DE60130769D1 - Förderer der nervenregeneration die als aktiven bestandteil einen semaphorinhemmer enthalten - Google Patents

Förderer der nervenregeneration die als aktiven bestandteil einen semaphorinhemmer enthalten

Info

Publication number
DE60130769D1
DE60130769D1 DE60130769T DE60130769T DE60130769D1 DE 60130769 D1 DE60130769 D1 DE 60130769D1 DE 60130769 T DE60130769 T DE 60130769T DE 60130769 T DE60130769 T DE 60130769T DE 60130769 D1 DE60130769 D1 DE 60130769D1
Authority
DE
Germany
Prior art keywords
semaphorin
inhibitor
nerve
active ingredient
nerve regeneration
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60130769T
Other languages
English (en)
Other versions
DE60130769T2 (de
Inventor
Toru Kimura
Kaoru Kikuchi
Kazuo Kumagai
Norio Hosotani
Akiyoshi Kishino
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sumitomo Pharma Co Ltd
Original Assignee
Sumitomo Dainippon Pharma Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sumitomo Dainippon Pharma Co Ltd filed Critical Sumitomo Dainippon Pharma Co Ltd
Application granted granted Critical
Publication of DE60130769D1 publication Critical patent/DE60130769D1/de
Publication of DE60130769T2 publication Critical patent/DE60130769T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/78—Ring systems having three or more relevant rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/78—Ring systems having three or more relevant rings
    • C07D311/80—Dibenzopyrans; Hydrogenated dibenzopyrans
    • C07D311/82—Xanthenes
    • C07D311/84—Xanthenes with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 9
    • C07D311/86—Oxygen atoms, e.g. xanthones

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Ophthalmology & Optometry (AREA)
  • Psychology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Fodder In General (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
DE60130769T 2000-07-28 2001-07-27 Förderer der nervenregeneration die als aktiven bestandteil einen semaphorinhemmer enthalten Expired - Lifetime DE60130769T2 (de)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
JP2000228555 2000-07-28
JP2000228555 2000-07-28
JP2000390985 2000-12-22
JP2000390985 2000-12-22
PCT/JP2001/006501 WO2002009756A1 (fr) 2000-07-28 2001-07-27 Promoteurs de la regeneration des nerfs contenant un inhibiteur de semaphorine en tant qu'ingredient actif

Publications (2)

Publication Number Publication Date
DE60130769D1 true DE60130769D1 (de) 2007-11-15
DE60130769T2 DE60130769T2 (de) 2008-07-17

Family

ID=26596897

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60130769T Expired - Lifetime DE60130769T2 (de) 2000-07-28 2001-07-27 Förderer der nervenregeneration die als aktiven bestandteil einen semaphorinhemmer enthalten

Country Status (8)

Country Link
US (2) US7244761B2 (de)
EP (1) EP1306093B1 (de)
JP (1) JP4975231B2 (de)
AT (1) ATE374623T1 (de)
AU (1) AU2001276694A1 (de)
DE (1) DE60130769T2 (de)
ES (1) ES2294014T3 (de)
WO (1) WO2002009756A1 (de)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4749667B2 (ja) * 2001-08-13 2011-08-17 ユニバーシティ オブ フロリダ リサーチ ファンデーション インコーポレーティッド 神経組織の修復を促進するための材料および方法
WO2003062440A1 (fr) * 2002-01-21 2003-07-31 Sumitomo Pharmaceuticals Co., Ltd. Derive de xanthone
EP1475382B1 (de) * 2002-01-24 2008-12-10 Dainippon Sumitomo Pharma Co., Ltd. Verbindungen als semaphorininhibitoren
JP4820170B2 (ja) * 2003-12-05 2011-11-24 大日本住友製薬株式会社 虚血性神経障害治療又は予防剤
WO2009067493A2 (en) * 2007-11-19 2009-05-28 Envivo Pharmaceuticals, Inc. 1,3,5 tri-subtituted benzenes for treatment of alzheimer's disease and other disorders
WO2012018069A1 (ja) 2010-08-06 2012-02-09 大日本住友製薬株式会社 脊髄損傷治療用製剤
ES2577009T3 (es) 2011-02-25 2016-07-12 Keio University Agente terapéutico para daño del nervio sensorial corneal que contiene un inhibidor de semaforina como principio activo
WO2014178427A1 (ja) * 2013-05-02 2014-11-06 学校法人順天堂 セマフォリン３ａの発現調節法
WO2015021226A1 (en) * 2013-08-07 2015-02-12 Board Of Regents, The University Of Texas System Analogs of vinaxanthone and xanthofulvin, methods of synthesis, and methods of treatments thereof
US20170216244A1 (en) * 2014-03-06 2017-08-03 Yale University Methods for treating diabetic nephropathy
CN104945389B (zh) * 2014-03-27 2018-04-13 中国科学院上海药物研究所 一类山酮串色酮类化合物及其制备方法和用途
CN108779090B (zh) * 2016-01-15 2022-07-26 住友制药株式会社 2环性杂环化合物
CN109956952B (zh) * 2017-12-14 2020-11-13 浙江工业大学 α-楝子素衍生物及其制备方法与应用
JP7093489B2 (ja) * 2018-02-27 2022-06-30 学校法人順天堂 脳梗塞に関する治療薬
JPWO2020122101A1 (ja) * 2018-12-12 2021-10-28 大日本住友製薬株式会社 新規投与方法
CN113174082B (zh) * 2021-03-30 2022-12-02 中国人民解放军空军军医大学 仿生硅化胶原材料的制备方法及其应用
CN113512018B (zh) * 2021-07-07 2023-07-18 合肥工业大学 一种黄酮类化合物及其制备方法和用途

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH06506202A (ja) 1991-03-22 1994-07-14 ゼノバ　リミテッド 医薬用キサントン誘導体
US5229123A (en) * 1991-10-09 1993-07-20 Hoffmann-La Roche Inc. Antifungal agents
US5639856A (en) 1993-09-13 1997-06-17 The Regents Of The University Of California Semaphorin gene family
US5416197A (en) 1993-10-15 1995-05-16 Trustees Of The University Of Pennsylvania Antibodies which bind human collapsin
US5674242A (en) 1995-06-06 1997-10-07 Quanam Medical Corporation Endoprosthetic device with therapeutic compound
JP4108755B2 (ja) 1996-09-11 2008-06-25 大日本住友製薬株式会社 新規セマフォリン遺伝子：セマフォリンｙ
CA2268006A1 (en) 1996-10-09 1998-04-16 Sumitomo Pharmaceuticals Co., Ltd. Novel semaphorin gene: semaphorin w
WO2000031252A1 (en) * 1998-11-26 2000-06-02 MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. Human semaphorin 6a-1 (sema6a-a), a gene involved in neuronal development and regeneration mechanisms during apoptosis, and its use as a potential drug target

Also Published As

Publication number Publication date
WO2002009756A1 (fr) 2002-02-07
EP1306093A1 (de) 2003-05-02
DE60130769T2 (de) 2008-07-17
US7244761B2 (en) 2007-07-17
EP1306093B1 (de) 2007-10-03
ES2294014T3 (es) 2008-04-01
EP1306093A4 (de) 2004-06-30
US20070015820A1 (en) 2007-01-18
AU2001276694A1 (en) 2002-02-13
US20030166711A1 (en) 2003-09-04
JP4975231B2 (ja) 2012-07-11
JPWO2002009756A1 (ja) 2004-01-08
US7317038B2 (en) 2008-01-08
ATE374623T1 (de) 2007-10-15

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