DE60128910D1 - Nullte-ordnung-freisetzung und temperatur-kontrollierte mikrokapseln sowie herstellungsverfahren - Google Patents

Nullte-ordnung-freisetzung und temperatur-kontrollierte mikrokapseln sowie herstellungsverfahren

Info

Publication number
DE60128910D1
DE60128910D1 DE60128910T DE60128910T DE60128910D1 DE 60128910 D1 DE60128910 D1 DE 60128910D1 DE 60128910 T DE60128910 T DE 60128910T DE 60128910 T DE60128910 T DE 60128910T DE 60128910 D1 DE60128910 D1 DE 60128910D1
Authority
DE
Germany
Prior art keywords
core material
water insoluble
shell material
matrix
microcapsules
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE60128910T
Other languages
English (en)
Other versions
DE60128910T2 (de
Inventor
Farid Vaghefi
Jeffry Lee
Vijendra Nalamothu
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Verion Inc
Original Assignee
Verion Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Verion Inc filed Critical Verion Inc
Publication of DE60128910D1 publication Critical patent/DE60128910D1/de
Application granted granted Critical
Publication of DE60128910T2 publication Critical patent/DE60128910T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J13/00—Colloid chemistry, e.g. the production of colloidal materials or their solutions, not otherwise provided for; Making microcapsules or microballoons
    • B01J13/02—Making microcapsules or microballoons
    • B01J13/04—Making microcapsules or microballoons by physical processes, e.g. drying, spraying
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1617—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J13/00—Colloid chemistry, e.g. the production of colloidal materials or their solutions, not otherwise provided for; Making microcapsules or microballoons
    • B01J13/02—Making microcapsules or microballoons
    • B01J13/20—After-treatment of capsule walls, e.g. hardening
    • B01J13/22—Coating
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5015—Organic compounds, e.g. fats, sugars
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
    • Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]
    • Y10T428/2984—Microcapsule with fluid core [includes liposome]
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
    • Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]
    • Y10T428/2989—Microcapsule with solid core [includes liposome]
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
    • Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]
    • Y10T428/2991—Coated

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Dispersion Chemistry (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Manufacturing Of Micro-Capsules (AREA)
  • Medicinal Preparation (AREA)
  • General Preparation And Processing Of Foods (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Glanulating (AREA)
DE60128910T 2000-04-27 2001-04-27 Nullte-ordnung-freisetzung und temperatur-kontrollierte mikrokapseln sowie herstellungsverfahren Expired - Fee Related DE60128910T2 (de)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US19997600P 2000-04-27 2000-04-27
US199976P 2000-04-27
US25251000P 2000-11-22 2000-11-22
US252510P 2000-11-22
PCT/US2001/013646 WO2001080831A2 (en) 2000-04-27 2001-04-27 Zero order release and temperature-controlled microcapsules and process for the preparation thereof

Publications (2)

Publication Number Publication Date
DE60128910D1 true DE60128910D1 (de) 2007-07-26
DE60128910T2 DE60128910T2 (de) 2008-02-28

Family

ID=26895339

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60128910T Expired - Fee Related DE60128910T2 (de) 2000-04-27 2001-04-27 Nullte-ordnung-freisetzung und temperatur-kontrollierte mikrokapseln sowie herstellungsverfahren

Country Status (9)

Country Link
US (2) US6544646B2 (de)
EP (1) EP1289645B1 (de)
JP (1) JP2003530996A (de)
AT (1) ATE364442T1 (de)
AU (1) AU2001257359A1 (de)
CA (1) CA2407154A1 (de)
DE (1) DE60128910T2 (de)
ES (1) ES2287126T3 (de)
WO (1) WO2001080831A2 (de)

