DE602004017777D1 - Tricyclische indolhydroxyethylaminderivate und deren verwendung bei der behandlung von alzheimer-krankheit - Google Patents

Tricyclische indolhydroxyethylaminderivate und deren verwendung bei der behandlung von alzheimer-krankheit

Info

Publication number
DE602004017777D1
DE602004017777D1 DE602004017777T DE602004017777T DE602004017777D1 DE 602004017777 D1 DE602004017777 D1 DE 602004017777D1 DE 602004017777 T DE602004017777 T DE 602004017777T DE 602004017777 T DE602004017777 T DE 602004017777T DE 602004017777 D1 DE602004017777 D1 DE 602004017777D1
Authority
DE
Germany
Prior art keywords
treatment
indolhydroxyethylamine
tricyclic
derivatives
alzheimer disease
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE602004017777T
Other languages
English (en)
Inventor
Sally Redshaw
Emmanuel Hubert Demont
Daryl Simon Walter
David R Vesey
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Glaxo Group Ltd
Original Assignee
Glaxo Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd
Publication of DE602004017777D1 publication Critical patent/DE602004017777D1/de
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/06—Peri-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
DE602004017777T 2003-12-12 2004-12-09 Tricyclische indolhydroxyethylaminderivate und deren verwendung bei der behandlung von alzheimer-krankheit Expired - Fee Related DE602004017777D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0328900.6A GB0328900D0 (en) 2003-12-12 2003-12-12 Novel compounds
PCT/EP2004/014076 WO2005058915A1 (en) 2003-12-12 2004-12-09 Tricyclic indole hydroxyethylamine derivatives and their use in the treatment of alzheimer's disease

Publications (1)

Publication Number Publication Date
DE602004017777D1 true DE602004017777D1 (de) 2008-12-24

Family

ID=30130158

Family Applications (1)

Application Number Title Priority Date Filing Date
DE602004017777T Expired - Fee Related DE602004017777D1 (de) 2003-12-12 2004-12-09 Tricyclische indolhydroxyethylaminderivate und deren verwendung bei der behandlung von alzheimer-krankheit

Country Status (17)

Country Link
US (1) US20070073060A1 (de)
EP (1) EP1692143B1 (de)
JP (1) JP2007513913A (de)
KR (1) KR20060121164A (de)
CN (1) CN1914214A (de)
AT (1) ATE414090T1 (de)
AU (1) AU2004299231A1 (de)
BR (1) BRPI0417476A (de)
CA (1) CA2549072A1 (de)
DE (1) DE602004017777D1 (de)
GB (1) GB0328900D0 (de)
IL (1) IL175819A0 (de)
IS (1) IS8521A (de)
MA (1) MA28241A1 (de)
NO (1) NO20063137L (de)
RU (1) RU2006124863A (de)
WO (1) WO2005058915A1 (de)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2007528400A (ja) 2004-03-09 2007-10-11 エラン ファーマシューティカルズ，インコーポレイテッド 置換ヒドロキシエチルアミン系のアスパラギン酸プロテアーゼ阻害薬
WO2006010095A2 (en) 2004-07-09 2006-01-26 Elan Pharmaceuticals Inc. Oxime derivative substituted hydroxyethylamine aspartyl protease inhibitors
MX2007003281A (es) * 2004-09-21 2007-05-18 Pfizer Prod Inc N-etilhidroxietilamina util en el tratamiento de afecciones del sistema nervioso central.
GB0422766D0 (en) * 2004-10-13 2004-11-17 Glaxo Group Ltd Novel compounds
GB0422765D0 (en) * 2004-10-13 2004-11-17 Glaxo Group Ltd Novel compounds
WO2007047305A1 (en) 2005-10-12 2007-04-26 Elan Pharmaceuticals, Inc. Methods of treating amyloidosis using cyclopropyl derivative aspartyl protease inhibitors
US7838676B2 (en) 2005-11-21 2010-11-23 Amgen Inc. Beta-secretase modulators and methods of use
US7872009B2 (en) 2005-11-21 2011-01-18 Amgen Inc. Beta-Secretase modulators and methods of use
FR2919288B1 (fr) * 2007-07-27 2009-09-04 Sanofi Aventis Sa Derives de 1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazine-6- carboxamides, leur preparation et leur application en therapeutique.
FR2919285B1 (fr) 2007-07-27 2012-08-31 Sanofi Aventis Derives de 1-oxo-isoindoline-4-carboxamides et de 1-oxo- 1,2,3,4-tetrahydroisoquinoleine-5-carboxamides, leur preparation et leur application en therapeutique.
FR2919286A1 (fr) 2007-07-27 2009-01-30 Sanofi Aventis Sa Derives de derives de 1-oxo-1,2-dihydroisoquinoleine-5- carboxamides et de 4-oxo-3,4-dihydroquinazoline-8- carboxamides,leur preparation et leur application en therapeutique.
AU2008306835A1 (en) * 2007-07-27 2009-04-09 Sanofi-Aventis 1,2,3,4-tetrahydropyrrolo[1,2-A]pyrazine-6-carboxamide and 2,3,4,5-tetrahydropyrrolo[1,2-A][1,4]-diazepine-7-carboxamide derivatives, preparation and therapeutic use thereof
FR2919289B1 (fr) * 2007-07-27 2009-09-04 Sanofi Aventis Sa Derives de 2,3,4,5-tetrahydropyrrolo[1,2-a][1,4]- diazepine-7-carboxamides, leur preparation et leur application en therapeutique.
MX2010012807A (es) * 2008-05-29 2010-12-21 Albany Molecular Res Inc Moduladores del rceptor 5-hidroxitriptamina 3, metodos de fabricacion y uso de los mismos.
FR2960876B1 (fr) 2010-06-03 2012-07-27 Sanofi Aventis Derives de 3,4-dihydropyrrolo[1,2-a]pyrazine-2,8(1h)-dicarboxamide leur preparation et leur application en therapeutique.
CN103096893B (zh) 2010-06-04 2016-05-04 阿尔巴尼分子研究公司 甘氨酸转运体-1抑制剂、其制备方法及其用途
MX365851B (es) * 2012-08-24 2019-06-17 Treventis Corp Compuestos de benzofurazano anti-amiloides y metodos.
WO2019075358A1 (en) * 2017-10-13 2019-04-18 Ghosh Arun K BACE1 INHIBITORS FOR THE TREATMENT OF ALZHEIMER'S DISEASE

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69828682T2 (de) * 1997-02-04 2006-04-06 The Regents Of The University Of California, Oakland Nanomolare, non-peptidische inhibitoren von cathepsin d
US6207664B1 (en) * 1998-11-25 2001-03-27 Pfizer Inc. Squalene synthetase inhibitor agents
US7119085B2 (en) * 2000-03-23 2006-10-10 Elan Pharmaceuticals, Inc. Methods to treat alzheimer's disease
CA2410680A1 (en) * 2000-06-30 2002-01-10 Elan Pharmaceuticals, Inc. Compounds to treat alzheimer's disease
AP2004003049A0 (en) * 2001-11-08 2004-06-30 Elan Pharm Inc N,N' -substituted-1,3-diamino -2-hydroxypropane derivatives.
GB0228410D0 (en) * 2002-12-05 2003-01-08 Glaxo Group Ltd Novel Compounds
GB0309221D0 (en) * 2003-04-23 2003-06-04 Glaxo Group Ltd Novel compounds

Also Published As

Publication number Publication date
WO2005058915A1 (en) 2005-06-30
GB0328900D0 (en) 2004-01-14
IL175819A0 (en) 2006-10-05
KR20060121164A (ko) 2006-11-28
MA28241A1 (fr) 2006-10-02
AU2004299231A1 (en) 2005-06-30
CA2549072A1 (en) 2005-06-30
ATE414090T1 (de) 2008-11-15
US20070073060A1 (en) 2007-03-29
IS8521A (is) 2006-06-26
EP1692143A1 (de) 2006-08-23
JP2007513913A (ja) 2007-05-31
EP1692143B1 (de) 2008-11-12
NO20063137L (no) 2006-08-31
BRPI0417476A (pt) 2007-05-08
RU2006124863A (ru) 2008-01-20
CN1914214A (zh) 2007-02-14

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Legal Events

Date Code Title Description
8339 Ceased/non-payment of the annual fee