DE602006009077D1 - Hiv-epitope und diese enthaltende pharmazeutische zusammensetzung - Google Patents
Hiv-epitope und diese enthaltende pharmazeutische zusammensetzungInfo
- Publication number
- DE602006009077D1 DE602006009077D1 DE602006009077T DE602006009077T DE602006009077D1 DE 602006009077 D1 DE602006009077 D1 DE 602006009077D1 DE 602006009077 T DE602006009077 T DE 602006009077T DE 602006009077 T DE602006009077 T DE 602006009077T DE 602006009077 D1 DE602006009077 D1 DE 602006009077D1
- Authority
- DE
- Germany
- Prior art keywords
- ala
- leu
- seq
- thr
- glu
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 108020004707 nucleic acids Proteins 0.000 abstract 4
- 150000007523 nucleic acids Chemical class 0.000 abstract 4
- 102000039446 nucleic acids Human genes 0.000 abstract 4
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 3
- 108010093013 HLA-DR1 Antigen Proteins 0.000 abstract 2
- 150000001413 amino acids Chemical class 0.000 abstract 2
- 230000036436 anti-hiv Effects 0.000 abstract 2
- 239000000427 antigen Substances 0.000 abstract 2
- 210000000612 antigen-presenting cell Anatomy 0.000 abstract 2
- 102000036639 antigens Human genes 0.000 abstract 2
- 108091007433 antigens Proteins 0.000 abstract 2
- 230000000694 effects Effects 0.000 abstract 2
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 abstract 1
- 238000009007 Diagnostic Kit Methods 0.000 abstract 1
- 208000031886 HIV Infections Diseases 0.000 abstract 1
- 208000037357 HIV infectious disease Diseases 0.000 abstract 1
- 108010090804 Streptavidin Proteins 0.000 abstract 1
- 210000001744 T-lymphocyte Anatomy 0.000 abstract 1
- 230000001419 dependent effect Effects 0.000 abstract 1
- 238000002405 diagnostic procedure Methods 0.000 abstract 1
- 239000013604 expression vector Substances 0.000 abstract 1
- 210000002443 helper t lymphocyte Anatomy 0.000 abstract 1
- 208000033519 human immunodeficiency virus infectious disease Diseases 0.000 abstract 1
- 230000028993 immune response Effects 0.000 abstract 1
- 230000010534 mechanism of action Effects 0.000 abstract 1
- 125000006850 spacer group Chemical group 0.000 abstract 1
- 229960005486 vaccine Drugs 0.000 abstract 1
- 239000013598 vector Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
- A61K39/21—Retroviridae, e.g. equine infectious anemia virus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55505—Inorganic adjuvants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2740/00—Reverse transcribing RNA viruses
- C12N2740/00011—Details
- C12N2740/10011—Retroviridae
- C12N2740/16011—Human Immunodeficiency Virus, HIV
- C12N2740/16211—Human Immunodeficiency Virus, HIV concerning HIV gagpol
- C12N2740/16222—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2740/00—Reverse transcribing RNA viruses
- C12N2740/00011—Details
- C12N2740/10011—Retroviridae
- C12N2740/16011—Human Immunodeficiency Virus, HIV
- C12N2740/16211—Human Immunodeficiency Virus, HIV concerning HIV gagpol
- C12N2740/16234—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR0550520A FR2882557A1 (fr) | 2005-02-25 | 2005-02-25 | Epitopes de vih et composition pharmaceutique les contenant |
PCT/FR2006/050167 WO2006090090A2 (fr) | 2005-02-25 | 2006-02-24 | Epitopes de vih et composition pharmaceutique les contenant |
Publications (1)
Publication Number | Publication Date |
---|---|
DE602006009077D1 true DE602006009077D1 (de) | 2009-10-22 |
Family
ID=34954973
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE602006009077T Active DE602006009077D1 (de) | 2005-02-25 | 2006-02-24 | Hiv-epitope und diese enthaltende pharmazeutische zusammensetzung |
Country Status (9)
Country | Link |
---|---|
US (1) | US20110142911A1 (de) |
EP (1) | EP1851321B1 (de) |
JP (1) | JP2008531530A (de) |
AT (1) | ATE442451T1 (de) |
CA (1) | CA2598929A1 (de) |
DE (1) | DE602006009077D1 (de) |
ES (1) | ES2332532T3 (de) |
FR (1) | FR2882557A1 (de) |
WO (1) | WO2006090090A2 (de) |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
RU2535034C2 (ru) * | 2010-08-06 | 2014-12-10 | Олег Ильич Эпштейн | Лекарственное средство и способ профилактики инфицирования вич, профилактики и лечения заболеваний, вызываемых вич или ассоциированных с вич, в том числе спида |
KR101476255B1 (ko) * | 2014-02-07 | 2014-12-26 | 대한민국 | HIV-l 유래 T 세포 항원결정기를 갖는 재조합 펩타이드 및 이를 포함하는 백신 조성물 |
WO2018208856A1 (en) | 2017-05-08 | 2018-11-15 | Gritstone Oncology, Inc. | Alphavirus neoantigen vectors |
TW202110870A (zh) | 2019-05-30 | 2021-03-16 | 美商葛利史東腫瘤科技公司 | 經修飾之腺病毒 |
WO2020248032A1 (pt) * | 2019-06-10 | 2020-12-17 | Ricardo Diaz | Método para a definição de uma vacina personalizada contra o hiv/aids |
WO2021003348A1 (en) * | 2019-07-02 | 2021-01-07 | Gritstone Oncology, Inc. | Hiv antigens and mhc complexes |
CN116438308A (zh) | 2020-08-06 | 2023-07-14 | 磨石生物公司 | 多表位疫苗盒 |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3650175T3 (de) * | 1985-04-29 | 2007-09-06 | Bio-Rad Laboratories, Inc., Hercules | Synthetische antigene zum nachweis von aids. |
US5034511A (en) * | 1987-04-13 | 1991-07-23 | Institut Pasteur | Variant of LAV viruses |
GB8910145D0 (en) * | 1989-05-03 | 1989-06-21 | Connaught Lab | Synthetic peptides for an hiv-1 vaccine |
ATE228248T1 (de) * | 1997-03-10 | 2002-12-15 | Roche Diagnostics Gmbh | Verfahren zur simultanen bestimmung von hiv- antigenen und hiv-antikörpern |
WO2001072298A1 (en) * | 2000-03-27 | 2001-10-04 | The General Hospital Corporation | Treatments for immune-mediated ear disorders |
AU2003245729A1 (en) * | 2002-06-27 | 2004-01-19 | Dana-Farber Cancer Institute, Inc. | Compositions and methods for modulating a cytotoxic t lymphocyte immune response |
US7663017B2 (en) * | 2003-07-30 | 2010-02-16 | Institut Pasteur | Transgenic mice having a human major histocompatability complex (MHC) phenotype, experimental uses and applications |
-
2005
- 2005-02-25 FR FR0550520A patent/FR2882557A1/fr not_active Withdrawn
-
2006
- 2006-02-24 WO PCT/FR2006/050167 patent/WO2006090090A2/fr active Application Filing
- 2006-02-24 DE DE602006009077T patent/DE602006009077D1/de active Active
- 2006-02-24 CA CA002598929A patent/CA2598929A1/fr not_active Abandoned
- 2006-02-24 JP JP2007556639A patent/JP2008531530A/ja active Pending
- 2006-02-24 AT AT06709536T patent/ATE442451T1/de not_active IP Right Cessation
- 2006-02-24 ES ES06709536T patent/ES2332532T3/es active Active
- 2006-02-24 EP EP06709536A patent/EP1851321B1/de not_active Revoked
-
2007
- 2007-08-20 US US11/894,172 patent/US20110142911A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
FR2882557A1 (fr) | 2006-09-01 |
ES2332532T3 (es) | 2010-02-08 |
JP2008531530A (ja) | 2008-08-14 |
WO2006090090A2 (fr) | 2006-08-31 |
EP1851321B1 (de) | 2009-09-09 |
ATE442451T1 (de) | 2009-09-15 |
CA2598929A1 (fr) | 2006-08-31 |
US20110142911A1 (en) | 2011-06-16 |
WO2006090090A3 (fr) | 2006-12-07 |
EP1851321A2 (de) | 2007-11-07 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
Tan et al. | Immunogenicity of prime-boost protein subunit vaccine strategies against SARS-CoV-2 in mice and macaques | |
Neidleman et al. | mRNA vaccine-induced T cells respond identically to SARS-CoV-2 variants of concern but differ in longevity and homing properties depending on prior infection status | |
Geluk et al. | Identification of major epitopes of Mycobacterium tuberculosis AG85B that are recognized by HLA-A* 0201-restricted CD8+ T cells in HLA-transgenic mice and humans | |
DE602006009077D1 (de) | Hiv-epitope und diese enthaltende pharmazeutische zusammensetzung | |
Earnhart et al. | An octavalent lyme disease vaccine induces antibodies that recognize all incorporated OspC type-specific sequences | |
Pardieck et al. | A third vaccination with a single T cell epitope confers protection in a murine model of SARS-CoV-2 infection | |
CN106103471A (zh) | 异源寡聚分枝杆菌抗原的融合 | |
JP2007526318A (ja) | Chlamydiapneumoniaeに対する免疫原性組成物 | |
Remakus et al. | Memory CD8+ T cells specific for a single immunodominant or subdominant determinant induced by peptide-dendritic cell immunization protect from an acute lethal viral disease | |
CN104918960A (zh) | 改进的人类疱疹病毒免疫疗法 | |
JPH03503166A (ja) | 抗hiv応答を喚起する合成抗原 | |
WO2007005627A3 (en) | Tuberculosis antigen detection assays and vaccines | |
Hauser et al. | Engineered receptor binding domain immunogens elicit pan-coronavirus neutralizing antibodies outside the receptor binding motif | |
Zivny et al. | A single nine-amino acid peptide induces virus-specific, CD8+ human cytotoxic T lymphocyte clones of heterogeneous serotype specificities. | |
Romano et al. | Induction of in vivo functional Db-restricted cytolytic T cell activity against a putative phosphate transport receptor of Mycobacterium tuberculosis | |
Joshi et al. | Flexibility in MHC and TCR recognition: degenerate specificity at the T cell level in the recognition of promiscuous Th epitopes exhibiting no primary sequence homology | |
CA2416761A1 (fr) | Procede de criblage de peptides utilisables en immunotherapie | |
Boesen et al. | Lassa fever virus peptides predicted by computational analysis induce epitope-specific cytotoxic-T-lymphocyte responses in HLA-A2. 1 transgenic mice | |
AR004567A1 (es) | Metodos para detectar la infeccion de t.cruzi, en una muestra biologica, un vector de expresion recombinante, un microorganismo modificado, un kit de diagnostico, una composicion farmaceutica, el uso de la composicion farmaceutica para la preparacion de un medicamento para estimular la produccion de anticuerpos que se liguen a t. cruzi. | |
WO2001016174A9 (en) | Induction of cytotoxic t lymphocyte response by hla class ia restricted epitopes of mycobacterial heat shock protein 65 | |
CN101370517B (zh) | 来源于c型肝炎病毒的肽 | |
Gadzinski et al. | Transfer of the ability of HIV-1 Tat to raise an adjuvant-free humoral immune response to unrelated antigens | |
WO2007049394A1 (ja) | C型肝炎ウイルス由来ペプチド | |
Fonseca et al. | Evaluation of T-cell responses to peptides and lipopeptides with MHC class I binding motifs derived from the amino acid sequence of the 19-kDa lipoprotein of Mycobacterium tuberculosis | |
ES2573105T3 (es) | Secuencias de péptidos y composiciones |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
8363 | Opposition against the patent |