DE602004031079D1 - Neue bifidobacterium-stämme mit der fähigkeit zur herstellung von glutamin - Google Patents

Neue bifidobacterium-stämme mit der fähigkeit zur herstellung von glutamin

Info

Publication number
DE602004031079D1
DE602004031079D1 DE602004031079T DE602004031079T DE602004031079D1 DE 602004031079 D1 DE602004031079 D1 DE 602004031079D1 DE 602004031079 T DE602004031079 T DE 602004031079T DE 602004031079 T DE602004031079 T DE 602004031079T DE 602004031079 D1 DE602004031079 D1 DE 602004031079D1
Authority
DE
Germany
Prior art keywords
colitis
strains
bifidobacterium
days
patients
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE602004031079T
Other languages
German (de)
English (en)
Inventor
Goeran Molin
Siv Ahrn
Bengt Jeppsson
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Probi AB
Original Assignee
Probi AB
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Probi AB filed Critical Probi AB
Publication of DE602004031079D1 publication Critical patent/DE602004031079D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/66Microorganisms or materials therefrom
    • A61K35/74Bacteria
    • A61K35/741Probiotics
    • A61K35/744Lactic acid bacteria, e.g. enterococci, pediococci, lactococci, streptococci or leuconostocs
    • A61K35/745Bifidobacteria
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/12Antidiarrhoeals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/12Drugs for disorders of the urinary system of the kidneys
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/30Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/32Alcohol-abuse
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00General protective or antinoxious agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P41/00Drugs used in surgical methods, e.g. surgery adjuvants for preventing adhesion or for vitreum substitution
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20Bacteria; Culture media therefor
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20Bacteria; Culture media therefor
    • C12N1/205Bacterial isolates
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23LFOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L33/00Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/135Bacteria or derivatives thereof, e.g. probiotics
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23VINDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2400/00Lactic or propionic acid bacteria
    • A23V2400/51Bifidobacterium
    • A23V2400/529Infantis
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12RINDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00Microorganisms ; Processes using microorganisms
    • C12R2001/01Bacteria or Actinomycetales ; using bacteria or Actinomycetales
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02ATECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Mycology (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Virology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Nutrition Science (AREA)
  • Food Science & Technology (AREA)
  • Polymers & Plastics (AREA)
  • Addiction (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Psychiatry (AREA)
  • Urology & Nephrology (AREA)
  • Diabetes (AREA)
  • Obesity (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
DE602004031079T 2003-01-31 2004-01-27 Neue bifidobacterium-stämme mit der fähigkeit zur herstellung von glutamin Expired - Lifetime DE602004031079D1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
SE0300245A SE526711C2 (sv) 2003-01-31 2003-01-31 Nya stammar av Bifidobacterium med förmåga att överleva i magtarmkanalen och producera glutamin in vivo, samt kompositioner och användningar därav
US44727403P 2003-02-14 2003-02-14
PCT/SE2004/000098 WO2004067731A1 (en) 2003-01-31 2004-01-27 New strains of bifidobacterium having the ability to produce glutamine

Publications (1)

Publication Number Publication Date
DE602004031079D1 true DE602004031079D1 (de) 2011-03-03

Family

ID=20290264

Family Applications (1)

Application Number Title Priority Date Filing Date
DE602004031079T Expired - Lifetime DE602004031079D1 (de) 2003-01-31 2004-01-27 Neue bifidobacterium-stämme mit der fähigkeit zur herstellung von glutamin

Country Status (16)

Country Link
US (1) US7947482B2 (enExample)
EP (1) EP1587913B1 (enExample)
JP (1) JP4540664B2 (enExample)
CN (1) CN100558883C (enExample)
AT (1) ATE496115T1 (enExample)
AU (1) AU2004208084B2 (enExample)
BR (1) BRPI0407176B8 (enExample)
CA (1) CA2514659C (enExample)
DE (1) DE602004031079D1 (enExample)
DK (1) DK1587913T3 (enExample)
ES (1) ES2362496T3 (enExample)
PL (1) PL212096B1 (enExample)
RU (1) RU2352628C2 (enExample)
SE (1) SE526711C2 (enExample)
WO (1) WO2004067731A1 (enExample)
ZA (1) ZA200505777B (enExample)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2561629T3 (es) 2005-09-28 2016-02-29 Nordisk Rebalance A/S Tratamiento del SII usando como efectores de tratamiento tanto bacterias probióticas como cereales fermentados
DK1951272T3 (en) * 2005-10-06 2016-09-19 Probi Ab Use of lactobacillus for treatment of virus infections
CN105671120B (zh) * 2010-07-05 2019-02-19 株式会社明治 具有肠内腐败物质的减少作用的双歧杆菌
CL2010001124A1 (es) 2010-10-14 2011-01-21 Univ De Concepcion 50% Ma Loreto Ormeno 50% Alimento funcional probiotico que comprende cepas viables de lactobacillus sp.; uso de dicho alimento funcional para contrarestar los efectos colaterales de la quimioterapia.
KR20130049671A (ko) 2011-11-04 2013-05-14 한미사이언스 주식회사 생리활성 폴리펩타이드 결합체 제조 방법
CN103131647B (zh) * 2011-11-29 2017-06-27 上海上药信谊药厂有限公司 婴儿双歧杆菌及其制剂
CN104780932A (zh) 2012-02-29 2015-07-15 伊西康内外科公司 微生物区系的组合物及与其相关的方法
AR090281A1 (es) 2012-03-08 2014-10-29 Hanmi Science Co Ltd Proceso mejorado para la preparacion de un complejo polipeptidico fisiologicamente activo
EP4529950A3 (en) 2014-10-31 2025-08-20 Pendulum Therapeutics, Inc. Methods and compositions relating to microbial treatment
WO2019046646A1 (en) 2017-08-30 2019-03-07 Whole Biome Inc. METHODS AND COMPOSITIONS FOR THE TREATMENT OF MICROBIOMA ASSOCIATED DISORDERS
CN108330166A (zh) * 2017-09-06 2018-07-27 深圳市百澳飞生物技术有限公司 一种酶制剂的饲用活性评估方法
WO2020018949A2 (en) 2018-07-19 2020-01-23 Pendulum Therapeutics, Inc. Methods and compositions for microbial engraftment
RU2699967C1 (ru) * 2018-12-25 2019-09-11 Федеральное государственное бюджетное образовательное учреждение высшего образования "Астраханский государственный медицинский университет" Министерства здравоохранения Российской Федерации (ФГБОУ ВО Астраханский ГМУ Минздрава России) Способ комплексного лечения энтеральной недостаточности у детей с тяжелой термической травмой
US11045507B2 (en) 2019-02-21 2021-06-29 Ewelina Sosnowska-Turek Bifidobacterium animalis AMT30 strain and the composition containing the strain of Bifidobacterium animalis AMT30

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS59155321A (ja) * 1983-02-25 1984-09-04 Riyoushiyoku Kenkyukai 整腸用製剤
DE3406772A1 (de) * 1984-02-24 1986-03-13 Angelo 8137 Berg Schuler Diaetetisches mittel zur herabsetzung der harnstoffkonzentration in koerperfluessigkeiten und seine herstellung
SE9002732D0 (sv) * 1990-08-24 1990-08-24 Kabivitrum Ab Product containing growth factor
IT1254210B (it) 1992-02-10 1995-09-14 Simone Claudio De Composizioni dietetiche e/o farmaceutiche a base di batteri lattici liofilizzati, loro preparazione e impiego
JP3623977B2 (ja) * 1993-10-29 2005-02-23 明治乳業株式会社 潰瘍性大腸炎治療剤
JP4852681B2 (ja) * 1996-02-28 2012-01-11 雪印メグミルク株式会社 腸管内細胞溶解活性抑制剤
IT1288119B1 (it) * 1996-06-28 1998-09-10 Renata Maria Anna Ve Cavaliere Composizioni dietetiche da utilizzare nell'alimentazione per via enterica
RU2112034C1 (ru) * 1996-12-26 1998-05-27 Московский научно-исследовательский институт эпидемиологии и микробиологии им.Г.Н.Габричевского Штамм bifidobacterium infantis 73-15, используемый для приготовления бифидосодержащих бактерийных препаратов и продуктов лечебно-диетического питания
CN1099289C (zh) * 1997-08-01 2003-01-22 北京东方百信生物技术有限公司 改善肠道生态平衡的微生物制剂及其工艺
US6203797B1 (en) * 1998-01-06 2001-03-20 Stephen C. Perry Dietary supplement and method for use as a probiotic, for alleviating the symptons associated with irritable bowel syndrome
ID29150A (id) * 1999-01-15 2001-08-02 Entpr Ireland Cs Penggunaan lactobacillus salivarius
AU6160200A (en) * 1999-08-05 2001-03-05 Societe Des Produits Nestle S.A. New bifidobacteria preventing diarrhea caused by pathogenic bacteria
US6468525B1 (en) * 1999-08-10 2002-10-22 Renew Life, Inc. Probiotic formulation
CA2407724A1 (en) 2000-05-03 2001-11-08 University Of Maryland, Baltimore Oral gram(+) bacteria and glutamine composition for prevention and/or treatment of gastro-intestinal
AU2001265253A1 (en) * 2000-07-07 2002-01-21 First Circle Medical, Inc. Treatment of hiv using hyperthermia
JP2002186422A (ja) * 2000-12-22 2002-07-02 Morinaga Milk Ind Co Ltd ラクトバシラス・ガッセリ及びビフィドバクテリウム属の菌を含有する非発酵食品
FI109602B (fi) * 2001-01-25 2002-09-13 Valio Oy Probioottiyhdistelmä
ATE375164T1 (de) * 2001-02-06 2007-10-15 Nestle Sa Endotoxin-bindung durch milchsäurebakterien und bifidobacteria
US20030017192A1 (en) * 2001-06-19 2003-01-23 Hanny Kanafani Process for producing extended shelf-life ready-to-use milk compositions containing probiotics
PE20030284A1 (es) * 2001-07-26 2003-05-01 Alimentary Health Ltd Cepas de bifidobacterium
JP3364491B2 (ja) * 2002-07-25 2003-01-08 株式会社アトリエ・ド・フロマージュ ヨーグルトおよびその製造方法

Also Published As

Publication number Publication date
US20060269533A1 (en) 2006-11-30
WO2004067731A1 (en) 2004-08-12
CN1777670A (zh) 2006-05-24
SE0300245L (sv) 2004-08-01
SE0300245D0 (sv) 2003-01-31
CA2514659C (en) 2014-07-08
EP1587913A1 (en) 2005-10-26
US7947482B2 (en) 2011-05-24
PL212096B1 (pl) 2012-08-31
PL378435A1 (pl) 2006-04-03
JP4540664B2 (ja) 2010-09-08
AU2004208084B2 (en) 2008-10-09
ES2362496T3 (es) 2011-07-06
SE526711C2 (sv) 2005-10-25
EP1587913B1 (en) 2011-01-19
CA2514659A1 (en) 2004-08-12
DK1587913T3 (da) 2011-04-11
JP2006516405A (ja) 2006-07-06
ATE496115T1 (de) 2011-02-15
RU2005127331A (ru) 2006-01-27
BRPI0407176A (pt) 2006-02-07
ZA200505777B (en) 2007-12-27
AU2004208084A1 (en) 2004-08-12
RU2352628C2 (ru) 2009-04-20
CN100558883C (zh) 2009-11-11
BRPI0407176B8 (pt) 2021-05-25
BRPI0407176B1 (pt) 2018-05-08

Similar Documents

Publication Publication Date Title
ATE496115T1 (de) Neue bifidobacterium-stämme mit der fähigkeit zur herstellung von glutamin
RU2465320C2 (ru) Композиция штаммов рода lactobacillus для производства лекарственного средства
CN108836956B (zh) 甘草查耳酮a在制备治疗鸡坏死性肠炎药物中的用途
JPH07126177A (ja) 潰瘍性大腸炎治療剤
CN1300617A (zh) 一种补正气、泻邪气、调整人体阳气升降出入的中药组合物
Şahin et al. The impact of oral feeding on the severity of acute pancreatitis
CA3232874A1 (en) Hygromycin a for treatment of diseases and infections
CN108309969B (zh) 鸢尾黄素在治疗鸡坏死性肠炎中的医用用途
Verdecia et al. Trivalvular infective endocarditis secondary to Granulicatella adiacens and Peptostreptococcus spp
CN118384186A (zh) Akkermansia muciniphila及其后生元在抗感染中的应用
Harboe Armauer Hansen-the man and his work
CN105343132B (zh) 治疗结肠炎的组合物、药物及其制备方法
MAKSUDOV et al. Development of a comprehensive programme for the comprehensive treatment of patients with maxillofacial phlegmon with viral hepatitis B
Ozcelik et al. The role of lactulose in the prevention of bacterial translocation in surgical trauma
GB1585863A (en) Pharmaceutical lactobacillus preparations
Marshall Jr et al. The variable effects of sulfonamides on fecal bacteria in patients with chronic ulcerative colitis: a preliminary report
Wang et al. Moxibustion at Front-Mu point of abdomen for intestinal dysbacteriosis in rats
Finley Dermato-Myositis
SU1588414A1 (ru) Способ лечени ожоговой болезни
Crisostomo et al. A randomized double blind controlled study on the efficacy of spirulina as an adjunct therapy in the management of pediatric community acquired pneumonia-c in patients 6 months to 5 years old admitted in a tertiary government hospital
CN120249099A (zh) 一株罗伊氏粘液乳杆菌ccfm1453制备的促进胃黏膜修复的多糖
CN120168459A (zh) 独活素在制备治疗和/或缓解新生儿感染性疾病及脏器损伤的药物中的应用
RU2008110773A (ru) Способ лечения онкологических заболеваний
Malsbary Rheumatism
Sharma et al. Therapeutic and dietary management of colibacillosis in calves