DE602004002856D1 - Dynamische signalauswahl in einem chromatographie-/massenspektometrie-/massenspektrometriesystem - Google Patents

Dynamische signalauswahl in einem chromatographie-/massenspektometrie-/massenspektrometriesystem

Info

Publication number
DE602004002856D1
DE602004002856D1 DE602004002856T DE602004002856T DE602004002856D1 DE 602004002856 D1 DE602004002856 D1 DE 602004002856D1 DE 602004002856 T DE602004002856 T DE 602004002856T DE 602004002856 T DE602004002856 T DE 602004002856T DE 602004002856 D1 DE602004002856 D1 DE 602004002856D1
Authority
DE
Germany
Prior art keywords
mass
output
ion
mass spectrometer
current
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE602004002856T
Other languages
English (en)
Other versions
DE602004002856T2 (de
Inventor
Blanc Yves Le
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Applied Biosystems Canada Ltd
Nordion Inc
Original Assignee
MDS Inc
Applera Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by MDS Inc, Applera Corp filed Critical MDS Inc
Publication of DE602004002856D1 publication Critical patent/DE602004002856D1/de
Application granted granted Critical
Publication of DE602004002856T2 publication Critical patent/DE602004002856T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/0027—Methods for using particle spectrometers
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/86—Signal analysis
    • G01N30/8675—Evaluation, i.e. decoding of the signal into analytical information
    • G01N30/8689—Peak purity of co-eluting compounds
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/004—Combinations of spectrometers, tandem spectrometers, e.g. MS/MS, MSn
    • H01J49/0045—Combinations of spectrometers, tandem spectrometers, e.g. MS/MS, MSn characterised by the fragmentation or other specific reaction
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/62—Detectors specially adapted therefor
    • G01N30/72—Mass spectrometers
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/86—Signal analysis
    • G01N30/8624—Detection of slopes or peaks; baseline correction
    • G01N30/8641—Baseline

Landscapes

  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Library & Information Science (AREA)
  • Physics & Mathematics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
  • Electron Tubes For Measurement (AREA)
DE602004002856T 2003-04-09 2004-04-08 Dynamische signalauswahl in einem chromatographie-/massenspektometrie-/massenspektrometriesystem Expired - Lifetime DE602004002856T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US46112603P 2003-04-09 2003-04-09
US461126P 2003-04-09
PCT/CA2004/000540 WO2004090933A2 (en) 2003-04-09 2004-04-08 Dynamic signal selection in chromatography/mass spectrometry/mass spectrometry system

Publications (2)

Publication Number Publication Date
DE602004002856D1 true DE602004002856D1 (de) 2006-11-30
DE602004002856T2 DE602004002856T2 (de) 2007-05-16

Family

ID=33159818

Family Applications (1)

Application Number Title Priority Date Filing Date
DE602004002856T Expired - Lifetime DE602004002856T2 (de) 2003-04-09 2004-04-08 Dynamische signalauswahl in einem chromatographie-/massenspektometrie-/massenspektrometriesystem

Country Status (7)

Country Link
US (1) US7009174B2 (de)
EP (1) EP1611595B1 (de)
JP (1) JP4676955B2 (de)
AT (1) ATE343221T1 (de)
CA (1) CA2518568C (de)
DE (1) DE602004002856T2 (de)
WO (1) WO2004090933A2 (de)

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SI1569907T1 (sl) * 2002-12-13 2016-06-30 Ym Biosciences Australia Pty Ltd Na nikotinamidu osnovani kinazni inhibitorji
US7498568B2 (en) 2005-04-29 2009-03-03 Agilent Technologies, Inc. Real-time analysis of mass spectrometry data for identifying peptidic data of interest
US7297941B2 (en) * 2005-06-02 2007-11-20 Thermo Finnigan Llc Methods for improved data dependent acquisition
WO2006130983A1 (en) * 2005-06-08 2006-12-14 Mds Inc. Doing Business Through Its Mds Sciex Division Dynamic background signal exclusion in chromatography/mass spectrometry data-dependent data acquisition
TWI422044B (zh) * 2005-06-30 2014-01-01 Cree Inc 封裝發光裝置之晶片尺度方法及經晶片尺度封裝之發光裝置
US7417223B2 (en) * 2005-10-28 2008-08-26 Mds Inc. Method, system and computer software product for specific identification of reaction pairs associated by specific neutral differences
WO2007079589A1 (en) * 2006-01-11 2007-07-19 Mds Inc., Doing Business Through Its Mds Sciex Division Fragmenting ions in mass spectrometry
JP4577266B2 (ja) * 2006-05-16 2010-11-10 株式会社島津製作所 クロマトグラフ質量分析装置
US8670941B2 (en) * 2006-08-18 2014-03-11 Huntington Medical Research Institutes Methods of determining levels of free amino acids and dipeptides and diagnosing Alzheimer's disease
CA2657809C (en) * 2006-08-25 2013-01-22 Thermo Finnigan Llc Data-dependent selection of dissociation type in a mass spectrometer
US7511267B2 (en) * 2006-11-10 2009-03-31 Thermo Finnigan Llc Data-dependent accurate mass neutral loss analysis
US7943899B2 (en) * 2006-12-21 2011-05-17 Thermo Finnigan Llc Method and apparatus for identifying the apex of a chromatographic peak
EP2232524A4 (de) * 2007-12-04 2016-06-08 Dh Technologies Dev Pte Ltd Systeme und verfahren zum analysieren von substanzen unter verwendung eines massenspektrometers
US7982181B1 (en) 2008-01-15 2011-07-19 Thermo Finnigan Llc Methods for identifying an apex for improved data-dependent acquisition
US8304719B2 (en) * 2009-02-22 2012-11-06 Xin Wang Precise and thorough background subtraction
US8987662B2 (en) * 2009-05-14 2015-03-24 Agilent Technologies, Inc. System and method for performing tandem mass spectrometry analysis
CA2763261A1 (en) * 2009-05-27 2010-12-02 Thermo Finnigan Llc Methods for identifying an apex for improved data-dependent acquisition
GB0919870D0 (en) * 2009-11-13 2009-12-30 Micromass Ltd A method to detect and quantitatively profile organic species using a mass spectrometer
JP5505110B2 (ja) * 2010-06-14 2014-05-28 株式会社島津製作所 クロマトグラフ質量分析装置
US20140374583A1 (en) * 2013-06-24 2014-12-25 Agilent Technologies, Inc. Electron ionization (ei) utilizing different ei energies
CN107148572A (zh) * 2014-10-30 2017-09-08 Dh科技发展私人贸易有限公司 用于选择离子进行离子碎裂的方法和系统
US10176977B2 (en) 2014-12-12 2019-01-08 Agilent Technologies, Inc. Ion source for soft electron ionization and related systems and methods
US10217619B2 (en) * 2015-03-12 2019-02-26 Thermo Finnigan Llc Methods for data-dependent mass spectrometry of mixed intact protein analytes
US9779922B1 (en) * 2017-01-17 2017-10-03 Advion Inc. Generation of discovery ion currents and mass spectrometry and uses thereof
MX2022009411A (es) * 2020-01-31 2022-08-25 Regeneron Pharma Identificacion de compuestos de alta confianza mediante cromatografia de liquidos-espectrometria de masas.
GB2619405B (en) * 2023-04-12 2024-05-08 Methuselah Health Uk Ltd Mass spectrometry

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JPS649359A (en) * 1987-06-30 1989-01-12 Shimadzu Corp Mass spectrograph
JPH087190B2 (ja) * 1987-10-31 1996-01-29 株式会社島津製作所 ガスクロマトグラフ質量分析計のスペクトル表示装置
JPH0943199A (ja) * 1995-07-26 1997-02-14 Shimadzu Corp Ｇｃ／ｍｓにおける同定方法
JP4057664B2 (ja) * 1996-05-31 2008-03-05 株式会社島津製作所 クロマトグラフ／質量分析装置のデータ処理装置
JP3509470B2 (ja) * 1997-05-16 2004-03-22 株式会社日立製作所 質量分析方法及び質量分析装置
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CA2255122C (en) * 1998-12-04 2007-10-09 Mds Inc. Improvements in ms/ms methods for a quadrupole/time of flight tandem mass spectrometer
US20020009394A1 (en) 1999-04-02 2002-01-24 Hubert Koster Automated process line
US6586727B2 (en) * 2000-06-09 2003-07-01 Micromass Limited Methods and apparatus for mass spectrometry
US7158862B2 (en) * 2000-06-12 2007-01-02 The Arizona Board Of Regents On Behalf Of The University Of Arizona Method and system for mining mass spectral data
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US6900431B2 (en) * 2003-03-21 2005-05-31 Predicant Biosciences, Inc. Multiplexed orthogonal time-of-flight mass spectrometer

Also Published As

Publication number Publication date
EP1611595A2 (de) 2006-01-04
US7009174B2 (en) 2006-03-07
JP2006522999A (ja) 2006-10-05
CA2518568A1 (en) 2004-10-21
US20040251409A1 (en) 2004-12-16
JP4676955B2 (ja) 2011-04-27
DE602004002856T2 (de) 2007-05-16
WO2004090933A2 (en) 2004-10-21
ATE343221T1 (de) 2006-11-15
CA2518568C (en) 2012-09-25
WO2004090933A3 (en) 2005-07-21
EP1611595B1 (de) 2006-10-18

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Legal Events

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8327 Change in the person/name/address of the patent owner

Owner name: APPLIED BIOSYSTEMS (CANADA) LTD., TORONTO, ONT, CA

Owner name: MDS INC. DOING BUSINESS THROUGH ITS MDS SCIEX , CA