DE60137212D1 - Oxidationsbeständige und abriebfeste polyethylene fur menschlichen gelenkersatz und verfahren zu deren herstellung - Google Patents

Oxidationsbeständige und abriebfeste polyethylene fur menschlichen gelenkersatz und verfahren zu deren herstellung

Info

Publication number
DE60137212D1
DE60137212D1 DE60137212T DE60137212T DE60137212D1 DE 60137212 D1 DE60137212 D1 DE 60137212D1 DE 60137212 T DE60137212 T DE 60137212T DE 60137212 T DE60137212 T DE 60137212T DE 60137212 D1 DE60137212 D1 DE 60137212D1
Authority
DE
Germany
Prior art keywords
resistant
oxidation
polyethylenes
abrasion
production
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60137212T
Other languages
English (en)
Inventor
Harry A Mckellop
Fu-Wen Shen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Orthopaedic Hospital
Original Assignee
Orthopaedic Hospital
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=22742074&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE60137212(D1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Orthopaedic Hospital filed Critical Orthopaedic Hospital
Application granted granted Critical
Publication of DE60137212D1 publication Critical patent/DE60137212D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/16—Macromolecular materials obtained by reactions only involving carbon-to-carbon unsaturated bonds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
    • A61L2/02—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor using physical phenomena
    • A61L2/08—Radiation
    • A61L2/081—Gamma radiation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C35/00—Heating, cooling or curing, e.g. crosslinking or vulcanising; Apparatus therefor
    • B29C35/02—Heating or curing, e.g. crosslinking or vulcanizing during moulding, e.g. in a mould
    • B29C35/08—Heating or curing, e.g. crosslinking or vulcanizing during moulding, e.g. in a mould by wave energy or particle radiation
    • B29C35/0805—Heating or curing, e.g. crosslinking or vulcanizing during moulding, e.g. in a mould by wave energy or particle radiation using electromagnetic radiation
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C35/00—Heating, cooling or curing, e.g. crosslinking or vulcanising; Apparatus therefor
    • B29C35/02—Heating or curing, e.g. crosslinking or vulcanizing during moulding, e.g. in a mould
    • B29C35/08—Heating or curing, e.g. crosslinking or vulcanizing during moulding, e.g. in a mould by wave energy or particle radiation
    • B29C35/0866—Heating or curing, e.g. crosslinking or vulcanizing during moulding, e.g. in a mould by wave energy or particle radiation using particle radiation
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C43/00—Compression moulding, i.e. applying external pressure to flow the moulding material; Apparatus therefor
    • B29C43/003—Compression moulding, i.e. applying external pressure to flow the moulding material; Apparatus therefor characterised by the choice of material
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C48/00—Extrusion moulding, i.e. expressing the moulding material through a die or nozzle which imparts the desired form; Apparatus therefor
    • B29C48/022—Extrusion moulding, i.e. expressing the moulding material through a die or nozzle which imparts the desired form; Apparatus therefor characterised by the choice of material
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65B—MACHINES, APPARATUS OR DEVICES FOR, OR METHODS OF, PACKAGING ARTICLES OR MATERIALS; UNPACKING
    • B65B55/00—Preserving, protecting or purifying packages or package contents in association with packaging
    • B65B55/02—Sterilising, e.g. of complete packages
    • B65B55/12—Sterilising contents prior to, or during, packaging
    • B65B55/16—Sterilising contents prior to, or during, packaging by irradiation
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
    • C08J3/00—Processes of treating or compounding macromolecular substances
    • C08J3/28—Treatment by wave energy or particle radiation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2/3094—Designing or manufacturing processes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2/32—Joints for the hip
    • A61F2/34—Acetabular cups
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2/38—Joints for elbows or knees
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2430/00—Materials or treatment for tissue regeneration
    • A61L2430/24—Materials or treatment for tissue regeneration for joint reconstruction
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C35/00—Heating, cooling or curing, e.g. crosslinking or vulcanising; Apparatus therefor
    • B29C35/02—Heating or curing, e.g. crosslinking or vulcanizing during moulding, e.g. in a mould
    • B29C35/08—Heating or curing, e.g. crosslinking or vulcanizing during moulding, e.g. in a mould by wave energy or particle radiation
    • B29C35/0805—Heating or curing, e.g. crosslinking or vulcanizing during moulding, e.g. in a mould by wave energy or particle radiation using electromagnetic radiation
    • B29C2035/085—Heating or curing, e.g. crosslinking or vulcanizing during moulding, e.g. in a mould by wave energy or particle radiation using electromagnetic radiation using gamma-ray
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C35/00—Heating, cooling or curing, e.g. crosslinking or vulcanising; Apparatus therefor
    • B29C35/02—Heating or curing, e.g. crosslinking or vulcanizing during moulding, e.g. in a mould
    • B29C35/08—Heating or curing, e.g. crosslinking or vulcanizing during moulding, e.g. in a mould by wave energy or particle radiation
    • B29C35/0866—Heating or curing, e.g. crosslinking or vulcanizing during moulding, e.g. in a mould by wave energy or particle radiation using particle radiation
    • B29C2035/0877—Heating or curing, e.g. crosslinking or vulcanizing during moulding, e.g. in a mould by wave energy or particle radiation using particle radiation using electron radiation, e.g. beta-rays
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29K—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES B29B, B29C OR B29D, RELATING TO MOULDING MATERIALS OR TO MATERIALS FOR MOULDS, REINFORCEMENTS, FILLERS OR PREFORMED PARTS, e.g. INSERTS
    • B29K2023/00—Use of polyalkenes or derivatives thereof as moulding material
    • B29K2023/04—Polymers of ethylene
    • B29K2023/06—PE, i.e. polyethylene
    • B29K2023/0658—PE, i.e. polyethylene characterised by its molecular weight
    • B29K2023/0683—UHMWPE, i.e. ultra high molecular weight polyethylene
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
    • C08J2323/00—Characterised by the use of homopolymers or copolymers of unsaturated aliphatic hydrocarbons having only one carbon-to-carbon double bond; Derivatives of such polymers
    • C08J2323/02—Characterised by the use of homopolymers or copolymers of unsaturated aliphatic hydrocarbons having only one carbon-to-carbon double bond; Derivatives of such polymers not modified by chemical after treatment
    • C08J2323/04—Homopolymers or copolymers of ethene
    • C08J2323/06—Polyethene

