DE60120374D1 - Methoden zur reinigung von stark anionischen proteinen - Google Patents

Methoden zur reinigung von stark anionischen proteinen

Info

Publication number
DE60120374D1
DE60120374D1 DE60120374T DE60120374T DE60120374D1 DE 60120374 D1 DE60120374 D1 DE 60120374D1 DE 60120374 T DE60120374 T DE 60120374T DE 60120374 T DE60120374 T DE 60120374T DE 60120374 D1 DE60120374 D1 DE 60120374D1
Authority
DE
Germany
Prior art keywords
methods
proteins
sulfations
strong anionic
anionic proteins
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60120374T
Other languages
English (en)
Other versions
DE60120374T2 (de
Inventor
L Coffman
Barry Foster
J Germain
Shujun Sun
J Robinson
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Genetics Institute LLC
Original Assignee
Genetics Institute LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genetics Institute LLC filed Critical Genetics Institute LLC
Application granted granted Critical
Publication of DE60120374D1 publication Critical patent/DE60120374D1/de
Publication of DE60120374T2 publication Critical patent/DE60120374T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C07K1/20—Partition-, reverse-phase or hydrophobic interaction chromatography
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C07K1/18—Ion-exchange chromatography
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/36—Extraction; Separation; Purification by a combination of two or more processes of different types
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70596—Molecules with a "CD"-designation not provided for elsewhere
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Medicinal Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • Zoology (AREA)
  • Immunology (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Cell Biology (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Detergent Compositions (AREA)
DE60120374T 2000-03-27 2001-03-27 Methoden zur reinigung von stark anionischen proteinen Expired - Lifetime DE60120374T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US19335100P 2000-03-27 2000-03-27
US193351P 2000-03-27
PCT/US2001/009815 WO2001072769A2 (en) 2000-03-27 2001-03-27 Methods for purifying highly anionic proteins

Publications (2)

Publication Number Publication Date
DE60120374D1 true DE60120374D1 (de) 2006-07-20
DE60120374T2 DE60120374T2 (de) 2007-06-06

Family

ID=22713294

Family Applications (3)

Application Number Title Priority Date Filing Date
DE60141657T Expired - Lifetime DE60141657D1 (de) 2000-03-27 2001-03-27 Verfahren zur Reinigung von stark anionischen Proteinen
DE60120374T Expired - Lifetime DE60120374T2 (de) 2000-03-27 2001-03-27 Methoden zur reinigung von stark anionischen proteinen
DE60140493T Expired - Lifetime DE60140493D1 (de) 2000-03-27 2001-03-27 Verfahren zur Reinigung stark anionischer Proteine

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DE60141657T Expired - Lifetime DE60141657D1 (de) 2000-03-27 2001-03-27 Verfahren zur Reinigung von stark anionischen Proteinen

Family Applications After (1)

Application Number Title Priority Date Filing Date
DE60140493T Expired - Lifetime DE60140493D1 (de) 2000-03-27 2001-03-27 Verfahren zur Reinigung stark anionischer Proteine

Country Status (11)

Country Link
US (1) US6933370B2 (de)
EP (3) EP1681298B1 (de)
JP (2) JP5025874B2 (de)
AT (3) ATE328895T1 (de)
AU (2) AU2001249515B2 (de)
CA (1) CA2404155C (de)
DE (3) DE60141657D1 (de)
DK (3) DK1681299T3 (de)
ES (3) ES2338687T3 (de)
NZ (1) NZ521578A (de)
WO (1) WO2001072769A2 (de)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2321539T3 (es) 2001-06-05 2009-06-08 Genetics Institute, Llc Procedimientos relativos a la purificacion de proteinas altamente anionicas.
CA2483476A1 (en) * 2002-04-22 2003-10-30 Absorber, Ab Fusion polypeptides and methods for inhibiting microbial adhesion
WO2005042569A1 (en) * 2003-10-24 2005-05-12 Amgen, Inc. Process for purifying proteins in a hydrophobic interaction chromatography flow-through fraction
AU2006261852B2 (en) * 2005-06-24 2012-07-19 Desert Lake Technologies Purified component of blue-green algae and method of use
AR058568A1 (es) 2005-12-20 2008-02-13 Bristol Myers Squibb Co Metodos para producir una composicion con moleculas ctla4-ig a partir de un medio de cultivo
ES2439641T3 (es) 2005-12-20 2014-01-24 Bristol-Myers Squibb Company Composiciones y procedimientos de producción de una composición
JP5448825B2 (ja) * 2006-10-19 2014-03-19 ヤンセン バイオテツク，インコーポレーテツド 非凝集抗体Ｆｃドメインの製造方法
EP2519537A4 (de) * 2009-12-29 2013-07-10 Reddys Lab Ltd Dr Reinigung von proteinen
AU2011214361C1 (en) * 2010-02-12 2016-01-14 Dpx Holdings B.V. Single unit antibody purification
WO2012040216A1 (en) 2010-09-20 2012-03-29 Bio-Rad Laboratories, Inc. Dissociation of product-complexed contaminants in chromatography
AU2017347809A1 (en) * 2016-10-28 2019-05-09 Merck Sharp & Dohme Llc Purification process for removal of tyrosine sulfation antibody variants; purified compositions
JP7065105B2 (ja) * 2017-02-09 2022-05-11 ブラッコ・スイス・ソシエテ・アノニム 可溶性ｐｓｇｌ－１タンパク質変異体の精製のための方法
US11447547B1 (en) 2017-12-13 2022-09-20 Amgen Inc. Method of antigen-binding protein production