Families Citing this family (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8828432B2 (en) 1996-10-28 2014-09-09 General Mills, Inc. Embedding and encapsulation of sensitive components into a matrix to obtain discrete controlled release particles
US7201923B1 (en) 1998-03-23 2007-04-10 General Mills, Inc. Encapsulation of sensitive liquid components into a matrix to obtain discrete shelf-stable particles
WO1999048372A1 (en) * 1998-03-23 1999-09-30 General Mills, Inc. Encapsulation of components into edible products
US6500463B1 (en) 1999-10-01 2002-12-31 General Mills, Inc. Encapsulation of sensitive components into a matrix to obtain discrete shelf-stable particles
US6558718B1 (en) * 2000-06-19 2003-05-06 General Mills, Inc. Nutrient clusters for food products and methods of preparation
JP4161652B2 (ja) * 2001-10-10 2008-10-08 株式会社デンソー セラミックス構造体の製造方法およびセラミックスハニカム構造体の製造方法
WO2003039514A1 (en) * 2001-10-18 2003-05-15 Verion Inc. Microcapsule matrix microspheres, absorption-enhancing pharmaceutical compositions and methods
DE10224607B4 (de) * 2002-06-04 2008-03-13 Lts Lohmann Therapie-Systeme Ag Filmförmige, zerfallsfähige Zubereitungen zur Wirkstofffreisetzung und Verfahren zu deren Herstellung
US7431986B2 (en) * 2002-07-24 2008-10-07 General Mills, Inc. Encapsulation of sensitive components using pre-emulsification
JP5189242B2 (ja) * 2002-09-23 2013-04-24 アルケルメス ファーマ アイルランド リミテッド 乱用抵抗性の医薬組成物
US20040229815A1 (en) 2003-01-03 2004-11-18 Nagasawa Herbert T. Methods for reducing oxidative stress in a cell with a sulfhydryl protected glutathione prodrug
EP1608347B1 (de) * 2003-03-28 2014-08-13 Sigmoid Pharma Limited Solide orale dosierform mit nahtlosen mikrokapseln
US20050161843A1 (en) * 2004-01-23 2005-07-28 Yongcai Wang Process of producing microcapsules and product thereof
US7431849B1 (en) * 2004-03-05 2008-10-07 Specialty Earth Sciences Llc Encapsulated reactant and process
US10335757B2 (en) * 2004-03-05 2019-07-02 Specialty Earth Sciences Process for making environmental reactant(s)
EP1937222B1 (de) * 2005-10-17 2014-02-26 GL PharmTech Corp. Neue multi-einheits-dosierform mit verzögerter freisetzung
US7803413B2 (en) * 2005-10-31 2010-09-28 General Mills Ip Holdings Ii, Llc. Encapsulation of readily oxidizable components
DE102006059510A1 (de) * 2006-12-14 2008-06-19 Grünenthal GmbH Beschichtete Pellets
EP2061440A2 (de) 2007-04-04 2009-05-27 Sigmoid Pharma Limited Pharmazeutische tacrolimus-zusammensetzung
ES2963291T3 (es) 2007-04-26 2024-03-26 Sublimity Therapeutics Ltd Fabricación de múltiples minicápsulas
US8729015B2 (en) * 2007-12-21 2014-05-20 Merck Patent Gmbh Solid lipid microcapsules containing growth hormone inner core microparticles
CN101969976A (zh) 2008-01-11 2011-02-09 美国政府健康与人类服务部秘书处 针对分枝杆菌的多肽疫苗和接种策略
US20120209396A1 (en) 2008-07-07 2012-08-16 David Myung Orthopedic implants having gradient polymer alloys
WO2010005992A1 (en) * 2008-07-07 2010-01-14 Biomimedica, Inc. Hydrophilic interpenetrating polymer networks derived from hydrophobic polymers
MX2011000825A (es) * 2008-07-22 2011-02-25 Gen Mills Inc Productos frutales que contienen acidos grasos omega-3.
US8846056B2 (en) 2009-08-04 2014-09-30 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services, Centers For Disease Control Anti-RSV immunogens and methods of immunization
WO2011100408A2 (en) 2010-02-10 2011-08-18 The Government Of The United States Of America, As Represented By The Secretary, Department Of Health & Human Services, Centers For Disease Control And Prevention Serologic correlates of protection against bacillis anthracis infection
US9102742B2 (en) 2010-02-10 2015-08-11 The United States Of America As Represented By The Secretary, Department Of Health And Human Services, Centers For Disease Control And Prevention Serologic correlates of protection against Bacillus anthracis infection
US20130103157A1 (en) 2011-10-03 2013-04-25 Lampros Kourtis Polymeric adhesive for anchoring compliant materials to another surface
GB201212010D0 (en) 2012-07-05 2012-08-22 Sigmoid Pharma Ltd Formulations
KR20150040271A (ko) * 2012-08-08 2015-04-14 세키스이가가쿠 고교가부시키가이샤 마이크로 캡슐의 제조 방법, 및 마이크로 캡슐
CN110575445B (zh) 2013-03-21 2023-08-18 优普顺药物公司美国分部 可注射的持续释放组合物及其用于治疗关节炎症及相关疼痛的方法
GB201319791D0 (en) 2013-11-08 2013-12-25 Sigmoid Pharma Ltd Formulations
WO2016007422A1 (en) * 2014-07-07 2016-01-14 The Regents Of The University Of California Medium independent pressure tolerant release device, system and method
US11077228B2 (en) 2015-08-10 2021-08-03 Hyalex Orthopaedics, Inc. Interpenetrating polymer networks
AU2016343952A1 (en) 2015-10-27 2018-05-10 Eupraxia Pharmaceuticals Inc. Sustained release formulations of local anesthetics
US10647045B1 (en) 2016-11-03 2020-05-12 Specialty Earth Sciences, Llc Shaped or sized encapsulated reactant and method of making
FR3062238A1 (fr) 2017-01-26 2018-07-27 Soitec Support pour une structure semi-conductrice
US10869950B2 (en) 2018-07-17 2020-12-22 Hyalex Orthopaedics, Inc. Ionic polymer compositions

