DE60106389D1 - Vielseitige hydrophile farbstoffe - Google Patents

Vielseitige hydrophile farbstoffe

Info

Publication number
DE60106389D1
DE60106389D1 DE2001606389 DE60106389T DE60106389D1 DE 60106389 D1 DE60106389 D1 DE 60106389D1 DE 2001606389 DE2001606389 DE 2001606389 DE 60106389 T DE60106389 T DE 60106389T DE 60106389 D1 DE60106389 D1 DE 60106389D1
Authority
DE
Germany
Prior art keywords
therapy
imaging
detection
dye
useful
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE2001606389
Other languages
English (en)
Other versions
DE60106389T8 (de
DE60106389T2 (de
Inventor
I Achilefu
Raghavan Rajagopalan
B Dorshow
E Bugaj
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Mallinckrodt Inc
Original Assignee
Mallinckrodt Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US09/484,321 external-priority patent/US6183726B1/en
Application filed by Mallinckrodt Inc filed Critical Mallinckrodt Inc
Publication of DE60106389D1 publication Critical patent/DE60106389D1/de
Application granted granted Critical
Publication of DE60106389T2 publication Critical patent/DE60106389T2/de
Publication of DE60106389T8 publication Critical patent/DE60106389T8/de
Active legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0013—Luminescence
    • A61K49/0017—Fluorescence in vivo
    • A61K49/0019—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules
    • A61K49/0021—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules the fluorescent group being a small organic molecule
    • A61K49/0032—Methine dyes, e.g. cyanine dyes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
    • A61K41/0028—Disruption, e.g. by heat or ultrasounds, sonophysical or sonochemical activation, e.g. thermosensitive or heat-sensitive liposomes, disruption of calculi with a medicinal preparation and ultrasounds
    • A61K41/0033—Sonodynamic cancer therapy with sonochemically active agents or sonosensitizers, having their cytotoxic effects enhanced through application of ultrasounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
    • A61K41/0057—Photodynamic therapy with a photosensitizer, i.e. agent able to produce reactive oxygen species upon exposure to light or radiation, e.g. UV or visible light; photocleavage of nucleic acids with an agent
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0013—Luminescence
    • A61K49/0017—Fluorescence in vivo
    • A61K49/005—Fluorescence in vivo characterised by the carrier molecule carrying the fluorescent agent
    • A61K49/0056—Peptides, proteins, polyamino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
DE60106389T 2000-01-18 2001-01-17 Vielseitige hydrophile farbstoffe Active DE60106389T8 (de)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US09/484,321 US6183726B1 (en) 2000-01-18 2000-01-18 Versatile hydrophilic dyes
US484321 2000-01-18
US757333 2001-01-09
US09/757,333 US6939532B2 (en) 2000-01-18 2001-01-09 Versatile hydrophilic dyes
PCT/US2001/001471 WO2001052746A1 (en) 2000-01-18 2001-01-17 Versatile hydrophilic dyes

Publications (3)

Publication Number Publication Date
DE60106389D1 true DE60106389D1 (de) 2004-11-18
DE60106389T2 DE60106389T2 (de) 2006-03-09
DE60106389T8 DE60106389T8 (de) 2006-06-08

Family

ID=27047955

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60106389T Active DE60106389T8 (de) 2000-01-18 2001-01-17 Vielseitige hydrophile farbstoffe

Country Status (8)

Country Link
US (2) US6939532B2 (de)
EP (1) EP1250095B1 (de)
JP (1) JP2003535041A (de)
AT (1) ATE279147T1 (de)
AU (1) AU2001234467A1 (de)
DE (1) DE60106389T8 (de)
ES (1) ES2231445T3 (de)
WO (1) WO2001052746A1 (de)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7790144B2 (en) * 2000-01-18 2010-09-07 Mallinckrodt Inc. Receptor-avid exogenous optical contrast and therapeutic agents
US6180086B1 (en) * 2000-01-18 2001-01-30 Mallinckrodt Inc. Hydrophilic cyanine dyes
US6939532B2 (en) 2000-01-18 2005-09-06 Mallinckrodt, Inc. Versatile hydrophilic dyes
US20030105299A1 (en) * 2001-10-17 2003-06-05 Mallinckrodt Inc. Carbocyanine dyes for tandem, photodiagnostic and therapeutic applications
US6761878B2 (en) * 2001-10-17 2004-07-13 Mallinckrodt, Inc. Pathological tissue detection and treatment employing targeted benzoindole optical agents
US20030105300A1 (en) * 2001-10-17 2003-06-05 Mallinckrodt Inc. Tumor targeted photodiagnostic-phototherapeutic agents
US20030152577A1 (en) * 2002-02-07 2003-08-14 Mallinckrodt Inc. Dye-bioconjugates for simultaneous optical diagnostic and therapeutic applications
US7226577B2 (en) 2003-01-13 2007-06-05 Bracco Imaging, S. P. A. Gastrin releasing peptide compounds
JP2006522102A (ja) * 2003-03-10 2006-09-28 エムピーエイ・テクノロジーズ・インコーポレイテッド 光診断法および光線力学的療法の両方のためのターゲット剤
US20100022449A1 (en) * 2006-03-09 2010-01-28 Mallinckrodt Inc. Receptor-avid exogenous optical contrast and therapeutic agents
WO2008017074A2 (en) * 2006-08-03 2008-02-07 Beth Israel Deaconess Medical Center, Inc. Dyes and precursors and conjugates thereof
EP2100621A1 (de) 2008-03-10 2009-09-16 mivenion GmbH Polyether-Polyol-Dendron-Konjugate mit Effektormolekülen für biologisches Targeting
WO2010129258A2 (en) 2009-04-27 2010-11-11 Mallinckrodt Inc. Tissue sealant compositions, vascular closure devices, and uses thereof
PT2530093T (pt) 2010-01-28 2018-12-28 Univ Nagoya Nat Univ Corp Composto de indocianina, método de síntese do mesmo, método de purificação do mesmo, composição de diagnóstico utilizando o composto de indocianina, e dispositivo para medição da cinética in vivo e dispositivo para visualização da circulação utilizando a composição de diagnóstico
US10053447B2 (en) 2010-12-21 2018-08-21 Pierce Biotechnology, Inc Fluorescent compounds
US8889884B1 (en) 2011-07-14 2014-11-18 Pierce Biotechnology, Inc. Phosphine derivatives of fluorescent compounds
US9249307B2 (en) 2011-08-16 2016-02-02 Pierce Biotechnology, Inc. Benzocyanine compounds
US9751868B2 (en) 2012-02-28 2017-09-05 Pierce Biotechnology, Inc. Benzocyanine compounds
EP2804860B1 (de) 2012-03-02 2016-06-15 Pierce Biotechnology, Inc. Indol-derivate als markierungsfarbstoff für biomoleküle
WO2014035712A1 (en) 2012-08-28 2014-03-06 Pierce Biotechnology, Inc. Benzopyrylium compounds
US20150073154A1 (en) * 2013-09-11 2015-03-12 Equip, Llc Discrete PEG Based Dyes
US9862682B2 (en) 2016-01-08 2018-01-09 BroadPharm Functionalized pegylated cyanine compounds, pharmaceutical compositions, and methods of use thereof

Family Cites Families (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS59192595A (ja) 1983-04-16 1984-10-31 Tdk Corp 光記録媒体
JPH0729496B2 (ja) 1986-03-07 1995-04-05 三菱レイヨン株式会社 光情報記録媒体
US6406713B1 (en) 1987-03-05 2002-06-18 The Liposome Company, Inc. Methods of preparing low-toxicity drug-lipid complexes
JP3023726B2 (ja) 1991-04-16 2000-03-21 コニカ株式会社 ハロゲン化銀写真感光材料
US5453505A (en) 1994-06-30 1995-09-26 Biometric Imaging, Inc. N-heteroaromatic ion and iminium ion substituted cyanine dyes for use as fluorescence labels
DE4445065A1 (de) 1994-12-07 1996-06-13 Diagnostikforschung Inst Verfahren zur In-vivo-Diagnostik mittels NIR-Strahlung
US5732104A (en) 1994-12-14 1998-03-24 Motorola, Inc. Signalling techniques and device for high speed data transmission over voiceband channels
US5709845A (en) 1996-05-13 1998-01-20 Rajagopalan; Raghavan Tricyclic functional dyes for contrast enhancement in optical imaging
US5672333A (en) 1996-05-13 1997-09-30 Mallinckrodt Medical, Inc. Delta1,6 bicyclo 4,4,0! functional dyes for contrast enhancement in optical imaging
US5723104A (en) 1996-05-13 1998-03-03 Fung; Ella Y. Monocyclic functional dyes for contrast enhancement in optical imaging
DE19649971A1 (de) 1996-11-19 1998-05-28 Diagnostikforschung Inst Optische Diagnostika zur Diagnostik neurodegenerativer Krankheiten mittels Nahinfrarot-Strahlung (NIR-Strahlung)
AUPO598797A0 (en) 1997-04-04 1997-05-01 Decor Corporation Pty Ltd, The Mops
GB9707133D0 (en) 1997-04-08 1997-05-28 Identalink Corp Identity systems
AU753196B2 (en) 1998-02-09 2002-10-10 Bracco Research S.A. Targeted delivery of biologically active media
US6180087B1 (en) 2000-01-18 2001-01-30 Mallinckrodt Inc. Tunable indocyanine dyes for biomedical applications
US6180085B1 (en) 2000-01-18 2001-01-30 Mallinckrodt Inc. Dyes
US6190641B1 (en) 2000-01-18 2001-02-20 Mallinckrodt Inc. Indocyanine dyes
US6180086B1 (en) * 2000-01-18 2001-01-30 Mallinckrodt Inc. Hydrophilic cyanine dyes
US6395257B1 (en) 2000-01-18 2002-05-28 Mallinckrodt Inc. Dendrimer precursor dyes for imaging
US6939532B2 (en) 2000-01-18 2005-09-06 Mallinckrodt, Inc. Versatile hydrophilic dyes
US6183726B1 (en) * 2000-01-18 2001-02-06 Mallinckrodt Inc. Versatile hydrophilic dyes
US6733744B1 (en) * 2000-10-16 2004-05-11 Mallinckrodt Inc. Indole compounds as minimally invasive physiological function monitoring agents
US6485704B1 (en) 2001-05-04 2002-11-26 Mallinckrodt Inc. Azo compound for type I pototherapy
US20030105299A1 (en) 2001-10-17 2003-06-05 Mallinckrodt Inc. Carbocyanine dyes for tandem, photodiagnostic and therapeutic applications

Also Published As

Publication number Publication date
JP2003535041A (ja) 2003-11-25
US7566444B2 (en) 2009-07-28
US20050201939A1 (en) 2005-09-15
ATE279147T1 (de) 2004-10-15
EP1250095A1 (de) 2002-10-23
US20030165432A1 (en) 2003-09-04
WO2001052746A9 (en) 2002-10-31
DE60106389T8 (de) 2006-06-08
EP1250095A4 (de) 2003-05-07
EP1250095B1 (de) 2004-10-13
WO2001052746A1 (en) 2001-07-26
US6939532B2 (en) 2005-09-06
ES2231445T3 (es) 2005-05-16
AU2001234467A1 (en) 2001-07-31
DE60106389T2 (de) 2006-03-09

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