DE60117781T2 - Peptidderivate des apolipoproteins-a1/aii - Google Patents
Peptidderivate des apolipoproteins-a1/aii Download PDFInfo
- Publication number
- DE60117781T2 DE60117781T2 DE60117781T DE60117781T DE60117781T2 DE 60117781 T2 DE60117781 T2 DE 60117781T2 DE 60117781 T DE60117781 T DE 60117781T DE 60117781 T DE60117781 T DE 60117781T DE 60117781 T2 DE60117781 T2 DE 60117781T2
- Authority
- DE
- Germany
- Prior art keywords
- peptide
- apo
- domain
- amphipathic helix
- helix peptide
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/775—Apolipopeptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
- A61P31/22—Antivirals for DNA viruses for herpes viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Virology (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Hematology (AREA)
- Gastroenterology & Hepatology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Diabetes (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Obesity (AREA)
- Genetics & Genomics (AREA)
- Toxicology (AREA)
- Zoology (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- AIDS & HIV (AREA)
- Biotechnology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US19892000P | 2000-04-21 | 2000-04-21 | |
| US198920P | 2000-04-21 | ||
| PCT/US2001/013068 WO2001081376A2 (en) | 2000-04-21 | 2001-04-23 | Apo-ai/aii peptide derivatives |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE60117781D1 DE60117781D1 (de) | 2006-05-04 |
| DE60117781T2 true DE60117781T2 (de) | 2006-11-23 |
Family
ID=22735445
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE60117781T Expired - Lifetime DE60117781T2 (de) | 2000-04-21 | 2001-04-23 | Peptidderivate des apolipoproteins-a1/aii |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US6743778B2 (https=) |
| EP (1) | EP1290013B1 (https=) |
| JP (1) | JP2003530870A (https=) |
| AT (1) | ATE319737T1 (https=) |
| AU (2) | AU2001257173B2 (https=) |
| CA (1) | CA2407083A1 (https=) |
| DE (1) | DE60117781T2 (https=) |
| DK (1) | DK1290013T3 (https=) |
| ES (1) | ES2260219T3 (https=) |
| MX (1) | MXPA02010324A (https=) |
| PT (1) | PT1290013E (https=) |
| WO (1) | WO2001081376A2 (https=) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CA2407086A1 (en) * | 2000-04-21 | 2001-11-01 | Amgen, Inc. | Integrin/adhesion antagonists |
| US8116889B2 (en) * | 2002-06-27 | 2012-02-14 | Openpeak Inc. | Method, system, and computer program product for managing controlled residential or non-residential environments |
| TWI353991B (en) | 2003-05-06 | 2011-12-11 | Syntonix Pharmaceuticals Inc | Immunoglobulin chimeric monomer-dimer hybrids |
| US7329725B1 (en) * | 2003-10-29 | 2008-02-12 | Nastech Pharmaceutical Company Inc. | Phage displayed Trp cage ligands |
| US8110665B2 (en) | 2003-11-13 | 2012-02-07 | Hanmi Holdings Co., Ltd. | Pharmaceutical composition comprising an immunoglobulin FC region as a carrier |
| ATE555133T1 (de) | 2003-11-13 | 2012-05-15 | Hanmi Holdings Co Ltd | Igg fc fragment für einen arzneimittelträger und verfahren zu dessen herstellung |
| WO2006063132A2 (en) * | 2004-12-06 | 2006-06-15 | The Regents Of The University Of California | Methods for improving the structure and function of arterioles |
| US7704953B2 (en) * | 2006-02-17 | 2010-04-27 | Mdrna, Inc. | Phage displayed cell binding peptides |
| WO2007103775A2 (en) * | 2006-03-03 | 2007-09-13 | Washington University In St. Louis | Biomaterials having nanoscale layers and coatings |
