DE602004029503D1 - Plasmid der 2-mikron-familie und verwendung davon - Google Patents
Plasmid der 2-mikron-familie und verwendung davonInfo
- Publication number
- DE602004029503D1 DE602004029503D1 DE602004029503T DE602004029503T DE602004029503D1 DE 602004029503 D1 DE602004029503 D1 DE 602004029503D1 DE 602004029503 T DE602004029503 T DE 602004029503T DE 602004029503 T DE602004029503 T DE 602004029503T DE 602004029503 D1 DE602004029503 D1 DE 602004029503D1
- Authority
- DE
- Germany
- Prior art keywords
- plasmid
- gene
- micron family
- last
- family
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/80—Vectors or expression systems specially adapted for eukaryotic hosts for fungi
- C12N15/81—Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/08—Plasma substitutes; Perfusion solutions; Dialytics or haemodialytics; Drugs for electrolytic or acid-base disorders, e.g. hypovolemic shock
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical & Material Sciences (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Biomedical Technology (AREA)
- Mycology (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Microbiology (AREA)
- Plant Pathology (AREA)
- Molecular Biology (AREA)
- Physics & Mathematics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Dermatology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Saccharide Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Breeding Of Plants And Reproduction By Means Of Culturing (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB0329722.3A GB0329722D0 (en) | 2003-12-23 | 2003-12-23 | Modified plasmid and use thereof |
PCT/GB2004/005435 WO2005061719A1 (en) | 2003-12-23 | 2004-12-23 | 2-micron family plasmid and use thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
DE602004029503D1 true DE602004029503D1 (de) | 2010-11-18 |
Family
ID=30776295
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE602004029503T Active DE602004029503D1 (de) | 2003-12-23 | 2004-12-23 | Plasmid der 2-mikron-familie und verwendung davon |
Country Status (14)
Country | Link |
---|---|
US (1) | US8252551B2 (de) |
EP (1) | EP1711602B1 (de) |
JP (1) | JP4964596B2 (de) |
KR (1) | KR101298157B1 (de) |
CN (2) | CN1922326B (de) |
AT (1) | ATE483812T1 (de) |
AU (1) | AU2004303597C1 (de) |
CA (1) | CA2551496C (de) |
DE (1) | DE602004029503D1 (de) |
DK (1) | DK1711602T3 (de) |
GB (2) | GB0329722D0 (de) |
NZ (1) | NZ548154A (de) |
WO (1) | WO2005061719A1 (de) |
ZA (1) | ZA200605589B (de) |
Families Citing this family (35)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2003066085A1 (en) * | 2002-02-07 | 2003-08-14 | Delta Biotechnology Limited | Albumin-fused anti-angiogenesis peptides |
US9057061B2 (en) | 2003-12-23 | 2015-06-16 | Novozymes Biopharma Dk A/S | Gene expression technique |
GB0329722D0 (en) | 2003-12-23 | 2004-01-28 | Delta Biotechnology Ltd | Modified plasmid and use thereof |
WO2005123915A1 (en) * | 2004-06-21 | 2005-12-29 | Novozymes A/S | Stably maintained multiple copies of at least two orf in the same orientation |
GB0512707D0 (en) * | 2005-06-22 | 2005-07-27 | Delta Biotechnology Ltd | Gene expression technique |
WO2009019314A1 (en) | 2007-08-08 | 2009-02-12 | Novozymes A/S | Transferrin variants and conjugates |
DK2393834T3 (da) | 2009-02-06 | 2013-06-24 | Novozymes Biopharma Dk As | Fremgangsmåde til oprensning |
CN106986933A (zh) | 2009-02-11 | 2017-07-28 | 阿尔布梅迪克斯医疗公司 | 白蛋白变体和缀合物 |
RU2607374C2 (ru) | 2009-10-30 | 2017-01-10 | Новозаймс Байофарма Дк А/С | Варианты альбумина |
KR20130070576A (ko) | 2010-04-09 | 2013-06-27 | 노보자임스 바이오파마 디케이 에이/에스 | 알부민 유도체 및 변이체 |
CN101974547B (zh) * | 2010-07-30 | 2012-06-27 | 天津大学 | 含FLP的pBBR1MCS-2重组质粒及运动发酵单胞菌基因组DNA修饰的方法 |
JP6008858B2 (ja) | 2010-09-07 | 2016-10-19 | ビュータマックス・アドバンスド・バイオフューエルズ・エルエルシー | ピルベートからアセトラクテートへの変換を触媒するポリペプチドをコードするポリヌクレオチドの組込み |
EP2622080A4 (de) * | 2010-09-30 | 2014-04-02 | Codexis Inc | Verwendung eines endogenen 2-mikrometer-hefeplasmids für genüberexpression |
BR112013024328A2 (pt) | 2011-03-24 | 2020-08-25 | Butamax (Tm) Advanced Biofuels Llc. | Células hospedeiras recombinantes, métodos para produzir isobutanol, composiçãofermentativa, métodos para produzir uma célula hospedeira recombinante, para reduzir oueliminar a conversão de isobutiraldeído, polipeptídeos, polinucleqtídeo, método paraconverter acetolactato, leveduras recombinantes, métodos para produzir butanol, paraaumentar a atividade e para aumentar a produtividade da enzima karl |
US20140315817A1 (en) | 2011-11-18 | 2014-10-23 | Eleven Biotherapeutics, Inc. | Variant serum albumin with improved half-life and other properties |
WO2013102147A2 (en) | 2011-12-30 | 2013-07-04 | Butamax (Tm) Advanced Biofuels Llc | Genetic switches for butanol production |
WO2013111754A1 (ja) | 2012-01-23 | 2013-08-01 | 旭硝子株式会社 | 発現ベクターおよび蛋白質の製造方法 |
CA2861592A1 (en) | 2012-03-16 | 2013-09-19 | Novozymes Biopharma Dk A/S | Albumin variants |
CN104902929A (zh) * | 2012-05-21 | 2015-09-09 | 沈维强 | 使用蛋白质前体作为前药的方法 |
WO2014072481A1 (en) | 2012-11-08 | 2014-05-15 | Novozymes Biopharma Dk A/S | Albumin variants |
CN103898142B (zh) * | 2014-03-04 | 2016-03-02 | 北京理工大学 | 一种硫醇过氧化物酶提高毕赤酵母外源蛋白质表达量的方法 |
WO2015176641A1 (zh) * | 2014-05-21 | 2015-11-26 | 中国科学院上海生命科学研究院 | 一种促进重组极端耐热α-淀粉酶可溶性表达的方法 |
CN104946659A (zh) * | 2015-03-27 | 2015-09-30 | 杭州北斗生物技术有限公司 | 重组人生长激素的制备方法及其peg化修饰物的制备方法 |
EP3337816B1 (de) | 2015-08-20 | 2024-02-14 | Albumedix Ltd | Albumin-varianten und -konjugate |
WO2017112847A1 (en) * | 2015-12-22 | 2017-06-29 | Albumedix A/S | Improved protein expression strains |
JP6801675B2 (ja) * | 2016-01-12 | 2020-12-16 | Agc株式会社 | 形質転換体、およびトランスフェリンの製造方法 |
CN107367619A (zh) * | 2017-08-30 | 2017-11-21 | 福建师范大学 | Tcp1蛋白在制备乳腺癌术后预后评估试剂盒中的应用、乳腺癌预后评估试剂盒及方法 |
FI3775222T3 (fi) * | 2018-03-26 | 2024-04-02 | Novozymes As | Sienten kaitsijaproteiineja |
CN110184292B (zh) * | 2019-06-17 | 2023-01-20 | 湖北大学 | 一种利用分子伴侣提高酵母细胞表面展示功能性Infliximab Fab片段的方法 |
CN112680371A (zh) * | 2019-10-18 | 2021-04-20 | 广东利世康低碳科技有限公司 | 一种水解餐厨垃圾中蛋白成分的产朊假丝酵母双基因共表达菌株及其构建方法 |