Family Cites Families (74)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US1627863A (en) 1924-12-01 1927-05-10 Western Cartridge Co Explosive powder and process of making same
US2876160A (en) 1954-07-26 1959-03-03 Corn Prod Refining Co Starch matrix material containing imbedded material and process for preparing same
US2827452A (en) 1955-05-31 1958-03-18 Univ Minnesota Stabilization of materials
US3265629A (en) 1958-12-22 1966-08-09 Ncr Co Coating by phase separation
US3080293A (en) 1960-08-02 1963-03-05 Hoffmann La Roche Process of making pleasant-tasting niacinamide beadlets
US3155590A (en) 1962-08-02 1964-11-03 Ncr Co Encapsulation process and its product
US3341416A (en) 1963-12-11 1967-09-12 Ncr Co Encapsulation of aspirin in ethylcellulose and its product
US3455838A (en) 1966-04-22 1969-07-15 Nat Starch Chem Corp Method of encapsulating water-insoluble substances and product thereof
US3499962A (en) 1967-08-24 1970-03-10 Nat Starch Chem Corp Encapsulation of water insoluble materials
US3565819A (en) 1969-02-13 1971-02-23 Westvaco Corp Process of producing microcapsules
US3664963A (en) 1969-10-22 1972-05-23 Balchem Corp Encapsulation process
JPS4910912B1 (de) 1970-03-17 1974-03-13
US3845770A (en) 1972-06-05 1974-11-05 Alza Corp Osmatic dispensing device for releasing beneficial agent
US4022917A (en) 1972-12-07 1977-05-10 Selenke William M Process for preparing a storage stable premixed batter
US4177056A (en) 1974-06-27 1979-12-04 Ciba-Geigy Corporation Water-insoluble hydrophilic copolymers used as carriers for medicaments and pesticides
US3949094A (en) 1974-07-31 1976-04-06 Scm Corporation Condiment-treating process and product
US4131648A (en) 1975-01-28 1978-12-26 Alza Corporation Structured orthoester and orthocarbonate drug delivery devices
US4093709A (en) 1975-01-28 1978-06-06 Alza Corporation Drug delivery devices manufactured from poly(orthoesters) and poly(orthocarbonates)
GB1561204A (en) 1977-06-01 1980-02-13 Ici Ltd Sustained release pharmaceutical composition
US4276312A (en) 1978-05-25 1981-06-30 Merritt Carleton G Encapsulation of materials
DE3013839A1 (de) 1979-04-13 1980-10-30 Freunt Ind Co Ltd Verfahren zur herstellung einer aktivierten pharmazeutischen zusammensetzung
FR2478431A1 (fr) 1980-03-24 1981-09-25 Rhone Poulenc Ind Sucroglycerides mis sur support, leur procede d'obtention et leur application
US4353962A (en) 1980-05-15 1982-10-12 Environmental Chemicals, Inc. In-flight encapsulation of particles
US4259315A (en) 1980-06-13 1981-03-31 A. H. Robins Company, Inc. Controlled release potassium dosage form
US4423099A (en) 1980-07-28 1983-12-27 Ciba-Geigy Corporation Membrane modified hydrogels
US4327725A (en) 1980-11-25 1982-05-04 Alza Corporation Osmotic device with hydrogel driving member
US4479911A (en) 1982-01-28 1984-10-30 Sandoz, Inc. Process for preparation of microspheres and modification of release rate of core material
DK152744C (da) 1982-08-13 1988-10-31 Benzon As Alfred Fremgangsmaade til fremstilling af et farmaceutisk peroralt polydepotpraeparat
FR2539626B2 (fr) 1983-01-25 1985-06-21 Lafon Labor Nouveau procede de preparation de formes galeniques utiles notamment en therapeutique, dietetique, cosmetique et diagnostic, et formes obtenues selon ce procede
US4927687A (en) 1984-10-01 1990-05-22 Biotek, Inc. Sustained release transdermal drug delivery composition
US4606940A (en) 1984-12-21 1986-08-19 The Ohio State University Research Foundation Small particle formation and encapsulation
JPH0661458B2 (ja) * 1985-04-18 1994-08-17 日本酸素株式会社 水又は酸・アルカリ水溶液との反応性又は溶解性を遅延させた組成物及びその製造方法
US4707287A (en) 1985-06-28 1987-11-17 The Procter & Gamble Company Dry bleach stable enzyme composition
JPS62201635A (ja) * 1986-02-27 1987-09-05 Snow Brand Milk Prod Co Ltd 噴霧冷却方式によるマイクロカプセルの製造方法
US4837381A (en) 1986-08-11 1989-06-06 American Cyanamid Company Compositions for parenteral administration and their use
ES2038669T3 (es) 1986-09-18 1993-08-01 London School Of Pharmacy Innovations Ltd Formulacion farmaceutica.
US5370881A (en) 1987-04-20 1994-12-06 Fuisz Technologies Ltd. Water-soluble delivery systems for hydrophobic liquids
US4786509A (en) 1987-05-18 1988-11-22 Schering Corporation Dry sustained release theophylline oral formulation
US4978483A (en) 1987-09-28 1990-12-18 Redding Bruce K Apparatus and method for making microcapsules
US5271881A (en) 1987-09-28 1993-12-21 Redding Bruce K Apparatus and method for making microcapsules
US4919841A (en) 1988-06-06 1990-04-24 Lever Brothers Company Wax encapsulated actives and emulsion process for their production
FR2643572A1 (fr) 1988-12-22 1990-08-31 Rhone Poulenc Chimie Procede d'encapsulation de particules par pelliculage au moyen d'un copolymere silicone thermoplastique
US5160530A (en) 1989-01-24 1992-11-03 Griffin Corporation Microencapsulated polymorphic agriculturally active material
WO1990013361A1 (en) 1989-05-04 1990-11-15 Southern Research Institute Improved encapsulation process and products therefrom
US5204029A (en) 1989-09-25 1993-04-20 Morgan Food Products, Inc. Methods of encapsulating liquids in fatty matrices, and products thereof
MY107937A (en) 1990-02-13 1996-06-29 Takeda Chemical Industries Ltd Prolonged release microcapsules.
US5213810A (en) 1990-03-30 1993-05-25 American Cyanamid Company Stable compositions for parenteral administration and method of making same
US5209879A (en) 1990-04-06 1993-05-11 Redding Bruce K Method for inducing transformations in waxes
IL97755A0 (en) 1990-04-06 1992-06-21 Redding Bruce K Capsules comprising environmentally sensitive materials
US5246636A (en) * 1991-05-07 1993-09-21 Southwest Research Institute Process for making microcapsules and apparatus therefor
US5252337A (en) 1991-06-25 1993-10-12 Eurand America, Inc. Controlled release calcium channel blocker microcapsules
JP2674720B2 (ja) 1991-08-12 1997-11-12 アライド−シグナル・インコーポレーテッド 剥離層状物質の高分子ナノ複合体の溶融加工形成法
KR100259989B1 (ko) 1991-10-01 2000-08-01 모리다 가쓰라 서방성 마이크로캡슐 제제 및 그의 제조법
WO1993021008A1 (en) 1992-04-20 1993-10-28 Redding Bruce K Jr Method and apparatus for the modification of starch and other polymers
GB9221329D0 (en) 1992-10-10 1992-11-25 Delta Biotechnology Ltd Preparation of further diagnostic agents
US6001346A (en) 1993-02-25 1999-12-14 The Regents Of The University Of California Aqueous emulsion comprising biodegradable carrier for insect pheromones and methods for controlled release thereof
US5482702A (en) 1993-04-27 1996-01-09 Church & Dwight Co., Inc. Hydrophilic polymer-coated microcrystallites of bicarbonate salt
US5395626A (en) 1994-03-23 1995-03-07 Ortho Pharmaceutical Corporation Multilayered controlled release pharmaceutical dosage form
US5599583A (en) 1994-05-27 1997-02-04 Micro Flo Company Encapsulation with water soluble polymer
US5601760A (en) 1994-09-01 1997-02-11 The Regents Of The University Of California, A California Corporation Milk derived whey protein-based microencapsulating agents and a method of use
US5631013A (en) 1995-08-07 1997-05-20 Church & Dwight Co., Inc. Cosmetic deodorant products containing encapsulated co-micronized bicarbonate ingredient
US5614179A (en) 1995-09-27 1997-03-25 Church & Dwight Co., Inc. Cosmetic deodorant products containing a polymer/fragrance-encapsulated bicarbonate ingredient
US5827539A (en) 1995-12-28 1998-10-27 Amway Corporation Dry carotenoid-oil powder and process for making same
IL117773A (en) 1996-04-02 2000-10-31 Pharmos Ltd Solid lipid compositions of coenzyme Q10 for enhanced oral bioavailability
ES2167634T3 (es) 1996-04-09 2002-05-16 Bayer Ag Procedimiento y dispositivo para la aglomeracion de sustancias sensibles a la hidrolisis mediante vapor de agua.
AU4424797A (en) 1996-09-18 1998-04-14 Dragoco Inc. Liposome encapsulated active agent dry powder composition
US5766637A (en) 1996-10-08 1998-06-16 University Of Delaware Microencapsulation process using supercritical fluids
US5952095A (en) 1996-12-06 1999-09-14 Amcol International Corporation Intercalates and exfoliates formed with long chain (C10 +) monomeric organic intercalant compounds; and composite materials containing same
US6096291A (en) 1996-12-27 2000-08-01 Biovector Therapeutics, S.A. Mucosal administration of substances to mammals
US5980942A (en) 1997-01-23 1999-11-09 Yissum Research Development Company Of The Hebrew University Of Jerusalem Zero-order sustained release matrix tablet formulations of carbamazepine
US5945085A (en) 1997-06-19 1999-08-31 Church & Dwight Co., Inc. Aerosol deodorant-antiperspirant product
JP4370429B2 (ja) 1998-09-10 2009-11-25 東和薬品株式会社 徐放性マイクロスフエアの製造法
WO2002026372A2 (en) 2000-09-27 2002-04-04 Verion Inc. Instant water dissolvable encapsulate and process
JP5189242B2 (ja) 2002-09-23 2013-04-24 アルケルメス ファーマ アイルランド リミテッド 乱用抵抗性の医薬組成物

