DE602006012734D1 - Bioreaktor für die zell- und gewebekultur - Google Patents

Bioreaktor für die zell- und gewebekultur

Info

Publication number
DE602006012734D1
DE602006012734D1 DE602006012734T DE602006012734T DE602006012734D1 DE 602006012734 D1 DE602006012734 D1 DE 602006012734D1 DE 602006012734 T DE602006012734 T DE 602006012734T DE 602006012734 T DE602006012734 T DE 602006012734T DE 602006012734 D1 DE602006012734 D1 DE 602006012734D1
Authority
DE
Germany
Prior art keywords
bioreactor
tissue
incubation
cell
volume
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
DE602006012734T
Other languages
English (en)
Inventor
Peter Mose Larsen
Stephen John Fey
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
DrugMode ApS
Original Assignee
DrugMode ApS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by DrugMode ApS filed Critical DrugMode ApS
Publication of DE602006012734D1 publication Critical patent/DE602006012734D1/de
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/502—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M23/00—Constructional details, e.g. recesses, hinges
    • C12M23/02—Form or structure of the vessel
    • C12M23/16—Microfluidic devices; Capillary tubes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M27/00—Means for mixing, agitating or circulating fluids in the vessel
    • C12M27/10—Rotating vessel
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M29/00—Means for introduction, extraction or recirculation of materials, e.g. pumps
    • C12M29/04—Filters; Permeable or porous membranes or plates, e.g. dialysis
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/067—Hepatocytes
    • C12N5/0671—Three-dimensional culture, tissue culture or organ culture; Encapsulated cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6809—Methods for determination or identification of nucleic acids involving differential detection

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Sustainable Development (AREA)
  • Analytical Chemistry (AREA)
  • Molecular Biology (AREA)
  • Cell Biology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Physics & Mathematics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Clinical Laboratory Science (AREA)
  • Biophysics (AREA)
  • Toxicology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Dispersion Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
DE602006012734T 2005-12-30 2006-12-22 Bioreaktor für die zell- und gewebekultur Active DE602006012734D1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DKPA200501852 2005-12-30
US83694306P 2006-08-11 2006-08-11
PCT/DK2006/000740 WO2007076865A1 (en) 2005-12-30 2006-12-22 Bioreactor for cell and tissue culture

Publications (1)

Publication Number Publication Date
DE602006012734D1 true DE602006012734D1 (de) 2010-04-15

Family

ID=37836613

Family Applications (1)

Application Number Title Priority Date Filing Date
DE602006012734T Active DE602006012734D1 (de) 2005-12-30 2006-12-22 Bioreaktor für die zell- und gewebekultur

Country Status (7)

Country Link
US (1) US20100120136A1 (de)
EP (1) EP1966367B1 (de)
JP (1) JP5042235B2 (de)
AT (1) ATE459701T1 (de)
DE (1) DE602006012734D1 (de)
DK (1) DK1966367T3 (de)
WO (1) WO2007076865A1 (de)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2257646A1 (de) * 2008-02-29 2010-12-08 ISIS Innovation Limited Diagnoseverfahren
US9817001B2 (en) 2008-05-27 2017-11-14 Boston Heart Diagnostics Corporation Methods for determining LDL cholesterol treatment
BRPI0802399B1 (pt) * 2008-07-08 2018-06-12 União Brasileira De Educação E Assistência- Mantenedora Da Pucrs Equipamento para incubação de peixes e outros animais e processo de cultivo de peixes e outros animais
US8470541B1 (en) * 2008-09-27 2013-06-25 Boston Heart Diagnostics Corporation Methods for separation and immuno-detection of biomolecules, and apparatus related thereto
US8778669B2 (en) 2009-07-22 2014-07-15 Corning Incorporated Multilayer tissue culture vessel
US9574166B2 (en) 2010-08-18 2017-02-21 Drugmode Aps Bioreactor system
CN103261395B (zh) * 2010-12-15 2017-09-08 药物模式有限责任公司 具有便于进入培养腔的盖子的生物反应器
JP5926747B2 (ja) 2011-02-24 2016-05-25 ジーイー・ヘルスケア・バイオサイエンス・アクチボラグ フィルターアセンブリを通る供給流及び回収流を有するバイオリアクター
ITTO20110432A1 (it) 2011-05-16 2011-08-15 Torino Politecnico Dispositivo generatore di microgravità.
US8765377B2 (en) 2011-10-13 2014-07-01 Boston Heart Diagnostics Corporation Compositions and methods for treating and preventing coronary heart disease
US9284521B2 (en) * 2012-03-24 2016-03-15 Therapeutic Proteins International, LLC Pivoting pressurized single-use bioreactor
JP6051730B2 (ja) 2012-09-24 2016-12-27 東洋製罐グループホールディングス株式会社 気泡除去方法、及び気泡除去装置
KR101470159B1 (ko) * 2013-05-21 2014-12-12 연세대학교 원주산학협력단 3차원 회전기와 초음파를 이용한 세포 자극장치 및 세포 자극방법
US9828624B2 (en) 2013-07-24 2017-11-28 Boston Heart Diagnostics Corporation Driving patient compliance with therapy
WO2016081471A1 (en) 2014-11-17 2016-05-26 Boston Heart Diagnostic Corporation Cardiovascular disease risk assessment
CN107667178A (zh) * 2015-03-26 2018-02-06 休斯敦大学系统 细胞的整合功能和分子概况
EP3370850A4 (de) * 2015-11-04 2019-08-28 Thrive Bioscience, Inc. Automatisierte zellkulturinkubatoren mit selektiv durchlässigen aufbewahrungskompartimenten eines zellkulturgefäss
US11104874B2 (en) * 2016-06-07 2021-08-31 Terumo Bct, Inc. Coating a bioreactor
US20180362914A1 (en) * 2017-06-16 2018-12-20 Matthew D. Millard Miniaturized rotating bioreactors
EP3810643A4 (de) * 2018-04-10 2022-04-27 Koniku, Inc. Universelle geruchscodesysteme und geruchscodierungsvorrichtungen
IT201800010212A1 (it) 2018-11-09 2020-05-09 Cellex S R L Dispositivo di coltura cellulare in sospensione
EP3760702A1 (de) 2019-07-04 2021-01-06 Celvivo ApS Bioreaktor und bioreaktorsystem für zell- und gewebewachstum
US20210332388A1 (en) * 2020-04-24 2021-10-28 Inscripta, Inc. Compositions, methods, modules and instruments for automated nucleic acid-guided nuclease editing in mammalian cells
KR20230138451A (ko) * 2021-01-21 2023-10-05 사토리우스 스테딤 바이오테크 게엠베하 스핀필터를 사용하여 배양물의 배양 배지를 교환하는방법