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Toxicology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Transplantation (AREA)
  • Dermatology (AREA)
  • Engineering & Computer Science (AREA)
  • Mechanical Engineering (AREA)
  • Physics & Mathematics (AREA)
  • Thermal Sciences (AREA)
  • Polymers & Plastics (AREA)
  • Organic Chemistry (AREA)
  • Electromagnetism (AREA)
  • Materials For Medical Uses (AREA)
  • Prostheses (AREA)
  • Laminated Bodies (AREA)
  • Treatments Of Macromolecular Shaped Articles (AREA)
  • Superconductors And Manufacturing Methods Therefor (AREA)
  • Non-Disconnectible Joints And Screw-Threaded Joints (AREA)
  • Lining Or Joining Of Plastics Or The Like (AREA)
  • Manufacture Of Macromolecular Shaped Articles (AREA)
  • Insulating Bodies (AREA)
DE60137212T 2000-04-27 2001-04-27 Oxidationsbeständige und abriebfeste polyethylene fur menschlichen gelenkersatz und verfahren zu deren herstellung Expired - Lifetime DE60137212D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US20052500P 2000-04-27 2000-04-27
PCT/US2001/013839 WO2001080778A1 (en) 2000-04-27 2001-04-27 Oxidation-resistant and wear-resistant polyethylenes for human joint replacements and methods for making them

Publications (1)

Publication Number Publication Date
DE60137212D1 true DE60137212D1 (de) 2009-02-12

Family

ID=22742074

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60137212T Expired - Lifetime DE60137212D1 (de) 2000-04-27 2001-04-27 Oxidationsbeständige und abriebfeste polyethylene fur menschlichen gelenkersatz und verfahren zu deren herstellung

Country Status (9)

Country Link
US (5) US8796347B2 (de)
EP (3) EP1276436B1 (de)
JP (2) JP4256096B2 (de)
AT (1) ATE418933T1 (de)
AU (2) AU2001261083B2 (de)
DE (1) DE60137212D1 (de)
DK (1) DK1276436T3 (de)
ES (1) ES2317905T3 (de)
WO (1) WO2001080778A1 (de)

Families Citing this family (93)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2166450C (en) * 1995-01-20 2008-03-25 Ronald Salovey Chemically crosslinked ultrahigh molecular weight polyethylene for artificial human joints
US20050125074A1 (en) * 1995-01-20 2005-06-09 Ronald Salovey Crosslinking of polyethylene for low wear using radiation and thermal treatments
EP1795212A3 (de) 1996-07-09 2007-09-05 Orthopaedic Hospital Vernetzung von Polyethylen für geringen Verschleiss mit Hilfe von Strahlen- und Wärmebehandlung
US8796347B2 (en) 2000-04-27 2014-08-05 Orthopaedic Hospital Oxidation-resistant and wear-resistant polyethylenes for human joint replacements and methods for making them
US6558426B1 (en) 2000-11-28 2003-05-06 Medidea, Llc Multiple-cam, posterior-stabilized knee prosthesis
JP2005511216A (ja) * 2001-12-12 2005-04-28 デピュイ・プロダクツ・インコーポレイテッド 整形外科装置およびその作製方法
EP1369094B1 (de) 2002-05-31 2014-11-26 Zimmer GmbH Implantat und Verfahren zur Herstellung eines steril verpackten Implantats
US20040110853A1 (en) * 2002-08-20 2004-06-10 Wang Louis Chun Process for preparing molded porous articles and the porous articles prepared therefrom
EP2664299A1 (de) * 2003-01-16 2013-11-20 Massachusetts General Hospital Verfahren zur Herstellung von oxidationsbeständigem Polymermaterial
AT412969B (de) * 2003-05-19 2005-09-26 Klaus Dr Lederer Vernetztes, ultra-hochmolekulares polyethylen (uhmw-pe)
US7214764B2 (en) * 2003-06-30 2007-05-08 Depuy Products, Inc. Free radical quench process for irradiated ultrahigh molecular weight polyethylene
EP3111895B1 (de) 2004-02-03 2019-09-04 The General Hospital Corporation Hochkristallines vernetztes oxidationsresistentes polyethylen
CA2565849C (en) 2004-05-11 2013-01-29 The General Hospital Corporation Dba Massachusetts General Hospital Methods for making oxidation resistant polymeric material
US8262976B2 (en) 2004-10-07 2012-09-11 Biomet Manufacturing Corp. Solid state deformation processing of crosslinked high molecular weight polymeric materials
US7462318B2 (en) 2004-10-07 2008-12-09 Biomet Manufacturing Corp. Crosslinked polymeric material with enhanced strength and process for manufacturing
US7344672B2 (en) 2004-10-07 2008-03-18 Biomet Manufacturing Corp. Solid state deformation processing of crosslinked high molecular weight polymeric materials
US7335697B2 (en) * 2004-12-23 2008-02-26 Depuy Products, Inc. Polymer composition comprising cross-linked polyethylene and methods for making the same
US7435372B2 (en) * 2005-03-31 2008-10-14 Zimmer, Inc. Liquid bath annealing of polymers for orthopaedic implants
EP2172229B1 (de) * 2005-08-18 2014-07-16 Zimmer GmbH Ultrahochmolekulare Polyethylen-Artikel und Verfahren zur Herstellung von ultrahochmolekularen Polyethylen-Artikeln
EP1919983B1 (de) 2005-08-22 2011-10-19 The General Hospital Corporation Dba Massachusetts General Hospital Oxidationsbeständiges homogenisiertes polymermaterial
JP2009504898A (ja) * 2005-08-22 2009-02-05 ザ ジェネラル ホスピタル コーポレイション ディー ビー エイ マサチューセッツ ジェネラル ホスピタル 溶融温度以下で製造した、耐摩耗性高架橋ポリエチレン
AU2006283596B2 (en) 2005-08-22 2012-10-11 The General Hospital Corporation Highly crystalline polyethylene
US8343230B2 (en) * 2005-09-22 2013-01-01 Depuy Products, Inc. Orthopaedic bearing material
US20070077268A1 (en) * 2005-09-30 2007-04-05 Depuy Products, Inc. Hydrophobic carrier modified implants for beneficial agent delivery
US7615075B2 (en) * 2005-11-04 2009-11-10 Rush University Medical Center Plastic implant impregnated with a degradation protector
US7812098B2 (en) * 2006-03-31 2010-10-12 Depuy Products, Inc. Bearing material of medical implant having reduced wear rate and method for reducing wear rate
US20070232762A1 (en) * 2006-03-31 2007-10-04 Depuy Products, Inc. Bearing material of medical implant having reduced wear rate and method for reducing wear rate
ITMI20061375A1 (it) * 2006-07-14 2008-01-15 Fabio Conteduca Maeriale protesico sintetico a ridotta ossidabilita' e relativo processo di preparazione
EP1891987B1 (de) * 2006-08-25 2010-09-22 DePuy Products, Inc. Material zum Tragen eines medizinischen Implantats
US8293811B2 (en) 2007-01-25 2012-10-23 The General Hospital Corporation Methods for making oxidation-resistant cross-linked polymeric materials
CA2679274C (en) 2007-03-02 2018-02-20 The General Hospital Corporation Cross-linking of antioxidant-containing polymers
CN101687942A (zh) * 2007-03-20 2010-03-31 施乐辉骨科用品股份公司 抗氧化的高度交联的uhmwpe
US8664290B2 (en) 2007-04-10 2014-03-04 Zimmer, Inc. Antioxidant stabilized crosslinked ultra-high molecular weight polyethylene for medical device applications
ATE544476T1 (de) 2007-04-10 2012-02-15 Zimmer Inc Antioxidans-stabilisiertes vernetztes ultrahochmolekulares polyethylen für anwendungen in medizinprodukten
US8641959B2 (en) 2007-07-27 2014-02-04 Biomet Manufacturing, Llc Antioxidant doping of crosslinked polymers to form non-eluting bearing components
JP6223653B2 (ja) 2007-09-04 2017-11-01 スミス・アンド・ネフュー・オルソペディクス・アーゲー 関節面用の超高分子量ポリエチレン
US20110035017A1 (en) * 2007-09-25 2011-02-10 Depuy Products, Inc. Prosthesis with cut-off pegs and surgical method
US8128703B2 (en) 2007-09-28 2012-03-06 Depuy Products, Inc. Fixed-bearing knee prosthesis having interchangeable components
US8632600B2 (en) 2007-09-25 2014-01-21 Depuy (Ireland) Prosthesis with modular extensions
US8715359B2 (en) 2009-10-30 2014-05-06 Depuy (Ireland) Prosthesis for cemented fixation and method for making the prosthesis
US9204967B2 (en) 2007-09-28 2015-12-08 Depuy (Ireland) Fixed-bearing knee prosthesis having interchangeable components
