DE60139959D1 - Nukleinsäureadjuvantien - Google Patents
NukleinsäureadjuvantienInfo
- Publication number
- DE60139959D1 DE60139959D1 DE60139959T DE60139959T DE60139959D1 DE 60139959 D1 DE60139959 D1 DE 60139959D1 DE 60139959 T DE60139959 T DE 60139959T DE 60139959 T DE60139959 T DE 60139959T DE 60139959 D1 DE60139959 D1 DE 60139959D1
- Authority
- DE
- Germany
- Prior art keywords
- nucleic acid
- molecules
- truncated
- coding region
- acid sequence
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 150000007523 nucleic acids Chemical class 0.000 abstract 5
- 108091026890 Coding region Proteins 0.000 abstract 2
- 108091028043 Nucleic acid sequence Proteins 0.000 abstract 2
- 239000000203 mixture Substances 0.000 abstract 2
- 108020004707 nucleic acids Proteins 0.000 abstract 2
- 102000039446 nucleic acids Human genes 0.000 abstract 2
- OTLLEIBWKHEHGU-UHFFFAOYSA-N 2-[5-[[5-(6-aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy]-3,4-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-3,5-dihydroxy-4-phosphonooxyhexanedioic acid Chemical compound C1=NC=2C(N)=NC=NC=2N1C(C(C1O)O)OC1COC1C(CO)OC(OC(C(O)C(OP(O)(O)=O)C(O)C(O)=O)C(O)=O)C(O)C1O OTLLEIBWKHEHGU-UHFFFAOYSA-N 0.000 abstract 1
- 239000000427 antigen Substances 0.000 abstract 1
- 102000036639 antigens Human genes 0.000 abstract 1
- 108091007433 antigens Proteins 0.000 abstract 1
- 230000001580 bacterial effect Effects 0.000 abstract 1
- 230000002708 enhancing effect Effects 0.000 abstract 1
- 239000002095 exotoxin Substances 0.000 abstract 1
- 231100000776 exotoxin Toxicity 0.000 abstract 1
- 230000028993 immune response Effects 0.000 abstract 1
- 239000013598 vector Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55544—Bacterial toxins
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Peptides Or Proteins (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US72431500A | 2000-11-27 | 2000-11-27 | |
| PCT/US2001/043151 WO2003004055A2 (en) | 2000-11-27 | 2001-11-26 | Nucleic acid adjuvants |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE60139959D1 true DE60139959D1 (de) | 2009-10-29 |
Family
ID=24909936
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE60139959T Expired - Lifetime DE60139959D1 (de) | 2000-11-27 | 2001-11-26 | Nukleinsäureadjuvantien |
Country Status (16)
| Country | Link |
|---|---|
| EP (1) | EP1379273B1 (https=) |
| JP (1) | JP4221289B2 (https=) |
| KR (1) | KR20040045391A (https=) |
| CN (1) | CN1317034C (https=) |
| AT (1) | ATE442858T1 (https=) |
| AU (1) | AU2001297988B2 (https=) |
| BR (1) | BR0115646A (https=) |
| CA (1) | CA2429708A1 (https=) |
| DE (1) | DE60139959D1 (https=) |
| DK (1) | DK1379273T3 (https=) |
| ES (1) | ES2332261T3 (https=) |
| IL (2) | IL156041A0 (https=) |
| MX (1) | MXPA03004638A (https=) |
| NZ (1) | NZ526175A (https=) |
| PT (1) | PT1379273E (https=) |
| WO (1) | WO2003004055A2 (https=) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2005035771A2 (en) | 2003-10-10 | 2005-04-21 | Powderject Vaccines, Inc. | Nucleic acid constructs |
| AU2005212479B2 (en) | 2004-02-11 | 2009-09-10 | Msd Italia S.R.L. | Carcinoembryonic antigen fusion proteins and uses thereof |
| GB0507997D0 (en) * | 2005-02-01 | 2005-05-25 | Powderject Vaccines Inc | Nucleic acid constructs |
| US8389686B2 (en) | 2008-05-07 | 2013-03-05 | Osaka University | Noncovalent collagen crosslinking agent |
| EP2616045B1 (en) | 2010-09-15 | 2017-10-25 | Randall J. Mrsny | Systems and methods of delivery of bioactive agents using bacterial toxin-derived transport sequences |
| US11246915B2 (en) | 2010-09-15 | 2022-02-15 | Applied Molecular Transport Inc. | Cholix toxin-derived fusion molecules for oral delivery of biologically active cargo |
| CN103060253A (zh) * | 2013-01-24 | 2013-04-24 | 麻丽丹 | 霍乱弧菌ctxAB基因的质粒克隆菌株以及制备方法和应用 |
| PL3139965T3 (pl) | 2014-05-07 | 2022-01-31 | Applied Molecular Transport Inc. | Cząsteczki fuzyjne pochodzące z toksyny cholix do doustnego dostarczania ładunku biologicznie czynnego |
| EP4082558B1 (en) | 2018-03-08 | 2023-08-23 | Applied Molecular Transport Inc. | Toxin-derived delivery constructs for oral delivery |
| KR20210110294A (ko) | 2018-11-07 | 2021-09-07 | 어플라이드 몰레큘라 트랜스포트 인크. | 통과세포외배출용 전달 구조체 및 관련 방법 |
| CN114599665A (zh) | 2019-08-16 | 2022-06-07 | 应用分子转运公司 | 组合物、制剂及白细胞介素产生和纯化 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5219740A (en) | 1987-02-13 | 1993-06-15 | Fred Hutchinson Cancer Research Center | Retroviral gene transfer into diploid fibroblasts for gene therapy |
| TW404844B (en) | 1993-04-08 | 2000-09-11 | Oxford Biosciences Ltd | Needleless syringe |
| GB9416663D0 (en) | 1994-08-17 | 1994-10-12 | Oxford Bioscience Limited | Particle delivery |
| CA2199417C (en) | 1994-10-24 | 2008-07-08 | Brian John Bellhouse | Particle delivery |
| GB9426379D0 (en) | 1994-12-23 | 1995-03-01 | Oxford Biosciences Ltd | Particle delivery |
| US6056960A (en) * | 1995-06-07 | 2000-05-02 | Kaslow; Harvey R. | Compositions exhibiting ADP-ribosyltransferase activity and methods for the preparation and use thereof |
| GB9612629D0 (en) | 1996-06-17 | 1996-08-21 | Oxford Biosciences Ltd | Method for providing dense particle compositions for use in transdermal particle delivery |
| US5980898A (en) * | 1996-11-14 | 1999-11-09 | The United States Of America As Represented By The U.S. Army Medical Research & Material Command | Adjuvant for transcutaneous immunization |
-
2001
- 2001-11-26 AT AT01274277T patent/ATE442858T1/de active
- 2001-11-26 ES ES01274277T patent/ES2332261T3/es not_active Expired - Lifetime
- 2001-11-26 CA CA002429708A patent/CA2429708A1/en not_active Abandoned
- 2001-11-26 IL IL15604101A patent/IL156041A0/xx unknown
- 2001-11-26 NZ NZ526175A patent/NZ526175A/en unknown
- 2001-11-26 KR KR10-2003-7007121A patent/KR20040045391A/ko not_active Ceased
- 2001-11-26 MX MXPA03004638A patent/MXPA03004638A/es active IP Right Grant
- 2001-11-26 DE DE60139959T patent/DE60139959D1/de not_active Expired - Lifetime
- 2001-11-26 WO PCT/US2001/043151 patent/WO2003004055A2/en not_active Ceased
- 2001-11-26 DK DK01274277T patent/DK1379273T3/da active
- 2001-11-26 AU AU2001297988A patent/AU2001297988B2/en not_active Ceased
- 2001-11-26 PT PT01274277T patent/PT1379273E/pt unknown
- 2001-11-26 EP EP01274277A patent/EP1379273B1/en not_active Expired - Lifetime
- 2001-11-26 JP JP2003510065A patent/JP4221289B2/ja not_active Expired - Fee Related
- 2001-11-26 BR BR0115646-2A patent/BR0115646A/pt not_active Application Discontinuation
- 2001-11-26 CN CNB018195709A patent/CN1317034C/zh not_active Expired - Fee Related
-
2003
- 2003-05-21 IL IL156041A patent/IL156041A/en not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| JP2004536107A (ja) | 2004-12-02 |
| EP1379273B1 (en) | 2009-09-16 |
| WO2003004055A2 (en) | 2003-01-16 |
| PT1379273E (pt) | 2009-11-27 |
| WO2003004055A3 (en) | 2003-11-20 |
| ATE442858T1 (de) | 2009-10-15 |
| DK1379273T3 (da) | 2009-11-09 |
| CN1537013A (zh) | 2004-10-13 |
| AU2001297988B2 (en) | 2006-10-26 |
| BR0115646A (pt) | 2005-12-13 |
| ES2332261T3 (es) | 2010-02-01 |
| JP4221289B2 (ja) | 2009-02-12 |
| NZ526175A (en) | 2006-01-27 |
| IL156041A (en) | 2010-05-17 |
| CA2429708A1 (en) | 2003-01-16 |
| EP1379273A2 (en) | 2004-01-14 |
| KR20040045391A (ko) | 2004-06-01 |
| IL156041A0 (en) | 2003-12-23 |
| MXPA03004638A (es) | 2004-04-20 |
| CN1317034C (zh) | 2007-05-23 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition |