DE60124594D1 - Makrolidantibiotika - Google Patents

Makrolidantibiotika

Info

Publication number
DE60124594D1
DE60124594D1 DE60124594T DE60124594T DE60124594D1 DE 60124594 D1 DE60124594 D1 DE 60124594D1 DE 60124594 T DE60124594 T DE 60124594T DE 60124594 T DE60124594 T DE 60124594T DE 60124594 D1 DE60124594 D1 DE 60124594D1
Authority
DE
Germany
Prior art keywords
macrolide antibiotics
macrolide
antibiotics
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE60124594T
Other languages
English (en)
Other versions
DE60124594T2 (de
Inventor
Daniele Andreotti
Luca Arista
Stefano Biondi
Francesca Cardullo
Frederica Damiani
Sergio Lociuro
Carla Marchioro
Giancarlo Merlo
Anna Mingardi
Daniela Niccolai
Alfredo Paio
Elisabetta Piga
Alfonso Pozzan
Catia Seri
Luca Tarsi
Silvia Terreni
Jessica Tibasco
Manuela Ciraco
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Glaxo Group Ltd
Fidelta doo
Original Assignee
Glaxo Group Ltd
Pliva Farmaceutika dd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB0031309A external-priority patent/GB0031309D0/en
Priority claimed from GB0126276A external-priority patent/GB0126276D0/en
Priority claimed from GB0126277A external-priority patent/GB0126277D0/en
Application filed by Glaxo Group Ltd, Pliva Farmaceutika dd filed Critical Glaxo Group Ltd
Publication of DE60124594D1 publication Critical patent/DE60124594D1/de
Application granted granted Critical
Publication of DE60124594T2 publication Critical patent/DE60124594T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Molecular Biology (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
DE60124594T 2000-12-21 2001-12-20 Makrolidantibiotika Expired - Fee Related DE60124594T2 (de)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
GB0031309 2000-12-21
GB0031309A GB0031309D0 (en) 2000-12-21 2000-12-21 Macrolides
GB0126276A GB0126276D0 (en) 2001-11-01 2001-11-01 Macolides
GB0126277 2001-11-01
GB0126277A GB0126277D0 (en) 2001-11-01 2001-11-01 Macrolides
GB0126276 2001-11-01
PCT/GB2001/005665 WO2002050091A1 (en) 2000-12-21 2001-12-20 Macrolide antibiotics

Publications (2)

Publication Number Publication Date
DE60124594D1 true DE60124594D1 (de) 2006-12-28
DE60124594T2 DE60124594T2 (de) 2007-10-04

Family

ID=27256023

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60124594T Expired - Fee Related DE60124594T2 (de) 2000-12-21 2001-12-20 Makrolidantibiotika

Country Status (20)

Country Link
US (3) US20040077557A1 (de)
EP (1) EP1363925B8 (de)
JP (1) JP2004531471A (de)
KR (1) KR20030068189A (de)
CN (1) CN1492874A (de)
AR (1) AR042583A1 (de)
AT (1) ATE345350T1 (de)
AU (2) AU1727702A (de)
BR (1) BR0116431A (de)
CA (1) CA2432429A1 (de)
CZ (1) CZ20031751A3 (de)
DE (1) DE60124594T2 (de)
ES (1) ES2275621T3 (de)
HU (1) HUP0302526A2 (de)
IL (1) IL156561A0 (de)
MX (1) MXPA03005668A (de)
NO (1) NO20032846L (de)
NZ (1) NZ526450A (de)
PL (1) PL365012A1 (de)
WO (1) WO2002050091A1 (de)