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5153131A (en) * 1990-12-11 1992-10-06 The United States Of America As Represented By The Administrator Of The National Aeronautics And Space Administration High aspect reactor vessel and method of use
US5507949A (en) 1992-03-20 1996-04-16 Monsanto Company Supported liquid membrane and separation process employing same
US5437998A (en) 1993-09-09 1995-08-01 Synthecon, Inc. Gas permeable bioreactor and method of use
US5702941A (en) * 1993-09-09 1997-12-30 Synthecon, Inc. Gas permeable bioreactor and method of use
WO1997028252A1 (en) * 1996-01-31 1997-08-07 Vivorx Pharmaceuticals, Inc. Process for aggregating cells and forming sheets of mammalian tissue in a horizontally rotating bioreactor
US6001642A (en) * 1998-06-29 1999-12-14 Wyle Laboratories, Inc. Life Sciences Bioreactor and cell culturing processes using the bioreactor
US5989913A (en) 1998-07-02 1999-11-23 Charles Daniel Anderson Culture vessel for growing or culturing cells, cellular aggregates, tissues and organoids and methods for using the same
DE60140120D1 (de) * 2000-06-14 2009-11-19 Vistagen Inc Toxizitätstypisierung unter verwendung von leberstammzellen
US7198940B2 (en) * 2000-10-25 2007-04-03 Shot Hardware Optimization Technology, Inc. Bioreactor apparatus and cell culturing system
US6607910B1 (en) * 2000-11-13 2003-08-19 Synthecon, Inc. Two chamber cell culture vessel
US6642019B1 (en) * 2000-11-22 2003-11-04 Synthecan, Inc. Vessel, preferably spherical or oblate spherical for growing or culturing cells, cellular aggregates, tissues and organoids and methods for using same
US20040058437A1 (en) * 2001-04-10 2004-03-25 Rodgers Seth T. Materials and reactor systems having humidity and gas control
US20040009495A1 (en) * 2001-12-07 2004-01-15 Whitehead Institute For Biomedical Research Methods and products related to drug screening using gene expression patterns
WO2003072764A1 (en) 2002-02-26 2003-09-04 Stelsys Llc Hepatocyte bioreactor system for long term culture of functional hepatocyte spheroids

Also Published As

Publication number Publication date
DK1966367T3 (da) 2010-05-03
EP1966367A1 (de) 2008-09-10
JP5042235B2 (ja) 2012-10-03
ATE459701T1 (de) 2010-03-15
US20100120136A1 (en) 2010-05-13
WO2007076865A1 (en) 2007-07-12
EP1966367B1 (de) 2010-03-03
JP2009521907A (ja) 2009-06-11

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Legal Events

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