DE602006020642D1 - Geschmacksunterdrückungssystem für nicht weichgemachte Arzneimittel - Google Patents

Geschmacksunterdrückungssystem für nicht weichgemachte Arzneimittel

Info

Publication number
DE602006020642D1
DE602006020642D1 DE602006020642T DE602006020642T DE602006020642D1 DE 602006020642 D1 DE602006020642 D1 DE 602006020642D1 DE 602006020642 T DE602006020642 T DE 602006020642T DE 602006020642 T DE602006020642 T DE 602006020642T DE 602006020642 D1 DE602006020642 D1 DE 602006020642D1
Authority
DE
Germany
Prior art keywords
plasticized
medicines
suppressant system
taste suppressant
usp
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
DE602006020642T
Other languages
English (en)
Inventor
Walid Habbib
Derek Moe
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Cima Labs Inc
Original Assignee
Cima Labs Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cima Labs Inc filed Critical Cima Labs Inc
Publication of DE602006020642D1 publication Critical patent/DE602006020642D1/de
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
    • A61K31/5513—1,4-Benzodiazepines, e.g. diazepam or clozapine
    • A61K31/5517—1,4-Benzodiazepines, e.g. diazepam or clozapine condensed with five-membered rings having nitrogen as a ring hetero atom, e.g. imidazobenzodiazepines, triazolam
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
    • A61K9/2081—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets with microcapsules or coated microparticles according to A61K9/50
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
    • A61K9/5078—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings with drug-free core
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5026—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Zoology (AREA)
  • Physiology (AREA)
  • Nutrition Science (AREA)
  • Inorganic Chemistry (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Neurosurgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
DE602006020642T 2005-01-06 2006-01-04 Geschmacksunterdrückungssystem für nicht weichgemachte Arzneimittel Active DE602006020642D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US64180705P 2005-01-06 2005-01-06
US64261905P 2005-01-10 2005-01-10

Publications (1)

Publication Number Publication Date
DE602006020642D1 true DE602006020642D1 (de) 2011-04-21

Family

ID=36648121

Family Applications (2)

Application Number Title Priority Date Filing Date
DE602006007538T Active DE602006007538D1 (de) 2005-01-06 2006-01-04 Geschmacksunterdrückungssystem für nicht geweichte arzneimittel
DE602006020642T Active DE602006020642D1 (de) 2005-01-06 2006-01-04 Geschmacksunterdrückungssystem für nicht weichgemachte Arzneimittel

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DE602006007538T Active DE602006007538D1 (de) 2005-01-06 2006-01-04 Geschmacksunterdrückungssystem für nicht geweichte arzneimittel

Country Status (11)

Country Link
US (3) US20060147517A1 (de)
EP (2) EP1830814B1 (de)
JP (1) JP4995099B2 (de)
AT (2) ATE500822T1 (de)
CA (1) CA2593016C (de)
DE (2) DE602006007538D1 (de)
DK (1) DK1830814T3 (de)
ES (1) ES2325599T3 (de)
HK (2) HK1107522A1 (de)
MX (1) MX2007008320A (de)
WO (1) WO2006074185A2 (de)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2593016C (en) * 2005-01-06 2012-05-15 Cima Labs Inc. Taste masking system for non-plasticizing drugs
US20080124387A1 (en) * 2006-11-27 2008-05-29 Kapac, Llc Methods and formulations for enhancing the absorption and decreasing the absorption variability of orally administered drugs, vitamins and nutrients
WO2009028487A1 (ja) * 2007-08-27 2009-03-05 Asahi Kasei Chemicals Corporation 結晶セルロース及び顆粒含有錠の製造方法
US20100190739A1 (en) * 2008-12-15 2010-07-29 Fleming And Company, Pharmaceuticals Rapidly Dissolving Vitamin Formulation and Methods of Using the Same
EP2701534A1 (de) 2011-04-28 2014-03-05 ACME Specialty Products, LLC Geschmacksmasizierende zusammensetzungen und essbare formen davon
MX2014001556A (es) 2011-08-12 2014-03-31 Boehringer Ingelheim Vetmed Composicion farmaceutica de sabor enmascarado.

Family Cites Families (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE418247B (sv) * 1975-11-17 1981-05-18 Haessle Ab Sett att framstella kroppar med reglerad frigoring av en aktiv komponent
US4747881A (en) * 1985-02-05 1988-05-31 Warner-Lambert Company Ingestible aggregate and delivery system prepared therefrom
US4874613A (en) * 1987-03-06 1989-10-17 Baker Cummins Pharmaceuticals, Inc. Taste concealing pharmaceutical dosage unit
US4851226A (en) * 1987-11-16 1989-07-25 Mcneil Consumer Products Company Chewable medicament tablet containing means for taste masking
US5234957A (en) * 1991-02-27 1993-08-10 Noven Pharmaceuticals, Inc. Compositions and methods for topical administration of pharmaceutically active agents
EP0361910B1 (de) * 1988-09-30 1994-06-29 Rhone-Poulenc Rorer Limited Pharmazeutisches Granulat
US4966770A (en) * 1989-07-26 1990-10-30 Himedics, Inc. Prednisone microencapsulated granules
US5178878A (en) * 1989-10-02 1993-01-12 Cima Labs, Inc. Effervescent dosage form with microparticles
US5223264A (en) * 1989-10-02 1993-06-29 Cima Labs, Inc. Pediatric effervescent dosage form
US5464632C1 (en) * 1991-07-22 2001-02-20 Prographarm Lab Rapidly disintegratable multiparticular tablet
DE69721559T2 (de) * 1997-01-06 2003-11-27 Pfizer Geschmacksmaskierte pharmazeutische dosisform mit schneller freisetzung
US6024981A (en) 1997-04-16 2000-02-15 Cima Labs Inc. Rapidly dissolving robust dosage form
EP1688131A1 (de) * 1998-08-12 2006-08-09 Cima Labs Inc. Oral zersetzbare Tablette mit Ausbildung eines zähen Schleims
US6368625B1 (en) * 1998-08-12 2002-04-09 Cima Labs Inc. Orally disintegrable tablet forming a viscous slurry
CA2351720C (en) * 1998-11-25 2006-11-21 Cima Labs Inc. Taste masking rapid release coating system
US6464632B1 (en) * 1999-02-13 2002-10-15 James M. Taylor Flexible inner liner for the working channel of an endoscope
GB9904629D0 (en) * 1999-03-02 1999-04-21 Danbiosyst Uk Oral drug delivery system
DE60115217T2 (de) * 2000-03-28 2006-07-20 Farmarc Nederland B.V. Alprazolam inklusion-komplexe und ihre pharmazeutischen zusammensetzungen
GB0027357D0 (en) * 2000-11-09 2000-12-27 Bradford Particle Design Plc Particle formation methods and their products
US20030143272A1 (en) * 2001-03-14 2003-07-31 Waterman Kenneth C. Pharmaceutical tablet and process for making thereof
US20030096791A1 (en) * 2001-05-31 2003-05-22 Cima Labs Inc. Taste masking of highly water-soluble drugs
FR2837100B1 (fr) * 2002-03-18 2004-07-23 Flamel Tech Sa Comprimes a bases de microcapsules a liberation modifiee
CA2497176A1 (en) * 2002-09-04 2004-03-18 Ranbaxy Laboratories Limited Taste masked dosage forms and processes for their preparation
US8110223B2 (en) * 2002-12-31 2012-02-07 University Of Maryland, Baltimore Methods for making pharmaceutical dosage forms containing active cushioning components
US20050232977A1 (en) * 2004-04-20 2005-10-20 Khan Sadath U Metered mixing technology for improved taste masking
CA2593016C (en) * 2005-01-06 2012-05-15 Cima Labs Inc. Taste masking system for non-plasticizing drugs

Also Published As

Publication number Publication date
US20150050336A1 (en) 2015-02-19
US20060147517A1 (en) 2006-07-06
CA2593016C (en) 2012-05-15
HK1107522A1 (en) 2008-04-11
JP2008526853A (ja) 2008-07-24
WO2006074185A3 (en) 2006-09-08
ATE435009T1 (de) 2009-07-15
EP1830814B1 (de) 2009-07-01
EP2098225B1 (de) 2011-03-09
EP1830814A2 (de) 2007-09-12
MX2007008320A (es) 2007-09-07
CA2593016A1 (en) 2006-07-13
WO2006074185A2 (en) 2006-07-13
JP4995099B2 (ja) 2012-08-08
EP2098225A2 (de) 2009-09-09
US20060147516A1 (en) 2006-07-06
DK1830814T3 (da) 2009-08-03
DE602006007538D1 (de) 2009-08-13
EP2098225B8 (de) 2011-06-22
ES2325599T3 (es) 2009-09-09
EP2098225A3 (de) 2009-10-21
HK1135612A1 (en) 2010-06-11
ATE500822T1 (de) 2011-03-15
EP1830814A4 (de) 2008-04-02

Similar Documents

Publication Publication Date Title
NO20073802L (no) Leuprolidacetat og acetylkolinsteraseinhibitor eller NMDA-reseptorantagonister for behandlingen av Alzheimers sykdom
DE602006020642D1 (de) Geschmacksunterdrückungssystem für nicht weichgemachte Arzneimittel
TW200716208A (en) Modified and immediate release memantine bead formulation
CY1111887T1 (el) Απαραβιαστες φαρμακευτικες μορφες δοσολογιας δια του στοματος περιλαμβανουσες ενα οπιουχο αναλγητικο
NO20063430L (no) Generelt lineaer, brusende oral fentanyl doseringsform, og metoder for administrering
WO2007070052A3 (en) Pharmaceutical compositions and methods for treating or preventing oxalate-related disease
EA200602294A1 (ru) Жевательная таблетка, таблетка для рассасывания и таблетка для глотания, содержащая кальцийсодержащее соединение в качестве активного вещества
WO2005020906A3 (en) Intranasal opioid compositions
WO2007084221A9 (en) Methods and apparatus for identifying subject matter in view data
WO2008144061A3 (en) Novel combinations comprising a phosphodiesterase-5 inhibitor and their use
WO2008017867A3 (en) Antiretroviral solid oral composition with at least one water insoluble polymer
WO2008028965A3 (en) Inhibitors of protein phosphatase 1, gadd34 and protein phosphatase 1/gadd34 complex, preparation and uses thereof
NO20084542L (no) Farmasoytisk kombinasjon inneholdende 3-(3-dimetylamino-1-etyl-2-metyl-propyl)-fenol og paracetamol
WO2003086343A3 (en) Fast disintegrating oral dosage forms
ATE505203T1 (de) Pharmazeutische kombination aus aliskiren und valsartan
Raimura et al. Neuronal nitric oxide synthase-derived nitric oxide is involved in gastric mucosal hyperemic response to capsaicin in rats
UA102254C2 (ru) Жидкий состав для деферипрона с приятным вкусом
EE200100104A (et) 5-HT4 agonisti või antagonisti uus peroraalne ravimvorm
EP1262196A3 (de) Kombination eines Inhibitoren der Monoaminwiederaufnahme und eines Opioidanatagonisten zur Verwendung in Alkoholismus und Alkoholsucht
WO2008021048A3 (en) Adp-ribosyltransferase based methods and compositions
WO2006023295A3 (en) Pharmaceutical compositions comprising effervescent agents and fenofibrate
ATE526058T1 (de) Saure feste orale zusammensetzungen ohne erosionspotential in speichel und verfahren zur bestimmung des erosionspotentials in speichel
WO2009094181A8 (en) Ph-responsive nanostructures
WO2011128631A3 (en) Vegetarian oral pharmaceutical and nutraceutical compositions
TH71264A (th) ขบวนการสำหรับการเตรียมผลึกซิเคิลโซไนด์ (ciclesonide) ที่มีขนาดที่กำหนด