
KR20070106703A (ko) * 2005-01-18 2007-11-05 국립대학법인 홋가이도 다이가쿠 입자를 지질막으로 피복하는 방법

Also Published As

Publication number Publication date
JPWO2007037444A1 (ja) 2009-04-16
EP1930436B1 (de) 2011-04-27
US20080241917A1 (en) 2008-10-02
EP1930436A1 (de) 2008-06-11
WO2007037444A1 (ja) 2007-04-05
EP1930436A4 (de) 2009-05-20

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