ES2175462T3 - Composiciones cristalizables que comprenden un complejo del dominio de proteasa ns3 del virus de la hepatitis c/ns4a, y cristales asi obtenidos. - Google Patents
Composiciones cristalizables que comprenden un complejo del dominio de proteasa ns3 del virus de la hepatitis c/ns4a, y cristales asi obtenidos.Info
- Publication number
- ES2175462T3 ES2175462T3 ES97942450T ES97942450T ES2175462T3 ES 2175462 T3 ES2175462 T3 ES 2175462T3 ES 97942450 T ES97942450 T ES 97942450T ES 97942450 T ES97942450 T ES 97942450T ES 2175462 T3 ES2175462 T3 ES 2175462T3
- Authority
- ES
- Spain
- Prior art keywords
- hepatitis
- complex
- crystals
- ns4a
- virus
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/576—Immunoassay; Biospecific binding assay; Materials therefor for hepatitis
- G01N33/5767—Immunoassay; Biospecific binding assay; Materials therefor for hepatitis non-A, non-B hepatitis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
-
- C—CHEMISTRY; METALLURGY
- C30—CRYSTAL GROWTH
- C30B—SINGLE-CRYSTAL GROWTH; UNIDIRECTIONAL SOLIDIFICATION OF EUTECTIC MATERIAL OR UNIDIRECTIONAL DEMIXING OF EUTECTOID MATERIAL; REFINING BY ZONE-MELTING OF MATERIAL; PRODUCTION OF A HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; SINGLE CRYSTALS OR HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; AFTER-TREATMENT OF SINGLE CRYSTALS OR A HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; APPARATUS THEREFOR
- C30B29/00—Single crystals or homogeneous polycrystalline material with defined structure characterised by the material or by their shape
- C30B29/54—Organic compounds
- C30B29/58—Macromolecular compounds
-
- C—CHEMISTRY; METALLURGY
- C30—CRYSTAL GROWTH
- C30B—SINGLE-CRYSTAL GROWTH; UNIDIRECTIONAL SOLIDIFICATION OF EUTECTIC MATERIAL OR UNIDIRECTIONAL DEMIXING OF EUTECTOID MATERIAL; REFINING BY ZONE-MELTING OF MATERIAL; PRODUCTION OF A HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; SINGLE CRYSTALS OR HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; AFTER-TREATMENT OF SINGLE CRYSTALS OR A HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; APPARATUS THEREFOR
- C30B7/00—Single-crystal growth from solutions using solvents which are liquid at normal temperature, e.g. aqueous solutions
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
- G16B15/00—ICT specially adapted for analysing two-dimensional or three-dimensional molecular structures, e.g. structural or functional relations or structure alignment
- G16B15/30—Drug targeting using structural data; Docking or binding prediction
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2299/00—Coordinates from 3D structures of peptides, e.g. proteins or enzymes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
- C12N2770/00011—Details
- C12N2770/24011—Flaviviridae
- C12N2770/24211—Hepacivirus, e.g. hepatitis C virus, hepatitis G virus
- C12N2770/24222—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/005—Assays involving biological materials from specific organisms or of a specific nature from viruses
- G01N2333/08—RNA viruses
- G01N2333/18—Togaviridae; Flaviviridae
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
- G16B15/00—ICT specially adapted for analysing two-dimensional or three-dimensional molecular structures, e.g. structural or functional relations or structure alignment
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Immunology (AREA)
- Physics & Mathematics (AREA)
- Crystallography & Structural Chemistry (AREA)
- Molecular Biology (AREA)
- Urology & Nephrology (AREA)
- Biomedical Technology (AREA)
- Metallurgy (AREA)
- Materials Engineering (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Hematology (AREA)
- Biotechnology (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Spectroscopy & Molecular Physics (AREA)
- Food Science & Technology (AREA)
- Pathology (AREA)
- Gastroenterology & Hepatology (AREA)
- Communicable Diseases (AREA)
- Pharmacology & Pharmacy (AREA)
- Virology (AREA)
- Cell Biology (AREA)
- Genetics & Genomics (AREA)
- Microbiology (AREA)
- Medical Informatics (AREA)
- Theoretical Computer Science (AREA)
- Analytical Chemistry (AREA)
- General Physics & Mathematics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Bioinformatics & Computational Biology (AREA)
- Evolutionary Biology (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Abstract
LA PRESENTE INVENCION SE REFIERE A COMPOSICIONES Y CRISTALES DEL VIRUS DE LA HEPATITIS C ASOCIADO CON SU COFACTOR VIRAL. LA INVENCION SE REFIERE ASIMISMO A PROCEDIMIENTOS DE UTILIZACION DE LOS COORDINADOS ESTRUCTURALES DE LA PROTEASA DEL VIRUS DE LA HEPATITIS C, FORMANDO COMPLEJO CON UN NS4A SINTETICO, PARA RESOLVER LOS PROBLEMAS RELACIONADOS CON LA ESTRUCTURA DE PROTEINAS O COMPLEJOS DE PROTEINAS SIMILARES U HOMOLOGAS.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US2527496P | 1996-09-12 | 1996-09-12 | |
US08/731,336 US6153579A (en) | 1996-09-12 | 1996-10-18 | Crystallizable compositions comprising a hepatitis C virus NS3 protease domain/NS4A complex |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2175462T3 true ES2175462T3 (es) | 2002-11-16 |
Family
ID=26699520
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES01101009T Expired - Lifetime ES2202228T3 (es) | 1996-09-12 | 1997-09-12 | Metodo para identificar agentes activos contra el hcv usando las coordenadas estructurales de la proteasa del virus de la hepatitis c. |
ES97942450T Expired - Lifetime ES2175462T3 (es) | 1996-09-12 | 1997-09-12 | Composiciones cristalizables que comprenden un complejo del dominio de proteasa ns3 del virus de la hepatitis c/ns4a, y cristales asi obtenidos. |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES01101009T Expired - Lifetime ES2202228T3 (es) | 1996-09-12 | 1997-09-12 | Metodo para identificar agentes activos contra el hcv usando las coordenadas estructurales de la proteasa del virus de la hepatitis c. |
Country Status (13)
Country | Link |
---|---|
US (2) | US6153579A (es) |
EP (1) | EP0935609B1 (es) |
JP (1) | JP2001501602A (es) |
AT (3) | ATE216400T1 (es) |
AU (1) | AU736857B2 (es) |
CA (1) | CA2264964A1 (es) |
DE (3) | DE69712085T2 (es) |
DK (1) | DK0935609T3 (es) |
ES (2) | ES2202228T3 (es) |
HK (2) | HK1022700A1 (es) |
IL (1) | IL128826A0 (es) |
PT (2) | PT935609E (es) |
WO (1) | WO1998011134A1 (es) |
Families Citing this family (28)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ATE212037T1 (de) | 1996-10-18 | 2002-02-15 | Vertex Pharma | Inhibitoren von serinproteasen, insbesondere von ns3-protease des hepatitis-c-virus |
IL143798A0 (en) | 1999-01-08 | 2002-04-21 | Bristol Myers Squibb Co | Hepatitis c virus ns3 protease |
US6524589B1 (en) * | 1999-04-08 | 2003-02-25 | Schering Corporation | Compositions of hepatitis C virus NS3/NS4A complex and methods for crystallizing same |
CA2388253A1 (en) | 1999-10-14 | 2001-04-19 | Bristol-Myers Squibb Company | Crystallographic structure of the androgen receptor ligand binding domain |
US7491808B2 (en) | 2000-06-15 | 2009-02-17 | Novartis Vaccines And Diagnostics, Inc. | HCV non-structural protein mutants and uses thereof |
SV2003000617A (es) | 2000-08-31 | 2003-01-13 | Lilly Co Eli | Inhibidores de la proteasa peptidomimetica ref. x-14912m |
AU2002217838A1 (en) | 2000-11-14 | 2002-05-27 | Bristol-Myers Squibb Company | A human serpin secreted from lymphoid cells LSI-01 |
CA2443393A1 (en) | 2001-04-03 | 2002-11-07 | Bristol-Myers Squibb Company | Polynucleotide encoding a novel cysteine protease of the calpain superfamily, can-12, and variants thereof |
US20030027315A1 (en) * | 2001-09-24 | 2003-02-06 | Ada Yonath | Methods of growing crystals of free and antibiotic complexed large ribosomal subunits, and methods of rationally designing or identifying antibiotics using structure coordinate data derived from such crystals |
US20050009877A1 (en) * | 2003-05-15 | 2005-01-13 | Henry Lu | Methods of identifying HCV NS5B polymerase inhibitors and their uses |
PE20050374A1 (es) | 2003-09-05 | 2005-05-30 | Vertex Pharma | Inhibidores de proteasas de serina, en particular proteasa ns3-ns4a del vhc |
US8187874B2 (en) | 2003-10-27 | 2012-05-29 | Vertex Pharmaceuticals Incorporated | Drug discovery method |
US7494660B2 (en) | 2003-10-27 | 2009-02-24 | Vertex Pharmaceuticals Incorporated | HCV NS3-NS4A protease resistance mutants |
US8399615B2 (en) | 2005-08-19 | 2013-03-19 | Vertex Pharmaceuticals Incorporated | Processes and intermediates |
AR055395A1 (es) | 2005-08-26 | 2007-08-22 | Vertex Pharma | Compuestos inhibidores de la actividad de la serina proteasa ns3-ns4a del virus de la hepatitis c |
US7964624B1 (en) | 2005-08-26 | 2011-06-21 | Vertex Pharmaceuticals Incorporated | Inhibitors of serine proteases |
AU2006315438A1 (en) | 2005-11-11 | 2007-05-24 | Vertex Pharmaceuticals Incorporated | Hepatitis C virus variants |
US7705138B2 (en) | 2005-11-11 | 2010-04-27 | Vertex Pharmaceuticals Incorporated | Hepatitis C virus variants |
AU2007217355B2 (en) | 2006-02-27 | 2012-06-21 | Vertex Pharmaceuticals Incorporated | Co-crystals comprising VX-950 and pharmaceutical compositions comprising the same |
JP2009531315A (ja) * | 2006-03-16 | 2009-09-03 | バーテックス ファーマシューティカルズ インコーポレイテッド | 重水素化c型肝炎プロテアーゼインヒビター |
US8440443B1 (en) | 2006-05-16 | 2013-05-14 | Merck Sharp & Dohme Corp. | MEK1 polypeptides |
AU2008219607B2 (en) | 2007-02-27 | 2013-09-12 | Vertex Pharmaceuticals Incorporated | Co-crystals and pharmaceutical compositions comprising the same |
NZ579295A (en) | 2007-02-27 | 2012-03-30 | Vertex Pharma | Inhibitors of serine proteases |
CL2008002549A1 (es) | 2007-08-30 | 2010-09-03 | Vertex Pharma | Cocristal que comprende vx-950 y un formador de cocristal seleccionado de acido 3-metoxi-4hidroxibenzoico,acido 2,4-dihidroxibenzoico y acido 2,5-dihidroxibenzoico; metodo de preparacion; composicion farmaceutica que comprende el cocristal, util como agente antiviral en el tratamiento del hcv. |
US8988881B2 (en) * | 2007-12-18 | 2015-03-24 | Sandia Corporation | Heat exchanger device and method for heat removal or transfer |
US9005417B1 (en) | 2008-10-01 | 2015-04-14 | Sandia Corporation | Devices, systems, and methods for microscale isoelectric fractionation |
US9795961B1 (en) | 2010-07-08 | 2017-10-24 | National Technology & Engineering Solutions Of Sandia, Llc | Devices, systems, and methods for detecting nucleic acids using sedimentation |
WO2012118982A2 (en) | 2011-03-02 | 2012-09-07 | Sandia Corporation | Axial flow heat exchanger devices and methods for heat transfer using axial flow devices |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4833233A (en) * | 1987-08-20 | 1989-05-23 | The United States Of America As Represented By The Administrator Of The National Aeronautics And Space Administration | Human serum albumin crystals and method of preparation |
US5353236A (en) * | 1992-04-23 | 1994-10-04 | The Board Of Trustees Of The Leland Stanford University | High-resolution crystallographic modelling of a macromolecule |
US5453937A (en) * | 1993-04-28 | 1995-09-26 | Immunex Corporation | Method and system for protein modeling |
IT1272179B (it) * | 1994-02-23 | 1997-06-16 | Angeletti P Ist Richerche Bio | Metodologia per riprodurre in vitro l'attivita' proteolitica della proteasi ns3 del virus hcv. |
-
1996
- 1996-10-18 US US08/731,336 patent/US6153579A/en not_active Expired - Lifetime
-
1997
- 1997-09-12 PT PT97942450T patent/PT935609E/pt unknown
- 1997-09-12 ES ES01101009T patent/ES2202228T3/es not_active Expired - Lifetime
- 1997-09-12 IL IL12882697A patent/IL128826A0/xx unknown
- 1997-09-12 EP EP97942450A patent/EP0935609B1/en not_active Expired - Lifetime
- 1997-09-12 AT AT97942450T patent/ATE216400T1/de not_active IP Right Cessation
- 1997-09-12 AU AU44145/97A patent/AU736857B2/en not_active Ceased
- 1997-09-12 AT AT01101009T patent/ATE244729T1/de not_active IP Right Cessation
- 1997-09-12 DE DE69712085T patent/DE69712085T2/de not_active Expired - Lifetime
- 1997-09-12 PT PT01101009T patent/PT1118619E/pt unknown
- 1997-09-12 WO PCT/US1997/016182 patent/WO1998011134A1/en active IP Right Grant
- 1997-09-12 ES ES97942450T patent/ES2175462T3/es not_active Expired - Lifetime
- 1997-09-12 DK DK97942450T patent/DK0935609T3/da active
- 1997-09-12 DE DE69736995T patent/DE69736995T2/de not_active Expired - Lifetime
- 1997-09-12 AT AT03015398T patent/ATE346088T1/de not_active IP Right Cessation
- 1997-09-12 DE DE69723485T patent/DE69723485T2/de not_active Expired - Lifetime
- 1997-09-12 CA CA002264964A patent/CA2264964A1/en not_active Abandoned
- 1997-09-12 JP JP10513899A patent/JP2001501602A/ja not_active Ceased
-
1999
- 1999-02-25 US US09/257,667 patent/US6303287B1/en not_active Expired - Lifetime
-
2000
- 2000-02-17 HK HK00100944A patent/HK1022700A1/xx not_active IP Right Cessation
- 2000-02-17 HK HK01108615A patent/HK1038573A1/xx not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
ATE346088T1 (de) | 2006-12-15 |
DE69736995T2 (de) | 2007-09-20 |
DE69712085T2 (de) | 2002-11-28 |
HK1022700A1 (en) | 2000-08-18 |
WO1998011134A1 (en) | 1998-03-19 |
US6153579A (en) | 2000-11-28 |
DK0935609T3 (da) | 2002-07-22 |
DE69723485D1 (de) | 2003-08-14 |
HK1038573A1 (en) | 2002-03-22 |
EP0935609A1 (en) | 1999-08-18 |
CA2264964A1 (en) | 1998-03-19 |
ATE216400T1 (de) | 2002-05-15 |
DE69723485T2 (de) | 2004-05-27 |
DE69736995D1 (de) | 2007-01-04 |
AU736857B2 (en) | 2001-08-02 |
DE69712085D1 (de) | 2002-05-23 |
ATE244729T1 (de) | 2003-07-15 |
PT935609E (pt) | 2002-09-30 |
PT1118619E (pt) | 2003-11-28 |
US6303287B1 (en) | 2001-10-16 |
AU4414597A (en) | 1998-04-02 |
JP2001501602A (ja) | 2001-02-06 |
EP0935609B1 (en) | 2002-04-17 |
IL128826A0 (en) | 2000-01-31 |
ES2202228T3 (es) | 2004-04-01 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG2A | Definitive protection |
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