DE602004012552D1 - Diaminopyrrolochinazoline als protein-tyrosin-phosphatase-inhibitoren - Google Patents
Diaminopyrrolochinazoline als protein-tyrosin-phosphatase-inhibitorenInfo
- Publication number
- DE602004012552D1 DE602004012552D1 DE602004012552T DE602004012552T DE602004012552D1 DE 602004012552 D1 DE602004012552 D1 DE 602004012552D1 DE 602004012552 T DE602004012552 T DE 602004012552T DE 602004012552 T DE602004012552 T DE 602004012552T DE 602004012552 D1 DE602004012552 D1 DE 602004012552D1
- Authority
- DE
- Germany
- Prior art keywords
- protein tyrosine
- diaminopyrolochinazoline
- tyrosine phosphatase
- phosphatase inhibitors
- useful
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 239000003806 protein tyrosine phosphatase inhibitor Substances 0.000 title 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 abstract 1
- 101001087394 Homo sapiens Tyrosine-protein phosphatase non-receptor type 1 Proteins 0.000 abstract 1
- 241000124008 Mammalia Species 0.000 abstract 1
- 102000002727 Protein Tyrosine Phosphatase Human genes 0.000 abstract 1
- 102100033001 Tyrosine-protein phosphatase non-receptor type 1 Human genes 0.000 abstract 1
- 239000008280 blood Substances 0.000 abstract 1
- 210000004369 blood Anatomy 0.000 abstract 1
- 239000008103 glucose Substances 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 108020000494 protein-tyrosine phosphatase Proteins 0.000 abstract 1
- ACMYQAYEINJXQI-UHFFFAOYSA-N pyrimido[5,4-e][1,2,4]triazine-5,7-diamine Chemical class N1=CN=NC2=NC(N)=NC(N)=C21 ACMYQAYEINJXQI-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
- A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Diabetes (AREA)
- Public Health (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Endocrinology (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Emergency Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Pyridine Compounds (AREA)
- Enzymes And Modification Thereof (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US47080303P | 2003-05-15 | 2003-05-15 | |
| US470803P | 2003-05-15 | ||
| US56358404P | 2004-04-19 | 2004-04-19 | |
| US563584P | 2004-04-19 | ||
| PCT/EP2004/004896 WO2004101568A1 (en) | 2003-05-15 | 2004-05-07 | Diaminopyrroloquinazolines compounds as protein tyrosine phosphatase inhibitors |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE602004012552D1 true DE602004012552D1 (de) | 2008-04-30 |
| DE602004012552T2 DE602004012552T2 (de) | 2009-04-30 |
Family
ID=33457200
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE602004012552T Expired - Lifetime DE602004012552T2 (de) | 2003-05-15 | 2004-05-07 | Diaminopyrrolochinazoline als protein-tyrosin-phosphatase-inhibitoren |
Country Status (15)
| Country | Link |
|---|---|
| US (2) | US7262297B2 (de) |
| EP (1) | EP1628979B1 (de) |
| JP (1) | JP4551401B2 (de) |
| KR (1) | KR100754624B1 (de) |
| CN (1) | CN100344629C (de) |
| AT (1) | ATE389657T1 (de) |
| AU (1) | AU2004238512B2 (de) |
| BR (1) | BRPI0410384A (de) |
| CA (1) | CA2523960C (de) |
| DE (1) | DE602004012552T2 (de) |
| ES (1) | ES2301989T3 (de) |
| MX (1) | MXPA05012207A (de) |
| PL (1) | PL1628979T3 (de) |
| RU (1) | RU2345079C2 (de) |
| WO (1) | WO2004101568A1 (de) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2592083A4 (de) * | 2010-05-21 | 2014-01-22 | Shenzhen Salubris Pharm Co Ltd | Kondensierte chinazolinderivate und deren verwendungen |