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4723000A (en) * 1983-07-05 1988-02-02 Biospectrum, Inc. Human interferon gamma and interleukin-2
US5115101A (en) 1988-06-08 1992-05-19 Miles Inc. Removal of protein A from antibody preparations
US5378464A (en) * 1989-03-08 1995-01-03 Board Of Regents Of The University Of Oklahoma Modulation of inflammatory responses by administration of GMP-140 or antibody to GMP-140
US5464778A (en) 1989-03-08 1995-11-07 Board Of Regents Of The University Of Oklahoma Glycoprotein ligand for P-selectin and methods of use thereof
US5034133A (en) * 1990-07-26 1991-07-23 Schering-Corporation Purification of human interleukin-4 from a CHO-cell line culture medium
US5530109A (en) * 1991-04-10 1996-06-25 Ludwig Institute For Cancer Research DNA encoding glial mitogenic factors
US6277975B1 (en) * 1992-10-23 2001-08-21 Genetics Institute, Inc. Fusions of P-selectin ligand protein and polynucleotides encoding same
DE69334350D1 (de) * 1992-10-23 2011-04-21 Genetics Inst Llc P- Selectin Ligandenprotein
US5843707A (en) * 1992-10-23 1998-12-01 Genetics Institute, Inc. Nucleic acid encoding a novel P-selectin ligand protein
US5429746A (en) * 1994-02-22 1995-07-04 Smith Kline Beecham Corporation Antibody purification
EP1104809A1 (de) 1994-04-09 2001-06-06 F. Hoffmann-La Roche Ag Verfahren zur Herstellung von Alpha-Interferon
US6008328A (en) 1994-10-13 1999-12-28 Amgen Inc. Method for purifying keratinocyte growth factors
SE503424C2 (sv) 1994-11-14 1996-06-10 Pharmacia Ab Process för rening av rekombinant koagulationsfaktor VIII
FR2737730B1 (fr) 1995-08-10 1997-09-05 Pasteur Merieux Serums Vacc Procede de purification de virus par chromatographie
FR2738009B1 (fr) 1995-08-24 1997-10-31 Centre Nat Rech Scient Procede d'obtention de polysaccharides sulfates
BR9713055A (pt) 1996-11-15 2000-04-04 Genentech Inc Processo para isolar uma neurotrofina humana recombinante, composição de neurotrofina e processo para purificar uma neurotrofina
WO1999019345A1 (en) * 1997-10-14 1999-04-22 Institute For Vaccine Development Method for purifying retroviral particles and soluble viral antigens

Also Published As

Publication number Publication date
US6933370B2 (en) 2005-08-23
US20020132991A1 (en) 2002-09-19
EP1681299A2 (de) 2006-07-19
CA2404155A1 (en) 2001-10-04
EP1268514B1 (de) 2006-06-07
EP1681299B1 (de) 2009-11-11
JP2003528884A (ja) 2003-09-30
DK1681299T3 (da) 2010-02-01
JP5596078B2 (ja) 2014-09-24
CA2404155C (en) 2011-08-09
EP1681298A3 (de) 2006-12-20
AU4951501A (en) 2001-10-08
JP5025874B2 (ja) 2012-09-12
DE60141657D1 (de) 2010-05-06
EP1681298B1 (de) 2010-03-24
DE60140493D1 (de) 2009-12-24
WO2001072769A2 (en) 2001-10-04
ES2338687T3 (es) 2010-05-11
EP1681298A2 (de) 2006-07-19
ES2266188T3 (es) 2007-03-01
DK1268514T3 (da) 2006-10-09
ATE328895T1 (de) 2006-06-15
ES2343023T3 (es) 2010-07-21
EP1268514A2 (de) 2003-01-02
JP2012184245A (ja) 2012-09-27
ATE461935T1 (de) 2010-04-15
ATE448241T1 (de) 2009-11-15
DE60120374T2 (de) 2007-06-06
DK1681298T3 (da) 2010-06-14
NZ521578A (en) 2004-08-27
WO2001072769A9 (en) 2003-04-03
WO2001072769A3 (en) 2002-02-07
EP1681299A3 (de) 2006-12-27
AU2001249515B2 (en) 2006-10-05

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