DE602004030112D1 - Verfahren zur herstellung von ace hemmern - Google Patents
Verfahren zur herstellung von ace hemmernInfo
- Publication number
- DE602004030112D1 DE602004030112D1 DE602004030112T DE602004030112T DE602004030112D1 DE 602004030112 D1 DE602004030112 D1 DE 602004030112D1 DE 602004030112 T DE602004030112 T DE 602004030112T DE 602004030112 T DE602004030112 T DE 602004030112T DE 602004030112 D1 DE602004030112 D1 DE 602004030112D1
- Authority
- DE
- Germany
- Prior art keywords
- preparation
- ace inhibitors
- amino acid
- activated
- ace
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 239000005541 ACE inhibitor Substances 0.000 title abstract 2
- 229940044094 angiotensin-converting-enzyme inhibitor Drugs 0.000 title abstract 2
- 150000001413 amino acids Chemical class 0.000 abstract 2
- 150000001224 Uranium Chemical class 0.000 abstract 1
- 150000001412 amines Chemical class 0.000 abstract 1
- 239000000010 aprotic solvent Substances 0.000 abstract 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 239000002243 precursor Substances 0.000 abstract 1
- 230000000707 stereoselective effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SI200300123A SI21507A (sl) | 2003-05-16 | 2003-05-16 | Postopek za pripravo spojin z ace inhibitornim delovanjem |
| PCT/SI2004/000021 WO2004101515A1 (en) | 2003-05-16 | 2004-05-07 | A process for the preparation of compounds having an ace inhibitory action |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE602004030112D1 true DE602004030112D1 (de) | 2010-12-30 |
Family
ID=33448812
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE602004030112T Expired - Lifetime DE602004030112D1 (de) | 2003-05-16 | 2004-05-07 | Verfahren zur herstellung von ace hemmern |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US7671215B2 (de) |
| EP (1) | EP1628956B1 (de) |
| AT (1) | ATE488498T1 (de) |
| DE (1) | DE602004030112D1 (de) |
| RU (1) | RU2377236C2 (de) |
| SI (2) | SI21507A (de) |
| WO (1) | WO2004101515A1 (de) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK2468724T3 (en) * | 2006-12-21 | 2016-02-22 | Zealand Pharma As | Synthesis of pyrrolidine compounds |
| US20090076126A1 (en) * | 2007-09-17 | 2009-03-19 | Protia, Llc | Deuterium-enriched enalapril |
| CA2768239A1 (en) | 2009-07-16 | 2011-01-20 | Abbott Laboratories | Processes for the synthesis of (2s, 3ar, 7as)-octahydro-1h-indole carboxylic acid as an intermediate for trandolapril |
| WO2014057404A1 (en) * | 2012-10-10 | 2014-04-17 | Piramal Enterprises Limited | An improved process for preparation of perindopril intermediate |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE289543C (de) | 1913-08-18 | |||
| FR2620709B1 (fr) * | 1987-09-17 | 1990-09-07 | Adir | Procede de synthese industrielle du perindopril et de ses principaux intermediaires de synthese |
| US5864040A (en) | 1996-01-11 | 1999-01-26 | American Home Products Corporation | Benzimidazole phosphono-amino acids |
| GB9710612D0 (en) | 1997-05-23 | 1997-07-16 | Glaxo Group Ltd | Synthesis of acridine derivatives |
| IL151923A0 (en) | 2000-03-31 | 2003-04-10 | Pfizer Prod Inc | Novel piperazine derivatives |
| GB2375762B (en) * | 2001-05-21 | 2003-10-01 | Fermenta Biotech Ltd | Stereospecific synthesis of 2-hydroxy-4-phenyl-butyric acid esters |
| WO2002094857A1 (en) * | 2001-05-23 | 2002-11-28 | The Curators Of The University Of Missouri | Inverse solid phase synthesis of peptides |
| AR036187A1 (es) * | 2001-07-24 | 2004-08-18 | Adir | Un proceso para la preparacion de perindopril, compuestos analogos y sus sales, compuesto intermediario 2,5-dioxo-oxazolidina y proceso para preparar un intermediario |
| GB0119795D0 (en) | 2001-08-14 | 2001-10-03 | Smithkline Beecham Plc | Novel process |
-
2003
- 2003-05-16 SI SI200300123A patent/SI21507A/sl not_active IP Right Cessation
-
2004
- 2004-05-07 DE DE602004030112T patent/DE602004030112D1/de not_active Expired - Lifetime
- 2004-05-07 RU RU2005139158/04A patent/RU2377236C2/ru not_active IP Right Cessation
- 2004-05-07 AT AT04731808T patent/ATE488498T1/de not_active IP Right Cessation
- 2004-05-07 EP EP04731808A patent/EP1628956B1/de not_active Expired - Lifetime
- 2004-05-07 WO PCT/SI2004/000021 patent/WO2004101515A1/en active Application Filing
- 2004-05-07 US US10/556,986 patent/US7671215B2/en not_active Expired - Fee Related
- 2004-05-07 SI SI200431600T patent/SI1628956T1/sl unknown
Also Published As
| Publication number | Publication date |
|---|---|
| US20070072919A1 (en) | 2007-03-29 |
| SI21507A (sl) | 2004-12-31 |
| EP1628956B1 (de) | 2010-11-17 |
| EP1628956A1 (de) | 2006-03-01 |
| SI1628956T1 (sl) | 2011-03-31 |
| RU2377236C2 (ru) | 2009-12-27 |
| ATE488498T1 (de) | 2010-12-15 |
| US7671215B2 (en) | 2010-03-02 |
| WO2004101515A1 (en) | 2004-11-25 |
| RU2005139158A (ru) | 2007-06-27 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8328 | Change in the person/name/address of the agent |
Representative=s name: DR. SCHOEN & PARTNER, 80336 MUENCHEN |