DE60132337T2 - Nicht-sedierende barbituratverbindungen als neuroprotektive wirkstoffe - Google Patents
Nicht-sedierende barbituratverbindungen als neuroprotektive wirkstoffe Download PDFInfo
- Publication number
- DE60132337T2 DE60132337T2 DE60132337T DE60132337T DE60132337T2 DE 60132337 T2 DE60132337 T2 DE 60132337T2 DE 60132337 T DE60132337 T DE 60132337T DE 60132337 T DE60132337 T DE 60132337T DE 60132337 T2 DE60132337 T2 DE 60132337T2
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- Prior art keywords
- barbiturate
- sedating
- pharmaceutical composition
- use according
- neuroprotective
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- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Classifications
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/513—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
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- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
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- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P9/00—Drugs for disorders of the cardiovascular system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- Hospice & Palliative Care (AREA)
- Epidemiology (AREA)
- Dermatology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Psychiatry (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Steroid Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US22167200P | 2000-07-26 | 2000-07-26 | |
| US221672P | 2000-07-26 | ||
| PCT/US2001/023420 WO2002007729A1 (en) | 2000-07-26 | 2001-07-26 | Non-sedating barbiturate compounds as neuroprotective agents |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE60132337D1 DE60132337D1 (de) | 2008-02-21 |
| DE60132337T2 true DE60132337T2 (de) | 2009-02-12 |
Family
ID=22828824
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE60132337T Expired - Lifetime DE60132337T2 (de) | 2000-07-26 | 2001-07-26 | Nicht-sedierende barbituratverbindungen als neuroprotektive wirkstoffe |
Country Status (13)
| Country | Link |
|---|---|
| EP (1) | EP1311270B1 (enExample) |
| JP (1) | JP5047442B2 (enExample) |
| CN (2) | CN100522172C (enExample) |
| AT (1) | ATE383159T1 (enExample) |
| AU (2) | AU8077801A (enExample) |
| BR (1) | BR0112775A (enExample) |
| CA (1) | CA2416535C (enExample) |
| DE (1) | DE60132337T2 (enExample) |
| ES (1) | ES2300349T3 (enExample) |
| IL (3) | IL154060A0 (enExample) |
| MX (1) | MXPA03000824A (enExample) |
| PT (1) | PT1311270E (enExample) |
| WO (1) | WO2002007729A1 (enExample) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6093820A (en) | 1997-10-02 | 2000-07-25 | Taro Pharmaceutical Industries Ltd. | Method and reagents for N-alkylating ureides |
| US7683071B2 (en) | 2000-07-26 | 2010-03-23 | Taro Pharmaceuticals Industries Ltd. | Composition and method for improved bioavailability and enhanced brain delivery of 5,5-diphenyl barbituric acid |
| US6756379B2 (en) | 2001-07-26 | 2004-06-29 | Taro Pharmaceutical Industries Ltd. | Non-sedating barbiturate compounds as neuroprotective agents |
| EP1311270B1 (en) * | 2000-07-26 | 2008-01-09 | Taro Pharmaceutical Industries Limited | Non-sedating barbiturate compounds as neuroprotective agents |
| US6939873B2 (en) | 2000-07-26 | 2005-09-06 | Taro Pharmaceuticals Industries Limited | Non-sedating barbituric acid derivatives |
| CN1896084A (zh) * | 2002-01-30 | 2007-01-17 | 塔罗制药工业有限公司 | 非镇静性巴比土酸衍生物 |
| CN102283821A (zh) * | 2002-10-11 | 2011-12-21 | 巴克斯特国际公司 | 含有卤化挥发性麻醉药的制剂在制备通过肠外给药用于治疗组织具有缺血事件的患者的制剂中的应用 |
| CN100502871C (zh) * | 2002-12-11 | 2009-06-24 | 塔罗制药工业有限公司 | 巴比土酸衍生物在制备用于治疗运动障碍的药物中的应用 |
| EP1625848A1 (en) * | 2004-08-10 | 2006-02-15 | Taro Pharmaceuticals North America, Inc. | Composition and method for enhanced delivery of 5,5-diphenyl barbituric acid |
| RU2370266C2 (ru) * | 2007-12-21 | 2009-10-20 | Федеральное государственное учреждение "Межотраслевой научно-технический комплекс "Микрохирургия глаза" имени академика С.Н. Федорова Федерального агентства по высокотехнологичной медицинской помощи" | Способ общего обезболивания |
| WO2013038427A1 (en) * | 2011-09-12 | 2013-03-21 | Council Of Scientific & Industrial Research | ARYLATED β-DICARBOIMYL COMPOUNDS AND PROCESS FOR THE PREPARATION THEREOF |
| CN102863579B (zh) * | 2012-09-14 | 2014-02-05 | 东南大学 | 一种巴比妥酸螯合树脂及其制备方法和应用 |
| CN113640512B (zh) | 2015-10-05 | 2024-12-31 | 北卡罗来纳-查佩尔山大学 | 用于多路测定的解码方法及相关流体设备、试剂盒和固体支持物 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL69722A (en) * | 1983-09-14 | 1986-09-30 | Taro Pharma Ind | Oxopyrimidine derivatives and pharmaceutical compositions containing them |
| US4833148A (en) * | 1987-04-09 | 1989-05-23 | Washington University | Method of using alkenyl- or alkynyl-substituted thiobarbiturates to reduce neurotoxic injury |
| US5474990A (en) * | 1989-10-20 | 1995-12-12 | Olney; John W. | Barbiturates as safening agents in conjunction with NMDA antagonists |
| EP1311270B1 (en) * | 2000-07-26 | 2008-01-09 | Taro Pharmaceutical Industries Limited | Non-sedating barbiturate compounds as neuroprotective agents |
-
2001
- 2001-07-26 EP EP01959195A patent/EP1311270B1/en not_active Expired - Lifetime
- 2001-07-26 AT AT01959195T patent/ATE383159T1/de not_active IP Right Cessation
- 2001-07-26 WO PCT/US2001/023420 patent/WO2002007729A1/en not_active Ceased
- 2001-07-26 PT PT01959195T patent/PT1311270E/pt unknown
- 2001-07-26 JP JP2002513464A patent/JP5047442B2/ja not_active Expired - Fee Related
- 2001-07-26 AU AU8077801A patent/AU8077801A/xx active Pending
- 2001-07-26 IL IL15406001A patent/IL154060A0/xx unknown
- 2001-07-26 CA CA2416535A patent/CA2416535C/en not_active Expired - Fee Related
- 2001-07-26 CN CNB2006100813267A patent/CN100522172C/zh not_active Expired - Fee Related
- 2001-07-26 ES ES01959195T patent/ES2300349T3/es not_active Expired - Lifetime
- 2001-07-26 MX MXPA03000824A patent/MXPA03000824A/es active IP Right Grant
- 2001-07-26 BR BR0112775-6A patent/BR0112775A/pt not_active Application Discontinuation
- 2001-07-26 DE DE60132337T patent/DE60132337T2/de not_active Expired - Lifetime
- 2001-07-26 CN CNB018151426A patent/CN1329032C/zh not_active Expired - Fee Related
- 2001-07-26 AU AU2001280778A patent/AU2001280778B2/en not_active Ceased
-
2003
- 2003-01-20 IL IL154060A patent/IL154060A/en not_active IP Right Cessation
-
2004
- 2004-11-03 IL IL16501704A patent/IL165017A0/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| IL154060A (en) | 2013-05-30 |
| CN100522172C (zh) | 2009-08-05 |
| AU8077801A (en) | 2002-02-05 |
| ATE383159T1 (de) | 2008-01-15 |
| BR0112775A (pt) | 2003-12-30 |
| WO2002007729A1 (en) | 2002-01-31 |
| JP5047442B2 (ja) | 2012-10-10 |
| CA2416535C (en) | 2010-11-16 |
| JP2004517808A (ja) | 2004-06-17 |
| IL154060A0 (en) | 2003-07-31 |
| MXPA03000824A (es) | 2004-11-01 |
| CA2416535A1 (en) | 2002-01-31 |
| IL165017A0 (en) | 2005-12-18 |
| WO2002007729A9 (en) | 2002-08-08 |
| ES2300349T3 (es) | 2008-06-16 |
| CN1872067A (zh) | 2006-12-06 |
| PT1311270E (pt) | 2008-04-15 |
| CN1461219A (zh) | 2003-12-10 |
| DE60132337D1 (de) | 2008-02-21 |
| EP1311270A4 (en) | 2006-04-12 |
| EP1311270A1 (en) | 2003-05-21 |
| AU2001280778B2 (en) | 2004-09-02 |
| CN1329032C (zh) | 2007-08-01 |
| EP1311270B1 (en) | 2008-01-09 |
| HK1100814A1 (en) | 2007-09-28 |
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