DE602005023266D1 - Azabenzofuransubstituierte thioharnstoffe als inhibitoren der virusreplikation - Google Patents
Azabenzofuransubstituierte thioharnstoffe als inhibitoren der virusreplikationInfo
- Publication number
- DE602005023266D1 DE602005023266D1 DE602005023266T DE602005023266T DE602005023266D1 DE 602005023266 D1 DE602005023266 D1 DE 602005023266D1 DE 602005023266 T DE602005023266 T DE 602005023266T DE 602005023266 T DE602005023266 T DE 602005023266T DE 602005023266 D1 DE602005023266 D1 DE 602005023266D1
- Authority
- DE
- Germany
- Prior art keywords
- thioscores
- azabenzofurans
- inhibitors
- substituted
- virus replication
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4355—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having oxygen as a ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Virology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Gastroenterology & Hepatology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US53483904P | 2004-01-06 | 2004-01-06 | |
| PCT/US2005/000339 WO2005067900A2 (en) | 2004-01-06 | 2005-01-05 | Azabenzofuran substituted thioureas as inhibitors of viral replication |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE602005023266D1 true DE602005023266D1 (de) | 2010-10-14 |
Family
ID=34794326
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE602005023266T Active DE602005023266D1 (de) | 2004-01-06 | 2005-01-05 | Azabenzofuransubstituierte thioharnstoffe als inhibitoren der virusreplikation |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US7439374B2 (de) |
| EP (1) | EP1709047B1 (de) |
| JP (1) | JP2007517887A (de) |
| KR (1) | KR20060121289A (de) |
| CN (1) | CN1946720A (de) |
| AP (1) | AP2006003659A0 (de) |
| AR (1) | AR047367A1 (de) |
| AT (1) | ATE479684T1 (de) |
| AU (1) | AU2005204369B2 (de) |
| BR (1) | BRPI0506705A (de) |
| CA (1) | CA2552002A1 (de) |
| DE (1) | DE602005023266D1 (de) |
| EA (1) | EA200601281A1 (de) |
| IL (1) | IL176486A0 (de) |
| NO (1) | NO20062928L (de) |
| NZ (1) | NZ548375A (de) |
| OA (1) | OA13357A (de) |
| TW (1) | TW200528459A (de) |
| WO (1) | WO2005067900A2 (de) |
Families Citing this family (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TW200600492A (en) * | 2004-05-18 | 2006-01-01 | Achillion Pharmaceuticals Inc | Substituted aryl acylthioureas and related compounds; inhibitors of viral replication |
| TWI329102B (en) * | 2006-08-15 | 2010-08-21 | Nat Health Research Institutes | Thiourea compounds and method for inhibiting hepatitis c virus infection |
| WO2008024763A2 (en) * | 2006-08-25 | 2008-02-28 | Wyeth | Identification and characterization of hcv replicon variants with reduced susceptibility to hcv-796, and methods related thereto |
| US7964580B2 (en) | 2007-03-30 | 2011-06-21 | Pharmasset, Inc. | Nucleoside phosphoramidate prodrugs |
| WO2008124300A1 (en) * | 2007-04-10 | 2008-10-16 | National Health Research Institutes | Hepatitis c virus inhibitors |
| US7897764B2 (en) * | 2007-06-08 | 2011-03-01 | National Health Research Institutes | Thiourea derivatives |
| TWI361808B (en) * | 2008-01-08 | 2012-04-11 | Nat Health Research Institutes | Imidazolidinone and imidazolidinethione derivatives |
| US8198284B2 (en) * | 2008-04-30 | 2012-06-12 | National Health Research Institutes | Treatment of neurodegenerative disorders with thiourea compounds |
| US8198449B2 (en) * | 2008-09-11 | 2012-06-12 | Bristol-Myers Squibb Company | Compounds for the treatment of hepatitis C |
| EP2376088B1 (de) | 2008-12-23 | 2017-02-22 | Gilead Pharmasset LLC | 6-O-Substituierte-2-Amino-Purin-Nukleosid-Phosphoramidate |
| US8551973B2 (en) | 2008-12-23 | 2013-10-08 | Gilead Pharmasset Llc | Nucleoside analogs |
| EA019295B1 (ru) | 2008-12-23 | 2014-02-28 | Джилид Фармассет, Ллс. | Соединения пуриновых нуклеозидов и способ их получения |
| TWI576352B (zh) | 2009-05-20 | 2017-04-01 | 基利法瑪席特有限責任公司 | 核苷磷醯胺 |
| US8618076B2 (en) | 2009-05-20 | 2013-12-31 | Gilead Pharmasset Llc | Nucleoside phosphoramidates |
| EP2609923B1 (de) | 2010-03-31 | 2017-05-24 | Gilead Pharmasset LLC | Verfahren zur krystallisierung von (s)-isopropyl 2-(((s)-(perfluorophenoxy)(phenoxy)phosphoryl)amino)propanoat |
| JP2013527145A (ja) | 2010-03-31 | 2013-06-27 | ギリード・ファーマセット・エルエルシー | リン含有活性化剤の立体選択的合成 |
| PL3290428T3 (pl) | 2010-03-31 | 2022-02-07 | Gilead Pharmasset Llc | Tabletka zawierająca krystaliczny (S)-2-(((S)-(((2R,3R,4R,5R)-5-(2,4-diokso-3,4-dihydropirymidyn-1(2H)-ylo)-4-fluoro-3-hydroksy-4-metylotetrahydrofuran-2-ylo)metoksy)(fenoksy)fosforylo)amino)propanian izopropylu |
| US8324239B2 (en) | 2010-04-21 | 2012-12-04 | Novartis Ag | Furopyridine compounds and uses thereof |
| AR084044A1 (es) | 2010-11-30 | 2013-04-17 | Pharmasset Inc | Compuestos 2’-espiro-nucleosidos |
| JP6073897B2 (ja) | 2011-09-16 | 2017-02-01 | ギリアド ファーマセット エルエルシー | Ｈｃｖを処置するための方法 |
| US8889159B2 (en) | 2011-11-29 | 2014-11-18 | Gilead Pharmasset Llc | Compositions and methods for treating hepatitis C virus |
| JP6077642B2 (ja) * | 2012-04-10 | 2017-02-08 | シャンハイ インリ ファーマシューティカル カンパニー リミティド | 縮合ピリミジン化合物、その調製法、中間体、組成物、及び使用 |
| ES2771458T3 (es) | 2013-01-31 | 2020-07-06 | Gilead Pharmasset Llc | Formulación de combinación de dos compuestos antivirales |
| PL3650014T3 (pl) | 2013-08-27 | 2022-01-31 | Gilead Pharmasset Llc | Preparat złożony dwóch związków przeciwwirusowych |
| WO2017197036A1 (en) | 2016-05-10 | 2017-11-16 | C4 Therapeutics, Inc. | Spirocyclic degronimers for target protein degradation |
| EP3454856A4 (de) | 2016-05-10 | 2019-12-25 | C4 Therapeutics, Inc. | Heterocyclische degronimere für zielproteinabbau |
| WO2017197046A1 (en) | 2016-05-10 | 2017-11-16 | C4 Therapeutics, Inc. | C3-carbon linked glutarimide degronimers for target protein degradation |
| EA201990001A1 (ru) | 2016-06-07 | 2019-05-31 | Джакобио Фармасьютикалс Ко., Лтд. | Новые гетероциклические производные, применимые в качестве ингибиторов shp2 |
| US10988466B2 (en) | 2017-03-23 | 2021-04-27 | Jacobio Pharmaceuticals Co., Ltd. | Heterocyclic derivatives useful as SHP2 inhibitors |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1408198A (en) * | 1971-08-23 | 1975-10-01 | Medizinska Akad | Antiviral compositions |
| CN1071930A (zh) | 1991-07-10 | 1993-05-12 | 伊莱利利公司 | 用作治疗艾滋病的人免疫缺陷病毒蛋白酶的抑制剂 |
| GB9504460D0 (en) * | 1995-03-06 | 1995-04-26 | Bayer Ag | N-(3-Benzofuranyl)urea-derivatives |
| EP0806205A3 (de) * | 1996-05-06 | 1997-11-19 | Eli Lilly And Company | Harnstoff-, Thioharnstoff- und Guanidinverbindungen und deren Verwendung als antivirale Mittel |
| US6174905B1 (en) * | 1996-09-30 | 2001-01-16 | Mitsui Chemicals, Inc. | Cell differentiation inducer |
| HN2003000348A (es) * | 2002-11-01 | 2008-10-14 | Viropharma Inc | Compuestos de benzofurano, composiciones y metodos para tratamiento y profilaxis de infeccion virales de hepatitis c y enfermedades asociadas. |
| CN1738797A (zh) * | 2002-11-19 | 2006-02-22 | 阿基里昂药品公司 | 取代的芳基硫脲和相关的化合物,病毒复制的抑制剂 |
| KR20070007759A (ko) | 2003-07-10 | 2007-01-16 | 아칠리온 파르마세우티칼스 인코포레이티드 | 바이러스 복제 억제제로서 유용한 치환된 아릴티오우레아유도체 |
-
2004
- 2004-12-30 TW TW093141409A patent/TW200528459A/zh unknown
-
2005
- 2005-01-05 EP EP05705124A patent/EP1709047B1/de not_active Not-in-force
- 2005-01-05 BR BRPI0506705-7A patent/BRPI0506705A/pt not_active IP Right Cessation
- 2005-01-05 OA OA1200600222A patent/OA13357A/en unknown
- 2005-01-05 DE DE602005023266T patent/DE602005023266D1/de active Active
- 2005-01-05 JP JP2006549390A patent/JP2007517887A/ja active Pending
- 2005-01-05 CA CA002552002A patent/CA2552002A1/en not_active Abandoned
- 2005-01-05 AU AU2005204369A patent/AU2005204369B2/en not_active Ceased
- 2005-01-05 AT AT05705124T patent/ATE479684T1/de not_active IP Right Cessation
- 2005-01-05 US US11/029,910 patent/US7439374B2/en not_active Expired - Fee Related
- 2005-01-05 WO PCT/US2005/000339 patent/WO2005067900A2/en active Application Filing
- 2005-01-05 EA EA200601281A patent/EA200601281A1/ru unknown
- 2005-01-05 AP AP2006003659A patent/AP2006003659A0/xx unknown
- 2005-01-05 NZ NZ548375A patent/NZ548375A/en unknown
- 2005-01-05 CN CNA200580007223XA patent/CN1946720A/zh active Pending
- 2005-01-05 AR ARP050100026A patent/AR047367A1/es not_active Application Discontinuation
- 2005-01-05 KR KR1020067013660A patent/KR20060121289A/ko not_active Application Discontinuation
-
2006
- 2006-06-21 IL IL176486A patent/IL176486A0/en unknown
- 2006-06-22 NO NO20062928A patent/NO20062928L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| IL176486A0 (en) | 2006-10-05 |
| EP1709047B1 (de) | 2010-09-01 |
| WO2005067900A2 (en) | 2005-07-28 |
| ATE479684T1 (de) | 2010-09-15 |
| CN1946720A (zh) | 2007-04-11 |
| NO20062928L (no) | 2006-08-03 |
| EA200601281A1 (ru) | 2006-12-29 |
| CA2552002A1 (en) | 2005-07-28 |
| US20050228013A1 (en) | 2005-10-13 |
| EP1709047A2 (de) | 2006-10-11 |
| JP2007517887A (ja) | 2007-07-05 |
| AP2006003659A0 (en) | 2006-06-30 |
| AR047367A1 (es) | 2006-01-18 |
| BRPI0506705A (pt) | 2007-05-02 |
| TW200528459A (en) | 2005-09-01 |
| US7439374B2 (en) | 2008-10-21 |
| NZ548375A (en) | 2010-07-30 |
| AU2005204369B2 (en) | 2010-06-10 |
| KR20060121289A (ko) | 2006-11-28 |
| AU2005204369A1 (en) | 2005-07-28 |
| WO2005067900A3 (en) | 2005-09-29 |
| OA13357A (en) | 2007-04-13 |
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