Families Citing this family (48)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2377847T3 (es) 1999-01-13 2012-04-02 Bayer Healthcare Llc Difenil ureas sustituidas con omega-carboxi arilo como agentes inhibidores de la cinasa p38
US8124630B2 (en) 1999-01-13 2012-02-28 Bayer Healthcare Llc ω-carboxyaryl substituted diphenyl ureas as raf kinase inhibitors
DK1478358T3 (da) 2002-02-11 2013-10-07 Bayer Healthcare Llc Sorafenibtosylat til behandling af sygdomme kendetegnet ved unormal angiogenese
US6995143B2 (en) 2002-02-28 2006-02-07 Basilea Pharmaceutica Ag Macrolides with antibacterial activity
US6727229B2 (en) 2002-08-19 2004-04-27 Enanta Pharmaceuticals, Inc. 11,12-substituted lactone ketolide derivatives having antibacterial activity
US6720308B1 (en) 2002-11-07 2004-04-13 Enanta Pharmaceuticals, Inc. Anhydrolide derivatives having antibacterial activity
HRP20020886A2 (en) * 2002-11-11 2005-06-30 PLIVA-ISTRAŽIVAČKI INSTITUT d.o.o. SUBSTITUTED 9a-N-[N'-(BENZENSULFONYL)CARBAMOYL-γ-AMINOPROPYL) AND 9a-N(N' -(?-CYANOETHIL)-N' -(b
HRP20020991A2 (en) * 2002-12-12 2005-02-28 Pliva-Istra�iva�ki institut d.o.o. N"-Substituted 9a-N-(N'-carbamoyl-Gamma-aminopropyl), 9a-N-(N'? -thiocarbamoyl-Gamma-aminopropyl), 9a-N-(N'-((Beta-cyanoethyl)-N'-carbamoyl-Gamma? -aminopropyl) and 9a-N-(N'-(Beta-cyanoethyl)-N'-thiocarbamoyl-Gamma? -aminopropyl) derivatives of 9-de
WO2004113274A2 (en) 2003-05-20 2004-12-29 Bayer Pharmaceuticals Corporation Diaryl ureas with kinase inhibiting activity
US6790835B1 (en) 2003-06-05 2004-09-14 Enanta Pharmaceuticals, Inc. Bicyclic macrolide derivatives
US6774115B1 (en) 2003-06-05 2004-08-10 Enanta Pharmaceuticals, Inc. 6-O-substituted bicyclic ketolides
US6716820B1 (en) 2003-06-05 2004-04-06 Enanta Pharmaceuticals, Inc. 6-O-substituted bicyclic macrolides
US6765016B1 (en) 2003-06-05 2004-07-20 Enanta Pharmaceuticals, Inc. Bicyclic ketolide derivatives
EA010485B1 (ru) 2003-07-23 2008-10-30 Байер Фамэсьютиклс Копэрейшн Производное n,n'-дифенилмочевины, фармацевтическая композиция (варианты) и способ лечения и предупреждения заболеваний и состояний с его использованием (варианты)
CN100471856C (zh) * 2003-07-31 2009-03-25 Irm责任有限公司 作为pdf抑制剂的二环化合物和组合物
DE602004004156T2 (de) 2003-08-20 2007-10-11 Eli Lilly And Co., Indianapolis Verbindungen, verfahren und formulierungen zur oralen verabreichung einer glucagon like peptide (glp)-1-verbindung oder eines am melanocortin-4-rezeptor (mc4) als agonist wirkenden peptids
ATE361294T1 (de) 2003-08-20 2007-05-15 Lilly Co Eli Verbindungen, verfahren und formulierungen zur oralen verabreichung einer glucagonartigen peptid (glp)-1-verbindung oder eines melanocortin-4- rezeptor-(mc4-)agonistschen peptids
RU2403237C2 (ru) * 2004-05-14 2010-11-10 Эмисфире Текнолоджис, Инк. Составы и смеси для доставки активных агентов
ES2339871T3 (es) 2004-12-21 2010-05-26 Pfizer Products Inc. Macrolidos.
CN101115764B (zh) * 2005-02-09 2012-09-26 巴斯利尔药物股份公司 大环内酯类化合物
EP1879903A1 (de) 2005-05-10 2008-01-23 GlaxoSmithKline istrazivacki centar Zagreb d.o.o. Etherverbrückte makrolide, die sich zur behandlung mikrobieller infektionen eignen
EP1994928A4 (de) * 2006-03-10 2010-08-11 Yuuzou Tsuchida Antimikrobiotikum und antimikrobielle zusammensetzung
CN103193840A (zh) * 2006-05-01 2013-07-10 大正制药株式会社 大环内酯衍生物
KR20090042971A (ko) 2006-08-24 2009-05-04 욱크하르트 리서치 센터 항미생물 활성을 갖는 신규한 마크로라이드 및 케토라이드
CN101506203B (zh) 2006-08-24 2013-10-16 诺瓦提斯公司 治疗代谢病、心血管病和其他病症的作为硬脂酰辅酶a脱饱和酶(scd)抑制剂的2-(吡嗪-2-基)-噻唑和2-(1h-吡唑-3-基)-噻唑衍生物及相关化合物
US8236835B2 (en) 2006-09-22 2012-08-07 Novartis Ag Heterocyclic inhibitors of stearoyl-CoA desaturase
CN101595105B (zh) 2006-12-20 2013-01-23 诺瓦提斯公司 作为scd抑制剂的2-取代的5元杂环化合物
US20110230428A1 (en) * 2008-07-22 2011-09-22 John Wityak Certain kynurenine-3-monooxygenase inhibitors, pharmaceutical compositions, and methods of use thereof
WO2010025436A2 (en) * 2008-08-29 2010-03-04 Triad Multitech Pharmaceuticals, Inc. Nitrogen and sulfur-containing heterocycle derivatives
US8541420B2 (en) * 2009-05-27 2013-09-24 Wockhardt Ltd. Ketolide compounds having antimicrobial activity
WO2012008549A1 (ja) 2010-07-15 2012-01-19 武田薬品工業株式会社 複素環化合物
CN102417530A (zh) * 2010-09-26 2012-04-18 中国医学科学院药物研究所 广谱抗菌素红霉素a大环酮内酯类衍生物的合成方法和用途
EP2673285B1 (de) 2010-12-09 2017-07-19 Wockhardt Limited Ketolidverbindungen
JP5718488B2 (ja) * 2011-03-01 2015-05-13 ウォックハート リミテッド ケトライド中間体の調製方法
BR112014004741B1 (pt) 2011-08-30 2021-10-13 Chdi Foundation, Inc Entidade química, seu uso e composição farmacêutica compreendendo a mesma
WO2013033068A1 (en) 2011-08-30 2013-03-07 Stephen Martin Courtney Kynurenine-3-monooxygenase inhibitors, pharmaceutical compositions, and methods of use thereof
US8940742B2 (en) * 2012-04-10 2015-01-27 Infinity Pharmaceuticals, Inc. Heterocyclic compounds and uses thereof
TWI657085B (zh) 2013-10-04 2019-04-21 英菲尼提製藥股份有限公司 雜環化合物及其用途
US9751888B2 (en) 2013-10-04 2017-09-05 Infinity Pharmaceuticals, Inc. Heterocyclic compounds and uses thereof
ES2913486T3 (es) 2014-03-19 2022-06-02 Infinity Pharmaceuticals Inc Compuestos heterocíclicos para la utilización en el tratamiento de trastornos mediados por PI3K-gamma
MX2017000779A (es) 2014-07-17 2017-07-27 Chdi Foundation Inc Metodos y composiciones para el tratamiento de trastornos relacionados con el vih.
WO2016054491A1 (en) 2014-10-03 2016-04-07 Infinity Pharmaceuticals, Inc. Heterocyclic compounds and uses thereof
KR20160061743A (ko) 2014-11-24 2016-06-01 주식회사 엘지화학 고흡수성 수지 및 이의 제조 방법
US10160761B2 (en) 2015-09-14 2018-12-25 Infinity Pharmaceuticals, Inc. Solid forms of isoquinolinones, and process of making, composition comprising, and methods of using the same
WO2017161116A1 (en) 2016-03-17 2017-09-21 Infinity Pharmaceuticals, Inc. Isotopologues of isoquinolinone and quinazolinone compounds and uses thereof as pi3k kinase inhibitors
WO2017214269A1 (en) 2016-06-08 2017-12-14 Infinity Pharmaceuticals, Inc. Heterocyclic compounds and uses thereof
CN110272417B (zh) * 2019-06-18 2021-07-13 五邑大学 2-甲基-1,8-萘啶类化合物及其制备方法与应用
AU2020394867A1 (en) 2019-12-02 2022-05-26 Storm Therapeutics Limited Polyheterocyclic compounds as METTL3 inhibitors

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2732684B1 (fr) * 1995-04-06 1997-04-30 Roussel Uclaf Nouveaux derives de l'erythromycine, leur procede de preparation et leur application comme medicaments
FR2742757B1 (fr) * 1995-12-22 1998-01-30 Roussel Uclaf Nouveaux derives de l'erythromycine, leur procede de preparation et leur application comme medicaments
WO1999021870A1 (en) * 1997-10-29 1999-05-06 Taisho Pharmaceutical Co., Ltd. Erythromycin a 11, 12-carbamate derivatives
WO1999021869A1 (en) * 1997-10-29 1999-05-06 Taisho Pharmaceutical Co., Ltd. Erythromycin a, 11,12-carbamate derivatives
ATE256694T1 (de) * 1999-01-27 2004-01-15 Pfizer Prod Inc Ketolid-antibiotika
US6355620B1 (en) * 1999-05-14 2002-03-12 Abbott Laboratories C-2 modified erythromycin derivatives
EP1114826A3 (de) * 1999-12-29 2001-10-31 Pfizer Products Inc. Antibakterielle und prokinetische Makroliden
KR100502031B1 (ko) * 2000-08-22 2005-07-25 바실리어 파마슈티카 아게 항균 활성을 갖는 신규한 매크롤라이드
CA2460947A1 (en) * 2001-09-17 2003-03-27 Ortho-Mcneil Pharmaceutical, Inc. 6-o-carbamate-11,12-lacto-ketolide antimicrobials

Also Published As

Publication number Publication date
PL365012A1 (en) 2004-12-27
NO20032846D0 (no) 2003-06-20
US20060211636A1 (en) 2006-09-21
CN1492874A (zh) 2004-04-28
AU2002217277B2 (en) 2005-06-16
EP1363925B1 (de) 2006-11-15
CA2432429A1 (en) 2002-06-27
NZ526450A (en) 2005-04-29
WO2002050091A1 (en) 2002-06-27
CZ20031751A3 (cs) 2004-03-17
BR0116431A (pt) 2004-06-22
AU1727702A (en) 2002-07-01
EP1363925A1 (de) 2003-11-26
US20040077557A1 (en) 2004-04-22
NO20032846L (no) 2003-08-20
JP2004531471A (ja) 2004-10-14
ATE345350T1 (de) 2006-12-15
US20050215495A1 (en) 2005-09-29
DE60124594T2 (de) 2007-10-04
ES2275621T3 (es) 2007-06-16
MXPA03005668A (es) 2004-12-03
IL156561A0 (en) 2004-01-04
KR20030068189A (ko) 2003-08-19
HUP0302526A2 (hu) 2003-11-28
EP1363925B8 (de) 2007-04-25
AR042583A1 (es) 2005-06-29

Similar Documents

Publication Publication Date Title
DE60124594D1 (de) Makrolidantibiotika
DE69913738D1 (de) Ketolid-antibiotika
ATE243703T1 (de) Antibiotische azalid-zusammensetzungen
MXPA03001148A (es) Antibioticos macrolidos.
AU2002217277A1 (en) Macrolide antibiotics
IS5528A (is) Ný makrólíð
PT1303521E (pt) Derivados de tetra-hidro-heterocicloazepinil-pirimidina
IS5919A (is) Ný makrólíð sýklalyf
ID27775A (id) Antibiotik-antibiotik nokatiasin
NO20014362D0 (no) Erytromycinderivater
PT1268453E (pt) Metabolitos de agonista/antagonista de estrogenio
AR028602A1 (es) Derivados de pirrol
DE60139257D1 (de) Bifunktionelle antibiotika
ATE264843T1 (de) Antibakterielle mutiline
AR028282A1 (es) Derivados de aminofenil pirimidona
DE60138450D1 (de) Elektrolumineszenselement
DE60113739D1 (de) Glascontainerplungervorrichtung
PT1317179E (pt) Formulacoes de mesotriona
PT1246791E (pt) Derivados de aminometilfenilciclo-hexanona
ATE440591T1 (de) Ionophore antibiotische formulierungen
FR2814511B1 (fr) Structure de portail
NO20016200L (no) Antibiotika
DK1212337T3 (da) Pesticidmakrolider
FIU20000469U0 (fi) Vaihtolavalaite
SE0000796D0 (sv) Arrangemang

Legal Events

Date Code Title Description
8327 Change in the person/name/address of the patent owner

Owner name: GLAXO GROUP LTD., GREENFORD, MIDDLESEX, GB

Owner name: GLAXOSMITHKLINE ISTRAZIVACKI CENTAR ZAGREB D.O, HR

8381 Inventor (new situation)

Inventor name: ANDREOTTI, DANIELE, 37100 VERONA, IT

Inventor name: ARISTA, LUCA, 37100 VERONA, IT

Inventor name: BIONDI, STEFANO, 37100 VERONA, IT

Inventor name: CARDULLO, FRANCESCA, 37100 VERONA, IT

Inventor name: DAMIANI, FREDERICA, 37100 VERONA, IT

Inventor name: LOCIURO, SERGIO, 37100 VERONA, IT

Inventor name: MARCHIORO, CARLA, 37100 VERONA, IT

Inventor name: MERLO, GIANCARLO, 37100 VERONA, IT

Inventor name: MINGARDI, ANNA, 37100 VERONA, IT

Inventor name: NICCOLAI, DANIELA, 37100 VERONA, IT

Inventor name: PAIO, ALFREDO, 37100 VERONA, IT

Inventor name: PIGA, ELISABETTA, 37100 VERONA, IT

Inventor name: POZZAN, ALFONSO, 37100 VERONA, IT

Inventor name: SERI, CATIA, 37100 VERONA, IT

Inventor name: TARSI, LUCA, 37100 VERONA, IT

Inventor name: TERRENI, SILVIA, 37100 VERONA, IT

Inventor name: TIBASCO, JESSICA, 37100 VERONA, IT

Inventor name: CIRACO, MANUELA, 20090 SETTALA, IT

8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee