WO2005019446A3 - Novel form of protein tyrosine phosphatases and methods for identifying molecules binding thereto - Google Patents

Novel form of protein tyrosine phosphatases and methods for identifying molecules binding thereto Download PDF

Info

Publication number
WO2005019446A3
WO2005019446A3 PCT/US2004/017710 US2004017710W WO2005019446A3 WO 2005019446 A3 WO2005019446 A3 WO 2005019446A3 US 2004017710 W US2004017710 W US 2004017710W WO 2005019446 A3 WO2005019446 A3 WO 2005019446A3
Authority
WO
WIPO (PCT)
Prior art keywords
protein tyrosine
methods
novel form
tyrosine phosphatases
identifying molecules
Prior art date
Application number
PCT/US2004/017710
Other languages
French (fr)
Other versions
WO2005019446A2 (en
Inventor
Nicholas K Tonks
David Barford
Benjamin G Neel
Andrew J Flint
Original Assignee
Nicholas K Tonks
David Barford
Benjamin G Neel
Andrew J Flint
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nicholas K Tonks, David Barford, Benjamin G Neel, Andrew J Flint filed Critical Nicholas K Tonks
Publication of WO2005019446A2 publication Critical patent/WO2005019446A2/en
Publication of WO2005019446A3 publication Critical patent/WO2005019446A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)

Abstract

The invention relates to novel forms of protein tyrosine phosphatase enzymes and methods of using such enzymes to identify agents or compounds capable of altering or modulating the activity of the native protein tyrosine phosphatase.
PCT/US2004/017710 2003-06-04 2004-06-04 Novel form of protein tyrosine phosphatases and methods for identifying molecules binding thereto WO2005019446A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US47603603P 2003-06-04 2003-06-04
US60/476,036 2003-06-04

Publications (2)

Publication Number Publication Date
WO2005019446A2 WO2005019446A2 (en) 2005-03-03
WO2005019446A3 true WO2005019446A3 (en) 2005-07-14

Family

ID=34215800

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2004/017710 WO2005019446A2 (en) 2003-06-04 2004-06-04 Novel form of protein tyrosine phosphatases and methods for identifying molecules binding thereto

Country Status (1)

Country Link
WO (1) WO2005019446A2 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010126590A1 (en) * 2009-04-27 2010-11-04 Cold Spring Harbor Laboratory Ptp1b inhibitors
GB201106225D0 (en) * 2011-04-13 2011-05-25 Glaxosmithkline Biolog Sa Fermentation process

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004087905A2 (en) * 2003-04-02 2004-10-14 Astex Therapeutics Limited Protein tyrosine phosphatase and inhibitors thereof

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004087905A2 (en) * 2003-04-02 2004-10-14 Astex Therapeutics Limited Protein tyrosine phosphatase and inhibitors thereof

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
BARRETT WILLIAM C ET AL: "Regulation of PTP1B via glutathionylation of the active site cysteine 215", BIOCHEMISTRY, vol. 38, no. 20, 18 May 1999 (1999-05-18), pages 6699 - 6705, XP002308664, ISSN: 0006-2960 *
LEE SEUNG-ROCK ET AL: "Reversible inactivation of protein-tyrosine phosphatase 1B in A431 cells stimulated with epidermal growth factor", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 273, no. 25, 19 June 1998 (1998-06-19), pages 15366 - 15372, XP002308665, ISSN: 0021-9258 *
MENG TZU-CHING ET AL: "Regulation of insulin signaling through reversible oxidation of the protein-tyrosine phosphatases TC45 and PTP1B", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 279, no. 36, 3 September 2004 (2004-09-03), pages 37716 - 37725, XP002308662, ISSN: 0021-9258 *
MENG TZU-CHING ET AL: "Reversible oxidation and inactivation of protein tyrosine phosphatases in vivo", MOLECULAR CELL, vol. 9, no. 2, February 2002 (2002-02-01), pages 387 - 399, XP002308663, ISSN: 1097-2765 *
MONTFORT VAN R L M ET AL: "Oxidation state of the active-site cysteine in protein tyrosine phosphatase 1B", NATURE, MACMILLAN JOURNALS LTD. LONDON, GB, vol. 423, 12 June 2003 (2003-06-12), pages 773 - 777, XP002298319, ISSN: 0028-0836 *
SALMEEN A ET AL: "Redox regulation of protein tyrosine phosphatase 1B involves a sulphenyl-amide intermediate", NATURE, MACMILLAN JOURNALS LTD. LONDON, GB, vol. 423, 12 June 2003 (2003-06-12), pages 769 - 773, XP002298318, ISSN: 0028-0836 *

Also Published As

Publication number Publication date
WO2005019446A2 (en) 2005-03-03

Similar Documents

Publication Publication Date Title
WO2003022028A3 (en) Methods, reagents, kits and apparatus for protein function analysis
WO2005035551A3 (en) Inhibitors of proteins that bind phosphorylated molecules
AU2002359522A1 (en) Compositions and methods of selective nucleic acid isolation
WO2005020921A3 (en) C-kit modulators and methods of use
AU7301898A (en) Survivin, a protein that inhibits cellular apoptosis, and its modulation
WO2003090691A3 (en) Method and compositions for identifying anti-hiv therapeutic compounds
DK1261368T3 (en) Crosslinked, non-fungal lipase-containing composition and methods for its use
WO1999054459A8 (en) Nucleic acid molecules with novel chemical compositions capable of modulating gene expression
WO2004047760A3 (en) Novel chemical compounds
WO2001036641A3 (en) DOUBLE-STRANDED RNA RECEPTOR (dsRNA-R) AND METHODS RELATING THERETO
WO2002065134A3 (en) Modulators of p53-p300 interactions and screening methods therefor
TW200700089A (en) Recombinant protein comprising starch binding domain and use thereof
ATE311388T1 (en) PYRIMIDOTRIAZINES AS PHOSPHATASE INHIBITORS
WO2008014401A3 (en) Methods for identifying modulators of rgs21 activity, compositions comprising an rgs21 modulator, and methods of use thereof to modulate taste sensation
WO2005089730A3 (en) Dna pkinase inhibitors for treating cancer and diabetes
DE60029429D1 (en) METHOD AND COMPOSITIONS FOR MONITORING THE MODIFICATION OF NATURAL BINDING PARTNERS
WO1997008934A3 (en) Aryl acrylic acid derivatives useful as protein tyrosine phosphatase inhibitors
WO2009100254A3 (en) Protein tyrosine phosphatase inhibitors
WO2005019446A3 (en) Novel form of protein tyrosine phosphatases and methods for identifying molecules binding thereto
WO2004042352A3 (en) Substrates of n-end rule ubiquitylation and methods for measuring the ubiquitylation of these substrates
NO20051301L (en) Proteintyrosinforfataseinhibitorer
WO2003014142A3 (en) Phosphorylated histone h2b as an apoptosis marker
WO2008008472A3 (en) Methods and compositions for modulating synapse formation
WO2006072048A3 (en) Compositions and methods for identifying modulators of hausp
WO2003074007A3 (en) Modulators of leukocyte activation, compositions, and methods of use

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A2

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BW BY BZ CA CH CN CO CR CU CZ DE DK DM DZ EC EE EG ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NA NI NO NZ OM PG PH PL PT RO RU SC SD SE SG SK SL SY TJ TM TN TR TT TZ UA UG US UZ VC VN YU ZA ZM ZW

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): GM KE LS MW MZ NA SD SL SZ TZ UG ZM ZW AM AZ BY KG KZ MD RU TJ TM AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LU MC NL PL PT RO SE SI SK TR BF BJ CF CG CI CM GA GN GQ GW ML MR NE SN TD TG

121 Ep: the epo has been informed by wipo that ep was designated in this application
122 Ep: pct application non-entry in european phase