DE602006007538D1 - Geschmacksunterdrückungssystem für nicht geweichte arzneimittel - Google Patents

Geschmacksunterdrückungssystem für nicht geweichte arzneimittel

Info

Publication number
DE602006007538D1
DE602006007538D1 DE602006007538T DE602006007538T DE602006007538D1 DE 602006007538 D1 DE602006007538 D1 DE 602006007538D1 DE 602006007538 T DE602006007538 T DE 602006007538T DE 602006007538 T DE602006007538 T DE 602006007538T DE 602006007538 D1 DE602006007538 D1 DE 602006007538D1
Authority
DE
Germany
Prior art keywords
suppression system
medicinal products
taste suppression
weighted
weighted medicinal
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
DE602006007538T
Other languages
English (en)
Inventor
Walid Habib
Derek Moe
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Cima Labs Inc
Original Assignee
Cima Labs Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cima Labs Inc filed Critical Cima Labs Inc
Publication of DE602006007538D1 publication Critical patent/DE602006007538D1/de
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
    • A61K31/5513—1,4-Benzodiazepines, e.g. diazepam or clozapine
    • A61K31/5517—1,4-Benzodiazepines, e.g. diazepam or clozapine condensed with five-membered rings having nitrogen as a ring hetero atom, e.g. imidazobenzodiazepines, triazolam
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
    • A61K9/2081—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets with microcapsules or coated microparticles according to A61K9/50
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
    • A61K9/5078—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings with drug-free core
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5026—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Zoology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Inorganic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
DE602006007538T 2005-01-06 2006-01-04 Geschmacksunterdrückungssystem für nicht geweichte arzneimittel Active DE602006007538D1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US64180705P 2005-01-06 2005-01-06
US64261905P 2005-01-10 2005-01-10
PCT/US2006/000118 WO2006074185A2 (en) 2005-01-06 2006-01-04 Taste masking system for non-plasticizing drugs

Publications (1)

Publication Number Publication Date
DE602006007538D1 true DE602006007538D1 (de) 2009-08-13

Family

ID=36648121

Family Applications (2)

Application Number Title Priority Date Filing Date
DE602006020642T Active DE602006020642D1 (de) 2005-01-06 2006-01-04 Geschmacksunterdrückungssystem für nicht weichgemachte Arzneimittel
DE602006007538T Active DE602006007538D1 (de) 2005-01-06 2006-01-04 Geschmacksunterdrückungssystem für nicht geweichte arzneimittel

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DE602006020642T Active DE602006020642D1 (de) 2005-01-06 2006-01-04 Geschmacksunterdrückungssystem für nicht weichgemachte Arzneimittel

Country Status (11)

Country Link
US (3) US20060147517A1 (de)
EP (2) EP1830814B1 (de)
JP (1) JP4995099B2 (de)
AT (2) ATE435009T1 (de)
CA (1) CA2593016C (de)
DE (2) DE602006020642D1 (de)
DK (1) DK1830814T3 (de)
ES (1) ES2325599T3 (de)
HK (2) HK1107522A1 (de)
MX (1) MX2007008320A (de)
WO (1) WO2006074185A2 (de)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE602006020642D1 (de) * 2005-01-06 2011-04-21 Cima Labs Inc Geschmacksunterdrückungssystem für nicht weichgemachte Arzneimittel
US20080124387A1 (en) * 2006-11-27 2008-05-29 Kapac, Llc Methods and formulations for enhancing the absorption and decreasing the absorption variability of orally administered drugs, vitamins and nutrients
US8367115B2 (en) * 2007-08-27 2013-02-05 Asahi Kasei Chemicals Corporation Process for production of crystalline cellulose and tablets containing granules
US20100190739A1 (en) * 2008-12-15 2010-07-29 Fleming And Company, Pharmaceuticals Rapidly Dissolving Vitamin Formulation and Methods of Using the Same
WO2012148432A1 (en) 2011-04-28 2012-11-01 Acme Specialty Products, Llc Taste masking compositions and edible forms thereof
EP3318247A1 (de) 2011-08-12 2018-05-09 Boehringer Ingelheim Vetmedica GmbH Geschmacksmaskierte pharmazeutische zusammensetzung

Family Cites Families (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE418247B (sv) * 1975-11-17 1981-05-18 Haessle Ab Sett att framstella kroppar med reglerad frigoring av en aktiv komponent
US4747881A (en) * 1985-02-05 1988-05-31 Warner-Lambert Company Ingestible aggregate and delivery system prepared therefrom
US4874613A (en) * 1987-03-06 1989-10-17 Baker Cummins Pharmaceuticals, Inc. Taste concealing pharmaceutical dosage unit
US4851226A (en) * 1987-11-16 1989-07-25 Mcneil Consumer Products Company Chewable medicament tablet containing means for taste masking
US5234957A (en) 1991-02-27 1993-08-10 Noven Pharmaceuticals, Inc. Compositions and methods for topical administration of pharmaceutically active agents
DE68916497T2 (de) * 1988-09-30 1994-11-17 Rhone Poulenc Rorer Ltd Pharmazeutisches Granulat.
US4966770A (en) * 1989-07-26 1990-10-30 Himedics, Inc. Prednisone microencapsulated granules
US5178878A (en) 1989-10-02 1993-01-12 Cima Labs, Inc. Effervescent dosage form with microparticles
US5223264A (en) * 1989-10-02 1993-06-29 Cima Labs, Inc. Pediatric effervescent dosage form
US5464632C1 (en) * 1991-07-22 2001-02-20 Prographarm Lab Rapidly disintegratable multiparticular tablet
KR20000069899A (ko) * 1997-01-06 2000-11-25 디. 제이. 우드, 스피겔 알렌 제이 속방성 및 미각 차폐성 약제학적 용량 형태
US6024981A (en) 1997-04-16 2000-02-15 Cima Labs Inc. Rapidly dissolving robust dosage form
EP1688131A1 (de) * 1998-08-12 2006-08-09 Cima Labs Inc. Oral zersetzbare Tablette mit Ausbildung eines zähen Schleims
US6368625B1 (en) * 1998-08-12 2002-04-09 Cima Labs Inc. Orally disintegrable tablet forming a viscous slurry
ES2601855T3 (es) * 1998-11-25 2017-02-16 Cima Labs Inc. Comprimido de liberación rápida con núcleo recubierto que contiene el fármaco y capa circundante de enmascaramiento del sabor
US6464632B1 (en) * 1999-02-13 2002-10-15 James M. Taylor Flexible inner liner for the working channel of an endoscope
GB9904629D0 (en) * 1999-03-02 1999-04-21 Danbiosyst Uk Oral drug delivery system
ES2253364T3 (es) * 2000-03-28 2006-06-01 Farmarc Nederland B.V. Complejos de inclusion de alprazolam y sus composiciones farmaceuticas.
GB0027357D0 (en) * 2000-11-09 2000-12-27 Bradford Particle Design Plc Particle formation methods and their products
US20030143272A1 (en) * 2001-03-14 2003-07-31 Waterman Kenneth C. Pharmaceutical tablet and process for making thereof
JP2004532257A (ja) * 2001-05-31 2004-10-21 シーマ・ラブス、インコーポレイテッド 高水溶性薬剤のテイスト・マスキング
FR2837100B1 (fr) * 2002-03-18 2004-07-23 Flamel Tech Sa Comprimes a bases de microcapsules a liberation modifiee
WO2004022037A1 (en) * 2002-09-04 2004-03-18 Ranbaxy Laboratories Limited Taste masked dosage forms and processes for their preparation
JP2006515320A (ja) * 2002-12-31 2006-05-25 ラリー エル オーグスバーガー 活性クッション性成分を含有する医薬品剤形の製造方法
US20050232977A1 (en) * 2004-04-20 2005-10-20 Khan Sadath U Metered mixing technology for improved taste masking
DE602006020642D1 (de) * 2005-01-06 2011-04-21 Cima Labs Inc Geschmacksunterdrückungssystem für nicht weichgemachte Arzneimittel

Also Published As

Publication number Publication date
WO2006074185A2 (en) 2006-07-13
CA2593016C (en) 2012-05-15
EP2098225B8 (de) 2011-06-22
JP2008526853A (ja) 2008-07-24
DK1830814T3 (da) 2009-08-03
US20060147517A1 (en) 2006-07-06
DE602006020642D1 (de) 2011-04-21
US20060147516A1 (en) 2006-07-06
US20150050336A1 (en) 2015-02-19
EP1830814A2 (de) 2007-09-12
HK1107522A1 (en) 2008-04-11
ES2325599T3 (es) 2009-09-09
ATE435009T1 (de) 2009-07-15
CA2593016A1 (en) 2006-07-13
EP2098225A3 (de) 2009-10-21
EP2098225A2 (de) 2009-09-09
ATE500822T1 (de) 2011-03-15
MX2007008320A (es) 2007-09-07
JP4995099B2 (ja) 2012-08-08
HK1135612A1 (en) 2010-06-11
EP2098225B1 (de) 2011-03-09
EP1830814B1 (de) 2009-07-01
WO2006074185A3 (en) 2006-09-08
EP1830814A4 (de) 2008-04-02

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Legal Events

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