| EP3811945A1 (de) | 2019-10-25 | 2021-04-28 | UMC Utrecht Holding B.V. | Verbindungen zur behandlung und vorbeugung von wachstumshormonrezeptorabhängigen zuständen |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IE45427B1 (en) * | 1976-07-09 | 1982-08-25 | American Home Prod | Pyrrold 3,2if quinazoline-1,3-diamine and related compounds |
| US4451466A (en) | 1982-07-02 | 1984-05-29 | Shell Oil Company | Use of pyrroloquinazolinediamines as pesticides |
| GB9123916D0 (en) * | 1991-11-11 | 1992-01-02 | Wellcome Found | Heterocyclic compounds |
| US6110962A (en) | 1998-05-12 | 2000-08-29 | American Home Products Corporation | 11-aryl-benzo[B]naphtho[2,3-D]furans and 11-aryl-benzo[B]naphtho[2,3-D]thiophenes useful in the treatment of insulin resistance and hyperglycemia |
| US6121271A (en) | 1998-05-12 | 2000-09-19 | American Home Products Corporation | Naphtho[2,3-B]heteroar-4-yl derivatives |
| ATE282041T1 (de) | 2001-02-23 | 2004-11-15 | Ortho Mcneil Pharm Inc | Aminomethylpyrrolochinazoline als thrombinrezeptor-antagonist |
| US7226915B2 (en) * | 2003-05-15 | 2007-06-05 | Hoffmann-La Roche Inc. | Diaminopyrroloquinazolines compounds as protein tyrosine phosphatase inhibitors |
-
2004
- 2004-04-30 US US10/836,507 patent/US7262297B2/en not_active Expired - Fee Related
- 2004-05-07 AT AT04731581T patent/ATE389657T1/de active
- 2004-05-07 JP JP2006529760A patent/JP4551401B2/ja not_active Expired - Fee Related
- 2004-05-07 PL PL04731581T patent/PL1628979T3/pl unknown
- 2004-05-07 RU RU2005138897/04A patent/RU2345079C2/ru not_active IP Right Cessation
- 2004-05-07 CN CNB2004800132363A patent/CN100344629C/zh not_active Expired - Fee Related
- 2004-05-07 MX MXPA05012207A patent/MXPA05012207A/es active IP Right Grant
- 2004-05-07 WO PCT/EP2004/004896 patent/WO2004101568A1/en active IP Right Grant
- 2004-05-07 BR BRPI0410384-0A patent/BRPI0410384A/pt not_active IP Right Cessation
- 2004-05-07 EP EP04731581A patent/EP1628979B1/de not_active Expired - Lifetime
- 2004-05-07 KR KR1020057021803A patent/KR100754624B1/ko not_active IP Right Cessation
- 2004-05-07 CA CA002523960A patent/CA2523960C/en not_active Expired - Fee Related
- 2004-05-07 AU AU2004238512A patent/AU2004238512B2/en not_active Ceased
- 2004-05-07 DE DE602004012552T patent/DE602004012552T2/de not_active Expired - Lifetime
- 2004-05-07 ES ES04731581T patent/ES2301989T3/es not_active Expired - Lifetime
-
2007
- 2007-06-27 US US11/823,776 patent/US20070270445A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| MXPA05012207A (es) | 2006-02-08 |
| US7262297B2 (en) | 2007-08-28 |
| RU2345079C2 (ru) | 2009-01-27 |
| CN100344629C (zh) | 2007-10-24 |
| EP1628979A1 (de) | 2006-03-01 |
| BRPI0410384A (pt) | 2006-07-18 |
| DE602004012552T2 (de) | 2009-04-30 |
| CN1791603A (zh) | 2006-06-21 |
| CA2523960A1 (en) | 2004-11-25 |
| KR100754624B1 (ko) | 2007-09-05 |
| RU2005138897A (ru) | 2007-06-27 |
| PL1628979T3 (pl) | 2008-08-29 |
| ATE389657T1 (de) | 2008-04-15 |
| AU2004238512B2 (en) | 2007-07-19 |
| US20040235872A1 (en) | 2004-11-25 |
| JP4551401B2 (ja) | 2010-09-29 |
| KR20060012619A (ko) | 2006-02-08 |
| EP1628979B1 (de) | 2008-03-19 |
| JP2006528216A (ja) | 2006-12-14 |
| ES2301989T3 (es) | 2008-07-01 |
| CA2523960C (en) | 2009-09-22 |
| AU2004238512A1 (en) | 2004-11-25 |
| WO2004101568A1 (en) | 2004-11-25 |
| US20070270445A1 (en) | 2007-11-22 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition |