DE60131730T2 - Agonisten und antagonisten für den lpa-rezeptor und anwendungsmethoden - Google Patents

Agonisten und antagonisten für den lpa-rezeptor und anwendungsmethoden Download PDF

Info

Publication number
DE60131730T2
DE60131730T2 DE60131730T DE60131730T DE60131730T2 DE 60131730 T2 DE60131730 T2 DE 60131730T2 DE 60131730 T DE60131730 T DE 60131730T DE 60131730 T DE60131730 T DE 60131730T DE 60131730 T2 DE60131730 T2 DE 60131730T2
Authority
DE
Germany
Prior art keywords
lpa
chain
alkyl
straight
edg
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60131730T
Other languages
German (de)
English (en)
Other versions
DE60131730D1 (de
Inventor
Duane D. Germantown MILLER
Gabor Memphis TIGYI
James T. Dalton
Vineet M. Cordova SARDAR
Don B. Memphis ELROD
Huiping Xu
Daniel L. Memphis BAKER
Dean Memphis WANG
Karoly Liliom
David J. Plymouth FISCHER
Tamas Memphis VIRAG
Nora Memphis NUSSER
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Tennessee Research Foundation
Original Assignee
University of Tennessee Research Foundation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of Tennessee Research Foundation filed Critical University of Tennessee Research Foundation
Publication of DE60131730D1 publication Critical patent/DE60131730D1/de
Application granted granted Critical
Publication of DE60131730T2 publication Critical patent/DE60131730T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/40—Esters thereof
    • C07F9/4003—Esters thereof the acid moiety containing a substituent or a structure which is considered as characteristic
    • C07F9/4025—Esters of poly(thio)phosphonic acids
    • C07F9/4028—Esters of poly(thio)phosphonic acids containing no further substituents than -PO3H2 groups in free or esterified form
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/27—Esters, e.g. nitroglycerine, selenocyanates of carbamic or thiocarbamic acids, meprobamate, carbachol, neostigmine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/08—Esters of oxyacids of phosphorus
    • C07F9/09—Esters of phosphoric acids
    • C07F9/091—Esters of phosphoric acids with hydroxyalkyl compounds with further substituents on alkyl
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/08—Esters of oxyacids of phosphorus
    • C07F9/09—Esters of phosphoric acids
    • C07F9/093—Polyol derivatives esterified at least twice by phosphoric acid groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/08—Esters of oxyacids of phosphorus
    • C07F9/09—Esters of phosphoric acids
    • C07F9/094—Esters of phosphoric acids with arylalkanols
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/08—Esters of oxyacids of phosphorus
    • C07F9/09—Esters of phosphoric acids
    • C07F9/098—Esters of polyphosphoric acids or anhydrides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/08—Esters of oxyacids of phosphorus
    • C07F9/09—Esters of phosphoric acids
    • C07F9/11—Esters of phosphoric acids with hydroxyalkyl compounds without further substituents on alkyl
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/16—Esters of thiophosphoric acids or thiophosphorous acids
    • C07F9/165—Esters of thiophosphoric acids
    • C07F9/17—Esters of thiophosphoric acids with hydroxyalkyl compounds without further substituents on alkyl
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/22—Amides of acids of phosphorus
    • C07F9/222—Amides of phosphoric acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/3804—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)] not used, see subgroups
    • C07F9/3808—Acyclic saturated acids which can have further substituents on alkyl

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Emergency Medicine (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
DE60131730T 2000-03-17 2001-03-19 Agonisten und antagonisten für den lpa-rezeptor und anwendungsmethoden Expired - Lifetime DE60131730T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US19037000P 2000-03-17 2000-03-17
US190370P 2000-03-17
PCT/US2001/008729 WO2001071022A2 (en) 2000-03-17 2001-03-19 Lpa receptor agonists and antagonists and methods of use

Publications (2)

Publication Number Publication Date
DE60131730D1 DE60131730D1 (de) 2008-01-17
DE60131730T2 true DE60131730T2 (de) 2008-11-20

Family

ID=22701059

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60131730T Expired - Lifetime DE60131730T2 (de) 2000-03-17 2001-03-19 Agonisten und antagonisten für den lpa-rezeptor und anwendungsmethoden

Country Status (13)

Country Link
US (2) US6875757B2 (enExample)
EP (2) EP1918287A3 (enExample)
JP (1) JP2004506604A (enExample)
KR (1) KR100874392B1 (enExample)
AT (1) ATE380187T1 (enExample)
AU (1) AU4926301A (enExample)
CA (1) CA2402038C (enExample)
CY (1) CY1107214T1 (enExample)
DE (1) DE60131730T2 (enExample)
DK (1) DK1263752T3 (enExample)
ES (1) ES2298227T3 (enExample)
PT (1) PT1263752E (enExample)
WO (1) WO2001071022A2 (enExample)

Families Citing this family (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030130237A1 (en) * 2000-03-17 2003-07-10 Miller Duane D. LPA receptor agonists and antagonists and methods of use
EP1918287A3 (en) * 2000-03-17 2008-08-20 The University Of Tennessee Research Corporation LPA receptor agonists and antagonists and methods of use
EP1361872A4 (en) 2000-10-03 2004-05-19 Univ Virginia NOVEL LYSOPHOSPHATIDIC ACID RECEPTOR AGONISTS AND ANTAGONISTS
US7064217B2 (en) 2001-01-30 2006-06-20 University Of Virginia Patent Foundation Agonists and antagonists of sphingosine-1-phosphate receptors
WO2002062389A1 (en) * 2001-02-08 2002-08-15 Ono Pharmaceutical Co., Ltd. Remedies for urinary diseases comprising lpa receptor controlling agents
JPWO2003007991A1 (ja) * 2001-07-17 2004-11-04 小野薬品工業株式会社 Ｌｐａ受容体調節剤からなる膵液分泌制御剤
AU2003225568A1 (en) * 2002-02-13 2003-09-04 The Scripps Research Institute Purification of the leading front migratory cells
WO2003099765A1 (en) * 2002-05-28 2003-12-04 Ono Pharmaceutical Co., Ltd. β-ALANINE DERIVATIVE AND USE THEREOF
DE10225651A1 (de) * 2002-06-08 2003-12-24 Aventis Pharma Gmbh Verfahren zur Identifizierung von Agonisten oder Antagonisten für den GPR45like/GPR63 Rezeptor
US7300764B2 (en) 2002-06-08 2007-11-27 Sanofi-Aventis Deutschland Gmbh Method for identifying agonists and antagonists of the GPR45-like/GPR63 receptor
AU2003241834A1 (en) * 2002-06-26 2004-01-19 Ono Pharmaceutical Co., Ltd. Remedy for chronic disease
EP1546110A4 (en) * 2002-07-30 2008-03-26 Univ Virginia COMPOUNDS WITH EFFECT ON SIGNAL TRANSMISSION BY SPHINGOSINE-1-PHOSPHATE
EP1597581A1 (en) * 2002-11-13 2005-11-23 Bayer HealthCare AG Diagnostics and therapeutics for diseases associated with endothelial differentiation, sphingolipid g-protein-coupled receptor 4 (edg4)
AU2003289024A1 (en) * 2002-12-12 2004-06-30 Takeda Pharmaceutical Company Limited Novel use of edg receptors
US7524638B1 (en) 2003-06-27 2009-04-28 Osi Pharmaceuticals, Inc. Methods for identification of modulators of OSGPR114 or OSGPR78 activity, and their use in the treatment of disease
WO2005009469A1 (ja) * 2003-07-28 2005-02-03 Sumitomo Pharmaceuticals Co., Ltd. 新規血糖調節薬及びそのスクリーニング方法
AU2004278042B2 (en) * 2003-10-09 2012-02-09 University Of Tennessee Research Foundation LPA receptor agonists and antagonists and methods of use
WO2005041899A2 (en) * 2003-11-03 2005-05-12 University Of Virginia Patent Foundation Orally available sphingosine 1-phosphate receptor agonists and antagonists
US7820703B2 (en) 2004-05-06 2010-10-26 University Of Virginia Patent Foundation Lysophosphatidic acid receptor selective antagonists
US20060223866A1 (en) * 2004-08-13 2006-10-05 Praecis Pharmaceuticals, Inc. Methods and compositions for modulating sphingosine-1-phosphate (S1P) receptor activity
JP2008509931A (ja) * 2004-08-13 2008-04-03 プレーシス ファーマスーティカルズ インコーポレイテッド スフィンゴシン−１−ホスフェート（ｓ１ｐ）レセプター活性を調節するための方法および組成物
EP1827606A2 (en) * 2004-12-06 2007-09-05 University Of Virginia Patent Foundation Aryl amide sphingosine 1-phosphate analogs
BRPI0607435A2 (pt) * 2005-02-14 2010-04-06 Univ Virginia composto ou um sal ou éster farmaceuticamente aceitável do mesmo, e, uso de um composto
JP2009502790A (ja) 2005-07-19 2009-01-29 ザ ユニバーシティー オブ テネシー リサーチ ファウンデーション Ｃｆｔｒのｌｐａ２受容体アゴニスト阻害因子
EP1986623A2 (en) 2006-01-27 2008-11-05 University Of Virginia Patent Foundation Method for treatment of neuropathic pain
JP2009526073A (ja) 2006-02-09 2009-07-16 ユニバーシティ オブ バージニア パテント ファンデーション 二環式スフィンゴシン−１−リン酸受容体アナログ
EP2097371A2 (en) * 2006-11-21 2009-09-09 University Of Virginia Patent Foundation Benzocycloheptyl analogs having sphingosine 1-phosphate receptor activity
NZ576893A (en) 2006-11-21 2012-01-12 Univ Virginia Patent Found Tetralin analogs having sphingosine 1-phosphate agonist activity
JP2010510250A (ja) * 2006-11-21 2010-04-02 ユニバーシティ オブ バージニア パテント ファンデーション スフィンゴシン＝１−燐酸受容体アゴニスト活性を有するヒドリンダンアナログ
NZ580707A (en) 2007-05-04 2011-11-25 Marina Biotech Inc Acylated cationic amino acids and uses thereof
CN101358609A (zh) * 2007-08-03 2009-02-04 富准精密工业(深圳)有限公司 风扇转子
WO2010016590A1 (ja) * 2008-08-07 2010-02-11 国立大学法人 長崎大学 全身性疼痛症候群の治療または予防薬
US9034820B2 (en) 2011-03-14 2015-05-19 Hsinyu Lee Method and composition for modulating erythropoiesis
PH12014500355A1 (en) 2011-08-15 2014-03-31 Intermune Inc Lysophosphatidic acid receptor antagonists
EP2858635A1 (en) * 2012-06-11 2015-04-15 The Regents of The University of California Inhibitors of hippo-yap signaling pathway
EP3089986B1 (en) * 2013-12-30 2019-06-26 Rxbio Inc. Crystalline salts of (z)-o-octadec-9-en-1-yl o,o-dihydrogen phosphorothioate

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB861463A (en) * 1957-05-03 1961-02-22 Ciba Ltd Process for the manufacture of phosphoric acid esters and piperazine and morpholine derivatives
US3639571A (en) * 1970-01-29 1972-02-01 Samuel Turesky Composition and method for retarding plaque and dental calculus
JPS5687590A (en) * 1979-12-19 1981-07-16 Yoshitomi Pharmaceut Ind Ltd Diphosphoglycerine derivative
JPS59104310A (ja) * 1982-12-07 1984-06-16 Lion Corp 口腔用組成物
US4670575A (en) * 1984-06-05 1987-06-02 Kao Corporation Process for purification of phosphoric mono esters
EP0340759A1 (en) * 1988-05-06 1989-11-08 MAGIS FARMACEUTICI S.p.A. Salts of O-mono (di)-acetyl-glycero-mono-(bis)-(di)-phosphates of L-acetyl-carnitine and of L-acetyl carnitine esters
WO1990010014A1 (fr) * 1989-02-28 1990-09-07 Teijin Limited Nouveau derive de vitamine b12, sa production et son application
JPH02250892A (ja) * 1989-03-24 1990-10-08 Idemitsu Kosan Co Ltd 新規フェロセン誘導体，それを含有する界面活性剤及び有機薄膜の製造方法
CA2072249C (en) 1991-06-28 2003-06-17 Saiko Hosokawa Human monoclonal antibody specifically binding to surface antigen of cancer cell membrane
US5565439A (en) 1992-11-24 1996-10-15 The Procter & Gamble Company Methods of using lysophosphatidic acid for treating hyperproliferative conditions
EP0692975A4 (en) * 1993-04-08 2000-11-29 Univ Queensland ADMINISTRATION OF A VASO-ACTIVE AGENT AND A THERAPEUTIC AGENT
US5480877A (en) * 1993-11-02 1996-01-02 Wisconsin Alumni Research Foundation Use of lysophosphatidic acids to enhance fibronectin binding
GB9618634D0 (en) 1996-09-06 1996-10-16 Univ Southampton Anti cancer drugs
EP1024812B1 (en) * 1997-03-19 2007-01-24 Sky High, LLC Compositions containing lysophosphatidic acids which inhibit apoptosis and uses thereof
CA2301921A1 (en) 1997-08-20 1999-02-25 John Graham Goddard Compositions containing polyethylene glycol and uses thereof
US5945522A (en) * 1997-12-22 1999-08-31 Genset Prostate cancer gene
EP1069895A4 (en) 1998-03-18 2002-07-31 Lxr Biotechnology Inc COMPOSITIONS CONTAINING LYSOPHOSPHATIDE ACIDS THAT INHIBIT APOPTOSIS AND USES THEREOF
EP1918287A3 (en) * 2000-03-17 2008-08-20 The University Of Tennessee Research Corporation LPA receptor agonists and antagonists and methods of use

Also Published As

Publication number Publication date
ATE380187T1 (de) 2007-12-15
EP1918287A3 (en) 2008-08-20
DE60131730D1 (de) 2008-01-17
PT1263752E (pt) 2008-03-18
CA2402038C (en) 2011-03-15
ES2298227T3 (es) 2008-05-16
US6875757B2 (en) 2005-04-05
EP1263752A4 (en) 2003-07-30
KR20020082890A (ko) 2002-10-31
US20030027800A1 (en) 2003-02-06
EP1918287A2 (en) 2008-05-07
CY1107214T1 (el) 2012-11-21
WO2001071022A3 (en) 2002-04-04
EP1263752A2 (en) 2002-12-11
WO2001071022A2 (en) 2001-09-27
EP1263752B1 (en) 2007-12-05
JP2004506604A (ja) 2004-03-04
DK1263752T3 (da) 2008-04-14
CA2402038A1 (en) 2001-09-27
AU4926301A (en) 2001-10-03
KR100874392B1 (ko) 2008-12-17
US20050261252A1 (en) 2005-11-24

Similar Documents

Publication Publication Date Title
DE60131730T2 (de) Agonisten und antagonisten für den lpa-rezeptor und anwendungsmethoden
US7947665B2 (en) LPA receptor agonists and antagonists and methods of use
AU2002336595B2 (en) LPA receptor agonists and antagonists and methods of use
AU2002336595A1 (en) LPA receptor agonists and antagonists and methods of use
US7153843B2 (en) Inhibitors of phosphatidyl myo-inositol cycle
US6245754B1 (en) Inhibitors of phosphatidyl myo-inositol cycle
AU2001249263B2 (en) LPA receptor agonists and antagonists and methods of use
AU2007202615A1 (en) LPA receptor agonists and antagonists and methods of use
AU2001249263A1 (en) LPA receptor agonists and antagonists and methods of use
Sardar Design and synthesis of phospholipid growth factor receptor inhibitors
CA2821433C (en) Lpa receptor agonists and antagonists and methods of use
Durgam Design, synthesis and evaluation of novel ligands for lysophosphatidic acid receptors
Heasley Design, synthesis and evaluation of subtype-selective and non-hydrolyzable lysophosphatidic acid receptor agonists and antagonists

Legal Events

Date Code Title Description
8364 No opposition during term of opposition