Also Published As

Publication number Publication date
DE60128910T2 (de) 2008-02-28
EP1289645A2 (de) 2003-03-12
JP2003530996A (ja) 2003-10-21
WO2001080831A2 (en) 2001-11-01
CA2407154A1 (en) 2001-11-01
US7179407B2 (en) 2007-02-20
US6544646B2 (en) 2003-04-08
ES2287126T3 (es) 2007-12-16
WO2001080831A3 (en) 2002-03-21
US20030146530A1 (en) 2003-08-07
US20010044026A1 (en) 2001-11-22
EP1289645B1 (de) 2007-06-13
AU2001257359A1 (en) 2001-11-07
ATE364442T1 (de) 2007-07-15

Similar Documents

Publication Publication Date Title
ATE364442T1 (de) Nullte-ordnung-freisetzung und temperatur- kontrollierte mikrokapseln sowie herstellungsverfahren
CA1060364A (en) Encapsulation process utilizing microorganisms and products produced thereby
EP0761213A3 (de) Verfahren zur Herstellung einer Zubereitung mit verzögerter Freisetzung
HUP0003121A3 (en) Method for producing orally administered, solid pharmaceutical products with controlled release of the active substance
US5827535A (en) Graphically impressed softgel and method for making same
ME02874B (de) Gekapselte manipulationssichere Darreichungsformen mit gesteuerter Freisetzung
ES8400872A1 (es) Mejoras introducidas en microcapsulas de etilcelulosa.
NO20001670L (no) Fremgangsmate for fremstilling av en smaksmaskert farmasoytisk blanding og smaksmaskert farmasoytisk blanding fremstilt ifolge denne fremgangsmaten, samt smaksmaskerte tyggbare tabletter
DE60222000D1 (de) Sprühgetrocknete zubereitungen und verfahren für deren herstellung
CA2461671A1 (en) Premixed and frozen seal caps
PL352210A1 (en) Bonding composition containing thermally expandable microcapsules
WO2008146162A8 (en) Wax capsules containing hydrophilic cores
BR0107899A (pt) Processo para produzir uma preparação de ingrediente ativo compreendendo ibuprofeno, preparação de ingrediente ativo, uso da mesma, preparação farmacêutica, uso da mesma, processo para produzir formas de dosagem sólidas, e, forma de dosagem sólida
EE04577B1 (et) Sferoidi südamik ja selle valmistamismeetod, sferoid ja kapseldatud, pikendatud toimeajaga ravimvorm
CA2335247A1 (en) Method for manufacturing a laminate consisting of individual layers
CA2372025A1 (en) Method for producing a water-insoluble amorphous or partially amorphous controlled release matrix
EP1757275A1 (de) Nahtlose kapsel mit einem wasserlöslichen wirkstoff
DE1068863B (de)
FR2801179B1 (fr) Procede d'encapsulation d'une composition topique
US20040161438A1 (en) Cosmetic preparations comprising active ingredients in microcapsules
RU2008121781A (ru) Жевательные составы с экстрактом коры магнолии быстрого высвобождения
YU33001A (sh) Postupak za proizvodnju kapsula punjenih tečnim supstancama
WO1987003805A1 (fr) Procede de production de formes propres a l'administration de doses individuelles et formes ainsi obtenues
ITMI961525A1 (it) Composizioni per integrazione nutrizionale comprendenti vitamine idrosolubili a rilascio prolungato
CA2585444A1 (en) Dosage forms having a microreliefed surface and methods and apparatus for their production

Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee