DE602004011548T2 - 4-aminochinolin-3-carbonsäureamid-derivate als pde4-hemmer - Google Patents
4-aminochinolin-3-carbonsäureamid-derivate als pde4-hemmer Download PDFInfo
- Publication number
- DE602004011548T2 DE602004011548T2 DE602004011548T DE602004011548T DE602004011548T2 DE 602004011548 T2 DE602004011548 T2 DE 602004011548T2 DE 602004011548 T DE602004011548 T DE 602004011548T DE 602004011548 T DE602004011548 T DE 602004011548T DE 602004011548 T2 DE602004011548 T2 DE 602004011548T2
- Authority
- DE
- Germany
- Prior art keywords
- alkyl
- quinolinecarboxamide
- optionally substituted
- methyl
- sulfonyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
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- 239000002587 phosphodiesterase IV inhibitor Substances 0.000 title description 10
- 229940123932 Phosphodiesterase 4 inhibitor Drugs 0.000 title description 9
- 239000002253 acid Substances 0.000 title description 6
- 150000001875 compounds Chemical class 0.000 claims description 158
- 125000000217 alkyl group Chemical group 0.000 claims description 78
- 150000003839 salts Chemical class 0.000 claims description 50
- -1 2,3-dihydro-1-benzofuran-4-ylamino Chemical group 0.000 claims description 48
- 239000001257 hydrogen Substances 0.000 claims description 44
- 229910052739 hydrogen Inorganic materials 0.000 claims description 44
- 125000000623 heterocyclic group Chemical group 0.000 claims description 41
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 39
- 229910052757 nitrogen Inorganic materials 0.000 claims description 37
- 238000000034 method Methods 0.000 claims description 33
- 125000001424 substituent group Chemical group 0.000 claims description 32
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical group N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims description 29
- 125000003545 alkoxy group Chemical group 0.000 claims description 28
- 125000003118 aryl group Chemical group 0.000 claims description 27
- 239000008194 pharmaceutical composition Substances 0.000 claims description 27
- 238000011282 treatment Methods 0.000 claims description 26
- 125000001072 heteroaryl group Chemical group 0.000 claims description 24
- 125000004433 nitrogen atom Chemical group N* 0.000 claims description 19
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 16
- 125000005842 heteroatom Chemical group 0.000 claims description 14
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims description 12
- 229910052760 oxygen Inorganic materials 0.000 claims description 12
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- 125000003453 indazolyl group Chemical group N1N=C(C2=C1C=CC=C2)* 0.000 claims description 6
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- 125000004076 pyridyl group Chemical group 0.000 claims description 4
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Classifications
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- C—CHEMISTRY; METALLURGY
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- C04B—LIME, MAGNESIA; SLAG; CEMENTS; COMPOSITIONS THEREOF, e.g. MORTARS, CONCRETE OR LIKE BUILDING MATERIALS; ARTIFICIAL STONE; CERAMICS; REFRACTORIES; TREATMENT OF NATURAL STONE
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- C04B35/63—Preparing or treating the powders individually or as batches ; preparing or treating macroscopic reinforcing agents for ceramic products, e.g. fibres; mechanical aspects section B using additives specially adapted for forming the products, e.g.. binder binders
- C04B35/632—Organic additives
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- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
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Landscapes
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- Chemical Kinetics & Catalysis (AREA)
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- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pulmonology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Ceramic Engineering (AREA)
- Manufacturing & Machinery (AREA)
- Pain & Pain Management (AREA)
- Dermatology (AREA)
- Immunology (AREA)
- Inorganic Chemistry (AREA)
- Structural Engineering (AREA)
- Materials Engineering (AREA)
- Heart & Thoracic Surgery (AREA)
- Rheumatology (AREA)
- Psychiatry (AREA)
- Urology & Nephrology (AREA)
- Cardiology (AREA)
- Hospice & Palliative Care (AREA)
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- Orthopedic Medicine & Surgery (AREA)
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0322722.0A GB0322722D0 (en) | 2003-09-27 | 2003-09-27 | Compounds |
| GB0322722 | 2003-09-27 | ||
| PCT/EP2004/010844 WO2005030212A1 (en) | 2003-09-27 | 2004-09-23 | 4-aminoquinoline-3-carboxamide derivatives as pde4 inhibitors |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE602004011548D1 DE602004011548D1 (de) | 2008-03-13 |
| DE602004011548T2 true DE602004011548T2 (de) | 2009-01-29 |
Family
ID=29287002
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE602004011548T Expired - Fee Related DE602004011548T2 (de) | 2003-09-27 | 2004-09-23 | 4-aminochinolin-3-carbonsäureamid-derivate als pde4-hemmer |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US20080096884A1 (enExample) |
| EP (1) | EP1673086B1 (enExample) |
| JP (1) | JP2007506703A (enExample) |
| AR (1) | AR045824A1 (enExample) |
| AT (1) | ATE384530T1 (enExample) |
| DE (1) | DE602004011548T2 (enExample) |
| ES (1) | ES2298806T3 (enExample) |
| GB (1) | GB0322722D0 (enExample) |
| TW (1) | TW200526584A (enExample) |
| WO (1) | WO2005030212A1 (enExample) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI328009B (en) * | 2003-05-21 | 2010-08-01 | Glaxo Group Ltd | Quinoline derivatives as phosphodiesterase inhibitors |
| GB0601951D0 (en) | 2006-01-31 | 2006-03-15 | Novartis Ag | Organic compounds |
| GB0605462D0 (en) * | 2006-03-17 | 2006-04-26 | Glaxo Group Ltd | Novel compounds |
| WO2008052734A1 (en) | 2006-10-30 | 2008-05-08 | Novartis Ag | Heterocyclic compounds as antiinflammatory agents |
| JP5584138B2 (ja) | 2008-01-11 | 2014-09-03 | ノバルティス アーゲー | キナーゼ阻害剤としてのピリミジン類 |
| EP2379076B1 (en) * | 2008-12-23 | 2014-11-12 | The Trustees of Columbia University in the City of New York | Phosphodiesterase inhibitors and uses thereof |
| WO2010097248A1 (en) | 2009-01-13 | 2010-09-02 | Glaxo Group Limited | Pyrimidinecarboxamide derivatives as inhibitors of syk kinase |
| US8367829B2 (en) | 2010-05-10 | 2013-02-05 | Gilead Sciences, Inc. | Bi-functional pyrazolopyridine compounds |
| US8394829B2 (en) | 2010-05-10 | 2013-03-12 | Gilead Sciences, Inc. | Bi-functional quinoline analogs |
| UY33597A (es) | 2010-09-09 | 2012-04-30 | Irm Llc | Compuestos y composiciones como inhibidores de la trk |
| WO2012034095A1 (en) | 2010-09-09 | 2012-03-15 | Irm Llc | Compounds and compositions as trk inhibitors |
| CA2828219A1 (en) | 2011-02-25 | 2012-08-30 | Irm Llc | Pyrazolo [1,5-a] pyridines as trk inhibitors |
| BR112015019276A2 (pt) | 2013-02-19 | 2017-07-18 | Pfizer | compostos de azabenzimidazol como inibidores de isoenzimas de pde4 para o tratamento de distúrbios do snc e outros distúrbios |
| US10131669B2 (en) | 2014-07-24 | 2018-11-20 | Pfizer Inc. | Pyrazolopyrimidine compounds |
| EA031201B1 (ru) | 2014-08-06 | 2018-11-30 | Пфайзер Инк. | Соединения имидазопиридазина |
| MA41140A (fr) | 2014-12-12 | 2017-10-17 | Cancer Research Tech Ltd | Dérivés de 2,4-dioxo-quinazoline-6-sulfonamide en tant qu'inhibiteurs de la parg |
| MA41179A (fr) | 2014-12-19 | 2017-10-24 | Cancer Research Tech Ltd | Composés inhibiteurs de parg |
| BR112018006873A2 (pt) | 2015-10-05 | 2018-11-06 | The Trustees Of Columbia University In The City Of New York | ativadores do fluxo autofágico e fosfolipase d e depuração de agregados de proteína incluindo tau e tratamento de proteinopatias |
| TW202345809A (zh) | 2022-03-23 | 2023-12-01 | 美商愛德亞生物科學公司 | 作為parg抑制劑之經哌取代的吲唑化合物 |
| TW202430172A (zh) * | 2023-01-17 | 2024-08-01 | 大陸商瑞石生物醫藥有限公司 | Ｐｄｅ４抑制劑、其製備方法及其在醫藥上的應用 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR920701162A (ko) * | 1990-03-28 | 1992-08-11 | 오츠카 아끼히코 | 퀴놀린 유도체, 당해 유도체를 함유하는 항궤양제 및 당해 유도체의 제조방법 |
| AU722662B2 (en) * | 1996-05-20 | 2000-08-10 | Darwin Discovery Limited | Quinoline sulfonamides as TNF inhibitors and as PDE-IV inhibitors |
| ATE303993T1 (de) * | 1997-12-22 | 2005-09-15 | Pharmacia & Upjohn Co Llc | 4-hydroxychinolin-3-carboxamide und hydrazide als antivirale wirkstoffe |
| US6576644B2 (en) * | 2000-09-06 | 2003-06-10 | Bristol-Myers Squibb Co. | Quinoline inhibitors of cGMP phosphodiesterase |
| SE0101675D0 (sv) * | 2001-05-11 | 2001-05-11 | Astrazeneca Ab | Novel composition |
| JO2311B1 (en) * | 2001-08-29 | 2005-09-12 | ميرك فروست كندا ليمتد | Alkyl inhibitors Ariel phosphodiesterase-4 |
-
2003
- 2003-09-27 GB GBGB0322722.0A patent/GB0322722D0/en not_active Ceased
-
2004
- 2004-09-23 ES ES04765656T patent/ES2298806T3/es not_active Expired - Lifetime
- 2004-09-23 DE DE602004011548T patent/DE602004011548T2/de not_active Expired - Fee Related
- 2004-09-23 WO PCT/EP2004/010844 patent/WO2005030212A1/en not_active Ceased
- 2004-09-23 US US10/572,914 patent/US20080096884A1/en not_active Abandoned
- 2004-09-23 JP JP2006527374A patent/JP2007506703A/ja active Pending
- 2004-09-23 EP EP04765656A patent/EP1673086B1/en not_active Expired - Lifetime
- 2004-09-23 AT AT04765656T patent/ATE384530T1/de not_active IP Right Cessation
- 2004-09-24 TW TW093129113A patent/TW200526584A/zh unknown
- 2004-09-24 AR ARP040103472A patent/AR045824A1/es not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| DE602004011548D1 (de) | 2008-03-13 |
| AR045824A1 (es) | 2005-11-16 |
| US20080096884A1 (en) | 2008-04-24 |
| ATE384530T1 (de) | 2008-02-15 |
| JP2007506703A (ja) | 2007-03-22 |
| WO2005030212A1 (en) | 2005-04-07 |
| GB0322722D0 (en) | 2003-10-29 |
| EP1673086B1 (en) | 2008-01-23 |
| EP1673086A1 (en) | 2006-06-28 |
| ES2298806T3 (es) | 2008-05-16 |
| TW200526584A (en) | 2005-08-16 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8381 | Inventor (new situation) |
Inventor name: WOODROW, MICHAEL, STEVENAGE, HERTFORDSHIRE, GB Inventor name: REDGRAVE, ALISON, JUDITH, STEVENAGE, HERTFORDS, GB Inventor name: LUNNISS, CHRISTOPHER, JAMES, STEVENAGE, HERTFO, GB Inventor name: ELDRED, COLIN, STEVENAGE,, HERTFORDSHIRE, GB Inventor name: EDLIN, CHRISTOPHER, D., STEVENAGE, HERTFORDSHI, GB Inventor name: REDFERN, TRACY, JANE, STEVENAGE, HERTFORDSHIRE, GB Inventor name: KEELING, STEVEN, PHILIP, STEVENAGE, HERTFORDSH, GB |
|
| 8364 | No opposition during term of opposition | ||
| 8339 | Ceased/non-payment of the annual fee |