EP2207848B1 (de) * 2007-11-06 2011-10-19 DSM IP Assets B.V. Verfahren zur herstellung von polyethylen mit ultrahohem molekulargewicht
EP2249887B1 (de) 2008-01-30 2017-06-21 Zimmer, Inc. Orthopädischer bestandteil geringer steifheit
US8586667B2 (en) 2008-05-13 2013-11-19 Smith & Nephew Orthopaedics Ag Oxidation resistant highly-crosslinked UHMWPE
JP5311457B2 (ja) * 2008-06-20 2013-10-09 ナカシマメディカル株式会社 人工関節用摺動部材の成形方法及びこの方法によって成形された人工関節用摺動部材
US8192498B2 (en) 2008-06-30 2012-06-05 Depuy Products, Inc. Posterior cructiate-retaining orthopaedic knee prosthesis having controlled condylar curvature
US9168145B2 (en) 2008-06-30 2015-10-27 Depuy (Ireland) Posterior stabilized orthopaedic knee prosthesis having controlled condylar curvature
US8187335B2 (en) 2008-06-30 2012-05-29 Depuy Products, Inc. Posterior stabilized orthopaedic knee prosthesis having controlled condylar curvature
US9119723B2 (en) 2008-06-30 2015-09-01 Depuy (Ireland) Posterior stabilized orthopaedic prosthesis assembly
US8206451B2 (en) 2008-06-30 2012-06-26 Depuy Products, Inc. Posterior stabilized orthopaedic prosthesis
US8236061B2 (en) 2008-06-30 2012-08-07 Depuy Products, Inc. Orthopaedic knee prosthesis having controlled condylar curvature
US8828086B2 (en) 2008-06-30 2014-09-09 Depuy (Ireland) Orthopaedic femoral component having controlled condylar curvature
DE102008047009B4 (de) * 2008-07-11 2020-08-06 Mathys Ag Bettlach Gelenkpfanne mit physiologischer Lastübertragung
WO2010057644A1 (en) 2008-11-20 2010-05-27 Zimmer Gmbh Polyethylene materials
WO2010096771A2 (en) 2009-02-20 2010-08-26 The General Hospital Corporation Dba High temperature melting
DE102009001145A1 (de) * 2009-02-25 2010-09-09 Leibniz-Institut Für Polymerforschung Dresden E.V. Verfahren zur Aushärtung und Oberflächenfunktionalisierung von Formteilen
WO2010129514A2 (en) 2009-05-04 2010-11-11 Smith & Nephew, Inc. Synergistic effects of blending multiple additives in uhmwpe
US11213397B2 (en) 2009-05-21 2022-01-04 Depuy Ireland Unlimited Company Prosthesis with surfaces having different textures and method of making the prosthesis
US9101476B2 (en) 2009-05-21 2015-08-11 Depuy (Ireland) Prosthesis with surfaces having different textures and method of making the prosthesis
JP4806717B2 (ja) * 2009-06-25 2011-11-02 株式会社沖データ 画像処理システム
DK2316382T3 (da) 2009-10-30 2014-05-12 Depuy Ireland Protese til ucementeret fiksering
ES2406154T3 (es) 2009-10-30 2013-06-05 Depuy Products, Inc. Prótesis con extensiones modulares
EP2316383B1 (de) 2009-10-30 2013-04-17 DePuy Products, Inc. Prothese mit Oberflächen unterschiedlicher Texturen
EP2606857A1 (de) 2009-10-30 2013-06-26 DePuy Products, Inc. Prothese mit Verbundstoffkomponente
EP2319460A1 (de) 2009-10-30 2011-05-11 DePuy Products, Inc. Prothese mit stumpfen Zapfen
US20120319332A1 (en) * 2009-12-21 2012-12-20 Mcminn Derek James Wallace Method of Forming a Polymer Component
GB0922339D0 (en) 2009-12-21 2010-02-03 Mcminn Derek J W Acetabular cup prothesis and introducer thereof
US9011547B2 (en) 2010-01-21 2015-04-21 Depuy (Ireland) Knee prosthesis system
US8399535B2 (en) 2010-06-10 2013-03-19 Zimmer, Inc. Polymer [[s]] compositions including an antioxidant
WO2012172293A2 (en) * 2011-06-15 2012-12-20 Derek James Wallace Mcminn Methods of forming a polymeric component
ITVR20110196A1 (it) * 2011-10-21 2013-04-22 Luigi Costa Metodo per la realizzazione di un dispositivo medicale, quale una protesi, in polietilene
WO2013180228A1 (ja) 2012-05-31 2013-12-05 京セラメディカル株式会社 摺動材料およびその製造方法
DE102012112159A1 (de) * 2012-12-12 2014-06-12 Krones Ag Vorrichtung zum Behandeln von Getränken mit Wandungselementen aus Kunststoff
US9237953B2 (en) 2013-03-15 2016-01-19 Depuy (Ireland) Mechanical assembly of pegs to prosthesis
US9586370B2 (en) 2013-08-15 2017-03-07 Biomet Manufacturing, Llc Method for making ultra high molecular weight polyethylene
WO2015050851A1 (en) 2013-10-01 2015-04-09 Zimmer, Inc. Polymer compositions comprising one or more protected antioxidants
JP6292815B2 (ja) * 2013-10-10 2018-03-14 京セラ株式会社 抗酸化性人工補綴部材
US10220547B2 (en) 2013-10-17 2019-03-05 The General Hospital Corporation Peroxide cross-linking and high temperature melting
US9144499B2 (en) 2013-12-17 2015-09-29 Depuy (Ireland) Low profile mobile/fixed prosthetic knee systems
DE102013226814A1 (de) * 2013-12-20 2015-06-25 Christof-Herbert Diener Plasmaanlage mit einem separat transportierbaren Gefäß
WO2015138137A1 (en) 2014-03-12 2015-09-17 Zimmer, Inc. Melt-stabilized ultra high molecular weight polyethylene and method of making the same
WO2016090084A1 (en) 2014-12-03 2016-06-09 Zimmer, Inc. Antioxidant-infused ultra high molecular weight polyethylene
US10765523B2 (en) * 2015-08-03 2020-09-08 Zanini Auto Grup, S.A. Prosthesis component and method for the production thereof
WO2017136726A1 (en) 2016-02-05 2017-08-10 The General Hospital Corporation Drug eluting polymer composed of biodegradable polymers applied to surface of medical device
DE102016110500B4 (de) 2016-06-07 2019-03-14 Karl Leibinger Medizintechnik Gmbh & Co. Kg Implantatherstellverfahren mittels additivem selektivem Lasersintern und Implantat
US10070959B2 (en) 2016-09-28 2018-09-11 DePuy Synthes Products, Inc. Method of texturing prosthetic implants
JP6340448B1 (ja) * 2017-03-21 2018-06-06 旭化成株式会社 ポリエチレン系重合体パウダー及びその製造方法
US11667762B2 (en) 2017-08-29 2023-06-06 The General Hospital Corporation UV-initiated reactions in polymeric materials
CN107754013B (zh) * 2017-12-04 2020-11-10 四川大学 高抗氧高交联超高分子量聚乙烯人工关节材料及制备方法
CN108950711A (zh) * 2018-09-06 2018-12-07 山东莱威新材料有限公司 一种超高分子量聚乙烯扁平丝及其制备方法
CN111135343B (zh) * 2019-12-19 2021-09-14 江苏集萃先进高分子材料研究所有限公司 一种高交联高抗氧剂掺杂的人工关节假体材料及其制备方法
CN111321474A (zh) * 2020-02-29 2020-06-23 山东新兴安全防护设备股份有限公司 一种超高分子量聚乙烯纤维的生产工艺
US11970600B2 (en) 2021-03-31 2024-04-30 The General Hospital Corporation Di-cumyl peroxide crosslinking of UHMWPE

Family Cites Families (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4036719A (en) 1973-10-11 1977-07-19 Raychem Corporation Irradiatable polymer composition with improved oxidation resistance
DE68926624T2 (de) 1988-12-02 1996-10-02 Du Pont Lineares polyäthylen von ultrahohem molekulargewicht, gegenstände und verfahren zu deren herstellung
US5505984A (en) 1993-01-21 1996-04-09 England; Garry L. Method for forming biocompatible components using an isostatic press
US5414049A (en) 1993-06-01 1995-05-09 Howmedica Inc. Non-oxidizing polymeric medical implant
EP0714460A4 (de) * 1993-08-20 1998-01-07 Smith & Nephew Richards Inc Selbstverstärkte verbundwerkstoffe aus polyethylen mit sehr hohem molekulargewicht
AU727279B2 (en) 1995-01-20 2000-12-07 Orthopaedic Hospital Chemically crosslinked ultrahigh molecular weight polyethylene for artificial human joints
CA2166450C (en) * 1995-01-20 2008-03-25 Ronald Salovey Chemically crosslinked ultrahigh molecular weight polyethylene for artificial human joints
US5577368A (en) * 1995-04-03 1996-11-26 Johnson & Johnson Professional, Inc. Method for improving wear resistance of polymeric bioimplantable components
ES2243980T3 (es) 1996-02-13 2005-12-01 Massachusetts Institute Of Technology Dispositivos de protesis de polietileno de ultra alto peso molecular tratados por fusion y radiacion.
US5879400A (en) 1996-02-13 1999-03-09 Massachusetts Institute Of Technology Melt-irradiated ultra high molecular weight polyethylene prosthetic devices
US8865788B2 (en) * 1996-02-13 2014-10-21 The General Hospital Corporation Radiation and melt treated ultra high molecular weight polyethylene prosthetic devices
US5753182A (en) * 1996-02-14 1998-05-19 Biomet, Inc. Method for reducing the number of free radicals present in ultrahigh molecular weight polyethylene orthopedic components
US5721334A (en) * 1996-02-16 1998-02-24 Newyork Society For The Ruptured And Crippled Maintaining The Hospital For Special Surgery Process for producing ultra-high molecular weight low modulus polyethylene shaped articles via controlled pressure and temperature and compositions and articles produced therefrom
EP1795212A3 (de) * 1996-07-09 2007-09-05 Orthopaedic Hospital Vernetzung von Polyethylen für geringen Verschleiss mit Hilfe von Strahlen- und Wärmebehandlung
US6228900B1 (en) * 1996-07-09 2001-05-08 The Orthopaedic Hospital And University Of Southern California Crosslinking of polyethylene for low wear using radiation and thermal treatments
US5827904A (en) * 1996-09-27 1998-10-27 Hahn; David Medical implant composition
US6017975A (en) * 1996-10-02 2000-01-25 Saum; Kenneth Ashley Process for medical implant of cross-linked ultrahigh molecular weight polyethylene having improved balance of wear properties and oxidation resistance
AU4986497A (en) * 1996-10-15 1998-05-11 Orthopaedic Hospital, The Wear resistant surface-gradient cross-linked polyethylene
US6468258B1 (en) * 1997-07-18 2002-10-22 Baxter International Inc. Plastic compositions including vitamin E for medical containers and methods for providing such compositions and containers
JP4315261B2 (ja) 1998-02-25 2009-08-19 ナカシマメディカル株式会社 人工関節用摺動部材および製造方法
US6692679B1 (en) 1998-06-10 2004-02-17 Depuy Orthopaedics, Inc. Cross-linked molded plastic bearings
EP0995449A1 (de) * 1998-10-21 2000-04-26 Sulzer Orthopädie AG UHMW-Polyethylen für Implantate
EP0995450B1 (de) 1998-10-21 2002-06-26 Sulzer Orthopädie AG UHMW-Polyethylen für Implantate
SE9900519D0 (sv) 1999-02-17 1999-02-17 Lars Lidgren A method for the preparation of UHMWPE doped with an antioxidant and an implant made thereof
US6355215B1 (en) * 1999-03-10 2002-03-12 Implex Corp. Wear-resistant olefinic medical implant and thermal treatment container therefor
US6627141B2 (en) * 1999-06-08 2003-09-30 Depuy Orthopaedics, Inc. Method for molding a cross-linked preform
US6245276B1 (en) * 1999-06-08 2001-06-12 Depuy Orthopaedics, Inc. Method for molding a cross-linked preform
US6143232A (en) * 1999-07-29 2000-11-07 Bristol-Meyers Squibb Company Method of manufacturing an articulating bearing surface for an orthopaedic implant
US6184265B1 (en) * 1999-07-29 2001-02-06 Depuy Orthopaedics, Inc. Low temperature pressure stabilization of implant component
US6794423B1 (en) 1999-07-30 2004-09-21 Stephen Li Fracture-resistant, cross-linked ultra high molecular weight polyethylene shaped material and articles made therefrom
US8796347B2 (en) 2000-04-27 2014-08-05 Orthopaedic Hospital Oxidation-resistant and wear-resistant polyethylenes for human joint replacements and methods for making them
US6503439B1 (en) * 2000-06-15 2003-01-07 Albert H. Burstein Process for forming shaped articles of ultra high molecular weight polyethylene suitable for use as a prosthetic device or a component thereof
KR200222734Y1 (ko) * 2000-10-11 2001-05-15 주식회사디엔브이 자동차 배기관용 연결구
US6547828B2 (en) 2001-02-23 2003-04-15 Smith & Nephew, Inc. Cross-linked ultra-high molecular weight polyethylene for medical implant use
EP2664299A1 (de) * 2003-01-16 2013-11-20 Massachusetts General Hospital Verfahren zur Herstellung von oxidationsbeständigem Polymermaterial

Also Published As

Publication number Publication date
US20150007527A1 (en) 2015-01-08
US20140235745A1 (en) 2014-08-21
ES2317905T3 (es) 2009-05-01
US9302028B2 (en) 2016-04-05
US20030212161A1 (en) 2003-11-13
ATE418933T1 (de) 2009-01-15
US9155817B2 (en) 2015-10-13
DK1276436T3 (da) 2009-04-06
US9242025B2 (en) 2016-01-26
US20150096264A1 (en) 2015-04-09
JP4256096B2 (ja) 2009-04-22
US8796347B2 (en) 2014-08-05
WO2001080778A1 (en) 2001-11-01
JP2009061283A (ja) 2009-03-26
AU6108301A (en) 2001-11-07
EP2275052A1 (de) 2011-01-19
EP1276436A1 (de) 2003-01-22
AU2001261083B2 (en) 2006-03-16
EP2047823A1 (de) 2009-04-15
EP1276436A4 (de) 2003-07-23
US8658710B2 (en) 2014-02-25
EP1276436B1 (de) 2008-12-31
JP2003530957A (ja) 2003-10-21
US20070293647A1 (en) 2007-12-20

Similar Documents

Publication Publication Date Title
DE60137212D1 (de) Oxidationsbeständige und abriebfeste polyethylene fur menschlichen gelenkersatz und verfahren zu deren herstellung
CA2166450A1 (en) Chemically crosslinked ultrahigh molecular weight polyethylene for artificial human joints
ATE487504T1 (de) Zusammensetzungen und verfahren für biomedizinische anwendungen
WO2005018491A3 (en) Acellular matrix implants for treatment of articular cartilage, bone or osteochondral defects and injuries and a method for use thereof
DE50106328D1 (de) Verfahren zur herstellung bioaktiver implantatoberflächen
DE60320430D1 (de) Medizinische vorrichtungen und herstellungsverfahren dafür
AU7574601A (en) Tissue implant
CY1109742T1 (el) Μεθοδοι και συνθεσεις για επουλωση και αποκατασταση αρθρικου χονδρου
ATE309196T1 (de) Verfahren zur herstellung von 3-aryloxy-3- arylpropylamine und deren zwischenprodukte
ATE513533T1 (de) Künstliches kniegelenk
BR0007720A (pt) Porfirinas substituìdas
IL139355A (en) 24-hydroxyvitamin d, analogs and uses thereof
NO2010020I2 (de)
ATE296116T1 (de) Ein kovalentes konjugat von clozapine und einer fettsäure und dessen verwendung zur behandlung von schizophrenie
WO2008090468A3 (en) An implant and a method for partial replacement of joint surfaces
ATE253554T1 (de) 1alpha-hydroxy-25-ene-vitamin d, deren analogen und verwendung davon
AU2002326178A1 (en) Artificial hip joint prosthesis
ATE471924T1 (de) 3-alkyl-5,5',6,6',7,7',8,8'-octahydro-2,2'- binaphthole und 3,3'-dialkyl-5,5',6,6',7,7',8,8'- octahydro-2,2'-binaphthole, sowie verfahren zur ihrer herstellung
DK1330347T3 (da) Behandling med superkritisk fluid af en bestrålet præform af et proteseleje fremstillet af polyethylen
WO2008130956A3 (en) Knee and shoulder joint prosthesis
ATE155336T1 (de) Ultrahochmolekulares lineares polyaethylen und verfahren zur herstellung
ATE112952T1 (de) Verfahren zur herstellung einer endoprothese.
DE602004027730D1 (de) Medizinisches knochenprothesematerial und verfahren zu seiner herstellung
HRP920811A2 (en) New benzophyranone-beta-d-thioxilozides, method fothe use of dextrin derivatives in the treatment ofr the preparation and use thereof acidic conditions
FR2853524B1 (fr) Gamme d'implants femoraux de protheses de hanche

Legal Events

Date Code Title Description
8363 Opposition against the patent