| CA2653840A1 (en) * | 2006-06-01 | 2007-12-06 | Institut De Cardiologie De Montreal | Use of a peptide/phospholipid complex acting as a reverse lipid transport agonist for treatment of valvular stenosis |
| AU2014268255B2 (en) * | 2009-02-16 | 2016-04-21 | Cerenis Therapeutics Holding Sa | Apolipoprotein a-i mimics |
| LT2939683T (lt) | 2009-02-16 | 2017-03-27 | Cerenis Therapeutics Holding Sa | Apolipoproteino a-i mimetikai |
| WO2015173633A2 (en) | 2014-05-02 | 2015-11-19 | Cerenis Therapeutics Holding Sa | Hdl therapy markers |
| WO2016154544A1 (en) | 2015-03-25 | 2016-09-29 | The Regents Of The University Of Michigan | Compositions and methods for delivery of biomacromolecule agents |
| EP3490579B1 (en) | 2016-07-27 | 2025-09-10 | Hartis-Pharma SA | Therapeutic combinations to treat red blood cell disorders |
| KR20230004605A (ko) | 2020-04-16 | 2023-01-06 | 아비오닉스 파마 에스에이 | 지질 결합 단백질-기반 복합체를 사용하여 급성 상태를 치료하는 방법 |
| MX2023003877A (es) | 2020-10-01 | 2023-04-18 | Abionyx Pharma Sa | Composiciones que comprenden complejos basados en proteina de union a lipidos para usarse en el tratamiento de enfermedades oculares. |
| KR20240018430A (ko) | 2021-04-15 | 2024-02-13 | 아비오닉스 파마 에스에이 | 기관 보존 용액에서의 지질 결합 단백질-기반 복합체의 사용 |
| AU2023250345A1 (en) | 2022-04-06 | 2024-11-14 | Abionyx Pharma Sa | Methods for treating eye diseases using lipid binding protein-based complexes |
| CA3247588A1 (en) | 2022-04-06 | 2023-10-12 | Abionyx Pharma Sa | METHODS FOR TREATING LEUKOCYTOSIS, ENDOTHELIAL DYSFUNCTION AND CARDITIS USING LIPID-BINDING PROTEIN COMPLEXES |
| WO2023237927A2 (en) | 2022-06-10 | 2023-12-14 | Abionyx Pharma Sa | Methods for treating hyperinflammatory conditions using lipid binding protein -based complexes |
| JP2025519606A (ja) | 2022-06-10 | 2025-06-26 | アビオニクス ファーマ エスエー | 脂質結合タンパク質に基づく複合体を使用して急性状態を処置するための方法 |
| WO2024150064A1 (en) | 2023-01-13 | 2024-07-18 | Abionyx Pharma Sa | Lipid binding protein molecule therapy |
| WO2025093929A1 (en) | 2023-10-31 | 2025-05-08 | Abionyx Pharma Sa | Lipid binding protein molecule therapy |
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| CA1023287A (en) | 1972-12-08 | 1977-12-27 | Boehringer Mannheim G.M.B.H. | Process for the preparation of carrier-bound proteins |
| US3941763A (en) | 1975-03-28 | 1976-03-02 | American Home Products Corporation | PGlu-D-Met-Trp-Ser-Tyr-D-Ala-Leu-Arg-Pro-Gly-NH2 and intermediates |
| US4195128A (en) | 1976-05-03 | 1980-03-25 | Bayer Aktiengesellschaft | Polymeric carrier bound ligands |
| US4330440A (en) | 1977-02-08 | 1982-05-18 | Development Finance Corporation Of New Zealand | Activated matrix and method of activation |
| CA1093991A (en) | 1977-02-17 | 1981-01-20 | Hideo Hirohara | Enzyme immobilization with pullulan gel |
| US4229537A (en) | 1978-02-09 | 1980-10-21 | New York University | Preparation of trichloro-s-triazine activated supports for coupling ligands |
| US4289872A (en) | 1979-04-06 | 1981-09-15 | Allied Corporation | Macromolecular highly branched homogeneous compound based on lysine units |
| EP0545913B1 (en) | 1986-08-18 | 1999-02-24 | Emisphere Technologies, Inc. | Delivery systems for pharmacological agents |
| US5229490A (en) | 1987-05-06 | 1993-07-20 | The Rockefeller University | Multiple antigen peptide system |
| US5223409A (en) | 1988-09-02 | 1993-06-29 | Protein Engineering Corp. | Directed evolution of novel binding proteins |
| US5013556A (en) | 1989-10-20 | 1991-05-07 | Liposome Technology, Inc. | Liposomes with enhanced circulation time |
| US5723286A (en) | 1990-06-20 | 1998-03-03 | Affymax Technologies N.V. | Peptide library and screening systems |
| US5733731A (en) | 1991-10-16 | 1998-03-31 | Affymax Technologies N.V. | Peptide library and screening method |
| US5270170A (en) | 1991-10-16 | 1993-12-14 | Affymax Technologies N.V. | Peptide library and screening method |
| SE9103701D0 (sv) | 1991-12-13 | 1991-12-13 | Kabi Pharmacia Ab | Apolipoprotein |
| CA2118130A1 (en) | 1992-04-14 | 1993-10-28 | Jean M. J. Frechet | Dendritic based macromolecules and method of production |
| US5792451A (en) | 1994-03-02 | 1998-08-11 | Emisphere Technologies, Inc. | Oral drug delivery compositions and methods |
| US5922545A (en) | 1993-10-29 | 1999-07-13 | Affymax Technologies N.V. | In vitro peptide and antibody display libraries |
| US6309853B1 (en) | 1994-08-17 | 2001-10-30 | The Rockfeller University | Modulators of body weight, corresponding nucleic acids and proteins, and diagnostic and therapeutic uses thereof |
| US5824784A (en) | 1994-10-12 | 1998-10-20 | Amgen Inc. | N-terminally chemically modified protein compositions and methods |
| US5739277A (en) | 1995-04-14 | 1998-04-14 | Genentech Inc. | Altered polypeptides with increased half-life |
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| JP4046354B2 (ja) * | 1996-03-18 | 2008-02-13 | ボード オブ リージェンツ，ザ ユニバーシティ オブ テキサス システム | 増大した半減期を有する免疫グロブリン様ドメイン |
| US6156727A (en) | 1996-09-05 | 2000-12-05 | Uab Research Foundation | Anti-atherosclerotic peptides and a transgenic mouse model of antherosclerosis |
| EP0934526B1 (en) | 1996-10-08 | 2003-01-08 | U-BISys B.V. | Methods and means for selecting peptides and proteins having specific affinity for a target |
| US6046166A (en) * | 1997-09-29 | 2000-04-04 | Jean-Louis Dasseux | Apolipoprotein A-I agonists and their use to treat dyslipidemic disorders |
| GB9815505D0 (en) | 1998-07-16 | 1998-09-16 | Adprotech Plc | Polypeptide derivatives |
| US6660843B1 (en) | 1998-10-23 | 2003-12-09 | Amgen Inc. | Modified peptides as therapeutic agents |
-
2001
- 2001-04-23 AU AU2001257173A patent/AU2001257173B2/en not_active Ceased
- 2001-04-23 EP EP01930664A patent/EP1290013B1/en not_active Expired - Lifetime
- 2001-04-23 JP JP2001578463A patent/JP2003530870A/ja not_active Withdrawn
- 2001-04-23 PT PT01930664T patent/PT1290013E/pt unknown
- 2001-04-23 DK DK01930664T patent/DK1290013T3/da active
- 2001-04-23 AU AU5717301A patent/AU5717301A/xx active Pending
- 2001-04-23 US US09/840,669 patent/US6743778B2/en not_active Expired - Fee Related
- 2001-04-23 WO PCT/US2001/013068 patent/WO2001081376A2/en not_active Ceased
- 2001-04-23 CA CA002407083A patent/CA2407083A1/en not_active Abandoned
- 2001-04-23 ES ES01930664T patent/ES2260219T3/es not_active Expired - Lifetime
- 2001-04-23 AT AT01930664T patent/ATE319737T1/de not_active IP Right Cessation
- 2001-04-23 MX MXPA02010324A patent/MXPA02010324A/es unknown
- 2001-04-23 DE DE60117781T patent/DE60117781T2/de not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| WO2001081376A3 (en) | 2003-01-09 |
| ES2260219T3 (es) | 2006-11-01 |
| EP1290013A2 (en) | 2003-03-12 |
| ATE319737T1 (de) | 2006-03-15 |
| EP1290013B1 (en) | 2006-03-08 |
| PT1290013E (pt) | 2006-06-30 |
| DE60117781D1 (de) | 2006-05-04 |
| DK1290013T3 (da) | 2006-06-26 |
| JP2003530870A (ja) | 2003-10-21 |
| US6743778B2 (en) | 2004-06-01 |
| WO2001081376A2 (en) | 2001-11-01 |
| CA2407083A1 (en) | 2001-11-01 |
| MXPA02010324A (es) | 2003-04-25 |
| AU5717301A (en) | 2001-11-07 |
| US20030040470A1 (en) | 2003-02-27 |
| AU2001257173B2 (en) | 2005-09-22 |
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