CN110592090A (zh) * | 2019-10-30 | 2019-12-20 | 福建师范大学 | Ssa4基因启动子及利用该启动子驱动外源基因转录的毕赤酵母表达载体 |
US11739166B2 (en) | 2020-07-02 | 2023-08-29 | Davol Inc. | Reactive polysaccharide-based hemostatic agent |
CN112501141A (zh) * | 2020-10-22 | 2021-03-16 | 重庆中元汇吉生物技术有限公司 | 一种增加人甲状腺过氧化物酶产量的试剂和表达方法 |
CN114410496B (zh) * | 2022-02-16 | 2023-10-03 | 江南大学 | 一种提高毕赤酵母外源蛋白产量的方法 |
CN114957488A (zh) * | 2022-05-19 | 2022-08-30 | 中国科学院生物物理研究所 | 芳香烃受体蛋白稳定高效表达的方法及其应用 |
Family Cites Families (49)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB9019919D0 (en) | 1990-09-12 | 1990-10-24 | Delta Biotechnology Ltd | Purification of proteins |
US4302386A (en) | 1978-08-25 | 1981-11-24 | The Ohio State University | Antigenic modification of polypeptides |
NZ199722A (en) | 1981-02-25 | 1985-12-13 | Genentech Inc | Dna transfer vector for expression of exogenous polypeptide in yeast;transformed yeast strain |
IL66614A (en) | 1981-08-28 | 1985-09-29 | Genentech Inc | Method of constructing a dna sequence encoding a polypeptide,microbial production of human serum albumin,and pharmaceutical compositions comprising it |
GB8615701D0 (en) | 1986-06-27 | 1986-08-06 | Delta Biotechnology Ltd | Stable gene integration vector |
GB8620926D0 (en) | 1986-08-29 | 1986-10-08 | Delta Biotechnology Ltd | Yeast promoter |
ES2052712T3 (es) | 1987-04-09 | 1994-07-16 | Delta Biotechnology Ltd | Vector de levadura. |
IL86455A0 (en) | 1987-06-01 | 1988-11-15 | Takeda Chemical Industries Ltd | Polypeptide and production thereof |
IL88326A (en) | 1987-11-18 | 1993-03-15 | Gist Brocades Nv | Purification of serum albumin |
EP0398944A4 (en) | 1988-02-05 | 1991-09-11 | Commonwealth Scientific And Industrial Research Organisation | Gene expression system (particularly for rotavirus vp7 protein) involving a foreign signal peptide and optionally a transmembrane anchor sequence |
AU633020B2 (en) | 1988-07-23 | 1993-01-21 | Novozymes Delta Limited | New secretory leader sequences |
US5759802A (en) | 1988-10-26 | 1998-06-02 | Tonen Corporation | Production of human serum alubumin A |
GB8909916D0 (en) | 1989-04-29 | 1989-06-14 | Delta Biotechnology Ltd | Polypeptides |
US5571691A (en) | 1989-05-05 | 1996-11-05 | Baylor College Of Medicine | Production of recombinant lactoferrin and lactoferrin polypeptides using CDNA sequences in various organisms |
GB8927480D0 (en) | 1989-12-05 | 1990-02-07 | Delta Biotechnology Ltd | Mutant fungal strain detection and new promoter |
JP3230091B2 (ja) | 1990-06-25 | 2001-11-19 | ウェルファイド株式会社 | ヒト血清アルブミンの着色抑制方法 |
WO1992001069A1 (en) | 1990-07-13 | 1992-01-23 | Transkaryotic Therapies, Inc. | Library screening method |
GB2249096A (en) * | 1990-10-11 | 1992-04-29 | Ciba Geigy | Saccharomyces cerevisiae strains lacking carboxypeptidase yscY activity for expression of proteins at high yields |
EP0724633A1 (de) | 1991-02-08 | 1996-08-07 | The University Of Vermont And State Agricultural College | Rekombinante transferrine, transferrinhalbe molekülen und mutanten davon |
SG84484A1 (en) | 1991-02-25 | 2001-11-20 | Ciba Geigy Ag | Improved yeast vectors |
EP0509841A3 (en) | 1991-04-18 | 1993-08-18 | Tonen Corporation | Co-expression system of protein disulfide isomerase gene and useful polypeptide gene and process for producing the polypeptide using its system |
ZA932568B (en) | 1992-04-24 | 1993-11-12 | Baylor College Midecine A Non | Production of recombinant human lactoferrin |
US6291205B1 (en) | 1992-06-12 | 2001-09-18 | Merck & Co., Inc. | Method of increasing production of disulfide bonded recombinant proteins by saccharomyces cerevisiae |
AU4571993A (en) | 1992-07-29 | 1994-03-03 | Unilever Plc | Process for producing anti-freeze peptides |
DE4226971C2 (de) | 1992-08-14 | 1997-01-16 | Widmar Prof Dr Tanner | Modifizierte Pilzzellen und Verfahren zur Herstellung rekombinanter Produkte |
US5728553A (en) | 1992-09-23 | 1998-03-17 | Delta Biotechnology Limited | High purity albumin and method of producing |
DE69329202T2 (de) | 1992-10-02 | 2001-03-29 | Res Corp Technologies Inc | Methoden der erhöhung der sekretion von überexpremierten proteinen |
GB9404270D0 (en) | 1994-03-05 | 1994-04-20 | Delta Biotechnology Ltd | Yeast strains and modified albumins |
GB9411356D0 (en) | 1994-06-07 | 1994-07-27 | Delta Biotechnology Ltd | Yeast strains |
JP3945866B2 (ja) | 1996-09-04 | 2007-07-18 | サントリー株式会社 | メタノール酵母由来のプロテインジスルフィドイソメラーゼ遺伝子 |
GB9703406D0 (en) | 1997-02-19 | 1997-04-09 | Chiron Spa | Expression of heterologous proteins |
WO1998056928A1 (en) | 1997-06-13 | 1998-12-17 | Stichting Instituut Voor Dierhouderij En Diergezondheid | Increased production of proteins by using chaperone-like proteins |
GB9713412D0 (en) | 1997-06-26 | 1997-08-27 | Delta Biotechnology Ltd | Improved protein expression strains |
JP2002534054A (ja) | 1997-09-05 | 2002-10-15 | ペンタファルム アクチェンゲゼルシャフト | 改良したイーストポリペプチドを製造するための発現ベクター |
IT1306207B1 (it) | 1999-01-15 | 2001-05-30 | Biopolo S C A R L | Produzione di proteine eterologhe da zygosaccharomyces bailii. |
GB9902000D0 (en) * | 1999-01-30 | 1999-03-17 | Delta Biotechnology Ltd | Process |
US20040010134A1 (en) | 2000-04-12 | 2004-01-15 | Rosen Craig A. | Albumin fusion proteins |
US7176278B2 (en) | 2001-08-30 | 2007-02-13 | Biorexis Technology, Inc. | Modified transferrin fusion proteins |
US20030226155A1 (en) | 2001-08-30 | 2003-12-04 | Biorexis Pharmaceutical Corporation | Modified transferrin-antibody fusion proteins |
WO2003066085A1 (en) | 2002-02-07 | 2003-08-14 | Delta Biotechnology Limited | Albumin-fused anti-angiogenesis peptides |
EP1529108A2 (de) | 2002-08-07 | 2005-05-11 | ZLB Behring GmbH | Albumin-fusionierter ciliar-neurotrophischer faktor |
DE10252245A1 (de) | 2002-11-07 | 2004-05-27 | Prof. Dr. Danilo Porro Università degli Studi di Milano-Bicocca Dipartimento die Biotechnologie e Bioscienze | Verfahren zur Expression und Sekretion von Proteinen mittels der nicht-konventionellen Hefe Zygosaccharomyces bailii |
US6939676B2 (en) | 2002-12-30 | 2005-09-06 | The United States Of America As Represented By The Secretary Of Argriculture | Selection procedure for identifying transgenic cells, embryos, and plants without the use of antibiotics |
GB0305989D0 (en) | 2003-03-15 | 2003-04-23 | Delta Biotechnology Ltd | Agent |
US9057061B2 (en) | 2003-12-23 | 2015-06-16 | Novozymes Biopharma Dk A/S | Gene expression technique |
GB0329722D0 (en) | 2003-12-23 | 2004-01-28 | Delta Biotechnology Ltd | Modified plasmid and use thereof |
GB0329681D0 (en) | 2003-12-23 | 2004-01-28 | Delta Biotechnology Ltd | Gene expression technique |
GB0402660D0 (en) | 2004-02-06 | 2004-03-10 | Medical Res Council | Heterologous protein expression |
EP1748071A4 (de) | 2004-05-21 | 2009-01-07 | Takara Bio Inc | Verfahren zur herstellung von polypeptid |
-
2003
- 2003-12-23 GB GBGB0329722.3A patent/GB0329722D0/en not_active Ceased
-
2004
- 2004-12-23 WO PCT/GB2004/005435 patent/WO2005061719A1/en active Application Filing
- 2004-12-23 US US10/584,486 patent/US8252551B2/en not_active Expired - Fee Related
- 2004-12-23 GB GB0614610A patent/GB2424888B/en not_active Expired - Fee Related
- 2004-12-23 AT AT04806229T patent/ATE483812T1/de active
- 2004-12-23 AU AU2004303597A patent/AU2004303597C1/en not_active Ceased
- 2004-12-23 ZA ZA200605589A patent/ZA200605589B/xx unknown
- 2004-12-23 EP EP04806229A patent/EP1711602B1/de not_active Not-in-force
- 2004-12-23 DK DK04806229.3T patent/DK1711602T3/da active
- 2004-12-23 CA CA2551496A patent/CA2551496C/en not_active Expired - Fee Related
- 2004-12-23 CN CN2004800420229A patent/CN1922326B/zh not_active Expired - Fee Related
- 2004-12-23 JP JP2006546328A patent/JP4964596B2/ja not_active Expired - Fee Related
- 2004-12-23 DE DE602004029503T patent/DE602004029503D1/de active Active
- 2004-12-23 NZ NZ548154A patent/NZ548154A/en not_active IP Right Cessation
- 2004-12-23 KR KR1020067014724A patent/KR101298157B1/ko not_active IP Right Cessation
-
2005
- 2005-12-23 CN CN200580048615.0A patent/CN101128587B/zh not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
CA2551496A1 (en) | 2005-07-07 |
DK1711602T3 (da) | 2011-01-31 |
AU2004303597C1 (en) | 2009-05-14 |
ZA200605589B (en) | 2007-12-27 |
CA2551496C (en) | 2014-12-09 |
GB2424888A (en) | 2006-10-11 |
KR101298157B1 (ko) | 2013-08-21 |
AU2004303597B2 (en) | 2008-09-25 |
GB2424888B (en) | 2008-03-26 |
GB0614610D0 (en) | 2006-08-30 |
WO2005061719A1 (en) | 2005-07-07 |
US8252551B2 (en) | 2012-08-28 |
EP1711602B1 (de) | 2010-10-06 |
NZ548154A (en) | 2009-05-31 |
JP2007515961A (ja) | 2007-06-21 |
AU2004303597A1 (en) | 2005-07-07 |
KR20070004585A (ko) | 2007-01-09 |
CN1922326A (zh) | 2007-02-28 |
CN101128587A (zh) | 2008-02-20 |
JP4964596B2 (ja) | 2012-07-04 |
GB0329722D0 (en) | 2004-01-28 |
EP1711602A1 (de) | 2006-10-18 |
CN1922326B (zh) | 2011-02-09 |
ATE483812T1 (de) | 2010-10-15 |
CN101128587B (zh) | 2014-02-12 |
US20080261861A1 (en) | 2008-10-23 |
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